The DOI matches its Crossref record; 313 of the 313 references it cites were found in a registry or an index.
Mitochondria as a therapeutic target for common pathologies
Open accessAbstract
Although the development of mitochondrial therapies has largely focused on diseases caused by mutations in mitochondrial DNA or in nuclear genes encoding mitochondrial proteins, it has been found that mitochondrial dysfunction also contributes to the pathology of many common disorders, including neurodegeneration, metabolic disease, heart failure, ischaemia–reperfusion injury and protozoal infections. Mitochondria therefore represent an important drug target for these highly prevalent diseases. Several strategies aimed at therapeutically restoring mitochondrial function are emerging, and a small number of agents have entered clinical trials. This Review discusses the opportunities and challenges faced for the further development of mitochondrial pharmacology for common pathologies.
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Citations
Cites
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Brain energy rescue: an emerging therapeutic concept for neurodegenerative disorders of ageing
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Self-citationBenefits of Metformin in Attenuating the Hallmarks of Aging
Kulkarni, A. S., Gubbi, S., & Barzilai, N. (2020) · Cell Metabolism · doi:10.1016/j.cmet.2020.04.001 · Cited by 766
Mitochondrial Dysfunction and Oxidative Stress in Alzheimer’s Disease
Misrani, A., Tabassum, S., & Yang, L. (2021) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2021.617588 · Cited by 654
Mitochondrial Sirtuin 3: New emerging biological function and therapeutic target
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Mitochondrial Diseases: Hope for the Future
Russell, O. M., Gorman, G. S., Lightowlers, R. N., & Turnbull, D. M. (2020) · Cell · doi:10.1016/j.cell.2020.02.051 · Cited by 459
Metadata
- Authors
- Murphy, M. P., & Hartley, R. C.
- Venue
- Nature Reviews Drug Discovery
- Published
- 2018-11-05
- Volume
- 17
- Issue
- 12
- Pages
- 865-886
- ISSN
- 1474-1776 (ISSN-L)
- 1474-1784
- OpenAlex
- W2899241243
- Cited by
- 827
- References
- 313
- FWCI
- 5.78
- Type
- journal article
- Language
- en
- Open access
- green
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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