Epigenetic mechanisms that underpin metabolic and cardiovascular diseases

Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls

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Epigenetic programming by maternal behavior

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Developmental Plasticity and Evolution

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Epigenetic differences arise during the lifetime of monozygotic twins

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Type 2 (non-insulin-dependent) diabetes mellitus: the thrifty phenotype hypothesis

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Persistent epigenetic differences associated with prenatal exposure to famine in humans

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The Wellcome Trust Case Control Consortium, U.K.

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Genome-scale DNA methylation maps of pluripotent and differentiated cells

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Epigenetics: A landscape takes shape

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Metabolic Syndrome in Childhood: Association With Birth Weight, Maternal Obesity, and Gestational Diabetes Mellitus

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Epidemiology of diabetes among South Asians in the United States: lessons from the MASALA study

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Link between depression and cardiovascular diseases due to epigenomics and proteomics: Focus on energy metabolism

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Hypomethylation of Dual Specificity Phosphatase 22 Promoter Correlates With Duration of Service in Firefighters and Is Inducible by Low-Dose Benzo[a]Pyrene

Ouyang, B., Baxter, C. S., Lam, H., Yeramaneni, S., Levin, L. S., Haynes, E. N., & Ho, S. (2012) · Journal of Occupational and Environmental Medicine · doi:10.1097/jom.0b013e31825296bc · Cited by 49

Impact of High Glucose and Proteasome Inhibitor MG132 on Histone H2A and H2B Ubiquitination in Rat Glomerular Mesangial Cells

Gao, C., Chen, G., Liu, L., Li, X., He, J., Jiang, L., Zhu, J., & Xu, Y. (2013) · Journal of Diabetes Research · doi:10.1155/2013/589474 · Cited by 44

Mechanisms Linking Suboptimal Early Nutrition and Increased Risk of Type 2 Diabetes and Obesity1–3

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Maternal diet-induced obesity and offspring cardiovascular health

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Is Cellular Heterogeneity Merely a Confounder to be Removed from Epigenome-Wide Association Studies?

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Inflammation: the driver of poor outcomes among children with severe acute malnutrition?

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Identification of Histone Lysine Acetoacetylation as a Dynamic Post‐Translational Modification Regulated by HBO1

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Association of maternal and nutrient supply line factors with DNA methylation at the imprinted IGF2/H19 locus in multiple tissues of newborn twins

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Vascular dysfunction in children conceived by assisted reproductive technologies: underlying mechanisms and future implications

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Fetal Growth Restriction Promotes Physical Inactivity and Obesity in Female Mice

Baker, M. S., Li, G., Kohorst, J. J., & Waterland, R. (2013) · International Journal of Obesity · doi:10.1038/ijo.2013.146 · Cited by 49

Investigating micronutrients and epigenetic mechanisms in relation to inflammatory bowel disease

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Role of placental insufficiency and intrauterine growth restriction on the activation of fetal hepatic glucose production

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Healthy ageing of cloned sheep

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Adipogenic effects of prenatal exposure to bisphenol S (BPS) in adult F1 male mice

Ahn, Y.-A., Baek, H., Choi, M., Park, J., Son, S. J., Seo, H., Jung, J., Seong, J. K., Lee, J., & Kim, S. (2020) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2020.138759 · Cited by 41

Copy Number Variant Risk Scores Associated With Cognition, Psychopathology, and Brain Structure in Youths in the Philadelphia Neurodevelopmental Cohort

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Integrated metabolic modelling reveals cell-type specific epigenetic control points of the macrophage metabolic network

Pacheco, M. P., John, E., Kaoma, T., Heinäniemi, M., Nicot, N., Vallar, L., Bueb, J., Sinkkonen, L., & Sauter, T. (2015) · BMC Genomics · doi:10.1186/s12864-015-1984-4 · Cited by 42

Single‐molecule genomics

McCaughan, F. M., & Dear, P. H. (2009) · The Journal of Pathology · doi:10.1002/path.2647 · Cited by 41

DNA Methylation as a Mechanism of Nutritional Plasticity: Limited Support From Horned Beetles

Snell‐Rood, E. C., Troth, A., & Moczek, A. P. (2012) · Journal of Experimental Zoology Part B Molecular and Developmental Evolution · doi:10.1002/jez.b.22479 · Cited by 41

Ancestral diet transgenerationally influences offspring in a parent-of-origin and sex-specific manner

Emborski, C. A., & Mikheyev, A. S. (2019) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2018.0181 · Cited by 43

Parental effects in development and evolution

Uller, T. (2012) · Oxford University Press eBooks · doi:10.1093/acprof:oso/9780199692576.003.0014 · Cited by 39

Mitochondrial DNA Copy Number and Developmental Origins of Health and Disease (DOHaD)

Fukunaga, H. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22126634 · Cited by 41

DNA methylation in an engineered heart tissue model of cardiac hypertrophy: common signatures and effects of DNA methylation inhibitors

Stenzig, J., Hirt, M. N., Löser, A., Bartholdt, L. M., Hensel, J.-T., Werner, T., Riemenschneider, M., Indenbirken, D., Guenther, T., Müller, C., et al. (2015) · Basic Research in Cardiology · doi:10.1007/s00395-015-0528-z · Cited by 40

The Periconceptional Environment and Cardiovascular Disease: Does In Vitro Embryo Culture and Transfer Influence Cardiovascular Development and Health?

Padhee, M., Zhang, S., Lie, S., Wang, K. C. W., Botting, K. J., McMillen, I. C., MacLaughlin, S. M., & Morrison, J. L. (2015) · Nutrients · doi:10.3390/nu7031378 · Cited by 38

Metabolism–epigenome crosstalk in physiology and diseases

Hino, S., Nagaoka, K., & Nakao, M. (2013) · Journal of Human Genetics · doi:10.1038/jhg.2013.57 · Cited by 39

Up-Regulated Expression and Aberrant DNA Methylation of LEP and SH3PXD2A in Pre-Eclampsia

Xiang, Y., Cheng, Y., Li, X., Li, Q., Xu, J., Zhang, J., Liu, Y., Xing, Q., Wang, L., He, L., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0059753 · Cited by 39

The implications for aquaculture practice of epigenomic programming of components of the endocrine system of teleostean embryos: lessons learned from mammalian studies

Li, M., & Leatherland, J. F. (2012) · Fish and Fisheries · doi:10.1111/j.1467-2979.2012.00486.x · Cited by 38

The Role of DNA Methylation in Gene Regulation

Bommarito, P. A., & Fry, R. C. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-812433-8.00005-8 · Cited by 40

Epigenetics and In Utero Acquired Predisposition to Metabolic Disease

Deodati, A., Inzaghi, E., & Cianfarani, S. (2020) · Frontiers in Genetics · doi:10.3389/fgene.2019.01270 · Cited by 40

The nutritionally responsive transcriptome of the polyphenic beetle Onthophagus taurus and the importance of sexual dimorphism and body region

Kijimoto, T., Snell‐Rood, E. C., Pespeni, M. H., Rocha, G., Kafadar, K., & Moczek, A. P. (2014) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.2014.2084 · Cited by 36

Counteracting aged DNA methylation states to combat ageing and age-related diseases

Reale, A., Tagliatesta, S., Zardo, G., & Zampieri, M. (2022) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2022.111695 · Cited by 42

Plasma homocysteine involved in methylation and expression of thrombomodulin in cerebral infarction

Yang, Z., Wang, L., Zhang, W., Wang, X., & Zhou, S. (2016) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2016.04.042 · Cited by 36

The Challenges of Precision Medicine in Obstructive Sleep Apnea

Khalyfa, A., Gileles‐Hillel, A., & Gozal, D. (2016) · Sleep Medicine Clinics · doi:10.1016/j.jsmc.2016.01.003 · Cited by 37

Omics Insights into Animal Resilience and Stress Factors

Basile, F., Capaccia, C., Zampini, D., Biagetti, T., Diverio, S., & Guelfi, G. (2020) · Animals · doi:10.3390/ani11010047 · Cited by 39

Pregnancy in obese women and mechanisms of increased cardiovascular risk in offspring

Cochrane, A. L. K., Murphy, M. P., Ozanne, S. E., & Giussani, D. A. (2024) · European Heart Journal · doi:10.1093/eurheartj/ehae671 · Cited by 33

Vascular factors and epigenetic modifications in the pathogenesis of Alzheimer's disease

Leszek, J., Sochocka, M., & Gąsiorowski, K. (2012) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2012.09.010 · Cited by 34

Major epigenetic development distinguishing neuronal and non-neuronal cells occurs postnatally in the murine hypothalamus

Li, G., Zhang, W., Baker, M. S., Laritsky, E., Mattan-Hung, N., Yu, D.-H., Kunde‐Ramamoorthy, G., Simerly, R. B., Chen, R., Shen, L., et al. (2013) · Human Molecular Genetics · doi:10.1093/hmg/ddt548 · Cited by 34

Perspective: a systems approach to diabetes research

Kussmann, M., Morine, M. J., Hager, J., Sonderegger, B., & Kaput, J. (2013) · Frontiers in Genetics · doi:10.3389/fgene.2013.00205 · Cited by 33

Histone H3 Lysine 9 Acetylation is Downregulated in GDM Placentas and Calcitriol Supplementation Enhanced This Effect

Hepp, P., Hutter, S., Knabl, J., Hofmann, S., Kühn, C., Mahner, S., & Jeschke, U. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19124061 · Cited by 34

Chemical Catalysis Intervening to Histone Epigenetics

Nozaki, T., & Kanai, M. (2021) · Accounts of Chemical Research · doi:10.1021/acs.accounts.1c00144 · Cited by 34

Inhibition of DNA methylation attenuates low‐dose cadmium‐induced cardiac contractile and intracellular Ca 2+ anomalies

Turdi, S., Sun, W., Tan, Y., Yang, X., Cai, L., & Ren, J. T. (2013) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/1440-1681.12158 · Cited by 34

Are Early-Life Socioeconomic Conditions Directly Related to Birth Outcomes? Grandmaternal Education, Grandchild Birth Weight, and Associated Bias Analyses

Huang, J. Y., Gavin, A. R., Richardson, T. S., Rowhani‐Rahbar, A., Siscovick, D. S., & Enquobahrie, D. A. (2015) · American Journal of Epidemiology · doi:10.1093/aje/kwv148 · Cited by 32

Recent advances in mammalian reproductive biology

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Multitarget Anticancer Agents Based on Histone Deacetylase and Protein Kinase CK2 Inhibitors

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Methylation potential associated with diet, genotype, protein, and metabolite levels in the Delta Obesity Vitamin Study

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Transgenerational plasticity is sex-dependent and persistent in yellow monkeyflower (Mimulus guttatus)

Akkerman, K. C., Sattarin, A., Kelly, J. K., & Scoville, A. (2016) · Current Zoology · doi:10.1093/eep/dvw003 · Cited by 33

In the womb's shadow

Nicoletto, S. F., & Rinaldi, A. C. (2011) · EMBO Reports · doi:10.1038/embor.2010.199 · Cited by 32

The epigenomics of polycystic ovarian syndrome: from pathogenesis to clinical manifestations

Li, S., Zhu, D., Duan, H., & Tan, Q. (2016) · Gynecological Endocrinology · doi:10.1080/09513590.2016.1203409 · Cited by 32

A translational model to determine rodent’s age from human foetal age

Ohmura, Y., & Kuniyoshi, Y. (2017) · Scientific Reports · doi:10.1038/s41598-017-17571-z · Cited by 34

The effect of a preconception care outreach strategy: the Healthy Pregnancy 4 All study

Sijpkens, M. K., van Voorst, S. F., de Jong-Potjer, L. C., Denktaş, S., Verhoeff, A. P., Bertens, L. C. M., Rosman, A. N., & Steegers, E. A. P. (2019) · BMC Health Services Research · doi:10.1186/s12913-019-3882-y · Cited by 32

Roles of Histone Acetylation Modifiers and Other Epigenetic Regulators in Vascular Calcification

Kwon, D., Ryu, J., Kim, Y., & Kook, H. Y. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21093246 · Cited by 32

Association between Serum Folate and Insulin Resistance among U.S. Nondiabetic Adults

Li, J., Goh, C. E., Demmer, R. T., Whitcomb, B. W., Du, P., & Liu, Z. (2017) · Scientific Reports · doi:10.1038/s41598-017-09522-5 · Cited by 36

Nutritional systems biology of type 2 diabetes

Zhao, Y., Barrere‐Cain, R., & Yang, X. (2015) · Genes & Nutrition · doi:10.1007/s12263-015-0481-3 · Cited by 31

Race/Ethnicity, Obesity, and Related Cardio-Metabolic Risk Factors: A Life-Course Perspective

Wahi, G., & Anand, S. S. (2013) · Current Cardiovascular Risk Reports · doi:10.1007/s12170-013-0329-6 · Cited by 32

Accounting for Life-Course Exposures in Epigenetic Biomarker Association Studies: Early Life Socioeconomic Position, Candidate Gene DNA Methylation, and Adult Cardiometabolic Risk

Huang, J. Y., Gavin, A. R., Richardson, T. S., Rowhani‐Rahbar, A., Siscovick, D. S., Hochner, H., Friedlander, Y., & Enquobahrie, D. A. (2016) · American Journal of Epidemiology · doi:10.1093/aje/kww014 · Cited by 31

Long-term consequences of disrupting adenosine signaling during embryonic development

Rivkees, S. A., & Wendler, C. C. (2017) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2017.02.001 · Cited by 31

The Effects of Two Influential Early Childhood Interventions on Health and Healthy Behaviors

Conti, G., Heckman, J. J., & Pinto, R. R. (2015) · National Bureau of Economic Research · doi:10.3386/w21454 · Cited by 31

Precision Medicine in Type 2 Diabetes Mellitus: Utility and Limitations

Galiero, R., Caturano, A., Vetrano, E., Monda, M., Marfella, R., Sardu, C., Salvatore, T., Rinaldi, L., & Sasso, F. C. (2023) · Diabetes Metabolic Syndrome and Obesity · doi:10.2147/dmso.s390752 · Cited by 36

Prenatal Programming and Epigenetics in the Genesis of the Cardiorenal Syndrome

Nistala, R., Hayden, M. R., DeMarco, V. G., Henriksen, E. J., Lackland, D. T., & Sowers, J. R. (2011) · Cardiorenal Medicine · doi:10.1159/000332756 · Cited by 32

IGF2 Methylation Is Associated with Lipid Profile in Obese Children

Deodati, A., Inzaghi, E., Liguori, A., Puglianiello, A., Germani, D., Brufani, C., Fintini, D., Cappa, M., Barbetti, F., & Cianfarani, S. (2013) · Hormone Research in Paediatrics · doi:10.1159/000351707 · Cited by 30

Pregestational diabetes in pregnancy: Complications, management, surveillance, and mechanisms of disease—A review

Shub, A., & Lappas, M. (2020) · Prenatal Diagnosis · doi:10.1002/pd.5718 · Cited by 31

Determinants of Infant Growth in Four Age Windows: A Twin Study

Touwslager, R. N. H., Gielen, M., Derom, C. A., Mulder, A., Gerver, W. M., Zimmermann, L. J. I., Houben, A. J. H. M., Stehouwer, C. D. A., VLIETINCK, R. F., Loos, R. J. F., et al. (2010) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2010.10.005 · Cited by 30

Diabetes: a look to the future

Alberti, K. G. M. M., & Zimmet, P. (2013) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(13)70187-6 · Cited by 30

Epigenetic programming at the Mogat1 locus may link neonatal overnutrition with long‐term hepatic steatosis and insulin resistance

Ramon‐Krauel, M., Pentinat, T., Bloks, V. W., Cebrià, J., Ribó, S., Pérez-Wienese, R., Vilà, M., Palacios‐Marin, I., Fernández-Pérez, A., Vallejo, M., et al. (2018) · The FASEB Journal · doi:10.1096/fj.201700717rr · Cited by 33

DNA Methylation of Five Core Circadian Genes Jointly Contributes to Glucose Metabolism: A Gene-Set Analysis in Monozygotic Twins

Peng, H. Y., Zhu, Y., Goldberg, J. H., Vaccarino, V., & Zhao, J. (2019) · Frontiers in Genetics · doi:10.3389/fgene.2019.00329 · Cited by 31

Early Roots of Childhood Obesity: Risk Factors, Mechanisms, and Prevention Strategies

Umano, G. R., Bellone, S., Buganza, R., Calcaterra, V., Corica, D., SANCTIS, L. D., Sessa, A. D., Faienza, M. F., Improda, N., Licenziati, M. R., et al. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26157388 · Cited by 41

Molecular and Genetic Mechanisms Involved in the Pathogenesis of Cardiorenal Cross Talk

Virzì, G. M., Clementi, A., Brocca, A., de Cal, M., & Ronco, C. (2016) · Pathobiology · doi:10.1159/000444502 · Cited by 28

DNA methylation and gene expression of TXNIP in adult offspring of women with diabetes in pregnancy

Houshmand‐Oeregaard, A. S., Hjort, L., Kelstrup, L., Hansen, N. S., Broholm, C., Gillberg, L., Clausen, T. D., Mathiesen, E. R., Damm, P., & Vaag, A. A. (2017) · PLoS ONE · doi:10.1371/journal.pone.0187038 · Cited by 29

Genetic association of human Corticotropin-Releasing Hormone Receptor 1 (CRHR1) with Internet gaming addiction in Korean male adolescents

Park, J., Sung, J., Kim, D.-K., Kong, I. D., Hughes, T. L., & Kim, N. (2018) · BMC Psychiatry · doi:10.1186/s12888-018-1974-6 · Cited by 34

Examining developmental plasticity in the skeletal system through a sensitive developmental windows framework

McPherson, C. B. (2021) · American Journal of Physical Anthropology · doi:10.1002/ajpa.24338 · Cited by 31

How can early life adversity still exert an effect decades later? A question of timing, tissues and mechanisms

Mposhi, A., & Turner, J. D. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1215544 · Cited by 30

Living long and ageing well: is epigenomics the missing link between nature and nurture?

The ACUME2 Project, Rea, I. M., Dellett, M., & Mills, K. (2015) · Biogerontology · doi:10.1007/s10522-015-9589-5 · Cited by 29

DNA methylation and demethylation probed by small molecules

Szyf, M. (2010) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2010.09.002 · Cited by 31

Epigenetics and diabetic cardiomyopathy

Singh, G. B., Sharma, R., & Khullar, M. (2011) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2011.05.033 · Cited by 28

Cisplatin treatment of testicular cancer patients introduces long-term changes in the epigenome

Bucher-Johannessen, C., Page, C. M., Haugen, T. B., Wojewodzic, M. W., Fosså, S. D., Grotmol, T., Haugnes, H. S., & Rounge, T. B. (2019) · Clinical Epigenetics · doi:10.1186/s13148-019-0764-4 · Cited by 28

Deficiency of IRTKS as an adaptor of insulin receptor leads to insulin resistance

Huang, L., Wang, Y., Wei, B., Yang, J., Wang, J., Wu, B., Zhang, Z.-Z., Hou, Y., Sun, W., Hu, R., et al. (2013) · Cell Research · doi:10.1038/cr.2013.99 · Cited by 28

Towards a Molecular Systems Model of Coronary Artery Disease

Abraham, G., Bhalala, O. G., de Bakker, P. I. W., Ripatti, S., & Inouye, M. (2014) · Current Cardiology Reports · doi:10.1007/s11886-014-0488-1 · Cited by 27

Developmental origins of diabetes mellitus: Environmental epigenomics and emerging patterns

Zhu, H., Ding, G., Liu, X., & Huang, H. (2023) · Journal of Diabetes · doi:10.1111/1753-0407.13403 · Cited by 28

The Cardio-Ankle Vascular Index and Ankle-Brachial Index in Young Russians

Sorokin, A. V., Kotani, K., Bushueva, O. Y., Taniguchi, N., & Lazarenko, V. (2014) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.26104 · Cited by 28

Prevalence of metabolic syndrome-like in the follow-up of very low birth weight preterm infants and associated factors

Heidemann, L. A., Procianoy, R. S., & Silveira, R. C. (2018) · Jornal de Pediatria · doi:10.1016/j.jped.2018.02.009 · Cited by 27

Quality Matters? The Involvement of Mitochondrial Quality Control in Cardiovascular Disease

Lin, K.-L., Chen, S., Lin, K.-J., Liou, C., Chuang, Y., Wang, P., Chuang, J., & Lin, T. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.636295 · Cited by 27

Multi-Omics Approach: New Potential Key Mechanisms Implicated in Cardiorenal Syndromes

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A cross sectional study of the relationship between the exposure of pregnant women to military attacks in 2014 in Gaza and the load of heavy metal contaminants in the hair of mothers and newborns

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