Inflammatory lipid mediators in adipocyte function and obesity

Obesity is associated with macrophage accumulation in adipose tissue

Weisberg, S. P., McCann, D., Desai, M., Rosenbaum, M., Leibel, R. L., & Ferrante, A. W. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319246 · Cited by 10,041

The metabolic syndrome—a new worldwide definition

Alberti, K. G. M., Zimmet, P., & Shaw, J. (2005) · The Lancet · doi:10.1016/s0140-6736(05)67402-8 · Cited by 9,352

Inflammation and metabolic disorders

Hotamisligil, G. S. (2006) · Nature · doi:10.1038/nature05485 · Cited by 9,199

Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance

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Origin and physiological roles of inflammation

Medzhitov, R. (2008) · Nature · doi:10.1038/nature07201 · Cited by 6,618

Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat diet-induced obesity and diabetes in mice

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Inflammation, stress, and diabetes

Wellen, K. E., & Hotamisligil, G. S. (2005) · Journal of Clinical Investigation · doi:10.1172/jci25102 · Cited by 4,143

Autophagy regulates lipid metabolism

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Resolving inflammation: dual anti-inflammatory and pro-resolution lipid mediators

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Mechanisms linking obesity with cardiovascular disease

Van Gaal, L. F., Mertens, I. L., & De Block, C. E. (2006) · Nature · doi:10.1038/nature05487 · Cited by 2,814

Resolution of inflammation: the beginning programs the end

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Elevated C-reactive protein levels in overweight and obese adults

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Local and systemic insulin resistance resulting from hepatic activation of IKK-β and NF-κB

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CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity

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Inflammation: the link between insulin resistance, obesity and diabetes

Dandona, P. (2004) · Trends in Immunology · doi:10.1016/j.it.2003.10.013 · Cited by 2,170

Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters

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Macrophage-specific PPARγ controls alternative activation and improves insulin resistance

Odegaard, J. I., Ricardo-Gonzalez, R. R., Goforth, M. H., Morel, C. R., Subramanian, V., Mukundan, L., Eagle, A. R., Vats, D., Brombacher, F., Ferrante, A. W., et al. (2007) · Nature · doi:10.1038/nature05894 · Cited by 2,107

Reversal of Obesity- and Diet-Induced Insulin Resistance with Salicylates or Targeted Disruption of Ikkβ

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Interleukin-1-receptor antagonist in type 2 diabetes mellitus

Larsen, C. M., Faulenbach, M., Vaag, A., Vølund, A., Ehses, J. A., Seifert, B., Mandrup-Poulsen, T., & Donath, M. Y. (2007) · New England Journal of Medicine · doi:10.1056/nejmoa065213 · Cited by 1,798

IKK-β links inflammation to obesity-induced insulin resistance

Arkan, M. C., Hevener, A. L., Greten, F. R., Maeda, S., Li, Z.-W., Long, J. M., Wynshaw-Boris, A., Poli, G., Olefsky, J., & Karin, M. (2005) · Nature Medicine · doi:10.1038/nm1185 · Cited by 1,773

Inflammation and Activated Innate Immunity in the Pathogenesis of Type 2 Diabetes

Pickup, J. C. (2004) · Diabetes Care · doi:10.2337/diacare.27.3.813 · Cited by 1,414

Normalization of obesity-associated insulin resistance through immunotherapy

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Peroxisome-Proliferator-Activated Receptor δ Activates Fat Metabolism to Prevent Obesity

Wang, Y.-X., Lee, C.-H., Tiep, S., Yu, R. T., Ham, J., Kang, H., & Evans, R. M. (2003) · Cell · doi:10.1016/s0092-8674(03)00269-1 · Cited by 1,296

Regulation of Lipolysis in Adipocytes

Duncan, R. E., Ahmadian, M., Jaworski, K., Sarkadi-Nagy, E., & Sul, H. S. (2007) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.27.061406.093734 · Cited by 1,021

Weight loss regulates inflammation‐related genes in white adipose tissue of obese subjects

ClÉment, K., Viguerie, N., Poitou, C., Carette, C., Pelloux, V., Curat, C. A., Sicard, A., Rome, S., Benis, A., Zucker, J., et al. (2004) · The FASEB Journal · doi:10.1096/fj.04-2204com · Cited by 640

Increase in Plasma Endotoxin Concentrations and the Expression of Toll-Like Receptors and Suppressor of Cytokine Signaling-3 in Mononuclear Cells After a High-Fat, High-Carbohydrate Meal

Ghanim, H., Abuaysheh, S., Sia, C. L., Korzeniewski, K., Chaudhuri, A., Fernandez-Real, J. M., & Dandona, P. (2009) · Diabetes Care · doi:10.2337/dc09-0979 · Cited by 494

The Chronic Inflammatory Hypothesis for the Morbidity Associated with Morbid Obesity: Implications and Effects of Weight Loss

Cottam, D. R., Mattar, S. G., Barinas-Mitchell, E., Eid, G., Kuller, L., Kelley, D. E., & Schauer, P. R. (2004) · Obesity Surgery · doi:10.1381/096089204323093345 · Cited by 461

Sustained effects of interleukin-1 receptor antagonist treatment in type 2 diabetes

Larsen, C. M., Faulenbach, M., Vaag, A., Ehses, J. A., Donath, M. Y., & Mandrup-Poulsen, T. (2009) · Diabetes Care · doi:10.2337/dc09-0533 · Cited by 401

Macrophage Inhibitory Factor, Plasminogen Activator Inhibitor-1, Other Acute Phase Proteins, and Inflammatory Mediators Normalize as a Result of Weight Loss in Morbidly Obese Subjects Treated with Gastric Restrictive Surgery

van Dielen, F. M. H., Buurman, W. A., Hadfoune, M., Nijhuis, J., & Greve, J. W. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-032125 · Cited by 158

Inflammatory Mechanisms in Obesity

Gregor, M. F., & Hotamisligil, G. S. (2011) · Annual Review of Immunology · doi:10.1146/annurev-immunol-031210-101322 · Cited by 3,754

NF-κB, Inflammation, and Metabolic Disease

Baker, R. G., Hayden, M. S., & Ghosh, S. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2010.12.008 · Cited by 1,952

The diverse metabolic roles of peripheral serotonin

Martin, A. M., Young, R. L., Leong, L., Rogers, G. B., Spencer, N. J., Jessup, C. F., & Keating, D. J. (2017) · Endocrinology · doi:10.1210/en.2016-1839 · Cited by 261

The role of exercise-induced myokines in regulating metabolism

Huh, J. Y. (2018) · Archives of Pharmacal Research · doi:10.1007/s12272-017-0994-y · Cited by 242

Bioactive lipid mediators in skin inflammation and immunity

Kendall, A. C., & Nicolaou, A. (2013) · Progress in Lipid Research · doi:10.1016/j.plipres.2012.10.003 · Cited by 229