The DOI matches its Crossref record; 173 of the 173 references it cites were found in a registry or an index.
Severe childhood malnutrition
Open accessAbstract
The main forms of childhood malnutrition occur predominantly in children <5 years of age living in low-income and middle-income countries and include stunting, wasting and kwashiorkor, of which severe wasting and kwashiorkor are commonly referred to as severe acute malnutrition. Here, we use the term ‘severe malnutrition’ to describe these conditions to better reflect the contributions of chronic poverty, poor living conditions with pervasive deficits in sanitation and hygiene, a high prevalence of infectious diseases and environmental insults, food insecurity, poor maternal and fetal nutritional status and suboptimal nutritional intake in infancy and early childhood. Children with severe malnutrition have an increased risk of serious illness and death, primarily from acute infectious diseases. International growth standards are used for the diagnosis of severe malnutrition and provide therapeutic end points. The early detection of severe wasting and kwashiorkor and outpatient therapy for these conditions using ready-to-use therapeutic foods form the cornerstone of modern therapy, and only a small percentage of children require inpatient care. However, the normalization of physiological and metabolic functions in children with malnutrition is challenging, and children remain at high risk of relapse and death. Further research is urgently needed to improve our understanding of the pathophysiology of severe malnutrition, especially the mechanisms causing kwashiorkor, and to develop new interventions for prevention and treatment.
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Cited by
The impact of malnutrition on childhood infections
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Self-citationThe Role of Nutrition in COVID-19 Susceptibility and Severity of Disease: A Systematic Review
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“The severe form of the latter, severe acute malnutrition, is associated with up to 50% mortality among children admitted to the hospital (25).”
BackgroundHulst, J. M., Huysentruyt, K., Gerasimidis, K., Shamir, R., Koletzko, B., Chourdakis, M., Fewtrell, M., Joosten, K. F., & Special Interest Group Clinical Malnutrition of ESPGHAN (2022) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0000000000003437 · Cited by 59
Global Burden of Nutritional Deficiencies among Children under 5 Years of Age from 2010 to 2019
Yue, T., Zhang, Q., Li, G., & Qin, H. (2022) · Nutrients · doi:10.3390/nu14132685 · Cited by 49
Kiosia, A., Dagbasi, A., Berkley, J. A., Wilding, J. P. H., Prendergast, A. J., Li, J. V., Swann, J., Mathers, J. C., Kerac, M., Morrison, D., et al. (2024) · Nutrition Bulletin · doi:10.1111/nbu.12670 · Cited by 43
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Metadata
- Authors
- Bhutta, Z. A., Berkley, J. A., Bandsma, R. H. J., Kerac, M., Trehan, I., & Briend, A.
- Venue
- Nature Reviews Disease Primers
- Published
- 2017-09-21
- Volume
- 3
- Issue
- 1
- Pages
- 17067-17067
- ISSN
- 2056-676X (ISSN-L)
- OpenAlex
- W2754934236
- Cited by
- 481
- References
- 173
- FWCI
- 1.95
- Type
- journal article
- Language
- en
- Open access
- green
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- Bhutta, Z. A., Berkley, J. A., Bandsma, R. H. J., Kerac, M., Trehan, I., & Briend, A. (2017). Severe childhood malnutrition. Nature Reviews Disease Primers. https://doi.org/10.1038/nrdp.2017.67
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