Small molecules, big targets: drug discovery faces the protein–protein interaction challenge

In Vivo Activation of the p53 Pathway by Small-Molecule Antagonists of MDM2

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Selective inhibition of BET bromodomains

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New Substructure Filters for Removal of Pan Assay Interference Compounds (PAINS) from Screening Libraries and for Their Exclusion in Bioassays

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The STRING database in 2011: functional interaction networks of proteins, globally integrated and scored

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ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets

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Principles of protein-protein interactions

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The Future of Peptide‐based Drugs

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Reaching for high-hanging fruit in drug discovery at protein–protein interfaces

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ABT-263: A Potent and Orally Bioavailable Bcl-2 Family Inhibitor

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Anatomy of hot spots in protein interfaces

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Characterization of the Binding of Small Molecules to Intrinsically Disordered Proteins

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Novel macrocyclic bis(Schiff bases) incorporating fused pyrazolo[1,5-a]pyrimidine units: Metal-free synthesis, antibacterial screening, biofilm inhibitory activity, and SAR study

Sanad, S. M. H., Ahmed, A. A. M., & Mekky, A. E. M. (2025) · Journal of Molecular Structure · doi:10.1016/j.molstruc.2025.144647 · Cited by 13

Structural analysis of TrkA mutations in patients with congenital insensitivity to pain reveals PLCγ as an analgesic drug target

de Moraes, B. C., Filho, H. V. R., Roldão, A. P., Toniolo, E. F., Carretero, G., Sgro, G. G., Batista, F. A. H., Berardi, D. E., Oliveira, V. R. D. S., Tomasin, R., et al. (2022) · Science Signaling · doi:10.1126/scisignal.abm6046 · Cited by 13

Chemical Evolution and Biological Evaluation of Natural Products for Efficient Therapy of Acute Lung Injury

Fan, C., Zhang, Z., Lai, Z., Yang, Y., Li, J., Liu, L., Chen, S., Hu, X., Zhao, H., & Cui, S. (2023) · Advanced Science · doi:10.1002/advs.202305432 · Cited by 17

Chemical screening by time-resolved X-ray scattering to discover allosteric probes

Brosey, C. A., Link, T. M., Shen, R., Moiani, D., Burnett, K. H., Hura, G. L., Jones, D. E., & Tainer, J. A. (2024) · Nature Chemical Biology · doi:10.1038/s41589-024-01609-1 · Cited by 13

Structure-based molecular hybridization design and synthesis of Keap1-Nrf2 inhibitors for anti-inflammatory treatment

Qin, X., Hou, R., Qu, Z., Yu, J., Zhang, W., Ma, H., & Zhuang, C. (2025) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2025.108350 · Cited by 14

PPI-Graphomer: enhanced protein-protein affinity prediction using pretrained and graph transformer models

Xie, J., Zhang, Y., Wang, Z., Jin, X., Lü, X., Ge, S., & Min, X. (2025) · BMC Bioinformatics · doi:10.1186/s12859-025-06123-2 · Cited by 15

Transglutaminase-mediated cross-linking of WDR54 regulates EGF receptor-signaling

Maeda, A., Nishino, T., Matsunaga, R., Yokoyama, A., Suga, H., Yagi, T., & Konishi, H. (2018) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2018.11.009 · Cited by 13

Quantitative Proteomics Reveals the Role of Lysine 2‐Hydroxyisobutyrylation Pathway Mediated by Tip60

Wang, N., Jiang, Y., Peng, P., Liu, G., Qi, S., Liu, K., Mei, Q., & Li, J. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/4571319 · Cited by 13

Network Pharmacology-Based Prediction and Verification of Ginsenoside Rh2-Induced Apoptosis of A549 Cells via the PI3K/Akt Pathway

Song, C., Yuan, Y., Zhou, J., He, Z., Hu, Y., Xie, Y., Liu, N., Wu, L., & Zhang, J. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.878937 · Cited by 13

Construction of a Mass-Tagged Oligo Probe Set for Revealing Protein Ratiometric Relationship Associated with EGFR–HER2 Heterodimerization in Living Cells

Li, X., Sun, B., Zhu, J., Qian, M., & Chen, Y. (2022) · Analytical Chemistry · doi:10.1021/acs.analchem.1c04989 · Cited by 13

Adaptor-Specific Antibody Fragment Inhibitors for the Intracellular Modulation of p97 (VCP) Protein–Protein Interactions

Jiang, Z., Kuo, Y.-H., Zhong, M., Zhang, J., Zhou, X. X., Xing, L., Wells, J. A., Wang, Y., & Arkin, M. R. (2022) · Journal of the American Chemical Society · doi:10.1021/jacs.2c03665 · Cited by 13

Construction of a synthetic methodology-based library and its application in identifying a GIT/PIX protein–protein interaction inhibitor

Gu, J., Peng, R.-K., Guo, C., Zhang, M., Yang, J., Yan, X. H., Zhou, Q., Li, H., Wang, N., Zhu, J., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-34598-7 · Cited by 15

Activity-Based Phosphatidylinositol Kinase Probes Detect Changes to Protein–Protein Interactions During Hepatitis C Virus Replication

Desrochers, G. F., Cornacchia, C., McKay, C. S., & Pezacki, J. P. (2018) · ACS Infectious Diseases · doi:10.1021/acsinfecdis.8b00047 · Cited by 13

Structural Optimization of Foldamer-Dendrimer Conjugates as Multivalent Agents against the Toxic Effects of Amyloid Beta Oligomers

Bartus, É., Olajos, G., Schuster, I., Bozsó, Z., Deli, M. A., Veszelka, S., Walter, F. R., Datki, Z., Szakonyi, Z., Martinek, T. A., et al. (2018) · Molecules · doi:10.3390/molecules23102523 · Cited by 12

Drug Design of “Undruggable” Targets

Wang, J., Li, S., & Li, H. (2019) · Chinese Journal of Chemistry · doi:10.1002/cjoc.201800552 · Cited by 13

BA-12 Inhibits Angiogenesis via Glutathione Metabolism Activation

Cui, H., Guo, W., Zhang, B., Li, G., Li, T., Yuan, Y., Zhang, N., Yang, Y., Feng, W., Chu, F., et al. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20164062 · Cited by 13

Analysis of Interactions Stabilized by Fusicoccin A Reveals an Expanded Suite of Potential 14–3–3 Binding Partners

Sengupta, A., Liriano, J., Miller, B. G., & Frederich, J. H. (2020) · ACS Chemical Biology · doi:10.1021/acschembio.9b00795 · Cited by 13

Multistage signal-interactive nanoparticles improve tumor targeting through efficient nanoparticle-cell communications

Zhang, F., Zhang, Y., Kong, L., Luo, H., Zhang, Y., Mäkilä, E. M., Salonen, J., Hirvonen, J. J., Zhu, Y., Cheng, Y., et al. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.109131 · Cited by 13

GM-Pep: A High Efficiency Strategy to De Novo Design Functional Peptide Sequences

Chen, Q., Yang, C., Xie, Y., Wang, Y., Li, X., Wang, K., Huang, J., & Yan, W. (2022) · Journal of Chemical Information and Modeling · doi:10.1021/acs.jcim.2c00089 · Cited by 12

Chemical Proteomics with Novel Fully Functionalized Fragments and Stringent Target Prioritization Identifies the Glutathione-Dependent Isomerase GSTZ1 as a Lung Cancer Target

Liao, Y., Chan, S. C., Welsh, E. A., Fang, B., Sun, L., Schönbrunn, E., Koomen, J. M., Duckett, D. R., Haura, E. B., Monastyrskyi, A., et al. (2023) · ACS Chemical Biology · doi:10.1021/acschembio.2c00587 · Cited by 12

The DarT/DarG Toxin–Antitoxin ADP-Ribosylation System as a Novel Target for a Rational Design of Innovative Antimicrobial Strategies

Catara, G., Caggiano, R., & Palazzo, L. (2023) · Pathogens · doi:10.3390/pathogens12020240 · Cited by 12

The case for complement component 5 as a target in neurodegenerative disease

Stennett, A., Friston, K., Harris, C. L., Wollman, A. J. M., Bronowska, A. K., & Madden, K. S. (2023) · Expert Opinion on Therapeutic Targets · doi:10.1080/14728222.2023.2177532 · Cited by 12

SCARdock: A Web Server and Manually Curated Resource for Discovering Covalent Ligands

Song, Q., Zeng, L., Zheng, Q., & Liu, S. (2023) · ACS Omega · doi:10.1021/acsomega.2c08147 · Cited by 11

Big Data and Artificial Intelligence in Drug Discovery for Gastric Cancer: Current Applications and Future Perspectives

Nguyen, M. H., Tran, N. D., & Le, N. Q. K. (2023) · Current Medicinal Chemistry · doi:10.2174/0929867331666230913105829 · Cited by 10

A novel apoferritin nanocage with ECM promoting, ferroptosis suppressing and inflammation targeting property for osteoarthritis therapy

Deng, Y., Chen, X., Zhang, Z., Zhao, X., Zhu, Z., Wu, C., Chen, Y., Li, C., Sun, L., Zhou, Y., et al. (2024) · Chemical Engineering Journal · doi:10.1016/j.cej.2024.152398 · Cited by 12

Bidirectional linkage of DNA barcodes for the multiplexed mapping of higher-order protein interactions in cells

Liu, Y., Sundah, N. R., Ho, N. R. Y., Shen, W. X., Xu, Y., Natalia, A., Yu, Z., Seet, J. E., Chan, C. W., Loh, T. P., et al. (2024) · Nature Biomedical Engineering · doi:10.1038/s41551-024-01225-3 · Cited by 13

Based on UPLC-Q-TOF/MS and Network Pharmacology to Explore the Mechanism of Qingre Lishi Decoction in the Treatment of Psoriasis

Wei, J., Liu, Z., Li, M., Du, L., Zhu, X., Leng, Y., Han, C., Xu, Q., & Zhang, C. (2024) · Drug Design Development and Therapy · doi:10.2147/dddt.s467066 · Cited by 12

Endocytic highways: Navigating macropinocytosis and other endocytic routes for precision drug delivery

Neupane, R., Malla, S., Karthikeyan, C., Asbhy, C. R., Boddu, S. H. S., Babu, R. J., & Tiwari, A. K. (2025) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2025.125356 · Cited by 12

Water in drug design: pitfalls and good practices

Zsidó, B. Z., & Hetényi, C. (2025) · Expert Opinion on Drug Discovery · doi:10.1080/17460441.2025.2497912 · Cited by 12

Superelectrophilic activation in superacid HF/SbF5: Expanding molecular diversity in nitrogen-containing compounds series by fluorination

Michelet, B., Carreyre, H., Lecornué, F., Martin‐Mingot, A., & Thibaudeau, S. (2018) · Journal of Fluorine Chemistry · doi:10.1016/j.jfluchem.2018.04.017 · Cited by 14

Predicting Protein–Protein Interactions Using Symmetric Logistic Matrix Factorization

Pei, F., Shi, Q., Zhang, H., & Bahar, İ. (2021) · Journal of Chemical Information and Modeling · doi:10.1021/acs.jcim.1c00173 · Cited by 14

Establishment of high-throughput screening HTRF assay for identification small molecule inhibitors of Skp2-Cks1

Hu, K., Li, X., Asmamaw, M. D., Shi, X., & Liu, H. (2021) · Scientific Reports · doi:10.1038/s41598-021-00646-3 · Cited by 12

Effective synthesis of new benzo-fused macrocyclic and heteromacrocyclic bis(Schiff bases)

Ahmed, A. A. M., Mekky, A. E. M., & Sanad, S. M. H. (2021) · Journal of the Iranian Chemical Society · doi:10.1007/s13738-021-02409-3 · Cited by 12

Identifying HSV-1 Inhibitors from Natural Compounds via Virtual Screening Targeting Surface Glycoprotein D

Wu, J., Power, H., Saksena, M. M., Valtchev, P., Schindeler, A., Cunningham, A. L., & Dehghani, F. (2022) · Pharmaceuticals · doi:10.3390/ph15030361 · Cited by 12

Small molecules to regulate the GH/IGF1 axis by inhibiting the growth hormone receptor synthesis

van der Velden, L. M., Maas, P., van Amersfoort, M., Timmermans‐Sprang, E. P. M., Mensinga, A., van der Vaart, E. D., Malergue, F., Viëtor, H. E., Derksen, P. W. B., Klumperman, J., et al. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.926210 · Cited by 12

A Flexible, Modular Platform for Multidimensional Ion Mobility of Native-like Ions

Eaton, R. M., Zercher, B. P., Wageman, A., & Bush, M. F. (2023) · Journal of the American Society for Mass Spectrometry · doi:10.1021/jasms.3c00112 · Cited by 12

A Sensitive, Semi-Quantitative Mammalian Two-Hybrid Assay

Riegel, E., Heimbucher, T., Höfer, T., & Czerny, T. (2017) · BioTechniques · doi:10.2144/000114544 · Cited by 12

Structure-based drug design, synthesis and biological assays of P. falciparum Atg3–Atg8 protein–protein interaction inhibitors

Villa, S., Legnani, L., Colombo, D., Gelain, A., Lammi, C., Bongiorno, D., Ilboudo, D. P., McGee, K., Bosch, J., & Grazioso, G. (2018) · Journal of Computer-Aided Molecular Design · doi:10.1007/s10822-018-0102-5 · Cited by 12

Split-BioID — Proteomic Analysis of Context-specific Protein Complexes in Their Native Cellular Environment

Schopp, I. M., & Béthune, J. (2018) · Journal of Visualized Experiments · doi:10.3791/57479 · Cited by 12

Quantifying the protein–protein association rate in polymer solutions: crowding-induced diffusion and energy modifications

Jing, Q., Chen, A., & Zhao, N. (2018) · Physical Chemistry Chemical Physics · doi:10.1039/c8cp05203d · Cited by 12

A BRET-based assay reveals collagen–Hsp47 interaction dynamics in the endoplasmic reticulum and small-molecule inhibition of this interaction

Ito, S., Saito, M., Yoshida, M., Takeuchi, K., Doi, T., & Nagata, K. (2019) · Journal of Biological Chemistry · doi:10.1074/jbc.ra119.010567 · Cited by 12

Recognition of PDL1/L2 by different induced-fit mechanisms of PD1: a comparative study of molecular dynamics simulations

Lyu, N., Wang, K., Zhang, F., Qin, H.-M., Zhao, Y., Wu, R., Si, Y., & Wang, L. (2019) · Physical Chemistry Chemical Physics · doi:10.1039/c9cp05531b · Cited by 12

Discovery of 5,5′-Methylenedi-2,3-Cresotic Acid as a Potent Inhibitor of the Chemotactic Activity of the HMGB1·CXCL12 Heterocomplex Using Virtual Screening and NMR Validation

Leo, F. D., Quilici, G., Marchis, F. D., Mantonico, M. V., Bianchi, M. E., & Musco, G. (2020) · Frontiers in Chemistry · doi:10.3389/fchem.2020.598710 · Cited by 11

Structural insights into Beclin 1 interactions with it's regulators for autophagy modulation

Sarmadhikari, D., & Asthana, S. (2025) · Computational and Structural Biotechnology Journal · doi:10.1016/j.csbj.2025.06.044 · Cited by 13

A Survey of Mamba

Qu, H., Ning, L., An, R., Fan, W., Derr, T., Liu, H., Xin, X., & Li, Q. (2026) · ACM Transactions on Intelligent Systems and Technology · doi:10.1145/3819582 · Cited by 127

Lysine-Specific Demethylase 1 (LSD1) Inhibitors: Peptides as an Emerging Class of Therapeutics

Baby, S., Shinde, S. D., Kulkarni, N., & Sahu, B. (2023) · ACS Chemical Biology · doi:10.1021/acschembio.3c00386 · Cited by 11

A Tumor‐Specific Cascade‐Activating Smart Prodrug System for Enhanced Targeted Therapy

Wang, Q., Jin, D., Liu, C., Shi, L., & Li, T. (2023) · Small · doi:10.1002/smll.202309482 · Cited by 11

Design of a covalent protein-protein interaction inhibitor of SRPKs to suppress angiogenesis and invasion of cancer cells

Cai, G., Bao, Y., Li, Q., Hsu, P., Xia, J., & Ngo, J. C. K. (2024) · Communications Chemistry · doi:10.1038/s42004-024-01230-2 · Cited by 11

Computer aided design and NMR characterization of an oligopeptide targeting the Ebola virus VP24 protein

Dapiaggi, F., Pieraccini, S., Potenza, D., Vasile, F., Macut, H., Pellegrino, S., Aliverti, A., & Sironi, M. (2017) · New Journal of Chemistry · doi:10.1039/c6nj04014d · Cited by 11

Core-shell assay based aptasensor for sensitive and selective thrombin detection using dark-field microscopy

Yang, R. X., Liu, S., Wu, Z., Tan, Y. C., & Sun, S. (2018) · Talanta · doi:10.1016/j.talanta.2018.01.070 · Cited by 11

A simple fluorescent assay for the discovery of protein-protein interaction inhibitors

Al‐Mugotir, M., Kolar, C., Vance, K. E., Kelly, D. L., Natarajan, A., & Borgstahl, G. E. O. (2019) · Analytical Biochemistry · doi:10.1016/j.ab.2019.01.010 · Cited by 11

Water envelope has a critical impact on the design of protein–protein interaction inhibitors

Ratkova, E. L., Dawidowski, M., Napolitano, V., Dubin, G., Fino, R., Ostertag, M. S., Sattler, M., Popowicz, G. M., & Tetko, I. V. (2020) · Chemical Communications · doi:10.1039/c9cc07714f · Cited by 11

Design and synthesis of a new orthogonally protected glutamic acid analog and its use in the preparation of high affinity polo-like kinase 1 polo-box domain – binding peptide macrocycles

Hymel, D., Tsuji, K., Grant, R. A., Chingle, R. M., Kunciw, D. L., Yaffe, M. B., & Burke, T. R. (2021) · Organic & Biomolecular Chemistry · doi:10.1039/d1ob01120k · Cited by 11

Effective synthesis of new benzo‐fused macrocyclic and thiamacrocyclic dilactams and related pyrazolo‐fused macrocycles

Ahmed, A. A. M., Mekky, A. E. M., & Sanad, S. M. H. (2021) · Journal of Heterocyclic Chemistry · doi:10.1002/jhet.4383 · Cited by 11

Deciphering Regulatory Proteins of Prenylated Protein via the FRET Technique Using Nitroso-Based Ene-Ligation and Sequential Azidation and Click Reaction

Gan, Y., Li, Y., Zhou, H., & Wang, R. (2022) · Organic Letters · doi:10.1021/acs.orglett.2c02662 · Cited by 11

A First-Class Degrader Candidate Targeting Both KRAS G12D and G12V Mediated by CANDDY Technology Independent of Ubiquitination

Miyamoto‐Sato, E., Imanishi, S., Huang, L., Itakura, S., Iwasaki, Y., & Ishizaka, M. (2023) · Molecules · doi:10.3390/molecules28145600 · Cited by 13

Identification and characterization of a novel Sso7d scaffold-based binder against Notch1

Gocha, T., Rao, B. M., & DasGupta, R. (2017) · Scientific Reports · doi:10.1038/s41598-017-12246-1 · Cited by 11

Comparative Proteomic Analysis of the Effect of Periplocoside P from Periploca sepium on Brush Border Membrane Vesicles in Midgut Epithelium of Mythimna separata Larvae

Feng, M., Li, Y., Chen, X., Wei, Q., Wu, W., & Hu, Z. (2017) · Toxins · doi:10.3390/toxins10010007 · Cited by 11

Synthetic fermentation of β-peptide macrocycles by thiadiazole-forming ring-closing reactions

Hubert, J. G., Stepek, I. A., Noda, H., & Bode, J. W. (2018) · Chemical Science · doi:10.1039/c7sc05057g · Cited by 11

Small molecule–based targeting of TTD-A dimerization to control TFIIH transcriptional activity represents a potential strategy for anticancer therapy

Gervais, V., Muller, I., Mari, P., Mourcet, A., Movellan, K. T., Ramos, P., Marcoux, J., Guillet, V., Javaid, S., Burlet‐Schiltz, O., et al. (2018) · Journal of Biological Chemistry · doi:10.1074/jbc.ra118.003444 · Cited by 11

Acylated-acyl carrier protein stabilizes the Pseudomonas aeruginosa WaaP lipopolysaccharide heptose kinase

Kreamer, N. N. K., Chopra, R., Caughlan, R. E., Fabbro, D., Fang, E., Gee, P., Hunt, I., Li, M., Leon, B. C., Muller, L., et al. (2018) · Scientific Reports · doi:10.1038/s41598-018-32379-1 · Cited by 10

Developing RNA Aptamers for Potential Treatment of Neurological Diseases

Huang, Z., & Niu, L. (2019) · Future Medicinal Chemistry · doi:10.4155/fmc-2018-0364 · Cited by 11

Interactions between PHD3-Bromo of MLL1 and H3K4me3 Revealed by Single-Molecule Magnetic Tweezers in a Parallel DNA Circuit

Ma, X., Zhu, M., Liu, J., Li, X., Qu, L., Liang, L., Huang, W., Wang, J., Li, N., Chen, J., et al. (2019) · Bioconjugate Chemistry · doi:10.1021/acs.bioconjchem.9b00665 · Cited by 11

Generalized–ensemble method study: A helix‐mimetic compound inhibits protein–protein interaction by long‐range and short‐range intermolecular interactions

Higo, J., Takashima, H., Fukunishi, Y., & Yoshimori, A. (2021) · Journal of Computational Chemistry · doi:10.1002/jcc.26516 · Cited by 11

Spontaneously Restoring Specific Bioaffinity of RGD in Linear RGD-containing Peptides by Conjugation with Zwitterionic Dendrimers

Xu, L., Xu, N., Wang, L., Qian, H., Li, Y., Fang, M., Xiang, Z., Lin, W., Zhang, F., Shao, Q., et al. (2022) · Acta Biomaterialia · doi:10.1016/j.actbio.2022.06.025 · Cited by 10

WNK Signaling Inhibitors as Potential Antihypertensive Drugs

Alamri, M. A., Kadri, H., Dhiani, B. A., Mahmood, S., Elzwawi, A., & Mehellou, Y. (2017) · ChemMedChem · doi:10.1002/cmdc.201700425 · Cited by 11

Transfer factor I: methods of therapy.

Levin, A. S., S̄pitler, L. E., & Fudenberg, H. H. (1975) · PubMed · Cited by 11

Unleashing the power of DNA-encoded libraries for challenging targets in drug discovery

Du, N., Li, Y., Lou, Q., Zhang, G., Li, Y., & Li, Y. (2026) · Pharmaceutical Science Advances · doi:10.1016/j.pscia.2026.100115 · Cited by 10

Inhibition of the Ubiquitin Transfer Cascade by a Peptidomimetic Foldamer Mimicking the E2 N-Terminal Helix

Zhou, L., Jeong, I. H., Xue, S., Xue, M., Wang, L., Li, S., Liu, R., Jeong, G. H., Wang, X., Cai, J., et al. (2022) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.2c01459 · Cited by 10

Homo cerevisiae—Leveraging Yeast for Investigating Protein–Protein Interactions and Their Role in Human Disease

Laval, F., Coppin, G., Twizere, J., & Vidal, M. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24119179 · Cited by 10

A novel universal small-molecule detection platform based on antibody-controlled Cas12a switching

Sun, T., Wang, W., Wang, F., Shen, W., Geng, L., Zhang, Y., Bi, M., Gong, T., Liu, C., Guo, C., et al. (2023) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2023.115897 · Cited by 10

Investigation of protein-protein interactions and hotspot region on the NSP7-NSP8 binding site in NSP12 of SARS-CoV-2

Neto, J. X., Bezerra, K. S., Barbosa, E. D., Araujo, R. L., Galvao, D. S., Lyra, M. L., Oliveira, J. I. N., Akash, S., Jardan, Y. A. B., Nafidi, H., et al. (2024) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2023.1325588 · Cited by 11

Nonsymmetrically Substituted 1,1′-Biphenyl-Based Small Molecule Inhibitors of the PD-1/PD-L1 Interaction

Hec, A., Tyrcha, U., Barczyński, J., Bielski, P., Mikitiuk, M., Gudz, G. P., Kitel, R., Musielak, B., Plewka, J., Sitar, T., et al. (2024) · ACS Medicinal Chemistry Letters · doi:10.1021/acsmedchemlett.4c00042 · Cited by 11

Understanding β-strand mediated protein–protein interactions: tuning binding behaviour of intrinsically disordered sequences by backbone modification

Cawood, E. E., Baker, E. G., Edwards, T. A., Woolfson, D. N., Karamanos, T. K., & Wilson, A. J. (2024) · Chemical Science · doi:10.1039/d4sc02240h · Cited by 10

DNA-modulated dimerization and oligomerization of cell membrane receptors

Ali, A. A., & You, M. (2024) · Chemical Communications · doi:10.1039/d4cc03077j · Cited by 10

TBL2 Promotes Tumorigenesis via PRMT5/WDR77‐Mediated AKT Activation in Breast Cancer

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Fragment‐Based Drug Discovery of Novel High‐affinity, Selective, and Anti‐inflammatory Inhibitors of the Keap1‐Nrf2 Protein‐Protein Interaction

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