Trends in the exploitation of novel drug targets

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Sequential Conformational Rearrangements Dictate the Dynamics of Class C GPCR Activation

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Role of Pharmacovigilance in Drug Development

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Block Copolymer Crosslinked Nanoassemblies Co-Entrapping Acridine Yellow and Doxorubicin for Cancer Theranostics

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Biological roles and therapeutic potential of G protein-coupled receptors for free fatty acids and metabolic intermediates

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Canine CD117-Specific Antibodies with Diverse Binding Properties Isolated from a Phage Display Library Using Cell-Based Biopanning

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In vivo antidiabetic potential of standardized Gymnocarpos decandrus Forssk. Extract

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Pharmacogenomics of Neuropsychiatric Disorders: Analysis of Genetic Variability in 162 Identified Neuroreceptors using 1000 Genomes Project Data

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Gut metabolites: make orphans adopted

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Wastewater‐derived antagonistic activities of G protein‐coupled receptor‐acting pharmaceuticals in river water

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Exploring Integrative Analysis Using the BioMedical Evidence Graph

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Physics and Its Interfaces with Medicinal Chemistry and Drug Design

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Themed section: molecular pharmacology of GPCRs

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Experimental Screening Strategies to Reduce Attrition Risk

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A map of molecular drug targets and therapeutics for the US FDA-approved drugs: The impact of expedited regulatory pathways and first-in-class drug approvals on drug innovation

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Atlas of the Open Reading Frames in Human Diseases: Dark Matter of the Human Genome

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Leveraging nuclear receptor mediated transcriptional signaling for drug discovery: Historical insights and current advances

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Protein-Protein Interaction Networks: Structures, Evolution, and Application to Drug Design

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Prediction of the structures of helical membrane proteins based on a minimum unfavorable contacts approach

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SCREENING OF PUTATIVE THERAPEUTIC CANDIDATES IN SUPERBUG (STAPHYLOCOCCUS AUREUS): A SYSTEMATIC IN SILICO APPROACH

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Nociceptin Receptor as a Target to Treat Alcohol Use Disorder: Challenges in Advancing Medications Development

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Evolutionary and Comparative Genomics to Drive Rational Drug Design, with Particular Focus on Neuropeptide Seven-Transmembrane Receptors

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Parallel Computation of Voxelised Protein Surfaces with OpenMP

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The Concept of Receptor and Molecule Interaction in Drug Discovery and Development

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Reaction of cell membrane bilayers “as a variable capacitor” with G-protein: a reason for neurotransmitter signaling

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Homology Modeling of Transporter Proteins

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pyGOMoDo: GPCRs modeling and docking with python

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Dynamic States of the Ligand-Free Class A G Protein-Coupled Receptor Extracellular Side

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iNEXT : a European facility network to stimulate translational structural biology

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An investigation into the allosteric mechanism of GPCR A 2A adenosine receptor with trajectory-based information theory and complex network model

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The Role of Norrish Type-I Chemistry in Photoactive Drugs: An ab initio Study of a Cyclopropenone-Enediyne Drug Precursor

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Modeling of Olfactory Receptors

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Molecular Docking in Drug Designing and Metabolism

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Systems Pharmacology for the Study of Anticancer Drugs: Promises and Challenges

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Non-Specificity of Drug-Target Interactions – Consequences for Drug Discovery

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A High-Throughput Time-Resolved Fluorescence Energy Transfer Assay to Screen for Modulators of RGS7/Gβ5/R7BP Complex

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Surface Plasmon Resonance, a Novel Technique for Sensing Cancer Biomarker: Folate Receptor and Nanoparticles Interface

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SAR Studies of N-[2-(1H-Tetrazol-5-yl)phenyl]benzamide Derivatives as Potent G Protein-Coupled Receptor-35 Agonists

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Bioinformatics of excretory/secretory proteins of Toxoplasma gondii strain ME49

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Evolution of the G protein-coupled receptor signaling system : Genomic and phylogenetic analyses

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Mining the Medical and Patent Literature to Support Healthcare and Pharmacovigilance

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Gene Knock Up via 3’UTR editing to study gene function in vivoPreprint

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Personalization of incretin therapy: can GLP-1 and GIP receptor polymorphisms influence therapy response?

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Structural dynamics of chemokine receptors

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Redefining the Game: MVAE-DFDPnet's Low-Dimensional Embeddings for Superior Drug-Protein Interaction Predictions

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GICL: A Cross-Modal Drug Property Prediction Framework Based on Knowledge Enhancement of Large Language Models

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Use of Escherichia coli for the Production and Purification of Membrane Proteins

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Exploring the Active Conformation of Cyclohexane Carboxylate Positive Allosteric Modulators of the Type 4 Metabotropic Glutamate Receptor

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Efficient Lead Finding, Activity Enhancement and Preliminary Selectivity Control of Nuclear Receptor Ligands Bearing a Phenanthridinone Skeleton

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Update of the GRIP web service

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Synthetic Strategies to Identify and Regulate Noncoding RNAs

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Advancing therapeutic discovery through phenotypic screening of the extracellular proteome using hydrodynamic intravascular injection

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Biosensors: On the Origin of Label-Free Cell Phenotypic Profiles of Drug-Target Interactions

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Structural Chemogenomics Databases to Navigate Protein–Ligand Interaction Space

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A red‐emitting indolium fluorescence probe for membranes ‐ flavonoids interactions

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Recent Advancements in Computing Reliable Binding Free Energies in Drug Discovery Projects

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Cancer drug target identification and node-level analysis of the network of MAPK pathways

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Rationally designed N-phenylsulfonylindoles as a tool for the analysis of the non-basic 5-HT6R ligands binding mode

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Novel Driver Strength Index highlights important cancer genes in TCGA PanCanAtlas patients

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New Advances in Diversity‐Oriented Synthesis

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Site‐Directed Fragment Discovery for Allostery

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Expanding precompetitive space

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Structural and functional effects of natural phenolic compounds on rhodopsin mutants associated with retinitis pigmentosa

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Modulation of Type 5 Metabotropic Glutamate Receptor-Mediated Intracellular Calcium Mobilization by Regulator of G Protein Signaling 4 (RGS4) in Cultured Astrocytes

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Can we develop effective direct or indirect inhibitors of transcription factors? On the clinical evolution of protein degraders for multiple myeloma therapy

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GPRASP1 deletion in mice abrogates adverse side effects associated with chronic stimulation of Beta2-adrenoceptor

Abu-Helo, A., Daubeuf, F., Tranchant, T., Lehalle, C., Elhabazi, K., Zeder‐Lutz, G., Kugler, V., Lugnier, C., Frossard, N., Lecat, S., et al. (2025) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2025.118073 · Cited by 2

Design, synthesis, and application of triazole-embedded maltose-neopentyl-glycol (TMNG) amphiphiles for membrane protein studies

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Do GPCRs constitute the target of 30% of newly approved drugs in Germany?

Schröer, S., & Seifert, R. (2025) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-025-04548-3 · Cited by 2

Therapeutic targeting LRPPRC-mediated OXPHOS synthesis for cancer intervention

Liang, Y., Wang, L., Yang, Z., Chen, W., Jiang, R., Wang, D., Wang, W., Zhou, W., & Fang, X. (2025) · Expert Opinion on Therapeutic Targets · doi:10.1080/14728222.2025.2608028 · Cited by 2

Central Nervous System Modulators from the Oceans

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Elucidating the active compound profile and mechanisms of Dendrophthoe pentandra on colorectal cancer: LCMS/MS identification and network pharmacology analysis

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Nuclear magnetic resonance technology for biological complex systems: Opportunities and challenges

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On the internal correlations of protein sequences probed by non-alignment methods: Novel signatures for drug and antibody targets via the Burrows-Wheeler Transform

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The Potential Targets and Mechanisms of a Carbazole and Pyrazole Containing Anticancer Compound

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Protein degradation induced by PROTAC molecules as an emerging drug discovery strategy

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Profiling Kinase Activities for Precision Oncology in Diffuse Gastric Cancer

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A-RFP: An Adaptive Residue Flexibility Prediction Method Improving Protein-ligand Docking Based on Homologous Proteins

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Computational aids for assessing bioactivities in phytochemical and natural products research

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Unraveling GPCRs Allosteric Modulation. Cannabinoid 1 Receptor as a Case Study

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An Alpha-glucosidase Enzyme Inhibitor Cycloeucalenol from Sarcolobus globosus Unveiled through In vitro and Computational Analysis

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From Linear ‘dogma‘ and Trastuzumab–Emtansine to Future Transcriptional Circuitry-Based Drug Discovery for Breast Cancer

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Inhibition and Inactivation of Enzymes

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Multiplexing Label-Free and Fluorescence-Based Methods for Pharmacological Characterization of GPCR Ligands

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The Accepted “Clinical Interaction Model”: A Special Case of Reality

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Computer Simulations of Membrane Proteins

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Trawling the Genome: Drug Target Identification in the Postgenomic Era

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Current Drug Targets and the Druggable Genome

Johns, M. A., Russ, A., & Fu, H. (2012) · Cambridge University Press eBooks · doi:10.1017/cbo9781139021500.029 · Cited by 2

Drug Discovery

Prabu, S. L. (2018) · Advances in medical technologies and clinical practice book series · doi:10.4018/978-1-5225-7326-5.ch001 · Cited by 2

PDID: Database of Experimental and Putative Drug Targets in Human Proteome

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In this issue

(2011) · Nature Reviews Drug Discovery · doi:10.1038/nrd3513

The Druggable Genome: Evaluation of Drug Targets in Clinical Trials Suggests Major Shifts in Molecular Class and Indication

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The evolving landscape of drug targets

Halip, L., Avram, S. I., Overington, J. P., Al‐Lazikani, B., Curpan, R. F., Sirimulla, S., Pushechnikov, A. O., Beccari, A. R., Savchuk, N., & Oprea, T. I. (2026) · Nature Reviews Drug Discovery · doi:10.1038/s41573-026-01530-3

Network Analysis of Drug–target Interactions: A Study on FDA-approved New Molecular Entities Between 2000 to 2015

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Network analysis of FDA approved drugs and their targets

Ma’ayan, A., Jenkins, S. L., Goldfarb, J., & Iyengar, R. (2007) · Mount Sinai Journal of Medicine A Journal of Translational and Personalized Medicine · doi:10.1002/msj.20002 · Cited by 115