The DOI matches its Crossref record; 167 of the 167 references it cites were found in a registry or an index.
New drugs for asthma
Open accessAbstract
Current therapy for asthma with inhaled corticosteroids and long-acting inhaled β(2)-agonists is highly effective, safe, and relatively inexpensive, but many patients remain poorly controlled. Most advances have been through improving these drug classes and a major developmental hurdle is to improve existing drug classes. Major unmet needs include better treatment of severe asthma (which has some similarity to chronic obstructive pulmonary disease), as well as curative therapies for mild to moderate asthma that do not result in the return of symptoms when the treatment is stopped. Several new treatments are in development, but many are specific, targeting a single mediator or receptor, and are unlikely to have a major clinical impact, although they may be effective in specific asthma phenotypes (endotypes). Drugs with more widespread effects, such as kinase inhibitors, may be more effective but have a greater risk of side effects so inhaled delivery may be needed. Several new treatments target the underlying allergic/immune process and would treat concomitant allergic diseases. Improved immunotherapy approaches have the potential for disease modification, although prospects for a cure are currently remote.
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Cites
1 retracted
Adcock, I. M., Nasuhara, Y., Stevens, D. A., & Barnes, P. J. (1999) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0702613 · Cited by 118
Self-citationRetractedInterleukin-13: Central Mediator of Allergic Asthma
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The Biology of Chemokines and their Receptors
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Functional antagonism between oncoprotein c-Jun and the glucocorticoid receptor
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p38 MAP kinases: key signalling molecules as therapeutic targets for inflammatory diseases
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INTERLEUKIN-1 RECEPTOR ANTAGONIST: Role in Biology
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Regular inhaled beta-agonist treatment in bronchial asthma
Sears, M. R., Taylor, D. R., Print, C. G., Lake, D. C., Li, Q., Flannery, E. M., Yates, D. M., Lucas, M. K., & Herbison, G. P. (1990) · The Lancet · doi:10.1016/0140-6736(90)93098-a · Cited by 1,065
Cited by
After asthma: redefining airways diseases
Pavord, I. D., Beasley, R., Agusti, A., Anderson, G. P., Bel, E., Brusselle, G., Cullinan, P., Custovic, A., Ducharme, F. M., Fahy, J. V., et al. (2018) · The Lancet · doi:10.1016/s0140-6736(17)30879-6 · Cited by 1,073
Phosphodiesterases in the CNS: targets for drug development
Menniti, F. S., Faraci, W. S., & Schmidt, C. J. (2006) · Nature Reviews Drug Discovery · doi:10.1038/nrd2058 · Cited by 391
Pathophysiology of allergic inflammation
Barnes, P. J. (2011) · Immunological Reviews · doi:10.1111/j.1600-065x.2011.01020.x · Cited by 361
Self-citationErin, E. M., Zacharasiewicz, A. S., Nicholson, G. C., Tan, A. J., Higgins, L. A., Williams, T. J., Murdoch, R. D., Durham, S. R., Barnes, P. J., & Hansel, T. T. (2005) · Clinical & Experimental Allergy · doi:10.1111/j.1365-2222.2005.02381.x · Cited by 76
Self-citation
Metadata
- Authors
- Barnes, P. J.
- Venue
- Nature Reviews Drug Discovery
- Published
- 2004-10
- Volume
- 3
- Issue
- 10
- Pages
- 831-844
- ISSN
- 1474-1776 (ISSN-L)
- 1474-1784
- OpenAlex
- W283814565
- Cited by
- 280
- References
- 167
- FWCI
- 0.43
- Type
- journal article
- Language
- en
- Open access
- bronze
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
