Trends in the exploitation of novel drug targets

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Items 201–300 of 872

1. Structural and Functional View of Polypharmacology
   Aurelio A. Moya‐García, Tolulope Tosin Adeyelu, Felix Alexander Krüger, Natalie L. Dawson, Jonathan Lees, John P. Overington, Christine Anne Orengo, Juan A. G. Ranea · 2017 · Scientific Reports
2. Specific interactions of peripheral membrane proteins with lipids: what can molecular simulations show us?
   Andreas Haahr Larsen, Laura John, Mark S.P. Sansom, Robin Adam Corey · 2022 · Bioscience Reports
3. Emergence of mass spectrometry detergents for membrane proteomics
   Jan‐Simon Behnke, Leonhard Hagen Urner · 2023 · Analytical and Bioanalytical Chemistry
4. PACAP receptor pharmacology and agonist bias: analysis in primary neurons and glia from the trigeminal ganglia and transfected cells
   Christopher S. Walker, Tahlia Sundrum, Debbie L. Hay · 2013 · British Journal of Pharmacology
5. Quantifying biased signaling in GPCRs using BRET-based biosensors
   Yoon Namkung, Olivier Radresa, Sylvain Armando, Dominic Devost, Alexandre Beautrait, Christian Le Gouill, Stéphane A. Laporte · 2015 · Methods
6. Drug‐Mediated Regulation of Glycosaminoglycan Biosynthesis
   Giancarlo Ghiselli · 2016 · Medicinal Research Reviews
7. A novel framework for the identification of drug target proteins: Combining stacked auto-encoders with a biased support vector machine
   Qi Wang, Yanghe Feng, Jincai Huang, Tengjiao Wang, Guangquan Cheng · 2017 · PLoS ONE
8. Allosteric targeted drug delivery for enhanced blood-brain barrier penetration via mimicking transmembrane domain interactions
   Kaicheng Tang, Zhongjie Tang, Miaomiao Niu, Zuyin Kuang, Weiwei Xue, Xinyu Wang, Xinlong Liu, Yang Yu, Seong Dong Jeong, Yifan Ma et al. · 2025 · Nature Communications
9. Analytical techniques and methods for study of drug-lipid membrane interactions
   Hewen Li, Tao Zhao, Zhihua Sun · 2017 · Reviews in Analytical Chemistry
10. A2A and A2B adenosine receptors: The extracellular loop 2 determines high (A2A) or low affinity (A2B) for adenosine
    Elisabetta De Filippo, Sonja Hinz, Veronica Pellizzari, Giuseppe Deganutti, Ali El‐Tayeb, Gemma Navarro, Rafael Franco, Stefano Moro, Anke C. Schiedel, Christa Elisabeth Müller · 2019 · Biochemical Pharmacology
11. Target-Directed Approaches for Screening Small Molecules against RNA Targets
    Hafeez S. Haniff, Laurent Knerr, Jonathan L. Chen, Matthew David Disney, Helen Louise Lightfoot · 2020 · SLAS DISCOVERY
12. Druggability predictions: methods, limitations, and applications
    Xavier Barril · 2012 · Wiley Interdisciplinary Reviews Computational Molecular Science
13. Quantifying the impact of transporters on cellular drug permeability
    Pär Matsson, Luca A. Fenu, Patrik Lundquist, Jacek R. Wiśniewski, Manfred Kansy, Per Artursson · 2015 · Trends in Pharmacological Sciences
14. A ‐kinase anchoring proteins: cAMP compartmentalization in neurodegenerative and obstructive pulmonary diseases
    Wilfred Jelco Poppinga, Pablo Muñoz-LLancao, Christian Enrique González-Billault, Martina Schmidt · 2014 · British Journal of Pharmacology
15. Defining the gene repertoire and spatiotemporal expression profiles of adhesion G protein-coupled receptors in zebrafish
    Breanne L. Harty, Arunkumar Krishnan, Nicholas Sanchez, Helgi B. Schiöth, Kelly R. Monk · 2015 · BMC Genomics
16. Bacterial transformation: ComFA is a DNA‐dependent ATPase that forms complexes with ComFC and DprA
    Amy Diallo, Hannah R. Foster, Katarzyna A. Gromek, Thomas N. Perry, Annick Dujeancourt-Henry, Petya Violinova Krasteva, Francesca Gubellini, Tanya G. Falbel, Briana M. Burton, Rémi Fronzes · 2017 · Molecular Microbiology
17. Hepatic Monoacylglycerol O-acyltransferase 1 as a Promising Therapeutic Target for Steatosis, Obesity, and Type 2 Diabetes
    Yasuhiro Hayashi, Erina Suemitsu, Kazuaki Kajimoto, Yusuke Sato, Afsana Akhter, Yu Sakurai, Hiroto Hatakeyama, Mamoru Hyodo, Noritada Kaji, Yoshinobu Baba et al. · 2014 · Molecular Therapy — Nucleic Acids
18. GPR88 in A2AR Neurons Enhances Anxiety-Like Behaviors
    Aura Carole Meirsman, Anne Robé, Alban de Kerchove d’Exaerde, Brigitte Lina Kieffer · 2016 · eNeuro
19. Metabolically re-modeling the drug pipeline
    Matthew Oberhardt, Keren Yizhak, Eytan Ruppin · 2013 · Current Opinion in Pharmacology
20. Comparing the Chemical Structure and Protein Content of ChEMBL, DrugBank, Human Metabolome Database and the Therapeutic Target Database
    Christopher Southan, Markus Sitzmann, Sorel Mureşan · 2013 · Molecular Informatics
21. Identifying Druggable Targets by Protein Microenvironments Matching: Application to Transcription Factors
    Tianyun Liu, Russ Biagio Altman · 2014 · CPT Pharmacometrics & Systems Pharmacology
22. Smart polymer brush nanostructures guide the self-assembly of pore-spanning lipid bilayers with integrated membrane proteins
    G. Wilhelmina de Groot, Sophie F. Demarche, Maria Gabriella Santonicola, Louis Tiefenauer, Gyula Julius Vancso · 2013 · Nanoscale
23. Hijacking GPCRs by viral pathogens and tumor
    Junjie Zhang, Hao Feng, Simin Xu, Pinghui Feng · 2016 · Biochemical Pharmacology
24. Deuteration and selective labeling of alanine methyl groups of β2-adrenergic receptor expressed in a baculovirus-insect cell expression system
    Yutaka Kofuku, Tomoki Yokomizo, Shunsuke Imai, Yutaro Shiraishi, Mei Natsume, Hiroaki Itoh, Masayuki Inoue, Kunio Nakata, Shunsuke Igarashi, Hideyuki Yamaguchi et al. · 2018 · Journal of Biomolecular NMR
25. Recent advances in metallodrug-like molecules targeting non-coding RNAs in cancer chemotherapy
    Farukh Arjmand, Zeenat Afsan, Surbhi Sharma, Sabiha Parveen, Imtiyaz Yousuf, Sara Sartaj, Hifzur Rahman Siddique, Sartaj Tabassum · 2019 · Coordination Chemistry Reviews
26. Flavonoids enhance rod opsin stability, folding, and self-association by directly binding to ligand-free opsin and modulating its conformation
    Joseph T. Ortega, Tanu Parmar, Beata Jastrzębska · 2019 · Journal of Biological Chemistry
27. Beyond detergent micelles: The advantages and applications of non-micellar and lipid-based membrane mimetics for solution-state NMR
    Kai Klöpfer, Franz Hagn · 2019 · Progress in Nuclear Magnetic Resonance Spectroscopy
28. Artificial intelligence and machine-learning approaches in structure and ligand-based discovery of drugs affecting central nervous system
    Vertika Gautam, Anand Gaurav, Neeraj Masand, Vannajan Sanghiran Lee, Vaishali Manikrao Patil · 2022 · Molecular Diversity
29. The expanding repertoire of receptor activity modifying protein (RAMP) function
    Klara Rachel Klein, Brooke C. Matson, Kathleen M. Caron · 2016 · Critical Reviews in Biochemistry and Molecular Biology
30. Precise assembly of inside-out cell membrane camouflaged nanoparticles via bioorthogonal reactions for improving drug leads capturing
    Xiaolin Zhang, Xueyan Zhen, Yixuan Yang, Quan Feng, Wanqing Yuan, Xiaoyu Xie · 2022 · Acta Pharmaceutica Sinica B
31. Troubleshooting and deconvoluting label-free cell phenotypic assays in drug discovery
    Fang Ye · 2013 · Journal of Pharmacological and Toxicological Methods
32. The Orphan Receptor GPR17 Is Unresponsive to Uracil Nucleotides and Cysteinyl Leukotrienes
    Katharina Simon, Nicole Merten, Ralf Jürgen Schröder, Stephanie Hennen, Philip Preis, Nina-Katharina Schmitt, Lucas Peters, Ramona Schrage, Céline Vermeiren, Michel R. Gillard et al. · 2017 · Molecular Pharmacology
33. Islet G-protein coupled receptors: therapeutic potential for diabetes
    Shanta Jean Persaud · 2017 · Current Opinion in Pharmacology
34. mRNA–miRNA bipartite network reconstruction to predict prognostic module biomarkers in colorectal cancer stage differentiation
    Habib MotieGhader, Morteza P Kouhsar, Ali Najafi, Balal Sadeghı, Ali Masoudi‐Nejad · 2017 · Molecular BioSystems
35. Structural biology and structure–function relationships of membrane proteins
    Rosana I. Reis, Isabel Moraes · 2018 · Biochemical Society Transactions
36. Detergent-free extraction of a functional low-expressing GPCR from a human cell line
    Juan F. Bada Juarez, Juan Carlos Muñoz-García, Rosana I. Reis, Alistair J. Henry, David McMillan, Marco Kriek, Martyn D. Wood, Catherine Vandenplas, Zara A. Sands, Luis Castro et al. · 2019 · Biochimica et Biophysica Acta (BBA) - Biomembranes
37. Activation of the Orphan G Protein–Coupled Receptor GPR27 by Surrogate Ligands Promotes β-Arrestin 2 Recruitment
    Nadine Dupuis, Céline Laschet, Delphine Franssen, Martyna Szpakowska, Julie Gilissen, Pierre Geubelle, Arvind Soni, Anne‐Simone Parent, Bernard Pirotte, Andy Chevigné et al. · 2017 · Molecular Pharmacology
38. G protein-coupled receptor GPR160 is associated with apoptosis and cell cycle arrest of prostate cancer cells
    Caihong Zhou, Xinchuan Dai, Yi Chen, Yanyan Shen, Saifei Lei, Ting Xiao, Tamás Bartfai, Jian Ding, Ming‐Wei Wang · 2016 · Oncotarget
39. Melting Point Distribution Analysis of Globally Approved and Discontinued Drugs: A Research for Improving the Chance of Success of Drug Design and Discovery
    Fei Mao, Qingya Kong, Wei Min NI, Xiang Xu, Dazheng Ling, Zhengyu Lu, Jian Li · 2016 · ChemistryOpen
40. RNAi-mediated silencing of MLL-AF9 reveals leukemia-associated downstream targets and processes
    Katrin Fleischmann, Philipp Pagel, Irene Schmid, Adelbert Anton Roscher · 2014 · Molecular Cancer
41. Orphan Receptor GPR88 as an Emerging Neurotherapeutic Target
    Na Ye, Bang Li, Qi Mao, Eric A. Wold, Sheng Tian, John Allen, Jia Zhou · 2018 · ACS Chemical Neuroscience
42. Comparison of The Quantification of A Therapeutic Protein Using Nominal And Accurate Mass MS/MS
    Robert S. Plumb, Gordon Fujimoto, Joanne Mather, Warren B. Potts, Paul D. Rainville, Nicholas Ellor, Christopher A. Evans, Jonathan R. Kehler, Matthew E. Szapacs · 2012 · Bioanalysis
43. Gene expression and network-based analysis reveals a novel role for hsa-miR-9 and drug control over the p38 network in glioblastoma multiforme progression
    Rotem Ben‐Hamo, Sol Efroni · 2011 · Genome Medicine
44. Pepducins and Other Lipidated Peptides as Mechanistic Probes and Therapeutics
    Ping Zhang, Lidija Covic, Athan Kuliopulos · 2015 · Methods in molecular biology
45. Marine-derived protein kinase inhibitors for neuroinflammatory diseases
    Chong Ning, Huimin Wang, Rong Gao, Yu‐Chia Chang, Fengqing Hu, Xianjun Meng, Shiying Huang · 2018 · BioMedical Engineering OnLine
46. In Silico Target Prediction for Small Molecules
    Ryan Byrne, Gisbert Schneider · 2018 · Methods in molecular biology
47. The Convergence of Stem Cell Technologies and Phenotypic Drug Discovery
    Alexandra Friese, Andrei Ursu, Andreas Hochheimer, Hans Robert Schöler, Herbert Waldmann, Jan M. Bruder · 2019 · Cell chemical biology
48. Moving targets in drug discovery
    Barbara Zdrazil, Lars Richter, Nathan Brown, Rajarshi Guha · 2020 · Scientific Reports
49. The fall and rise of pharmacology – (Re-)defining the discipline?
    Raymond J. Winquist, Kevin Mullane, Michael J. Williams · 2013 · Biochemical Pharmacology
50. Remarkable similarities between the hemichordate (Saccoglossus kowalevskii) and vertebrate GPCR repertoire
    Arunkumar Krishnan, Markus Sällman Almén, Robert Fredriksson, Helgi Birgir Schiöth · 2013 · Gene
51. Model-Based Discovery of Synthetic Agonists for the Zn2+-Sensing G-Protein-Coupled Receptor 39 (GPR39) Reveals Novel Biological Functions
    Thomas M. Frimurer, Franziska Mende, Anne-Sofie Graae, Maja Storm Engelstoft, Kristoffer Lihme Egerod, Rie Nygaard, Lars‐Ole Gerlach, Jakob Bondo Hansen, Thue Walter Schwartz, Birgitte Holst · 2017 · Journal of Medicinal Chemistry
52. Relating Essential Proteins to Drug Side-Effects Using Canonical Component Analysis: A Structure-Based Approach
    Tianyun Liu, Russ Biagio Altman · 2015 · Journal of Chemical Information and Modeling
53. Genome-Scale Screening of Drug-Target Associations Relevant to Ki Using a Chemogenomics Approach
    Dongsheng Cao, Yi‐Zeng Liang, Zhe Deng, Qian‐Nan Hu, Min He, Qing‐Song Xu, Guanghua Zhou, Liu‐Xia Zhang, Zixin Deng, Shao Liu · 2013 · PLoS ONE
54. Comprehensive analysis of the numbers, lengths and amino acid compositions of transmembrane helices in prokaryotic, eukaryotic and viral integral membrane proteins of high-resolution structure
    Massoud Saidijam, Sonia Azizpour, Simon G. Patching · 2017 · Journal of Biomolecular Structure and Dynamics
55. Direct and indirect approaches to identify drug modes of action
    L.B. Tulloch, Stefanie K. Menzies, Ross P. Coron, Matthew D. Roberts, Gordon J. Florence, Terry Smith · 2017 · IUBMB Life
56. The orphan GPR50 receptor promotes constitutive TGFβ receptor signaling and protects against cancer development
    Stéfanie Wojciech, Raise Ahmad, Zakia Belaid, Anne‐Sophie Journé, Sarah Gallet, Julie Dam, Avais M. Daulat, Delphine Ndiaye‐Lobry, Olivier Lahuna, Angeliki Karamitri et al. · 2018 · Nature Communications
57. Three-Dimensional Cell Cultures in Drug Discovery and Development
    Fang Ye, Richard M. Eglen · 2017 · SLAS DISCOVERY
58. Human Transporter Database: Comprehensive Knowledge and Discovery Tools in the Human Transporter Genes
    Adam Yongxin Ye, Qing‐Rong Liu, Chuan‐Yun Li, Min Zhao, Hong Qu · 2014 · PLoS ONE
59. Reconstitution of Human Ion Channels into Solvent-free Lipid Bilayers Enhanced by Centrifugal Forces
    Ayumi Hirano‐Iwata, Yutaka Ishinari, Miyu Yoshida, Shun Araki, Daisuke Tadaki, Ryusuke Miyata, Kenichi Ishibashi, Hideaki Yamamoto, Yasuo N. Kimura, Michio Niwano · 2016 · Biophysical Journal
60. Universality of the Sodium Ion Binding Mechanism in Class A G‐Protein‐Coupled Receptors
    Balaji Selvam, Zahra Shamsi, Diwakar Shukla · 2018 · Angewandte Chemie
61. Sensing Small Molecule Interactions with Lipid Membranes by Local pH Modulation
    Da Huang, Tao Zhao, Wei Xu, Tinglu Yang, Paul S. Cremer · 2013 · Analytical Chemistry
62. Probing the Complex Binding Modes of the PPARγ Partial Agonist 2-Chloro-N-(3-chloro-4-((5-chlorobenzo[d]thiazol-2-yl)thio)phenyl)-4-(trifluoromethyl)benzenesulfonamide (T2384) to Orthosteric and Allosteric Sites with NMR Spectroscopy
    Tudor Hughes, Jinsai Shang, Richard Brust, Ian Mitchelle S. de Vera, Jakob Fuhrmann, Claudia H. Ruiz, Michael D. Cameron, Theodore M. Kamenecka, Douglas J. Kojetin · 2016 · Journal of Medicinal Chemistry
63. Mapping in vivo signal transduction defects by phosphoproteomics
    Taras Stasyk, Lukas Alfons Huber · 2011 · Trends in Molecular Medicine
64. Prognostic value of epithelial-mesenchymal transition markers in clear cell renal cell carcinoma
    Hua Xu, Wenhao Xu, Fei Ren, Jun Wang, Hongkai Wang, Dalong Cao, Guohai Shi, Yuan-Yuan Qu, Hai‐Liang Zhang, Dingwei Ye · 2020 · Aging
65. Rationalizing the Optimization of Detergents for Membrane Protein Purification
    Leonhard Hagen Urner, Florian Junge, Francesco Fiorentino, Tarick J. El‐Baba, Denis Shutin, Gideon Nölte, Rainer Haag, Carol V. Robinson · 2023 · Chemistry - A European Journal
66. Direct Selection of DNA-Encoded Libraries for Biased Agonists of GPCRs on Live Cells
    Bo Cai, Amal El Daibani, Yuntian Brian Bai, Tao Che, Casey J. Krusemark · 2023 · JACS Au
67. Recent developments of topoisomerase inhibitors: Clinical trials, emerging indications, novel molecules and global sales
    Andrey D. Bondarev, Jörgen Jonsson, Vladimir N. Chubarev, Vadim V. Tarasov, Francisco Alejandro Lagunas‐Rangel, Helgi B. Schiöth · 2024 · Pharmacological Research
68. Computational Profiling of Bioactive Compounds Using a Target-Dependent Composite Workflow
    Jamel Eddine Meslamani, Ricky Bhajun, François Martz, Didier Rognan · 2013 · Journal of Chemical Information and Modeling
69. GPR37 promotes cancer growth by binding to CDK6 and represents a new theranostic target in lung adenocarcinoma
    Xiaona Xie, Xueding Cai, Feng Zhou, Yaozhe Li, Qianzi Liu, Luqiong Cai, Wenjing Zhu, Jinqiu Wei, Chenying Jin, Zitian Liu et al. · 2022 · Pharmacological Research
70. Bioportides: Bioactive cell‐penetrating peptides that modulate cellular dynamics
    Monika Lukanowska, John Howl, Sarah Jones · 2013 · Biotechnology Journal
71. Open innovation in early drug discovery: roadmaps and roadblocks
    Melvin Reichman, Peter B. Simpson · 2015 · Drug Discovery Today
72. Role of protein dynamics in transmembrane receptor signalling
    Yong Wang, Katrine Bugge, Birthe Brandt Kragelund, Kresten Lindorff‐Larsen · 2017 · Current Opinion in Structural Biology
73. Prediction of individualized therapeutic vulnerabilities in cancer from genomic profiles
    Bülent Arman Aksoy, Emek Demir, Özgün Babur, Weiqing Wang, Xiaohong Jing, Nikolaus D. Schultz, Chris Sander · 2014 · Bioinformatics
74. 5′-Substituted Amiloride Derivatives as Allosteric Modulators Binding in the Sodium Ion Pocket of the Adenosine A2AReceptor
    Arnault Massink, Julien Louvel, Ilze Adlere, Corine van Veen, Berend J. H. Huisman, Gabrielle S. Dijksteel, Dong Ming Guo, Eelke Bart Lenselink, Benjamin J. Buckley, Hayden Matthews et al. · 2016 · Journal of Medicinal Chemistry
75. Spatiotemporal diversification of intrapatient genomic clones and early drug development concepts realize the roadmap of precision cancer medicine
    Dimitrios H Roukos · 2017 · Drug Discovery Today
76. A new azobenzene-based design strategy for detergents in membrane protein research
    Leonhard Hagen Urner, Maiko Schulze, Yasmine B. Maier, Waldemar Hoffmann, Stephan Warnke, Idlir Liko, Kristin Folmert, Christian Manz, Carol V. Robinson, Rainer Haag et al. · 2020 · Chemical Science
77. GPR125 positively regulates osteoclastogenesis potentially through AKT-NF-κB and MAPK signaling pathways
    Chen-Yi Tang, He Wang, Yan Zhang, Zhongliang Wang, Guochun Zhu, Abigail McVicar, Yiping Li, Wei Chen · 2022 · International Journal of Biological Sciences
78. Evaluating Protein-protein Interaction (PPI) Networks for Diseases Pathway, Target Discovery, and Drug-design Using ‘In silico Pharmacology’
    Chiranjib Chakraborty, George C, Luonan Chen, Hailong Zhu · 2014 · Current Protein and Peptide Science
79. A Prospective Cross-Screening Study on G-Protein-Coupled Receptors: Lessons Learned in Virtual Compound Library Design
    Marijn P. A. Sanders, Luc Roumen, Eelke van der Horst, J. Robert Lane, Henry F. Vischer, Jody van Offenbeek, Henk de Vries, Stefan Verhoeven, Ken Y.C. Chow, Folkert Verkaar et al. · 2012 · Journal of Medicinal Chemistry
80. Phytochemical Information and Biological Activities of Quinolizidine Alkaloids in Sophora: A Comprehensive Review
    Hanqing Wang, Changbo Xia, Li Chen, Jianjun Zhao, Weiwei Tao, Xia Zhang, Jianhuan Wang, Xiaojuan Gao, Jingjiao Yong, Jin‐Ao Duan · 2019 · Current Drug Targets
81. Frontier of therapeutic antibody discovery: The challenges and how to face them
    Zhijian Lu · 2012 · World Journal of Biological Chemistry
82. Fitting Transporter Activities to Cellular Drug Concentrations and Fluxes: Why the Bumblebee Can Fly
    Pedro Mendes, Stephen G. Oliver, Douglas Bruce Kell · 2015 · Trends in Pharmacological Sciences
83. Molecular fingerprinting of principal neurons in the rodent hippocampus: A neuroinformatics approach
    David James Hamilton, Charise M. White, Christopher L. Rees, Diek W. Wheeler, Giorgio A. Ascoli · 2017 · Journal of Pharmaceutical and Biomedical Analysis
84. Microfluidics contribution to pharmaceutical sciences: From drug discovery to post marketing product management
    Gwenaël Nys, Marianne Fillet · 2018 · Journal of Pharmaceutical and Biomedical Analysis
85. The ghrelin O-acyltransferase structure reveals a catalytic channel for transmembrane hormone acylation
    Maria B. Campaña, Flaviyan Jerome Irudayanathan, Tasha R. Davis, Kayleigh R. McGovern-Gooch, Rosemary Loftus, Mohammad Ashkar, Najae Escoffery, Melissa Navarro, Michelle A. Sieburg, Shikha Nangia et al. · 2019 · Journal of Biological Chemistry
86. Recent applications of computational methods to allosteric drug discovery
    Rajiv Gandhi Govindaraj, Sundar Thangapandian, Michael Schauperl, R. Aldrin Denny, David Diller · 2023 · Frontiers in Molecular Biosciences
87. Mutational analysis of genes coding for cell surface proteins in colorectal cancer cell lines reveal novel altered pathways, druggable mutations and mutated epitopes for targeted therapy
    Elisa R. Donnard, Paula Fontes Asprino, Bruna Corrêa, Fabiana Bettoni, Fernanda Christtanini Koyama, Fábio C. P. Navarro, Rodrigo Oliva Perez, John M. Mariadason, Oliver M. Sieber, Robert L. Strausberg et al. · 2014 · Oncotarget
88. Bioinformatics and Evolution of Vertebrate Nociceptin and Opioid Receptors
    Craig W. Stevens · 2015 · Vitamins and hormones
89. Discovery of 2H-Chromen-2-one Derivatives as G Protein-Coupled Receptor-35 Agonists
    Lai Wei, Jixia Wang, Xiuli Zhang, Ping Wang, Yaopeng Zhao, Jiaqi Li, Tao Hou, Lala Qu, Liying Shi, Xinmiao Liang et al. · 2016 · Journal of Medicinal Chemistry
90. Review and comparative assessment of similarity-based methods for prediction of drug–protein interactions in the druggable human proteome
    Chen Wang, Lukasz Kurgan · 2018 · Briefings in Bioinformatics
91. Drug resistance: origins, evolution and characterization of genomic clones and the tumor ecosystem to optimize precise individualized therapy
    Ioannis D Kyrochristos, Dimosthenis E. Ziogas, Dimitrios H Roukos · 2019 · Drug Discovery Today
92. Biological Activity-Based Prioritization of Pharmaceuticals in Wastewater for Environmental Monitoring: G Protein-Coupled Receptor Inhibitors
    Han Zhang, Mariko O. Ihara, Norihide Nakada, Hiroaki Tanaka, Masaru Ihara · 2020 · Environmental Science & Technology
93. Effect of Niacin on Growth Performance, Intestinal Morphology, Mucosal Immunity and Microbiota Composition in Weaned Piglets
    Shilong Liu, Xiaoping Zhu, Yueqin Qiu, Li Wang, Xiuguo Shang, Kaiguo Gao, Xuefen Yang, Zongyong Jiang · 2021 · Animals
94. The GPR139 reference agonists 1a and 7c, and tryptophan and phenylalanine share a common binding site
    Anne Cathrine Nøhr, Willem Jespers, Mohamed A. Shehata, Leonard Floryan, Vignir Ísberg, Kirsten Bayer Andersen, Johan Åqvist, Hugo Gutiérrez‐de‐Terán, Hans Bräuner‐Osborne, David E.I. Gloriam · 2017 · Scientific Reports
95. Responsive polymeric nanoparticles for controlled drug delivery
    Kevin Neumann, Annamaria Lilienkampf, Mark Bradley · 2017 · Polymer International
96. The Ancient Link between G-Protein-Coupled Receptors and C-Terminal Phospholipid Kinase Domains
    Johan van den Hoogen, H.J.G. Meijer, Michael F. Seidl, Francine Govers · 2018 · mBio
97. Calcium channels and cancer stem cells
    Debbie O’Reilly, Paul Buchanan · 2019 · Cell Calcium
98. Potential of antibody–drug conjugates and novel therapeutics in breast cancer management
    Dimitrios H Roukos, Georgios D. Lianos, Christina D. Bali, Konstantinos Vlachos, Odysseas Zoras, Christos G. Katsios, Margaret Tzaphlidou, Yong‐Yeon Cho · 2014 · OncoTargets and Therapy
99. Modulation of α‐adrenoceptor signalling protects photoreceptors after retinal detachment by inhibiting oxidative stress and inflammation
    Tong Li, Shiqi Yang, Xiangjun She, Quan Yan, Pengfei Zhang, Hong Zhu, Fenghua Wang, Xueting Luo, Xiaodong Sun · 2018 · British Journal of Pharmacology
100. Defining Structure–Functional Selectivity Relationships (SFSR) for a Class of Non-Catechol Dopamine D1 Receptor Agonists
     Michael L. Martini, Jing Liu, Caroline Ray, Xufen Yu, Xi‐Ping Huang, Aarti N. Urs, Nikhil M. Urs, John D. McCorvy, Marc G. Caron, Bryan L. Roth et al. · 2019 · Journal of Medicinal Chemistry