Trends in the exploitation of novel drug targets
Rask-Andersen, Mathias, Almén, Markus Sällman, Schiöth, Helgi B.·2011·Nature Reviews Drug Discovery
DOI 10.1038/nrd3478
Cited by (872)
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- Prediscovery Research: Challenges and OpportunitiesOdilia Osakwe · 2016 · Elsevier eBooks
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- Metabolic Network Analysis of Apicomplexan Parasites to Identify Novel Drug TargetsStacy S. Hung · 2014 · TSpace (University of Toronto)
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- Modulation of Receptor Signaling and Functional Selectivity in NeutrophilsMichael Gabl · 2017 · Gothenburg University Publications Electronic Archive (Gothenburg University)
- Selection and testing of protein target focused compound libraries using chemoinformatics methods integrated with MTS biological assayKrisztina Dobi · 2017
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- The Role of Chemical Biology in Drug DiscoveryAndrew J. Pope · 2012 · Wiley eBooks
- BibliographyChristophe Furger · 2016 · Wiley eBooks
- Faculty Opinions recommendation of Therapeutic target database update 2012: a resource for facilitating target-oriented drug discovery.Carlos Medicis Morel · 2011 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
- Evolution of Membrane Bound Proteins and their Ligands : The Melanocortin (MC) Receptor Inverse Agonists AgRP2, ASIP2, Drug/Metabolite Transporters, and SPNS1Åke Västermark · 2012 · KTH Publication Database DiVA (KTH Royal Institute of Technology)
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