Molecular aspects of circadian pharmacology and relevance for cancer chronotherapy

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mCRY1 and mCRY2 are essential components of the negative limb of the circadian clock feedback loop

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Mammalian Cry1 and Cry2 are essential for maintenance of circadian rhythms

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Positional Cloning of the Mouse Circadian Gene

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Interacting molecular loops in the mammalian circadian clock

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Induction of phase I, II and III drug metabolism/transport by xenobiotics

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Abl Protein-Tyrosine Kinase Inhibitor STI571 Inhibits In Vitro Signal Transduction Mediated by c-Kit and Platelet-Derived Growth Factor Receptors

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The Circadian Gene Period2 Plays an Important Role in Tumor Suppression and DNA Damage Response In Vivo

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Control Mechanism of the Circadian Clock for Timing of Cell Division in Vivo

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Nuclear Receptor Expression Links the Circadian Clock to Metabolism

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The Meter of Metabolism

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p53 in the DNA–Damage–Repair Process

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The basic-helix–loop–helix-PAS orphan MOP3 forms transcriptionally active complexes with circadian and hypoxia factors

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Circadian Cycling of the Mouse Liver Transcriptome, as Revealed by cDNA Microarray, Is Driven by the Suprachiasmatic Nucleus

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Thymidylate synthase gene and protein expression correlate and are associated with response to 5-fluorouracil in human colorectal and gastric tumors.

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System-Driven and Oscillator-Dependent Circadian Transcription in Mice with a Conditionally Active Liver Clock

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Circadian Rhythms: Mechanisms and Therapeutic Implications

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A CLOCK Polymorphism Associated with Human Diurnal Preference

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Delayed Sleep Phase Syndrome

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The circadian PAR-domain basic leucine zipper transcription factors DBP, TEF, and HLF modulate basal and inducible xenobiotic detoxification

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Circadian Timing in Cancer Treatments

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Induction of Drug Metabolism: The Role of Nuclear Receptors

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Relationship between dihydropyrimidine dehydrogenase activity and plasma 5-fluorouracil levels with evidence for circadian variation of enzyme activity and plasma drug levels in cancer patients receiving 5-fluorouracil by protracted continuous infusion.

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Marked 24-h rest/activity rhythms are associated with better quality of life, better response, and longer survival in patients with metastatic colorectal cancer and good performance status.

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Modeling of a Human Circadian Mutation Yields Insights into Clock Regulation by PER2

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Differential effects of PER2 phosphorylation: molecular basis for the human familial advanced sleep phase syndrome (FASPS)Preprint

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The mammalian circadian timing system: from gene expression to physiology

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Circadian Expression of Clock Genes in Human Oral Mucosa and Skin

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Differential Association of Circadian Genes with Mood Disorders: CRY1 and NPAS2 are Associated with Unipolar Major Depression and CLOCK and VIP with Bipolar Disorder

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Systems Chronotherapeutics

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Understanding, recognizing, and managing toxicities of targeted anticancer therapies

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Circadian clock genes and sleep homeostasis

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Circadian transcription of the cholesterol 7 alpha hydroxylase gene may involve the liver-enriched bZIP protein DBP.Preprint

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Dosing-Time Makes the Poison: Circadian Regulation and Pharmacotherapy

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Cell cycle regulation of human WEE1.

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Association study of eight circadian genes with bipolar I disorder, schizoaffective disorder and schizophrenia

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Chronobiology, drug delivery, and chronotherapeutics

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Effects of Blocking Platelet-Derived Growth Factor-Receptor Signaling in a Mouse Model of Experimental Prostate Cancer Bone Metastases

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Circadian molecular clocks and cancer

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Circadian sensitivity to the chemotherapeutic agent cyclophosphamide depends on the functional status of the CLOCK/BMAL1 transactivation complex

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CYCLOPS reveals human transcriptional rhythms in health and disease

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The circadian clock in cancer development and therapy

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Chronopharmacology: New Insights and Therapeutic Implications

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Immunological quantitation of thymidylate synthase using the monoclonal antibody TS 106 in 5-fluorouracil-sensitive and -resistant human cancer cell lines.

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The role of circadian clock genes in mental disorders

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A molecular mechanism regulating circadian expression of vascular endothelial growth factor in tumor cells.

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The circadian timing system in clinical oncology

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Circadian Rhythm Abnormalities

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Cellular Circadian Clocks in Mood Disorders

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Implications of circadian clocks for the rhythmic delivery of cancer therapeutics

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Circadian Expression Profiles of Drug-Processing Genes and Transcription Factors in Mouse Liver

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Circadian Variation in the Expression of Cell-Cycle Proteins in Human Oral Epithelium

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Circadian clocks: genes, sleep, and cognition

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Circadian Clock, Cancer, and Chemotherapy

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Circadian Expression of the Steroid 15 α-Hydroxylase (Cyp2a4) and Coumarin 7-Hydroxylase (Cyp2a5) Genes in Mouse Liver Is Regulated by the PAR Leucine Zipper Transcription Factor DBP

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Circadian regulation of cell cycle and apoptosis proteins in mouse bone marrow and tumor

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Rat liver cholesterol 7 alpha-hydroxylase. Pretranslational regulation for circadian rhythm.

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Conversion to resection of liver metastases from colorectal cancer with hepatic artery infusion of combined chemotherapy and systemic cetuximab in multicenter trial OPTILIV

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Overexpression of the Circadian Clock Gene Bmal1 Increases Sensitivity to Oxaliplatin in Colorectal Cancer

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A length polymorphism in the circadian clock gene Per3 influences age at onset of bipolar disorder

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Machine Learning Helps Identify CHRONO as a Circadian Clock Component

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Chronotherapeutic strategy: Rhythm monitoring, manipulation and disruption☆

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Sex moderates circadian chemotherapy effects on survival of patients with metastatic colorectal cancer: a meta-analysis

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Neurobiology of Circadian Systems

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A Missense Variation in Human Casein Kinase I Epsilon Gene that Induces Functional Alteration and Shows an Inverse Association with Circadian Rhythm Sleep Disorders

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Glutathione S-transferase P1 (GSTP1) directly influences platinum drug chemosensitivity in ovarian tumour cell lines

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Targeting cell cycle regulators in hematologic malignancies

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Circadian Clock-Controlled Intestinal Expression of the Multidrug-Resistance Gene mdr1a in Mice

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Topoisomerase I inhibition in colorectal cancer: biomarkers and therapeutic targets

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Sex Differences in the Circadian Variation of Cytochrome P450 Genes and Corresponding Nuclear Receptors in Mouse Liver

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Circadian clock coordinates cancer cell cycle progression, thymidylate synthase, and 5-fluorouracil therapeutic index

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Nuclear receptors rock around the clock

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The role of circadian timing system on drug metabolism and detoxification

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The Role of Clock Genes in Pharmacology

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Improved Tumor Control through Circadian Clock Induction by Seliciclib, a Cyclin-Dependent Kinase Inhibitor

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Circadian repressors CRY1 and CRY2 broadly interact with nuclear receptors and modulate transcriptional activity

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Circadian rhythms and clock genes in psychotic disorders.

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The Role of Checkpoint Kinase 1 in Sensitivity to Topoisomerase I Poisons

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