Apoptosis-based anticancer drugs

A controlled trial of intratumoral ONYX-015, a selectively-replicating adenovirus, in combination with cisplatin and 5-fluorouracil in patients with recurrent head and neck cancer

Khuri, F. R., Nemunaitis, J. J., Ganly, I., Arseneau, J. C., Tannock, I. F., Romel, L., Gore, M. E., Ironside, J. A. D., MacDougall, R. H., Heise, C. C., et al. (2000) · Nature Medicine · doi:10.1038/78638 · Cited by 1,099 · see citing works

Chemosensitisation of malignant melanoma by BCL2 antisense therapy

Jansen, B., Wacheck, V., Heere‐Ress, E., Schlagbauer‐Wadl, H., Höeller, C., Lucas, T., Hoermann, M., Hollenstein, U., Wolff, K., & Pehamberger, H. (2000) · The Lancet · doi:10.1016/s0140-6736(00)03207-4 · Cited by 481 · see citing works

Adenovirus-mediated p53 gene transfer in patients with advanced recurrent head and neck squamous cell carcinoma.

Clayman, G. L., El‐Naggar, A. K., Lippman, S. M., Henderson, Y. C., Frederick, M. J., Merritt, J. A., Zumstein, L. A., Timmons, T. M., Liu, T.-J., Ginsberg, L. E., et al. (1998) · Journal of Clinical Oncology · doi:10.1200/jco.1998.16.6.2221 · Cited by 371 · see citing works

The promising future of microalgae: Current status, challenges, and optimization of a sustainable and renewable industry for biofuels, feed, and other products

Khan, M. I., Shin, J. H., & Kim, J. D. (2018) · Microbial Cell Factories · doi:10.1186/s12934-018-0879-x · Cited by 2,082 · see citing works

Apoptosis: its origin, history, maintenance and the medical implications for cancer and aging

Kaczanowski, S. (2016) · Physical Biology · doi:10.1088/1478-3975/13/3/031001 · Cited by 227 · see citing works

Fungal apoptosis: function, genes and gene function

Sharon, A., Finkelstein, A., Shlezinger, N., & Hatam, I. (2009) · FEMS Microbiology Reviews · doi:10.1111/j.1574-6976.2009.00180.x · Cited by 224 · see citing works

Recent advances in therapeutic chalcones

Ni, L., Meng, C. Q., & Sikorski, J. A. (2004) · Expert Opinion on Therapeutic Patents · doi:10.1517/13543776.14.12.1669 · Cited by 203 · see citing works

Marine cyanobacteria compounds with anticancer properties: A review on the implication of apoptosis

Costa, M., Costa-Rodrigues, J., Fernandes, M. H., Barros, P., Vasconcelos, V., & Martins, R. (2012) · Marine Drugs · doi:10.3390/md10102181 · Cited by 147 · see citing works

Development and characterization of hyaluronic acid–anchored PLGA nanoparticulate carriers of doxorubicin

Yadav, A. K., Mishra, P., Mishra, A. K., Mishra, P., Jain, S., & Agrawal, G. P. (2007) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2007.09.004 · Cited by 138 · see citing works

A Review of the Current Impact of Inhibitors of Apoptosis Proteins and Their Repression in Cancer

Cetraro, P., Plaza‐Díaz, J., MacKenzie, A., & Abadía‐Molina, F. (2022) · Cancers · doi:10.3390/cancers14071671 · Cited by 116 · see citing works

Homeodomain-interacting protein kinase-2 activity and p53 phosphorylation are critical events for cisplatin-mediated apoptosis

Stefano, V. D., Rinaldo, C., Sacchi, A., Soddu, S., & D’Orazi, G. (2003) · Experimental Cell Research · doi:10.1016/j.yexcr.2003.09.032 · Cited by 103 · see citing works

Antiproliferation and Induction of Apoptosis in Ca9-22 Oral Cancer Cells by Ethanolic Extract of Gracilaria tenuistipitata

Yeh, C.-C., Tseng, C., Yang, J.-I., Huang, H., Fang, Y., Tang, J., Chang, F., & Chang, H. (2012) · Molecules · doi:10.3390/molecules170910916 · Cited by 101 · see citing works

Effective ferroptotic small-cell lung cancer cell death from SLC7A11 inhibition by sulforaphane

Iida, Y., Okamoto-Κatsuyama, M., Maruoka, S., Mizumura, K., Shimizu, T., Shikano, S., Hikichi, M., Takahashi, M., Tsuya, K., Okamoto, S., et al. (2020) · Oncology Letters · doi:10.3892/ol.2020.12332 · Cited by 82 · see citing works

Small molecule modulators of protein-protein interactions: selected case studies

Aeluri, M., Chamakuri, S., Dasari, B., Guduru, S. K. R., Jimmidi, R., Jogula, S., & Arya, P. (2014) · Chemical Reviews · doi:10.1021/cr4004049 · Cited by 79 · see citing works

Design and synthesis of novel 5,6-disubstituted pyridine-2,3-dione-3-thiosemicarbazone derivatives as potential anticancer agents

Xie, W., Xie, S., Zhou, Y., Tang, X., Liu, J., Yang, W., & Qiu, M. (2014) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2014.05.001 · Cited by 78 · see citing works

Quercetin-induced autophagy flux enhances TRAIL-mediated tumor cell death

Moon, J.-H., Eo, S. K., Lee, J. H., & Park, S. (2015) · Oncology Reports · doi:10.3892/or.2015.3991 · Cited by 61 · see citing works

Scaffold hybridization in generation of indenoindolones as anticancer agents that induce apoptosis with cell cycle arrest at G2/M phase

Kashyap, M., Das, D., Preet, R., Mohapatra, P., Satapathy, S. R., Siddharth, S., Kundu, C. N., & Guchhait, S. K. (2012) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2012.02.007 · Cited by 60 · see citing works

Antitumor activities of a novel indolin-2-ketone compound, Z24: more potent inhibition on bFGF-induced angiogenesis and bcl-2 over-expressing cancer cells

Wang, L., Li, J., Zheng, Z., Liu, H.-Y., Du, G., & Li, S. (2004) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2004.07.048 · Cited by 35 · see citing works

Discovery and Preclinical Evaluation of a Novel Class of Cytotoxic Propynoic Acid Carbamoyl Methyl Amides (PACMAs)

Yamada, R., Cao, X., Butkevich, A. N., Millard, M., Odde, S., Mordwinkin, N., Gundla, R., Zandi, E., Louie, S. G., Petasis, N. A., et al. (2011) · Journal of Medicinal Chemistry · doi:10.1021/jm101655d · Cited by 34 · see citing works

Deferoxamine inhibits TRAIL-mediated apoptosis via regulation of autophagy in human colon cancer cells

Moon, J.-H., Jeong, J., & Park, S. (2014) · Oncology Reports · doi:10.3892/or.2014.3676 · Cited by 30 · see citing works

Molecular mechanisms of antiproliferative effects induced by Schisandra-derived dibenzocyclooctadiene lignans (+)-deoxyschisandrin and (−)-gomisin N in human tumour cell lines

Casarin, E., Dall’Acqua, S., Šmejkal, K., Šlapetová, T., Innocenti, G., & Carrara, M. (2014) · Fitoterapia · doi:10.1016/j.fitote.2014.08.001 · Cited by 29 · see citing works

Regioselective synthesis and theoretical studies of an anti-neoplastic fluoro-substituted dispiro-oxindole

Girgis, A. S., Panda, S. S., Shalaby, E. M., Mabied, A. F., Steel, P. J., Hall, C. D., & KATRITZKY, A. R. (2015) · RSC Advances · doi:10.1039/c4ra13433h · Cited by 26 · see citing works

Synthesis and Cytotoxic Effect of Some Novel 1,2-Dihydropyridin-3-carbonitrile and Nicotinonitrile Derivatives

Flefel, E. M., Abbas, H. S., Mageid, R. E. A., & Zaghary, W. A. (2015) · Molecules · doi:10.3390/molecules21010030 · Cited by 21 · see citing works

Drugs That Inhibit Signalling Pathways for Tumor Cell Growth and Proliferation

Avendaño, C., & Menéndez, J. (2008) · Elsevier eBooks · doi:10.1016/b978-0-444-52824-7.00009-3 · Cited by 11 · see citing works

Synthesis and evaluation of a series of caffeic acid derivatives as anticancer agents

Singh, P., Grewal, A. S., Pandita, D., & Lather, V. (2018) · Future Journal of Pharmaceutical Sciences · doi:10.1016/j.fjps.2017.11.002 · Cited by 21 · see citing works

Costunolide, a sesquiterpene lactone induces G2/M phase arrest and mitochondria-mediated apoptosis in human gastric adenocarcinoma SGC-7901 cells

Rasul, A. (2012) · Journal of Medicinal Plants Research · doi:10.5897/jmpr11.922 · Cited by 18 · see citing works

Synthesis and biological evaluation of novel 4,5-dihydropyrazole derivatives as potent anticancer and antimicrobial agents

Prasad, Y. R., Kumar, G. V. S., & Chandrashekar, S. M. (2012) · Medicinal Chemistry Research · doi:10.1007/s00044-012-0191-y · Cited by 17 · see citing works

Brain-Targeted Delivery of Estradiol

Bodor, N. S., & Buchwald, P. (2006) · American Journal of Drug Delivery · doi:10.2165/00137696-200604030-00004 · Cited by 16 · see citing works

Phytochemical screening, antioxidant, anti-diabetic and cytotoxic activity of leaves of Pandanus canaranus Warb

Balamurugan, V., Raja, K., Selvakumar, S., & Vasanth, K. (2020) · Materials Today Proceedings · doi:10.1016/j.matpr.2020.07.603 · Cited by 15 · see citing works

Sulforaphane blocks hypoxia-mediated resistance to TRAIL-induced tumor cell death

Park (2011) · Molecular Medicine Reports · doi:10.3892/mmr.2011.422 · Cited by 14 · see citing works

Novel bis(thiazolidin-4-ones) linked to aliphatic or aromatic spacers: synthesis, characterization, and anticancer evaluation

Hebishy, A. M. S., Abdelfattah, M. S., Elmorsy, A., & Elwahy, A. H. M. (2020) · Journal of Sulfur Chemistry · doi:10.1080/17415993.2020.1823978 · Cited by 13 · see citing works

PCW-1001, a Novel Pyrazole Derivative, Exerts Antitumor and Radio-Sensitizing Activities in Breast Cancer

Kang, M., Pandit, N., Kim, A.-Y., Cho, S. J., Kwon, Y.-J., Ahn, J., Lee, K. M., Wu, S., Oh, J. S., Jung, K., et al. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.835833 · Cited by 10 · see citing works

Elucidation of the Molecular Mechanisms of a Salicylhydrazide Class of Compounds by Proteomic Analysis

Cao, X., Plasencia, C., Kanzaki, A., Yang, A. J., Burke, T. R., & Neamati, N. (2009) · Current Cancer Drug Targets · doi:10.2174/156800909787580971 · Cited by 9 · see citing works

Anti-gastric cancer activity of 1,2,3-triazolo[4,5-d]pyrimidine hybrids (1,2,3-TPH): QSAR and molecular docking approaches

Oyebamiji, A. K., Fadare, O. A., & Semire, B. (2020) · Heliyon · doi:10.1016/j.heliyon.2020.e03561 · Cited by 9 · see citing works

Design, synthesis, and biological evaluation of N-acetyl-S-(p-chlorophenylcarbamoyl)cysteine and its analogs as a novel class of anticancer agents

Chen, W., Seefeldt, T. M., Young, A. J., Zhang, X., & Guan, X. (2010) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2010.11.026 · Cited by 8 · see citing works

Algal engineering for bioremediation, bioenergy production, and biomedical applications

Ahmad, A., BANAT, F. A., & Taher, H. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-90476-6.00015-7 · Cited by 8 · see citing works

ACTIVIDAD CITOTÓXICA DEL EXTRACTO ETANÓLICO DE Gnaphalium spicatum "KETO KETO " EN CULTIVOS DE LÍNEAS CELULARES TUMORALES HUMANAS

Callacondo, D., Quispe-Mauricio, A., Lindo-Gamarra, S., & Vaisberg, A. (2008) · DOAJ (DOAJ: Directory of Open Access Journals) · Cited by 8 · see citing works

Jaceosidin inhibits proliferation of human bladder cancer T24 cells through induction of cell cycle arrest and apoptosis

Li, Y., & Tan, Y. (2013) · Bangladesh Journal of Pharmacology · doi:10.3329/bjp.v8i3.15620 · Cited by 8 · see citing works

Synthesis and in vitro anticancer evaluation of novel pyridine derivatives bearing tetrahydronaphthalene scaffold

Hamza, E. K., Hamdy, N. A., Zarie, E. S., Fakhr, I. M. I., Elwahy, A. H. M., & Awad, H. M. (2020) · ARKIVOC · doi:10.24820/ark.5550190.p011.056 · Cited by 8 · see citing works

Apoptosis in health, disease, and therapy: overview and methodology

LaCasse, E. C., Holčı́k, M., Korneluk, R. G., & MacKenzie, A. (2005) · Cambridge University Press eBooks · doi:10.1017/cbo9780511663543.002 · Cited by 7 · see citing works

Pharmacological Perspectives of 2‐alkoxy‐3‐Cyanopyridine Scaffolds: An Up‐to‐Date Review

Mahesha, P., & Shetty, N. S. (2024) · ChemistrySelect · doi:10.1002/slct.202401770 · Cited by 6 · see citing works

Novel ethyl 2-hydrazineylidenethiazolidin-5-ylidene acetate clubbed with coumarinylthiazolyl pyrazole system as potential VEGFR-2 inhibitors and apoptosis inducer: synthesis, cytotoxic evaluation, cell cycle, autophagy, in silico ADMET and molecular docking studies

Bawazir, W. A., Tarik El-Sayed, A. L. I., Alsolimani, A. K., Assiri, M. A., Shati, A. A., Alfaifi, M. Y., & Elbehairi, S. E. I. (2025) · RSC Advances · doi:10.1039/d5ra00250h · Cited by 5 · see citing works

Anticancer Drug Development from Cyanobacteria

Mandal, S., & Rath, J. (2014) · SpringerBriefs in pharmaceutical science & drug development · doi:10.1007/978-3-319-12009-6_4 · Cited by 4 · see citing works

A Review on the Present and Future Aspects of Various Prokaryotic Pigments and Metabolites Demonstrating Anti-Cancerous Properties

Mukherjee, A. G., & Kamla Nehru Mahavidyalaya, N.-2. (2020) · International Journal of Engineering Research and · doi:10.17577/ijertv9is070578 · Cited by 4 · see citing works

Synthesis and anticancer studies of Ru/Ir arene complexes bearing oleanolic acid in acute promyelocytic leukemia cells

Dai, X., Shen, Z., Zhang, Y., Liu, H., Ren, M., Wang, P., Li, J., Xue, X., & Liu, H. (2025) · Journal of Inorganic Biochemistry · doi:10.1016/j.jinorgbio.2025.112959 · Cited by 3 · see citing works

An investigation into the cytotoxic properties of isatin-derived compounds: potential for use in targeted cancer therapy

Vine, K. L. (2007) · Research Online (University of Wollongong) · Cited by 3 · see citing works

Metastasis

Horak, C. E., Bronder, J. L., Bouadis, A., & Steeg, P. S. (2007) · Humana Press eBooks · doi:10.1007/978-1-59745-200-7_3 · Cited by 2 · see citing works

Assembly of Mesoporous Silica Nanoparticle Drug Conjugates for Enhanced Delivery

Yu, J., Chlebanowski, L., Hammer, J. L., Thapa, P. S., Shrestha, T. B., Wang, H., Covarrubias‐Zambrano, O., Troyer, D. L., & Bossmann, S. H. (2023) · doi:10.1002/9783527834044.ch28 · Cited by 2 · see citing works

Novel chromone-based thiazolidinone-5-ylidene through hydrazone linker: synthesis, antiproliferative activity, apoptosis induction, cell cycle arrest, autophagy, in silico ADMET and molecular docking studies

Abdel‐Kariem, S. M., Tarik El-Sayed, A. L. I., Assiri, M. A., Shati, A. A., Alfaifi, M. Y., & Elbehairi, S. E. I. (2025) · Phosphorus, sulfur, and silicon and the related elements · doi:10.1080/10426507.2025.2560493 · Cited by 1 · see citing works

A Patent Review on Thiazole Derivatives (2008-2013)

Leoni, A., Aless, Locatelli, R., Morigi, R., & Rambaldi, M. (2017) · Archivio istituzionale della ricerca (Alma Mater Studiorum Università di Bologna) · Cited by 1 · see citing works

Theoretical Bioevaluation of 1,2,4-Thiadiazole-1,2,4-triazole Derivatives via Molecular Modelling Approach

Kolawole, O. A., Adewale, A. S., Odoemene, S. N., Emmanuel, O. O., & Semire, B. (2021) · Asian Journal of Organic & Medicinal Chemistry · doi:10.14233/ajomc.2021.ajomc-p307 · Cited by 1 · see citing works

Teaching cancer cells to die

Zawel, L. S. (2004) · Journal of Cellular Biochemistry · doi:10.1002/jcb.20103

Lentivirus-mediated shRNA targeting decoy receptor 3 (DcR3) inhibits proliferation and augments apoptosis in pancreatic cancer Capan-1 cells

Zhang, Y. (2013) · African Journal of Pharmacy and Pharmacology · doi:10.5897/ajpp12.994

Nine Glorious Years

Russell, W. M. S. (2004) · Alternatives to Laboratory Animals · doi:10.1177/026119290403201s05

Therapeutic Approaches to Modulation of Cell Death (non-HIV)

Ditsworth, D., Elstrom, R., & Thompson, C. B. (2005) · CRC Press eBooks · doi:10.1201/9781420038156-31

Chemical Delivery Systems

Bodor, N. S., & Buchwald, P. (2012) · Wiley eBooks · doi:10.1002/9781118407738.ch6

Therapeutic Approaches to Modulation of Cell Death (non-HIV)

Thompson, C. B., Ditsworth, D., & Elstrom, R. (2005) · CRC Press eBooks · doi:10.1201/9781420038156.ch27

Green Chemicals From Microalgae

Makhlof, M. E. M., Shehata, N., & EL‐Sayed, A. I. M. (2023) · Elsevier eBooks · doi:10.1016/b978-0-443-15738-7.00014-3

Application of Antisense Technology in Malignant Melanoma

Gao, M. (2006) · Jiepou kexue jinzhan

Apoptosis, Bcl-2 antisense, and cancer therapy.

Piro, L. D. (2004) · PubMed · doi:10.12673/jant.2011.15.2.256

Potential roles of antisense therapy in the molecular targeting of genes involved in cancer (Review)

Kim, R., Tanabe, K., Emi, M., Uchida, Y., & Toge, T. (2004) · International Journal of Oncology · doi:10.3892/ijo.24.1.5 · Cited by 15 · see citing works

Induction of chemosensitivity in human lung cancer cells in vivo by adenovirus-mediated transfer of the wild-type p53 gene.

Fujiwara, T., Grimm, E. A., Mukhopadhyay, T., Zhang, W. W., Owen‐Schaub, L. B., & Roth, J. A. (1994) · PubMed · Cited by 464 · see citing works

Therapeutic potential of antisense Bcl‐2 as a chemosensitizer for cancer therapy

Kim, R., Emi, M., Tanabe, K., & Toge, T. (2004) · Cancer · doi:10.1002/cncr.20696 · Cited by 109 · see citing works