The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.
Genomic-scale prioritization of drug targets: the TDR Targets database
Open accessAbstract
The increasing availability of genomic data for pathogens that cause tropical diseases has created new opportunities for drug discovery and development. However, if the potential of such data is to be fully exploited, the data must be effectively integrated and be easy to interrogate. Here, we discuss the development of the TDR Targets database (http://tdrtargets.org), which encompasses extensive genetic, biochemical and pharmacological data related to tropical disease pathogens, as well as computationally predicted druggability for potential targets and compound desirability information. By allowing the integration and weighting of this information, this database aims to facilitate the identification and prioritization of candidate drug targets for pathogens.
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How many drug targets are there?
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Metadata
- Authors
- Agüero, F., Al-Lazikani, B., Aslett, M., Berriman, M., Buckner, F. S., Campbell, R. K., Carmona, S., Carruthers, I. M., Chan, A. W. E., Chen, F., Crowther, G. J., Doyle, M. A., Hertz-Fowler, C., Hopkins, A. L., McAllister, G., Nwaka, S., Overington, J. P., Pain, A., Paolini, G. V., Pieper, U., Ralph, S. A., Riechers, A., Roos, D. S., Sali, A., Shanmugam, D., Suzuki, T., Van Voorhis, W. C., & Verlinde, C. L. M. J.
- Venue
- Nature Reviews Drug Discovery
- Published
- 2008-10-17
- Volume
- 7
- Issue
- 11
- Pages
- 900-907
- ISSN
- 1474-1776 (ISSN-L)
- 1474-1784
- OpenAlex
- W1995498227
- Cited by
- 306
- References
- 27
- FWCI
- 2.83
- Type
- journal article
- Language
- en
- Open access
- green
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- Agüero, F., Al-Lazikani, B., Aslett, M., Berriman, M., Buckner, F. S., Campbell, R. K., Carmona, S., Carruthers, I. M., Chan, A. W. E., Chen, F., Crowther, G. J., Doyle, M. A., Hertz-Fowler, C., Hopkins, A. L., McAllister, G., Nwaka, S., Overington, J. P., Pain, A., Paolini, G. V., . . . Verlinde, C. L. M. J. (2008). Genomic-scale prioritization of drug targets: the TDR Targets database. Nature Reviews Drug Discovery. https://doi.org/10.1038/nrd2684
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
