The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Transgenerational neuroendocrine disruption of reproduction
Open accessAbstract
Exposure to endocrine disrupting chemicals (EDCs) is associated with dysfunctions of metabolism, energy balance, thyroid function and reproduction, and an increased risk of endocrine cancers. These multifactorial disorders can be 'programmed' through molecular epigenetic changes induced by exposure to EDCs early in life, the expression of which may not manifest until adulthood. In some cases, EDCs have detrimental effects on subsequent generations, which indicates that traits for disease predisposition may be passed to future generations by nongenomic inheritance. This Review discusses current understanding of the epigenetic mechanisms that underlie sexual differentiation of reproductive neuroendocrine systems in mammals and summarizes the literature on transgenerational epigenetic effects of representative EDCs: vinclozolin, diethylstilbesterol, bisphenol A and polychlorinated biphenyls. The article differentiates between context-dependent epigenetic transgenerational changes—namely, those that require environmental exposure, either via the EDC itself or through behavioral or physiological differences in parents—and germline-dependent epigenetic mechanisms. These processes, albeit discrete, are not mutually exclusive and can involve similar molecular mechanisms including DNA methylation and histone modifications and may predispose exposed individuals to transgenerational disruption of reproductive processes. New insights stress the crucial need to develop a clear understanding of how EDCs may program the epigenome of exposed individuals and their descendants.
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Cites
Epigenetic Reprogramming in Mammalian Development
Reik, W., Dean, W., & Walter, J. (2001) · Science · doi:10.1126/science.1063443 · Cited by 3,078
PHOENIX, C. H., GOY, R. W., GERALL, A. A., & YOUNG, W. C. (1959) · Endocrinology · doi:10.1210/endo-65-3-369 · Cited by 1,934
Dolinoy, D. C., Huang, D., & Jirtle, R. L. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0703739104 · Cited by 1,369 · cited 1×
“and shifted coat color by decreasing DNA methylation of the agouti gene in viable, yellow, agouti A vy mice”
BackgroundEpigenetic mechanisms and the transgenerational effects of maternal care
Champagne, F. A. (2008) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2008.03.003 · Cited by 812
Ho, S.-M., Tang, W.-Y., Belmonte de Frausto, J., & Prins, G. S. (2006) · Cancer Research · doi:10.1158/0008-5472.can-06-0516 · Cited by 796
Davis, E. C., Popper, P., & Gorski, R. A. (1996) · Brain Research · doi:10.1016/0006-8993(96)00298-3 · Cited by 330
Bakker, J., De Mees, C., Douhard, Q., Balthazart, J., Gabant, P., Szpirer, J., & Szpirer, C. (2006) · Nature Neuroscience · doi:10.1038/nn1624 · Cited by 305
Palanza, P. L., Howdeshell, K. L., Parmigiani, S., & vom Saal, F. S. (2002) · Environmental Health Perspectives · doi:10.1289/ehp.02110s3415 · Cited by 268
Ryan, B. C., Hotchkiss, A. K., Crofton, K. M., & Gray, L. E. (2010) · Toxicological Sciences · doi:10.1093/toxsci/kfp266 · Cited by 182
Desaulniers, D., Xiao, G.-H., Lian, H., Feng, Y.-L., Zhu, J., Nakai, J., & Bowers, W. J. (2009) · International Journal of Toxicology · doi:10.1177/1091581809337918 · Cited by 114
Cited by
EDC-2: the endocrine society's second scientific statement on endocrine-disrupting chemicals
Gore, A. C., Chappell, V. A., Fenton, S. E., Flaws, J. A., Nadal, A., Prins, G. S., Toppari, J., & Zoeller, R. T. (2015) · Endocrine Reviews · doi:10.1210/er.2015-1010 · Cited by 2,407
Self-citationBabenko, O., Kovalchuk, I., & Metz, G. A. S. (2015) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.11.013 · Cited by 513
Frye, C., Bo, E., Calamandrei, G., Calzà, L., Dessì‐Fulgheri, F., Fernández, M., Fusani, L., Kah, O., Kajta, M., Le Page, Y., et al. (2012) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2011.02229.x · Cited by 431
Transgenerational developmental programming
Aiken, C. E., & Ozanne, S. E. (2014) · Human Reproduction Update · doi:10.1093/humupd/dmt043 · Cited by 286
Minireview: Endocrine disruptors: Past lessons and future directions
Schug, T. T., Johnson, A. F., Birnbaum, L. S., Colborn, T., Guillette, L. J., Crews, D. P., Collins, T., Soto, A. M., vom Saal, F. S., McLachlan, J. A., et al. (2016) · Molecular Endocrinology · doi:10.1210/me.2016-1096 · Cited by 282
Metadata
- Authors
- Walker, D. M., & Gore, A. C.
- Venue
- Nature Reviews Endocrinology
- Published
- 2011-01-25
- Volume
- 7
- Issue
- 4
- Pages
- 197-207
- ISSN
- 1759-5029 (ISSN-L)
- 1759-5037
- OpenAlex
- W1979142152
- Cited by
- 166
- References
- 10
- FWCI
- 3.18
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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