The 2018 Revision to the Process of Care Model for Evaluation of Erectile Dysfunction
Abstract
BACKGROUND: Erectile dysfunction (ED) is a common condition that may affect men of all ages; in 1999, a Process of Care Model was developed to provide clinicians with recommendations regarding the evaluation and management of ED. AIM: To reflect the evolution of the study of ED since 1999, this update to the process of care model presents health care providers with a tool kit to facilitate patient interactions, comprehensive evaluation, and counseling for ED. METHODS: A cross-disciplinary panel of international experts met to propose updates to the 1999 process of care model from a global perspective. The updated model was designed to be evidence-based, data-driven, and accessible to a wide range of health care providers. OUTCOMES: This article summarizes the resulting discussion of the expert meeting and focuses on ED evaluation. The management of ED is discussed in an article by Muhall et al (J Sex Med 2018;15:1280-1292). RESULTS: A comprehensive approach to the evaluation of ED is warranted because ED may involve both psychological and organic components. The updated process of care model for evaluation was divided into core and optional components and now focuses on the combination of first-line pharmacotherapy and counseling in consideration of patient sexual dynamics. CLINICAL IMPLICATIONS: Patient evaluation for ED should encompass a variety of aspects, including medical history, sexual history, physical examination, psychological evaluation, laboratory testing, and possibly adjunctive testing. STRENGTHS & LIMITATIONS: This update draws on author expertise and experience to provide multi-faceted guidance for the evaluation of ED in a modern context. Although a limited number of contributors provided input on the update, these experts represent diverse fields that encounter patients with ED. Additionally, no meta-analyses were performed to further support the ED evaluation guidelines presented. CONCLUSION: Comprehensive evaluation of ED affords health care providers an opportunity to address medical, psychological/psycho-social, and sexual issues associated with ED, with the ultimate goal being effective management and possibly resolution of ED. While some or all techniques described in the updated model may be needed for each patient, evaluation should in all cases be thorough. Mulhall JP, Giraldi A, Hackett G, et al. The 2018 Revision to the Process of Care Model for Evaluation of Erectile Dysfunction. J Sex Med 2018;15:1280-1292.
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Medical treatments, especially pharmacotherapy, are often viewed as more effective and cost-efficient than psychological treatments.
“Medical treatments, especially pharmacotherapy, are often viewed as more effective and cost-efficient than psychological treatments because the latter raise uncertainty about treatment duration and outcome.49,87,104,105”
From A Psychosocial Approach to Erectile Dysfunction: Position Statements from the European Society of Sexual Medicine (ESSM) (2021) · cites this paper as [87]
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Behavioural Therapy and Counselling
Jannini, E. A., Lenzi, A., & Wagner, G. (2006) · Springer eBooks · doi:10.1007/3-540-33713-x_100 · Cited by 17 · see citing works
Rastrelli, G., Boddi, V., Corona, G., Mannucci, E., & Maggi, M. (2013) · The Journal of Sexual Medicine · doi:10.1111/jsm.12052 · Cited by 16 · see citing works
Vicari, E. S. D., Pino, L. D., Vignera, S. L., Fratantonio, E., Signorelli, S. S., Battiato, C., & Calogero, A. E. (2005) · International Journal of Impotence Research · doi:10.1038/sj.ijir.3901387 · Cited by 14 · see citing works
How to Identify Subjects with Poly-Vascular Disease?
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Mulhall, J. P., Hassan, T. A., & Rienow, J. (2018) · International Journal of Clinical Practice · doi:10.1111/ijcp.13074 · Cited by 11 · see citing works
PREDICTION OF CARDIOVASCULAR EVENTS WITH AORTIC STIFFNESS IN PATIENTS WITH ERECTILE DYSFUNCTION
Vlachopoulos, C. V., Ioakeimidis, N., Aznaouridis, K. A., Terentes-Printzios, D. G., Rokkas, K., Aggelis, A., Synodinos, A., Christoforatou, E., Panagiotakos, D., & Stefanadis, C. (2012) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(12)62073-7 · Cited by 7 · see citing works
POTENCY, CONTINENCE AND COMPLICATION RATES IN 1,870 CONSECUTIVE RADICAL RETROPUBIC PROSTATECTOMIES
(1999) · The Journal of Urology · doi:10.1016/s0022-5347(05)68579-5 · Cited by 6 · see citing works
Rastrelli, G., Boddi, V., Corona, G., Forti, G., & Maggi, M. (2013) · Endocrine Abstracts · doi:10.1530/endoabs.32.p657 · Cited by 2 · see citing works
Urologic and Clinical Evaluation of the Male with Erectile Dysfunction
Berookhim, B. M., Pastuszak, A. W., Bar-Chama, N. C., & Khera, M. (2016) · Springer eBooks · doi:10.1007/978-1-4939-3100-2_6 · Cited by 2 · see citing works
Flagged first, then by citations
9 of the 108 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Corona, G., Cucinotta, D., Lorenzo, G. D., Ferlin, A., Giagulli, V. A., Gnessi, L., Isidori, A. M., Maiorino, M. I., Miserendino, P., Murrone, A., et al. (2023) · Journal of Endocrinological Investigation · doi:10.1007/s40618-023-02015-5 · Cited by 125 · see citing works
“The maximum response is defined as a PSV value above 25–35 cm/s, while enddiastolic velocity (EDV) value cut-off is < 5 cm/s [197].”
BackgroundMethodInfluentialSansone, A., Mollaioli, D., Ciocca, G., Colonnello, E., Limoncin, E., Balercia, G., & Jannini, E. A. (2021) · Andrology · doi:10.1111/andr.13003 · Cited by 102 · see citing works
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“10,87 Given the involvement of psychosocial factors in the etiology of ED, it should be standard practice to take a detailed psychosexual history that focuses on the cognitive, emotional, and relational experiences associated with ED.”
BackgroundAssessment of Combination Therapies vs Monotherapy for Erectile Dysfunction
Mykoniatis, I., Pyrgidis, N., Sokolakis, I., Ouranidis, A., Sountoulides, P., Haidich, A., van Renterghem, K., Hatzichristodoulou, G., & Hatzichristou, D. G. (2021) · JAMA Network Open · doi:10.1001/jamanetworkopen.2020.36337 · Cited by 79 · see citing works
An update on the diagnosis and treatment of diabetic somatic and autonomic neuropathy
Azmi, S., Petropoulos, I. N., Ferdousi, M., Ponirakis, G., Alam, U., & Malik, R. A. (2019) · F1000Research · doi:10.12688/f1000research.17118.1 · Cited by 41 · see citing works
Pyrgidis, N., Mykoniatis, I., Nigdelis, M. P., Kalyvianakis, D., Memmos, E., Sountoulides, P., & Hatzichristou, D. G. (2020) · The Journal of Sexual Medicine · doi:10.1016/j.jsxm.2020.10.012 · Cited by 37 · see citing works
Erectile dysfunction links to cardiovascular disease—defining the clinical value
Orimoloye, O. A., Feldman, D. I., & Blaha, M. J. (2019) · Trends in Cardiovascular Medicine · doi:10.1016/j.tcm.2019.01.002 · Cited by 36 · see citing works
Sansone, A., Cuzin, B., & Jannini, E. A. (2021) · Sexual Medicine · doi:10.1016/j.esxm.2021.100437 · Cited by 35 · see citing works
Relationship between hyperuricemia with deposition and sexual dysfunction in males and females
Sansone, A., Reisman, Y., & Jannini, E. A. (2022) · Journal of Endocrinological Investigation · doi:10.1007/s40618-021-01719-w · Cited by 31 · see citing works
Sansone, A., Yuan, J., Hou, G., Zhang, L., Gao, M. J., Zhang, Z., Jiang, H., Wang, F., Guo, J., Geng, Q., et al. (2023) · Andrology · doi:10.1111/andr.13403 · Cited by 23 · see citing works
Diagnosing and managing diabetic somatic and autonomic neuropathy
Azmi, S., Ferdousi, M., Kalteniece, A., Almuhannadi, H., Al‐Mohamedi, A., Hadid, N. H., Mahmoud, S., Bhat, H., Gad, H., Khan, A., et al. (2019) · Therapeutic Advances in Endocrinology and Metabolism · doi:10.1177/2042018819826890 · Cited by 22 · see citing works
Capogrosso, P., Pozzi, E., Celentano, V., Sánchez-Salas, R., & Salonia, A. (2019) · The Journal of Sexual Medicine · doi:10.1016/j.jsxm.2019.09.013 · Cited by 19 · see citing works
Stern, N., Bajic, P., Campbell, J. D., Capogrosso, P., Domes, T., Miranda, E., Mulhall, J. P., Nascimento, B., Pignanelli, M., Pastuszak, A. W., et al. (2025) · Sexual Medicine Reviews · doi:10.1093/sxmrev/qeaf035 · Cited by 17 · see citing works
Chung, E., Lowy, M. P., Gillman, M., Love, C., Katz, D. J., & Neilsen, G. A. (2022) · The Medical Journal of Australia · doi:10.5694/mja2.51694 · Cited by 15 · see citing works
Chung, E., Moon, D. G., Jiang, H., Chang, H., Hakim, L., Nagao, K., Tan, R., Mak, S. K., Tantiwongse, K., Lin, H., et al. (2023) · Sexual Medicine · doi:10.1093/sexmed/qfad003 · Cited by 12 · see citing works
The Role of the “Anti-Inflammatory” Couple for the Management of Hyperuricemia With Deposition
Sansone, A., Reisman, Y., Meto, S., Dolci, S., & Jannini, E. A. (2022) · Sexual Medicine · doi:10.1016/j.esxm.2022.100562 · Cited by 12 · see citing works
“Based on the initial screening, sexual function could be investigated by focused physical examination and laboratory and instrumental tests aiming to identify the severity of the symptom (subclinical, mild, moderate, severe), to identify the comorbidity with other sexual dysfunctions, to find other comorbid NCDs and r…”
BackgroundSansone, A., Frangione, V., Lanzarotti, A., Cocci, A., Ceruti, C., SIO, M. D., Imbimbo, C., Mirone, V. G., Schips, L., Terrone, C., et al. (2023) · Sexual Medicine · doi:10.1093/sexmed/qfac007 · Cited by 9 · see citing works
Male sexual dysfunction: Clinical diagnosis and management strategies for common sexual problems
Nicol, A. V., & Chung, E. (2023) · Australian Journal of General Practice · doi:10.31128/ajgp-09-22-6559 · Cited by 9 · see citing works
Gerbild, H. N., Josefsson, K. A., Larsen, C. M., & Laursen, B. S. (2021) · Sexual Medicine · doi:10.1016/j.esxm.2021.100369 · Cited by 10 · see citing works
Capogrosso, P., Boeri, L., Pozzi, E., Ventimiglia, E., Schifano, N., Abbate, C., Matloob, R., Dehò, F., Montorsi, F., & Salonia, A. (2019) · European Urology Focus · doi:10.1016/j.euf.2019.08.007 · Cited by 7 · see citing works
Huang, Y., Ho, D., Lin, J.-H., Huang, K.-T., Cheng, C., & Shi, C. (2019) · The Journal of Sexual Medicine · doi:10.1016/j.jsxm.2019.03.013 · Cited by 6 · see citing works
Sansone, A., Kliesch, S., Dugas, M., Sandhowe‐Klaverkamp, R., Isidori, A. M., Schlatt, S., & Zitzmann, M. (2021) · Journal of Endocrinological Investigation · doi:10.1007/s40618-021-01561-0 · Cited by 6 · see citing works
“The diagnostic workup of patients’ symptoms of hypogonadism in general and especially with erectile dysfunction must include adequate medical, sexual and psychosocial history taking [62], as also suggested by recent guidelines [3, 63, 64].”
MethodLuria, M., Park, K., Gewirtz‐Meydan, A., Arbanas, G., Ho, C. C. K., Ros, C. T. D., Srini, V. S., & Faubion, S. S. (2025) · Sexual Medicine Reviews · doi:10.1093/sxmrev/qeaf069 · Cited by 5 · see citing works
Jannini, T. B., & Giraldi, A. G. E. (2025) · Trends in andrology and sexual medicine · doi:10.1007/978-3-031-98580-5_4 · Cited by 4 · see citing works
Lin, J.-H., Ho, D., Shi, C., Cheng, C., Li, J., & Huang, Y. (2020) · Translational Andrology and Urology · doi:10.21037/tau.2019.12.45 · Cited by 4 · see citing works
“While ED is a benign disorder, it nevertheless adversely affects the quality of life of the patients and their partners (3).”
BackgroundWang, M., Dai, Y., Jiang, H., Sansone, A., Jannini, E. A., & Zhang, X. (2022) · The Aging Male · doi:10.1080/13685538.2022.2121815 · Cited by 4 · see citing works
Albarakati, M., El‐Tholoth, H. S., Alzahrani, A., Alghamdi, O. S., Alquliti, A., Alnuami, M., Althobity, A., Almardawi, A., & Bedaiwi, K. (2023) · Cureus · doi:10.7759/cureus.50515 · Cited by 4 · see citing works
“Consequently, it is vital to take a detailed sexual history and gather other relevant data (including age, sexual orientation, marital status, and past sexual experiences) to identify the cause of ED and to detect the possible comorbidities, toxic habits, or drugs that could result in ED [8].”
BackgroundGerbild, H. N., Josefsson, K. A., Larsen, C. M., & Laursen, B. S. (2021) · Scandinavian Journal of Caring Sciences · doi:10.1111/scs.13021 · Cited by 4 · see citing works
The Canary and the Bone: A Darwinian Lecture on Erectile Dysfunction
Hassan, T. A., Vignesh, S. O., Sansone, A., Jannini, T. B., Dolci, S., Zhang, C., Zhang, Y., & Jannini, E. A. (2025) · Trends in andrology and sexual medicine · doi:10.1007/978-3-031-98580-5_1 · Cited by 3 · see citing works
Management of Sexual Dysfunction
Rochira, V., Carani, C., & Granata, A. R. M. (2022) · doi:10.1093/med/9780198870197.003.0193 · Cited by 3 · see citing works
Modern Management of Erectile Dysfunction: An Integrative and Regenerative Therapeutic Framework
Klokol, D., Wong, M. B., Chernykh, V., Iemeliyanova, M., Nishkumai, O., Alvin, G., & Chan, M. K. S. (2026) · SSP Modern Pharmacy and Medicine · doi:10.53933/7z0cx674 · Cited by 2 · see citing works
Abichandani, V. K., & Kalhan, A. (2023) · Chronicle of Diabetes Research and Practice · doi:10.4103/cdrp.cdrp_cdrp_20_22 · Cited by 1 · see citing works
Autonome diabetische Neuropathie
Ziegler, D. (2020) · Der Diabetologe · doi:10.1007/s11428-020-00596-w · Cited by 1 · see citing works
“ohne Diabetes um das 1,5- bis 2,9-Fache erhöht [20].”
BackgroundAhmed, H. A. S., Abdallah, E. M., Mohamed, M. A. E., Aboelfotoh, T. M., Nour-Eldein, H., & Fouad, A. (2024) · Diabetology International · doi:10.1007/s13340-024-00699-5
“Patient management seeks to restore sexual pleasure for the patient or couple and enhance quality of life [41].”
Clinical Aspects of Erectile Dysfunction
Miranda, E., & Carneiro, F. (2024) · Springer eBooks · doi:10.1007/978-3-031-55649-4_5
Mengesha, A. K., Limenh, L. W., Ayenew, W. A., Chanie, G. S., Seid, A. M., Mitku, M. L., Melese, M., Gela, Y. Y., Esubalew, D., & Beyna, A. T. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e36317
“When identifying organic etiology, the primary focus shifts to managing comorbid diseases that contribute to the issue [10,11].”
BackgroundAidoo, S., Afoko, A. A., Adams, Y., Dapare, P. P. M., Bani, S. B., Afoko, V., & Alliah, V. (2025) · Open Journal of Urology · doi:10.4236/oju.2025.153010
Haddad, A., Alzarooni, A. I. M. A., Kassem, H., El‐Khoury, J., Hussein, S., Hassan, T., Vignesh, S. O., Siddiqui, U., & Zubaidi, O. (2025) · Journal of Multidisciplinary Healthcare · doi:10.2147/jmdh.s554974
“The current evidence-based international guidelines on the treatment of ED, particularly the EAU Guidelines on Sexual and Reproductive Health 2025 12 and the 2018 Revision to the Process of Care Model for Evaluation of Erectile Dysfunction, 8 as well as the epidemiological data on ED in Arab countries, were reviewed b…”
Advances in Penile Implants and Mechanical Devices for Erectile Dysfunction
Chung, E., Rojas-Cruz, C., & Shah, R. S. (2026) · Springer eBooks · doi:10.1007/978-3-032-29112-7_19
- Authors
- Mulhall, J. P., Giraldi, A., Hackett, G., Hellstrom, W. J. G., Jannini, E. A., Rubio-Aurioles, E., Trost, L., & Hassan, T. A.
- Affiliations
- Memorial Sloan Kettering Cancer Center (US)
- University of Copenhagen (DK)
- Aston University Birmingham , Birmingham , United Kingdom
- Tulane University (US)
- University of Rome Tor Vergata (IT)
- Asociación Mexicana para la Salud Sexual A.C. (AMSSAC), La Joya , Mexico City , Mexico
- Mayo Clinic (US)
- Pfizer (United States) (US)
- Corresponding author
- Mulhall, John P.
- Venue
- The Journal of Sexual Medicine
- Publisher
- Oxford University Press (OUP)
- Published
- 2018-07-26
- Volume
- 15
- Issue
- 9
- Pages
- 1280-1292
- ISSN
- 1743-6095 (ISSN-L)
- 1743-6109
- OpenAlex
- W2884841306
- Cited by
- 40
- References
- 108
- Citations by year
- 2026: 2 · 2025: 6 · 2024: 3 · 2023: 7 · 2022: 5 · 2021: 8 · 2020: 3 · 2019: 6
- FWCI
- 3.32
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- The Journal of Sexual Medicine (publishedVersion)
- PubMed (publishedVersion)
- Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
- Funders
- Pfizer Inc. Editorial
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Sexual function and dysfunction studies
- Health Sciences › Medicine › Urology › Urological Disorders and Treatments
- Social Sciences › Psychology › Clinical Psychology › Sexuality, Behavior, and Technology
- Keywords
- erectile dysfunction, psychological assessment, sexual counseling, first-line pharmacotherapy, sexual history, laboratory testing
- MeSH terms
- Humans, Erectile Dysfunction, Male, Models, Theoretical
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