Trends in the exploitation of novel drug targets

Rask-Andersen, Mathias, Almén, Markus Sällman, Schiöth, Helgi B.·2011·Nature Reviews Drug Discovery

Cited by (872)

Items 701–800 of 872

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  8. The Role of NMR in Target Identification and Validation for Pharmaceutical R&D
    Krishna Saxena, Harald Schwalbe · 2015 · Wiley eBooks
  9. Target Identification and Validation
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    Michael Viereck, Anna Gaulton, Daniela Digles · 2017 · Methods and principles in medicinal chemistry
  11. Precision in Cancer Pharmacogenomics
    Ioannis D Kyrochristos, Evangelos G. Baltagiannis, Michail C. Mitsis, Dimitrios H Roukos · 2020 · Pharmacogenomics
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    Martin Cramer Pedersen, Nicolai Tidemand Johansen, Jennifer Virginia Roche, Michael A. Järvå, Susanna Törnroth‐Horsefield, Lise Arleth · 2022 · bioRxiv (Cold Spring Harbor Laboratory)
  13. Dimensionality Reduction-Based Analysis of the Molecular Dynamics of G Protein-Coupled Receptors
    Juan Manuel López-Correa, Caroline König, Alfredo Vellido · 2025 · IEEE Transactions on Computational Biology and Bioinformatics
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    Gage M. Connors, Juliet V. Spencer · 2025 · Pathogens
  16. A novel Halo Tag-based photo-crosslinking system for efficient drug target identification via chemoproteomic profiling
    Xing Liu, Wenjing Ji, Yulin Tao, Yuxiang Gong, Qiannan Zhang, Ruoyao Lin, Yang Yang, Yiting Wang, Shasha Li, Yufan Zhang et al. · 2025 · Analytica Chimica Acta
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    Ami Nakajima, Hiroto Kaneko, Kosuke Oyama, Misumi Kuchiji, Ayane Itakura, Chiaki Arai, Mitsunori Shiroishi · 2025 · Protein Science
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    Simone Aureli, Nicola Piasentin, Thorben Fröhlking, Valerio Rizzi, Francesco Luigi Gervasio · 2026 · The Journal of Physical Chemistry Letters
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    Markus Boehm, Liying Zhang, Nicole E. Bodycombe, Mateusz Maciejewski, Anne Mai Wassermann · 2016 · ACS symposium series
  20. Photoaffinity Labeling in Drug Discovery Research
    Hideyuki Muranaka, Takaki Momose, Chiaki Handa, Tomonaga Ozawa · 2017 · Springer eBooks
  21. Role of Membrane Transporters in Pharmacogenomics
    Lidija Bach‐Rojecky, Dragan Primorac, Elizabeta Topić, Mario Štefanović, Wolfgang Höppner · 2023 · Springer eBooks
  22. The Essentiality of Effective Anticancer Drugs in the Essential Medicines Lists: A Comparative Analysis
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  23. Role of Metabolomics in the Discovery of Modern Drugs from Traditional Resources
    Shyamalima Saikia, Minakshi Puzari, Pankaj Chetia · 2024 · Interdisciplinary biotechnological advances
  24. A Study on the Present Use of Nanotechnology in Agriculture and Food
    Himanshu S. Bardhiya, Mutyala Pavitra, Prateek Verma, Palash Gourshettiwar · 2025 · Lecture notes in networks and systems
  25. Membrane Proteins: Targets That Should Not Be Overlooked for Assessing Human and Ecological Health Effects of Chemicals
    Han Zhang, Masaru Ihara, Jingwen Chen · 2025 · Environmental Science & Technology
  26. The Science and Technology Challenge: How to Find New Drugs
    Oliver Gassmann, Alexander Schuhmacher, Maximilian von Zedtwitz, Gerrit Reepmeyer · 2018 · Springer eBooks
  27. BCTD: A Drug-Target Relation Database for Drug Repositioning
    克强 王 · 2015 · Hans Journal of Computational Biology
  28. Genome-based approaches for the diagnosis of breast cancer: a review with perspective
    Dimosthenis E. Ziogas · 2014 · Breast Cancer Management
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    Yoshiaki Yano, Kenichi Kawano, Kaoru Omae, Yuki Takeda, Sayaka Matsuzaki, Katsumi Matsuzaki · 2014 · YAKUGAKU ZASSHI
  30. Computational Approaches to Analyze the Strategies of Drug Repositioning*
    Da-Fei XIE, Peng Li, Fei Li, Xiaochen Bo, Shengqi Wang · 2012 · PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS
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    Sebastian Daberdaku, Carlo Ferrari · 2018 · International Conference on High Performance Computing & Simulation (HPCS)
  32. Pathogenic Protist Transmembranome database (PPTdb): a web-based platform for searching and analysis of protist transmembrane proteins
    Chi‐Ching Lee, Po-Jung Huang, Yuan‐Ming Yeh, Sin-You Chen, Cheng‐Hsun Chiu, Wei-Hung Cheng, Petrus Tang · 2019 · BMC Bioinformatics
  33. Machine learning strategies for identifying repurposed drugs for cancer therapy
    Hansaim Lim, Lei Xie · 2020 · Elsevier eBooks
  34. Computational Methods and Approaches in Pharmacogenomic Research
    Yitian Zhou, Volker Martin Lauschke · 2021 · Elsevier eBooks
  35. 2D QSAR of 3-(Piperidin-1-yl)-5,6,7,8-Tetrahydropyrido[3,4-b] Pyrazine Derivatives With GPCR-6 Inhibitory Activity
    Kaushik Sarkar, Biswajit Debsarma, Rajesh Kumar Das · 2022 · International Journal of Quantitative Structure-Property Relationships
  36. Advances in the molecular level understanding of G-protein coupled receptor
    Adhiraj Roy · 2022 · Progress in molecular biology and translational science
  37. Two‐Dimensional Crystallisation of Membrane Proteins and Structural Assessment
    Dimitrios Fotiadis, Andreas H. Engel · 2015 · Wiley eBooks
  38. Pharmaceutical discovery and development
    Pitchai Balakumar, Gowraganahalli Jagadeesh · 2012 · Rajiv Gandhi University of Health Sciences Journal of Pharmaceutical Sciences
  39. Solubilisation and characterisation of G-protein-coupled receptors using styrene maleic acid polymer
    Jack Charlton · 2016 · University of Birmingham Institutional Research Archive (University of Birmingham)
  40. Studies on Ligands of the Kappa Opioid Receptor
    Kelly M. DiMattio · 2016 · TUScholarShare (Temple University)
  41. References
    2012 · Elsevier eBooks
  42. TRANSPORTERS AS THERAPEUTIC TARGETS IN HUMAN DISEASES
    Robert S. Jones, Eugene C. Chen · 2022 · Wiley eBooks
  43. A Chemogenomic Toolkit to Evaluate the “Ins and Outs” of Yeast Plasma Membrane Transporters
    Rajendra Prasad, Atanu Banerjee · 2022 · mBio
  44. AlphaFold meets de novo drug design: leveraging structural protein information in multi-target molecular generative models
    Andrius Bernatavicius, Martin Šícho, Antonius P. A. Janssen, Alan Kai Hassen, Mike Preuß, Gerard J. P. van Westen · 2024 · ChemRxiv
  45. Novel Drug Targets for Small Molecule‐based Drug Discovery
    Raghu Ram Achar, Ipsita Panigrahi, Aditi Singh, Nuthakki Venkata Chandana, Shivananju Nanjunda Swamy · 2024 · Wiley eBooks
  46. Intestinal Gene Expression Profiling and Fatty Acid Responses to a High-fat Diet
    Jonathan Cedernaes · 2013 · KTH Publication Database DiVA (KTH Royal Institute of Technology)
  47. Targeting Different States of Breast Cancer Stem Cells
    Sean McDermott, Max S. Wicha · 2014 · Wiley eBooks
  48. Medicinal Chemistry in the Context of the Human Genome
    Andreas Brunschweiger, Jonathan Hall · 2013 · Methods and principles in medicinal chemistry
  49. Análise comparativa de perfis de sinalização do receptor AT1 ativado por agonistas seletivos para a via de -arrestinas
    Geisa A. Santos · 2013 · Digital Library of Theses and Dissertations (Universidade de São Paulo)
  50. Predicting Therapeutic Targets with Integration of Heterogeneous Data Sources
    Yan-Fen Dai, Yin‐Ying Wang, Xing-Ming Zhao · 2013 · Lecture notes in computer science
  51. Network-based drugs: promise and clinical challenges in cardiovascular disease
    Dimitrios H Roukos, Christos S. Katsouras, Giannis Baltogiannis, Katerina Κ. Naka, Lampros K. Michalis · 2013 · Expert Review of Proteomics
  52. Evolutionary and Pharmacological Studies of NPY and QRFP Receptors
    Bo Xu · 2014 · Uppsala University Publications (Uppsala University)
  53. GPCRs — einzelnen Rezeptoren auf der Spur
    Martin J. Lohse, Carsten Hoffmann, Davide Calebiro · 2013 · BIOspektrum
  54. Navigations of chemical space to further the understanding of polypharmacology in human nuclear receptors
    Antonio Macchiarulo, Andrea Carotti, Marco Cellanetti, Roccaldo Sardella, Antimo Gioiello · 2012 · MedChemComm
  55. The Next Horizon in Proteomics and Genomics Research
    Ramaswamy Narayanan · 2014 · MOJ Proteomics & Bioinformatics
  56. The Role of Chemical Biology in Drug Discovery
    Andrew J. Pope · 2012 · Chemical biology
  57. A Weighted Cramér’s V Index for the Assessment of Stability in the Fuzzy Clustering of Class C G Protein-Coupled Receptors
    Alfredo Vellido, Christiana Halka, Àngela Nebot B · 2015 · Lecture notes in computer science
  58. The N-t erminus of the Saccharomyces cerevisiae G protein-coupled receptor Ste2p: formation of dimer interfaces and negative regulation
    M. Seraj Uddin · 2013
  59. METHOD Open Access
    Lasse Maretty, Jonas A. Sibbesen, Anders Krogh · 2014
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    Bob Chermin · 2013 · TU/e Research Portal
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    Marilee Ann Benore · 2015 · American journal of biochemistry & biotechnology/American journal of biochemistry and biotechnology
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    Joslynn S. Lee · 2014
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    Owen Williams · 2014
  64. The Membrane Proteome : Evolution, Characteristics and Classification
    Markus Sällman Almén · 2012
  65. Image Analysis of Membrane Receptors in Living Cells by Coiled-coil Labeling Method
    Yoshiaki Yano, Katsumi Matsuzaki · 2013 · MEMBRANE
  66. Expanding the Target Space: Druggability Assessments
    Peter Schmidtke, Daniel Álvarez-García, Jesús Seco, Xavier Barril · 2012 · Royal Society of Chemistry eBooks
  67. Interações moleculares no mecanismo de ação da galectina-4 humana
    Patricia S. Kumagai · 2016 · Digital Library of Theses and Dissertations (Universidade de São Paulo)
  68. Prediscovery Research: Challenges and Opportunities
    Odilia Osakwe · 2016 · Elsevier eBooks
  69. In Silico Approaches Assisting the Rational Design of Low Molecular Weight Protein–Protein Interaction Modulators
    Bruno O. Villoutreix, Mélaine A. Kuenemann, David Lagorce, Olivier Spérandio, Maria A. Miteva · 2015 · CRC Press eBooks
  70. Metabolic Network Analysis of Apicomplexan Parasites to Identify Novel Drug Targets
    Stacy S. Hung · 2014 · TSpace (University of Toronto)
  71. Synthetic Receptors for RNA Recognition
    Sayantan Bhaduri, Meredith Newby Spano, Dev P. Arya · 2016 · Elsevier eBooks
  72. Drugs development and fragile X syndrome translational success story
    Dejan B. Budimirovic, Dragana D. Protic · 2016 · Medicinski podmladak
  73. Ion Channels: Their Discovery and their Role in Pharmacology and Biomedicine
    Erwin Neher · 2017 · Journal of Science Humanities and Arts - JOSHA
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    Deisy Yurley Rodríguez-Sarmiento · 2017 · Digital Library of Theses and Dissertations (Universidade de São Paulo)
  76. Modulation of Receptor Signaling and Functional Selectivity in Neutrophils
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  80. Drug-Drug Interactions Prediction Based on Similarity Calculation and Pharmacokinetics Mechanism
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  81. Analysis of class C G-protein coupled receptors using supervised classification methods
    Caroline König · 2018
  82. Nanopore-spanning lipid bilayer formed by self-spreading method
    Zugui Peng, Kenta Shimba, Yoshitaka Miyamoto, Tohru Yagi · 2018 · Biomedical Engineering International Conference
  83. Target Identification of HDAC8 Isoform for the Treatment of Cancer
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  84. Combinatorial Phosphorylation-Dependent Synergy Between a G Protein Subunit and the Ste5 Scaffold Regulates Differential MAP-Kinase Activation in Yeast
    Shilpa Choudhury, Parastoo Baradaran-Mashinchi, Matthew P. Torres · 2018 · SSRN Electronic Journal
  85. Micelles and Bicelles as Membrane Mimics for Membrane Protein Investigations
    Ashton T. Brock · 2016
  86. Nano-pore Lipid Bilayer Formed by Self-spreading Method
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  87. Coordination of G Protein and Mitogen-Activated Protein Kinase Signaling Pathways by Branched-Chain Amino Acid Metabolite Second Messengers during Osmotic Stress
    James P. Shellhammer · 2019 · Carolina Digital Repository (University of North Carolina at Chapel Hill)
  88. Exploring Voltage-gated Sodium Channel NaV1.6 as an Interacting Partner with G Protein-coupled Receptors
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  89. Elucidation of molecular mechanism underlying juvenile hormone action and development of molecular-targeted insecticide
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  90. An Evolutionary Based Strategy for Predicting Rational Mutations in G Protein-Coupled Receptors
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  91. Proteomic approaches to understanding G protein beta gamma subunit signalling networks
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  92. Using fuzzy methods for rule extraction in the discrimination of class C GPCR subtypes from their subsequences
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  94. The Role of Chemical Biology in Drug Discovery
    Andrew J. Pope · 2012 · Wiley eBooks
  95. Bibliography
    Christophe Furger · 2016 · Wiley eBooks
  96. Faculty Opinions recommendation of Therapeutic target database update 2012: a resource for facilitating target-oriented drug discovery.
    Carlos Medicis Morel · 2011 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
  97. Evolution of Membrane Bound Proteins and their Ligands : The Melanocortin (MC) Receptor Inverse Agonists AgRP2, ASIP2, Drug/Metabolite Transporters, and SPNS1
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  98. Introduction
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  99. Natural compounds for the drug targets of Sexually Transmitted Diseases (STD) using virtual screening
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  100. Overview of the drug target compendium
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