The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.
Asthma
Open accessAbstract
Asthma is the most common inflammatory disease of the lungs. The prevalence of asthma is increasing in many parts of the world that have adopted aspects of the Western lifestyle, and the disease poses a substantial global health and economic burden. Asthma involves both the large-conducting and the small-conducting airways, and is characterized by a combination of inflammation and structural remodelling that might begin in utero. Disease progression occurs in the context of a developmental background in which the postnatal acquisition of asthma is strongly linked with allergic sensitization. Most asthma cases follow a variable course, involving viral-induced wheezing and allergen sensitization, that is associated with various underlying mechanisms (or endotypes) that can differ between individuals. Each set of endotypes, in turn, produces specific asthma characteristics that evolve across the lifecourse of the patient. Strong genetic and environmental drivers of asthma interconnect through novel epigenetic mechanisms that operate prenatally and throughout childhood. Asthma can spontaneously remit or begin de novo in adulthood, and the factors that lead to the emergence and regression of asthma, irrespective of age, are poorly understood. Nonetheless, there is mounting evidence that supports a primary role for structural changes in the airways with asthma acquisition, on which altered innate immune mechanisms and microbiota interactions are superimposed. On the basis of the identification of new causative pathways, the subphenotyping of asthma across the lifecourse of patients is paving the way for more-personalized and precise pathway-specific approaches for the prevention and treatment of asthma, creating the real possibility of total prevention and cure for this chronic inflammatory disease.
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Citations
Cites
Hay fever, hygiene, and household size.
Strachan, D. P. (1989) · BMJ · doi:10.1136/bmj.299.6710.1259 · Cited by 5,054
Outdoor air pollution and asthma.
Guarnieri, M., & Balmes, J. R. (2014) · The Lancet · doi:10.1016/s0140-6736(14)60617-6 · Cited by 1,889
Lambrecht, B. N., & Hammad, H. (2015) · Nature Immunology · doi:10.1038/ni.3049 · Cited by 1,673
Sporik, R., Holgate, S. T., Platts-Mills, T. A. E., & Cogswell, J. J. (1990) · New England Journal of Medicine · doi:10.1056/nejm199008233230802 · Cited by 1,648
Self-citationExposure to Environmental Microorganisms and Childhood Asthma
Ege, M. J., Mayer, M., Normand, A.-C., Genuneit, J., Cookson, W. O. C. M., Braun-Fahrländer, C., Heederik, D., Piarroux, R., & von Mutius, E. (2011) · New England Journal of Medicine · doi:10.1056/nejmoa1007302 · Cited by 1,529
Outcome of Asthma and Wheezing in the First 6 Years of Life
Morgan, W. J., Stern, D. A., Sherrill, D. L., Guerra, S., Holberg, C. J., Guilbert, T. W., Taussig, L. M., Wright, A. L., & Martinez, F. D. (2005) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200504-525oc · Cited by 650
Rhinitis and onset of asthma: a longitudinal population-based study
Shaaban, R., Zureik, M., Soussan, D., Neukirch, C., Heinrich, J., Sunyer, J., Wjst, M., Cerveri, I., Pin, I., Bousquet, J., et al. (2008) · The Lancet · doi:10.1016/s0140-6736(08)61446-4 · Cited by 610
T H 2 and T H 17 inflammatory pathways are reciprocally regulated in asthma
Choy, D. F., Hart, K. M., Borthwick, L. A., Shikotra, A., Nagarkar, D. R., Siddiqui, S., Jia, G., Ohri, C. M., Doran, E., Vannella, K. M., et al. (2015) · Science Translational Medicine · doi:10.1126/scitranslmed.aab3142 · Cited by 450
Beyond Atopy: Multiple Patterns of Sensitization in Relation to Asthma in a Birth Cohort Study
Simpson, A., Tan, V. Y. F., Winn, J., Svensén, M., Bishop, C. M., Heckerman, D. E., Buchan, I., & Custovic, A. (2010) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200907-1101oc · Cited by 415
Overdiagnosis of asthma in obese and nonobese adults
Aaron, S. D., Vandemheen, K. L., Boulet, L.-P., McIvor, R. A., FitzGerald, J. M., Hernandez, P., Lemiere, C., Sharma, S., Field, S. K., Alvarez, G. G., et al. (2008) · Canadian Medical Association Journal · doi:10.1503/cmaj.081332 · Cited by 400
Cited by
A cellular census of human lungs identifies novel cell states in health and in asthma
Vieira Braga, F. A., Kar, G., Berg, M., Carpaij, O. A., Polanski, K., Simon, L. M., Brouwer, S., Gomes, T., Hesse, L., Jiang, J., et al. (2019) · Nature Medicine · doi:10.1038/s41591-019-0468-5 · Cited by 896
Reassessing the Host Defense Peptide Landscape
Haney, E. F., Straus, S. K., & Hancock, R. E. W. (2019) · Frontiers in Chemistry · doi:10.3389/fchem.2019.00043 · Cited by 359
Interleukin-5 in the Pathophysiology of Severe Asthma.
Pelaia, C., Paoletti, G., Puggioni, F., Racca, F., Pelaia, G., Canonica, G. W., & Heffler, E. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2019.01514 · Cited by 337
Epigenetics and Allergy: from Basic Mechanisms to Clinical Applications
Potaczek, D. P., Harb, H., Michel, S., Alhamwe, B. A., Renz, H., & Tost, J. (2017) · Epigenomics · doi:10.2217/epi-2016-0162 · Cited by 284
Self-citationEpithelial barrier repair and prevention of allergy
Goleva, E., Berdyshev, E., & Leung, D. Y. M. (2019) · Journal of Clinical Investigation · doi:10.1172/jci124608 · Cited by 251
Metadata
- Authors
- Holgate, S. T., Wenzel, S., Postma, D. S., Weiss, S. T., Renz, H., & Sly, P. D.
- Venue
- Nature Reviews Disease Primers
- Published
- 2015-09-10
- Volume
- 1
- Issue
- 1
- Pages
- 15025-15025
- ISSN
- 2056-676X (ISSN-L)
- OpenAlex
- W4210991698
- Cited by
- 652
- References
- 16
- FWCI
- 2.25
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Holgate, S. T., Wenzel, S., Postma, D. S., Weiss, S. T., Renz, H., & Sly, P. D. (2015). Asthma. Nature Reviews Disease Primers. https://doi.org/10.1038/nrdp.2015.25
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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