Small molecules, big targets: drug discovery faces the protein–protein interaction challenge

Scott, Duncan E., Bayly, Andrew R., Abell, Chris, Skidmore, John·2016·Nature Reviews Drug Discovery

Cited by (1,001)

Items 401–500 of 1,001

  1. Robust principal component analysis‐based prediction of protein‐protein interaction hot spots
    Divya Sitani, Alejandro Giorgetti, Mercedes Alfonso‐Prieto, Paolo Carloni · 2021 · Proteins Structure Function and Bioinformatics
  2. Query-guided protein–protein interaction inhibitor discovery
    Sergio Celis, Fruzsina Hóbor, Thomas James, Gail J. Bartlett, Amaurys Ávila Ibarra, Deborah K. Shoemark, Zsófia Hegedüs, Kristina Hetherington, Derek N. Woolfson, Richard Barry Sessions et al. · 2021 · Chemical Science
  3. Targeting protein conformations with small molecules to control protein complexes
    Emmanouil Zacharioudakis, Evripidis Gavathiotis · 2022 · Trends in Biochemical Sciences
  4. Estrogen Receptor-α Targeting: PROTACs, SNIPERs, Peptide-PROTACs, Antibody Conjugated PROTACs and SNIPERs
    Arvind Negi, K. Kesari, A. Voisin‐Chiret · 2022 · Pharmaceutics
  5. Machine learning in computational modelling of membrane protein sequences and structures: From methodologies to applications
    Jianfeng Sun, Arulsamy Kulandaisamy, Jacklyn Liu, Kai Hu, M. Michael Gromiha, Yuan Zhang · 2023 · Computational and Structural Biotechnology Journal
  6. Identification of inhibitors targeting the energy-coupling factor (ECF) transporters
    Eleonora Diamanti, Paulo C. T. Souza, Inda Setyawati, Spyridon Bousis, Leticia Monjas, Lotteke J. Y. M. Swier, Atanaz Shams, Aleksei Tsarenko, Weronika K. Stanek, Manuel Jäger et al. · 2023 · Communications Biology
  7. Cyclic peptides discriminate BCL-2 and its clinical mutants from BCL-XL by engaging a single-residue discrepancy
    Fengwei Li, Jun-Jie Liu, Chao Liu, Ziyan Liu, Xiangda Peng, Yinyue Huang, Xiaoyu Chen, Xiangnan Sun, Sen Wang, Wei Chen et al. · 2024 · Nature Communications
  8. Development of small molecule drugs targeting immune checkpoints
    Luoyi Chen, Xinchen Zhao, Xiaowei Liu, Yujie Ouyang, Chuan Shan Xu, Ying Kang Shi · 2024 · Cancer Biology and Medicine
  9. Cross-Talk between Alternatively Spliced UGT1A Isoforms and Colon Cancer Cell Metabolism
    Yannick Audet-Delage, Michèle Rouleau, Mélanie Rouleau, Joannie Roberge, Stéphanie Miard, Frédéric Picard, Bernard Têtu, Chantal Guillemette · 2017 · Molecular Pharmacology
  10. Identification of the Molecular Mechanisms of Peimine in the Treatment of Cough Using Computational Target Fishing
    Lihua Zhang, Mingchao Cui, Shaojun Chen · 2020 · Molecules
  11. Activity‐Directed Synthesis of Inhibitors of the p53/ h DM2 Protein–Protein Interaction
    Adam I. Green, Fruzsina Hóbor, Christopher P. Tinworth, Stuart L. Warriner, Andrew John Wilson, Adam S. Nelson · 2020 · Chemistry - A European Journal
  12. GATA-targeted compounds modulate cardiac subtype cell differentiation in dual reporter stem cell line
    Mika J. Välimäki, Robert S. Leigh, Sini M. Kinnunen, Alexander R. March, Ana Hernández de Sande, Matias Kinnunen, Markku T Varjosalo, Merja Heinäniemi, Bogac L. Kaynak, Heikki J Ruskoaho · 2021 · Stem Cell Research & Therapy
  13. Interaction Analysis on the SARS-CoV-2 Spike Protein Receptor Binding Domain Using Visualization of the Interfacial Electrostatic Complementarity
    Takeshi Ishikawa, Hiroki Ozono, Kazuki Akisawa, Ryo Hatada, Koji Okuwaki, Yuji Mochizuki · 2021 · The Journal of Physical Chemistry Letters
  14. Development of peptide aptamers as alternatives for antibody in the detection of amyloid-beta 42 aggregates
    Sang‐Heon Kim, Eun-Hye Lee, Sang‐Choon Lee, A-Ru Kim, Hyun‐Hee Park, Jeong‐Woo Son, Seong‐Ho Koh, Moon‐Young Yoon · 2020 · Analytical Biochemistry
  15. Protein arginine methylation in transcription and epigenetic regulation
    Hoang Quoc Hai Pham, Xiaoqun Tao, Yanzhong Yang · 2023 · Frontiers in Epigenetics and Epigenomics
  16. RNA-Targeting Techniques: A Comparative Analysis of Modern Approaches for RNA Manipulation in Cancer Research and Therapeutics
    Michaela A. Boti, Marios A. Diamantopoulos, Andreas Scorilas · 2025 · Genes
  17. Predicting small molecule–RNA interactions without RNA tertiary structures
    Fei-YuHan, Pengfei Wang, Jiasheng Zhang, Xinyue Shan, Zilin Cai, Jianbo Ma, Yangming Wang, Qiangfeng Cliff Zhang · 2026 · Nature Biotechnology
  18. Hybrid MoS2/g-C3N4-assisted LDI mass spectrometry for rapid detection of small molecules and polyethylene glycols and direct determination of uric acid in complicated biological samples
    Yuanxia Lv, Xiao-Huan Qin, Kun Hu, Yong Xiang Huang, Shulin Zhao · 2021 · Microchimica Acta
  19. Inhibition of Amyloid Protein Aggregation Using Selected Peptidomimetics
    Debabrata Maity · 2022 · ChemMedChem
  20. Leveraging Advanced In Silico Techniques in Early Drug Discovery: A Study of Potent Small-Molecule YAP-TEAD PPI Disruptors
    Ernest Awoonor‐Williams, Callum J. Dickson, Pascal Furet, Andrei A. Golosov, Viktor Horn̆ák · 2023 · Journal of Chemical Information and Modeling
  21. Coupling of surface plasmon resonance and mass spectrometry for molecular interaction studies in drug discovery
    Yuandi Zhao, Darya Hadavi, Ingrid Dijkgraaf, Maarten Honing · 2024 · Drug Discovery Today
  22. Current status of nucleic acid therapy and its new progress in cancer treatment
    Wenting Lou, Leqi Zhang, Jianwei Wang · 2024 · International Immunopharmacology
  23. Reversible and Versatile On-Tether Modification of Chiral-Center-Induced Helical Peptides
    Kuan Hu, Chengjie Sun, Zigang Li · 2017 · Bioconjugate Chemistry
  24. High-Throughput Chemical Probing of Full-Length Protein–Protein Interactions
    James M. Song, Arya Menon, Dylan Charles Mitchell, Oleta T. Johnson, Amanda L. Garner · 2017 · ACS Combinatorial Science
  25. Histidine N(τ)-cyclized macrocycles as a new genre of polo-like kinase 1 polo-box domain-binding inhibitors
    David Hymel, Robert A. Grant, Kohei Tsuji, Michael B. Yaffe, Terrence R. Burke · 2018 · Bioorganic & Medicinal Chemistry Letters
  26. Investigation of Hot Spot Region in XIAP Inhibitor Binding Site by Fragment Molecular Orbital Method
    Hocheol Lim, Xuemei Jin, Jongwan Kim, Sungbo Hwang, Ki Beom Shin, Jiwon Choi, Ky-Youb Nam, Kyoung Tai No · 2019 · Computational and Structural Biotechnology Journal
  27. Quantitative Lysine Reactivity Profiling Reveals Conformational Inhibition Dynamics and Potency of Aurora A Kinase Inhibitors
    Jin Chen, Anhui Wang, Bing Liu, Ye Zhou, Pan Luo, Zhichao Zhang, Guohui Li, Quentin Liu, Fangjun Wang · 2019 · Analytical Chemistry
  28. Computational approaches for identifying potential inhibitors on targeting protein interactions in drug discovery
    Vishnupriya Kanakaveti, Shanmugam Anusuya, C. V. Ramakrishnan, P. Anoosha, Ramasamy Sakthivel, Suresh Kumar Rayala, M. Michael Gromiha · 2020 · Advances in protein chemistry and structural biology
  29. Complexation with a Cognate Antibody Fragment Facilitates Affinity Measurements of Fluorescein-Linked Small Molecule Ligands
    Marco Catalano, Sebastian Oehler, Luca Prati, Nicholas Favalli, Gabriele Bassi, Jörg Scheuermann, Dario Neri · 2020 · Analytical Chemistry
  30. In silico identification of small molecule modulators for disruption of Hsp90–Cdc37 protein–protein interaction interface for cancer therapeutic application
    Prajakta Prakash Dike, Shovonlal Bhowmick, Gaber E. Eldesoky, Saikh Mohammad Wabaidur, Preeti Chunarkar Patil, Md Ataul Islam · 2020 · Journal of Biomolecular Structure and Dynamics
  31. TRPM8-Rap1A Interaction Sites as Critical Determinants for Adhesion and Migration of Prostate and Other Epithelial Cancer Cells
    Giorgia Chinigò, Guillaume Paul Grolez, Madelaine Magalì Audero, Alexandre Bokhobza, Michela Bernardini, Julien Cicero, Robert‐Alain Toillon, Quentin Bailleul, Luca Visentin, Federico Alessandro Ruffinatti et al. · 2022 · Cancers
  32. Mimicking Intermolecular Interactions of Tight Protein–Protein Complexes for Small‐Molecule Antagonists
    David Daqiang Xu, Khuchtumur Bum‐Erdene, Yubing Si, Donghui Zhou, Mona K. Ghozayel, Samy O. Meroueh · 2017 · ChemMedChem
  33. MaSS‐Simulator: A Highly Configurable Simulator for Generating MS/MS Datasets for Benchmarking of Proteomics Algorithms
    Muaaz Gul Awan, Fahad Saeed · 2018 · PROTEOMICS
  34. Rational Modulator Design By Exploitation of protein–protein Complex Structures
    Kanin Wichapong, Hessel Poelman, Bogac Ercig, Johana Hrdinová, Xiaosong Liu, Esther Lutgens, Gerry A. F. Nicolaes · 2019 · Future Medicinal Chemistry
  35. At The Interface: Small-Molecule Inhibitors of Soluble Cytokines
    Raavi, Angela N. Koehler, Arturo J. Vegas · 2025 · Chemical Reviews
  36. Destabilization of the human RED–SMU1 splicing complex as a basis for host-directed antiinfluenza strategy
    Usama Ashraf, Laura Tengo, Laurent Le Corre, Guillaume Fournier, Patricia Busca, Andrew A. McCarthy, Marie‐Anne Rameix‐Welti, Christine Gravier‐Pelletier, Rob W. H. Ruigrok, Yves Jacob et al. · 2019 · Proceedings of the National Academy of Sciences
  37. Structures of the SARS-CoV-2 spike glycoprotein and applications for novel drug development
    Xiao-Huan Liu, Ting Cheng, Baoyu Liu, Jia Chi, Ting Shu, Tao Wang · 2022 · Frontiers in Pharmacology
  38. Antimicrobial peptides with cell-penetrating activity as prophylactic and treatment drugs
    Gabriel del Rio, Mario A. Trejo Perez, Carlos A. Brizuela · 2022 · Bioscience Reports
  39. Forces Driving a Magic Bullet to Its Target: Revisiting the Role of Thermodynamics in Drug Design, Development, and Optimization
    Conceição A.S.A. Minetti, David P. Remeta · 2022 · Life
  40. DeepPRObind: Modular Deep Learner that Accurately Predicts Structure and Disorder-Annotated Protein Binding Residues
    Fuhao Zhang, Min Li, Jian Zhang, Wenbo Shi, Lukasz Kurgan · 2023 · Journal of Molecular Biology
  41. Selected Approaches to Disrupting Protein–Protein Interactions within the MAPK/RAS Pathway
    Stephen J. Harwood, Christopher R. Smith, J. David Lawson, John M. Ketcham · 2023 · International Journal of Molecular Sciences
  42. Cyclobutane-bearing restricted anchoring residues enabled geometry-specific hydrocarbon peptide stapling
    Baobao Chen, Chao Liu, Wei Cong, Fei Gao, Yan Zou, Li Su, Lei Liu, Alexander Hillisch, Lutz Eric Lehmann, Donald E. Bierer et al. · 2023 · Chemical Science
  43. Two halogenated coplanar Schiff base complexes: Insights into the impact of halogen substitution on intermolecular interactions via theoretical calculations
    Liang Jiao, Meifen Huang, Jiajun Xu, Qiuling Yang, Qiong Wu · 2024 · Journal of Molecular Structure
  44. Activity-Based DNA-Encoded Library Screening for Selective Inhibitors of Eukaryotic Translation
    Huda Barhoosh, Anjali Dixit, Wesley G. Cochrane, Valerie J. Cavett, Robin N. Prince, Brooke O. Blair, Fred R. Ward, Kim F. McClure, Phillip A. Patten, Margot G. Paulick et al. · 2024 · ACS Central Science
  45. Natural products used as a chemical library for protein–protein interaction targeted drug discovery
    Xuemei Jin, Kyungro Lee, Nam Hee Kim, Hyun Sil Kim, Jong In Yook, Jiwon Choi, Kyoung Tai No · 2017 · Journal of Molecular Graphics and Modelling
  46. Synthetic Evaluation of Standard and Microwave-Assisted Solid Phase Peptide Synthesis of a Long Chimeric Peptide Derived from Four Plasmodium falciparum Proteins
    Yahson Varela, Magnolia Vanegas, Manuel Elkin Patarroyo · 2018 · Molecules
  47. Dendrimers as Competitors of Protein–Protein Interactions of the Intrinsically Disordered Nuclear Chromatin Protein NUPR1
    José L. Neira, Juan Correa, Bruno Rizzuti, Patricia Santofimia‐Castaño, Olga Abián, Adrián Velázquez‐Campoy, Eduardo Fernández-Megía, Juan Iovanna · 2019 · Biomacromolecules
  48. Discovery of novel nonpeptide small-molecule NRP1 antagonists: Virtual screening, molecular simulation and structural modification
    Kewen Peng, Yu Li, Ying Bai, Teng Jiang, Huiyong Sun, Qihua Zhu, Yungen Xu · 2019 · Bioorganic & Medicinal Chemistry
  49. Ligand-activated BRET9 imaging for measuring protein–protein interactions in living mice
    Sung Bae Kim, Rika Fujii, Arutselvan Natarajan, Tarik F. Massoud, Ramasamy Paulmurugan · 2019 · Chemical Communications
  50. Noncellular screening for the discovery of protein–protein interaction modulators
    Charline Kieffer, Jean‐Pierre Jourdan, Marie Jouanne, Anne Sophie Voisin‐Chiret · 2020 · Drug Discovery Today
  51. Design of Drug‐Like Protein–Protein Interaction Stabilizers Guided By Chelation‐Controlled Bioactive Conformation Stabilization
    Francesco Bosica, Sebastian A. Andrei, João Filipe Neves, Peter Brandt, Anders Gunnarsson, Isabelle Landrieu, Christian Ottmann, Gavin O’Mahony · 2020 · Desy Publications Database (Deutsches Elektronen-Synchrotron DESY)
  52. A cell-based screening method using an intracellular antibody for discovering small molecules targeting the translocation protein LMO2
    Nicolas Béry, Carole J. R. Bataille, Angela J. Russell, Angela Hayes, Florence I. Raynaud, Sabine Milhas, Sneha Anand, Hanna Tulmin, Ami Miller, Terence Howard Rabbitts · 2021 · Science Advances
  53. Pharmaceutical therapeutics for articular regeneration and restoration: state-of-the-art technology for screening small molecular drugs
    Yishan Chen, Heng Sun, Xudong Yao, Yeke Yu, Tian Tian, Weiyang Xu, Yujie Zhou, Hongwei Ouyang · 2021 · Cellular and Molecular Life Sciences
  54. Serotonergic drugs modulate the phase behavior of complex lipid bilayers.
    Guzel S. Musabirova, Oskar Engberg, Ankur Gupta, Debsankar Saha Roy, S. Maiti, D. Huster · 2022 · Biochimie
  55. Machine Learning Models to Predict Protein–Protein Interaction Inhibitors
    Bárbara I. Díaz‐Eufracio, José L. Medina‐Franco · 2022 · Molecules
  56. Divergent Protein Synthesis of Bowman–Birk Protease Inhibitors, their Hydrodynamic Behavior and Co-crystallization with α-Chymotrypsin
    Christian Wenzel Tornøe, Eva Johansson, Per‐Olof Wahlund · 2017 · Synlett
  57. A Computational Investigation of Small-Molecule Engagement of Hot Spots at Protein–Protein Interaction Interfaces
    David Daqiang Xu, Yubing Si, Samy O. Meroueh · 2017 · Journal of Chemical Information and Modeling
  58. Oral aktive Peptide: Gibt es ein Patentrezept?
    Andreas F. B. Räder, Michael Weinmüller, Florian Reichart, Adi Schumacher‐Klinger, Shira Merzbach, Chaim Gilon, Amnon Hoffman, Horst Kessler · 2018 · Angewandte Chemie
  59. Biophysical Screens Identify Fragments That Bind to the Viral DNA-Binding Proteins EBNA1 and LANA
    Troy E. Messick, Lois Tolvinski, Edward R. Zartler, Anna Moberg, Åsa Frostell, Garry R. Smith, Allen B. Reitz, Paul M. Lieberman · 2020 · Molecules
  60. 1,5-Disubstituted 1,2,3-triazoles: Molecular scaffolds for medicinal chemistry and biomolecular mimetics
    Kunj B. Mishra · 2025 · European Journal of Medicinal Chemistry
  61. Evaluating ligand docking methods for drugging protein–protein interfaces: insights from AlphaFold2 and molecular dynamics refinement
    Jordi Gómez Borrego, Marc Torrent · 2025 · Journal of Cheminformatics
  62. Thiophene‐2,3‐Dialdehyde Enables Chemoselective Cyclization on Unprotected Peptides, Proteins, and Phage Displayed Peptides
    Tongyao Wei, Dongfang Li, Yue Zhang, Yubo Tang, Haiyan Zhou, Han Liu, Xuechen Li · 2022 · Small Methods
  63. Research progress on intranasal treatment for Parkinson's disease
    Puyuan Wen, Chao Ren · 2024 · Neuroprotection/Neuroprotection (Chichester, England. Print)
  64. Structure-activity relationships of middle-size cyclic peptides, KRAS inhibitors derived from an mRNA display
    Mirai Kage, Ryuji Hayashi, Atsushi Matsuo, Minoru Tamiya, Shino Kuramoto, Kazuhiro Ohara, Machiko Irie, Aya Chiyoda, Koji Takano, Toshiya Ito et al. · 2024 · Bioorganic & Medicinal Chemistry
  65. Latest Advances Towards Ras Inhibition: A Medicinal Chemistry Perspective
    Brice Sautier, Carl Friedrich Nising, Lars Wortmann · 2016 · Angewandte Chemie International Edition
  66. Combination of SAXS and Protein Painting Discloses the Three-Dimensional Organization of the Bacterial Cysteine Synthase Complex, a Potential Target for Enhancers of Antibiotic Action
    Brenda Rosa, Marialaura Marchetti, Gianluca Paredi, Heinz Wilfried Amenitsch, Nina Franko, Roberto Benoni, Barbara Giabbai, Maria Giovanna De Marino, Andrea Mozzarelli, Luca Ronda et al. · 2019 · International Journal of Molecular Sciences
  67. Stapled Peptides as HIF‐1α/p300 Inhibitors: Helicity Enhancement in the Bound State Increases Inhibitory Potency
    Kristina Hetherington, Zsófia Hegedüs, Thomas A. Edwards, Richard Barry Sessions, Adam S. Nelson, Andrew John Wilson · 2020 · Chemistry - A European Journal
  68. In silico derived small molecules targeting the finger-finger interaction between the histone lysine methyltransferase NSD1 and Nizp1 repressor
    Andrea Berardi, Michela Ghitti, Giacomo Quilici, Giovanna Musco · 2020 · Computational and Structural Biotechnology Journal
  69. IAP-1 promoted cisplatin resistance in nasopharyngeal carcinoma via inhibition of caspase-3-mediated apoptosis.
    Xiangwan Miao, Zeyi Deng, Siqi Wang, Huanhuan Weng, Xinting Zhang, Hai-Liang Li, Huifen Xie, Juan Zhang, Ying Zhong, Bohui Zhang et al. · 2021 · PubMed Central
  70. Computational design of stapled peptide inhibitor against SARS‐CoV ‐2 receptor binding domain
    Asha Rani Choudhury, Atanu Maity, Sayantani Chakraborty, Rajarshi Chakrabarti · 2022 · Peptide Science
  71. Challenges and frontiers of computational modelling of biomolecular recognition
    Jinan Wang, Apurba Bhattarai, Hung Nguyen Do, Yinglong Miao · 2022 · QRB Discovery
  72. Design, Synthesis, and Evaluation of Novel Immunomodulatory Small Molecules Targeting the CD40–CD154 Costimulatory Protein-Protein Interaction
    Damir Bojadzic, Jinshui Chen, Oscar Alcazar, Péter Buchwald · 2018 · Molecules
  73. Design, in silico prioritization and biological profiling of apoptosis-inducing lactams amenable by the Castagnoli-Cushman reaction
    Mikhail Krasavin, Maxim Gureev, Dmitry Viktorovich Dar’in, Olga Bakulina, Maria Chizhova, Anastasia Lepikhina, Daria Novikova, Tatyana A. Grigoreva, Gleb S. Ivanov, Aisulu Zhumagalieva et al. · 2018 · Bioorganic & Medicinal Chemistry
  74. Design of indole- and MCR-based macrocycles as p53-MDM2 antagonists
    Constantinos G. Neochoritis, Maryam Kazemi Miraki, Eman M. M. Abdelraheem, Ewa Surmiak, Tryfon Zarganes‐Tzitzikas, Beata Łabuzek, Tad A. Holak, Alexander S. S. Dömling · 2019 · Beilstein Journal of Organic Chemistry
  75. Emerging Roles of Downstream of Kinase 3 in Cell Signaling
    Jia Tong Loh, Joey Kay Hui Teo, Hong Hwa Lim, Kong‐Peng Lam · 2020 · Frontiers in Immunology
  76. Small-Angle X-ray Scattering Data in Combination with RosettaDock Improves the Docking Energy Landscape
    Pernille Sønderby, Åsmund Rinnan, Jesper J. Madsen, Pernille Harris, Jens T. Bukrinski, Günther Herbert Johannes Peters · 2017 · Journal of Chemical Information and Modeling
  77. Machine learning and deep learning in clinical practice: Advancing neurodegenerative disease diagnosis with multimodal markers
    Omid Zarei, Maryam Talebi moghaddam, Sadegh Moradi Vastegani · 2025 · Brain Research Bulletin
  78. Rotavirus Viroplasm Biogenesis Involves Microtubule-Based Dynein Transport Mediated by an Interaction between NSP2 and Dynein Intermediate Chain
    Zhaoyang Jing, Hongyan Shi, Jianfei Chen, Da Shi, Jianbo Liu, Longjun Guo, Jin Tian, Yang Wu, Hui Dong, Zhaoyang Ji et al. · 2021 · Journal of Virology
  79. Induction of open-form bile canaliculus formation by hepatocytes for evaluation of biliary drug excretion
    Hiroshi Arakawa, Yuya Nakazono, Natsumi Matsuoka, Momoka Hayashi, Yoshiyuki Shirasaka, Atsushi Hirao, Ikumi Tamai · 2023 · Communications Biology
  80. Addressing Challenges of Macrocyclic Conformational Sampling in Polar and Apolar Solvents: Lessons for Chameleonicity
    Xuechen Tang, Janik Kokot, Franz Waibl, Monica L. Fernández‐Quintero, Anna Sophia Kamenik, Klaus Roman Liedl · 2023 · Journal of Chemical Information and Modeling
  81. Nanoplasmonic Affinity Analysis System for Molecular Screening Based on Bright‐Field Imaging
    Mingqian Chen, Hongli Fan, Wen Li, Jingyan Ruan, Yihui Yang, Cuixuan Mao, Rui Li, Gang Logan Liu, Wenjun Hu · 2024 · Advanced Functional Materials
  82. Stapled peptides: targeting protein-protein interactions in drug development
    Qian Zhang, Ziyang Wang, Xiaohan Mei, Quan Chen, Chunqiu Zhang · 2024 · Exploration of Drug Science
  83. Systematic computational strategies for identifying protein targets and lead discovery
    Arti Kataria, Ankit Srivastava, Desh Deepak Singh, Shafiul Haque, Ihn Han, Dharmendra Kumar Yadav · 2024 · RSC Medicinal Chemistry
  84. Fragment-Based Interrogation of the 14–3–3/TAZ Protein–Protein Interaction
    Blaž Andlovic, Dario Valenti, Federica Centorrino, Francesca Picarazzi, Stanimira Hristeva, Malgorzata Hiltmann, Alexander Wolf, François‐Xavier Cantrelle, Mattia Mori, Isabelle Landrieu et al. · 2024 · Biochemistry
  85. CHIRAL, FLUORINE-CONTAINING PHARMACEUTICALS
    Jianlin Han, Alicja Wzorek, Gagan Dhawan, Wei Zhang, Alexander E. Sorochinsky, Daniel Baecker, Taizo Ono, Karel Douglas Klika, Vadim A. Soloshonok · 2025 · Ukrainian Chemistry Journal
  86. Magnetic silica nanoparticles for use in matrix-assisted laser desorption ionization mass spectrometry of labile biomolecules such as oligosaccharides, amino acids, peptides and nucleosides
    Hongmei Yang, Rui Su, John S. Wishnok, Ning Liu, Changbao Chen, Shuying Liu, Steven R. Tannenbaum · 2019 · Microchimica Acta
  87. Sequential Delivery and Cascade Targeting of Peptide Therapeutics for Triplexed Synergistic Therapy with Real-Time Monitoring Shuttled by Magnetic Gold Nanostars
    RONG TSUN WU, Qianhao Min, Jingjing Guo, Tingting Zheng, Liping Jiang, Jun‐Jie Zhu · 2019 · Analytical Chemistry
  88. Multi-targeting protein-protein interaction inhibitors: Evolution of macrocyclic ligands with embedded carbohydrates (MECs) to improve selectivity
    Arvind Negi, C Reilly, Dilip V. Jarikote, Jian Er Zhou, Paul V. Murphy · 2019 · European Journal of Medicinal Chemistry
  89. Explore Protein–Protein Interactions for Cancer Target Discovery Using the OncoPPi Portal
    Andrei A. Ivanov · 2019 · Methods in molecular biology
  90. Swinhopeptolides A and B: Cyclic Depsipeptides from the Sponge Theonella swinhoei That Inhibit Ras/Raf Interaction
    Chang‐Kwon Kim, Dongdong Wang, Heidi Rose Bokesch, Richard W. Fuller, Emily A. Smith, Curtis J. Henrich, David Durrant, Deborah K. Morrison, Carole A. Bewley, Kirk R. Gustafson · 2020 · Journal of Natural Products
  91. Variable‐Length Ester‐Based Staples for α‐Helical Peptides by Using A Double Thiol‐ene Reaction
    Danielle L. Paterson, Jack U. Flanagan, Peter Robin Shepherd, Paul W. R. Harris, Margaret Anne Brimble · 2020 · Chemistry - A European Journal
  92. A Hybrid Deep Learning Model for Protein–Protein Interactions Extraction from Biomedical Literature
    Changqin Quan, Zhiwei Luo, Song Wang · 2020 · Applied Sciences
  93. Single-Chain Lanthanide Luminescence Biosensors for Cell-Based Imaging and Screening of Protein-Protein Interactions
    Ting Chen, Ha T. T. Pham, Ali Mohamadi, Lawrence W. Miller · 2020 · iScience
  94. Prognostic Roles of N6-Methyladenosine METTL3 in Different Cancers: A System Review and Meta-Analysis
    Kuangzheng Liu, Yue Gao, Kai Gan, Yuqing Wu, Bin Xu, Lihua Zhang, Ming Chen · 2021 · Cancer Control
  95. Immunoassay of Small Molecule Mediated by a Triply Functional DNA
    Yapiao Li, Fangzhi Yu, Shaokun Chen, Ning Zhang, Hailin Wang, Qiang Zhao · 2021 · Analytical Chemistry
  96. Identification and Validation of New Interleukin-2 Ligands Using DNA-Encoded Libraries
    Adrián Gironda-Martínez, Émile M. D. Gorre, Luca Prati, Jean-François Gosalbes, Sheila Dakhel Plaza, Samuele Cazzamalli, Florent Samain, Etienne J. Donckèle, Dario Neri · 2021 · Journal of Medicinal Chemistry
  97. Fragment-based exploration of the 14-3-3/Amot-p130 interface
    Federica Centorrino, Blaž Andlovic, Peter J. Cossar, Luc Brunsveld, Christian Ottmann · 2021 · Current Research in Structural Biology
  98. Guest Binding Drives Host Redistribution in Libraries of CoII4L4 Cages
    Marion Kieffer, Rana A. Bilbeisi, John D. Thoburn, Jack Kay Clegg, Jonathan R. Nitschke · 2020 · Angewandte Chemie
  99. A robust protein language model for SARS-CoV-2 protein–protein interaction network prediction
    Zeynep Banu Özger · 2023 · Artificial Intelligence in Medicine
  100. Structure‐Guided Design of Peptides as Tools to Probe the Protein–Protein Interaction between Cullin‐2 and Elongin BC Substrate Adaptor in Cullin RING E3 Ubiquitin Ligases
    Teresa A.F. Cardote, Alessio Ciulli · 2017 · ChemMedChem