CoChat
Sign Up
Cited by 431Effects and risks of endocrine disrupting chemicalsSexual Differentiation and DisordersEstrogen and related hormone effects

Endocrine Disrupters: A Review of Some Sources, Effects, and Mechanisms of Actions on Behaviour and Neuroendocrine Systems

Open access
Frye, C., Bo, E., Calamandrei, G., Calzà, L., Dessì‐Fulgheri, F., Fernández, M., Fusani, L., Kah, O. +6 more·2012·Journal of Neuroendocrinology
DOI 10.1111/j.1365-2826.2011.02229.xPMC PMC3245362
Open this paper in CoChat — free account

Abstract

Some environmental contaminants interact with hormones and may exert adverse consequences as a result of their actions as endocrine disrupting chemicals (EDCs). Exposure in people is typically a result of contamination of the food chain, inhalation of contaminated house dust or occupational exposure. EDCs include pesticides and herbicides (such as dichlorodiphenyl trichloroethane or its metabolites), methoxychlor, biocides, heat stabilisers and chemical catalysts (such as tributyltin), plastic contaminants (e.g. bisphenol A), pharmaceuticals (i.e. diethylstilbestrol; 17α‐ethinylestradiol) or dietary components (such as phytoestrogens). The goal of this review is to address the sources, effects and actions of EDCs, with an emphasis on topics discussed at the International Congress on Steroids and the Nervous System. EDCs may alter reproductively‐relevant or nonreproductive, sexually‐dimorphic behaviours. In addition, EDCs may have significant effects on neurodevelopmental processes, influencing the morphology of sexually‐dimorphic cerebral circuits. Exposure to EDCs is more dangerous if it occurs during specific ‘critical periods’ of life, such as intrauterine, perinatal, juvenile or puberty periods, when organisms are more sensitive to hormonal disruption, compared to other periods. However, exposure to EDCs in adulthood can also alter physiology. Several EDCs are xenoestrogens, which can alter serum lipid concentrations or metabolism enzymes that are necessary for converting cholesterol to steroid hormones. This can ultimately alter the production of oestradiol and/or other steroids. Finally, many EDCs may have actions via (or independent of) classic actions at cognate steroid receptors. EDCs may have effects through numerous other substrates, such as the aryl hydrocarbon receptor, the peroxisome proliferator‐activated receptor and the retinoid X receptor, signal transduction pathways, calcium influx and/or neurotransmitter receptors. Thus, EDCs, from varied sources, may have organisational effects during development and/or activational effects in adulthood that influence sexually‐dimorphic, reproductively‐relevant processes or other functions, by mimicking, antagonising or altering steroidal actions.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1111/j.1365-2826.2011.02229.x

Cites

19 of 19 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • NO endocrine disruption by GEN, BPA, and other EDCs has been found in parvocellular aspects of AVP signaling.

    “Concomitant work focused on the parvocellular aspects of AVP signaling has also found evidence of NO endocrine disruption by GEN, BPA, and other EDCs (39, 74, 151).”

    From Endocrine Disruption of Vasopressin Systems and Related Behaviors (2017) · cites this paper as [39]

    In “EDCs Influence Brain Morphology” (page unavailable), the review reports that embryonic exposure to genistein, DES, or DDE significantly demasculinized the sexually dimorphic parvocellular AVT system in Japanese quail. That is contrary to the claim of no endocrine disruption in this system. The passage concerns avian AVT, the counterpart the review discusses alongside mammalian AVP; it does not establish a BPA effect on parvocellular AVP signaling. (LLM, conf=0.85)

    Checked by a reasoning model — may be wrong.

    Experimental — accuracy not yet measured

  • Disruption of steroid hormone action was found to be causal in reproductive outcomes of EDC exposure, particularly during critical developmental windows.

    “Invariably, disruption of steroid hormone action was found to be causal, particularly during critical developmental windows (39–41).”

    From Endocrine Disruption of Vasopressin Systems and Related Behaviors (2017) · cites this paper as [39]

    The Introduction says EDCs can act by mimicking, antagonizing, or altering endogenous steroids, and the Summary/Conclusions says exposure during critical developmental phases may have more salient reproductive effects. But the review does not establish that disrupted steroid action was invariably causal: the Summary/Conclusions also identifies effects through other pathways and uses qualified language. (LLM, conf=0.88)

    Experimental — accuracy not yet measured

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

Research works printed but not linked: 187

  1. [1]Panzica GC Aste N Viglietti-Panzica C Ottinger MA Structural sex differences in the brain: influence of gonadal steroids and behavioral correlates J Endocrinol Invest 1995 18 232 52 7615911
  2. [2]McCarthy MM Wright CL Schwarz JM New tricks by an old dogma: mechanisms of the Organizational/Activational Hypothesis of steroid-mediated sexual differentiation of brain and behavior Horm Behav 2009 55 655 65 19682425 PMC2742630
  3. [3]Panzica GC Viglietti-Panzica C Mura E Quinn MJ Jr Palanza P Ottinger MA Effects of xenoestrogens on the differentiation of behaviorally relevant neural circuits Front Neuroendocrinol 2007 28 179 200 17868795
  4. [4]Patisaul HB Polston EK Influence of endocrine active compounds on the developing rodent brain Brain Res Rev 2008 57 352 62 17822772
  5. [5]Baccarelli A Pesatori AC Bertazzi PA Occupational and environmental agents as endocrine disruptors: experimental and human evidence J Endocrinol Invest 2000 23 771 81 11194713
  6. [6]Hwang HM Park EK Young TM Hammock BD Occurrence of endocrine-disrupting chemicals in indoor dust Sci Total Environ 2008 404 26 35 18632138 PMC2858057
  7. [7]Stapleton HM Klosterhaus S Eagle S Fuh J Meeker JD Blum A Webster TF Detection of organophosphate flame retardants in furniture foam and U.S. house dust Environ Sci Technol 2009 43 7490 95 19848166 PMC2782704
  8. [8]Harrad S de Wit CA Abdallah MA Bergh C Bjorklund JA Covaci A Darnerud PO de Boer J Diamond M Huber S Leonards P Mandalakis M Ostman C Haug LS Thomsen C Webster TF Indoor contamination with hexabromocyclododecanes, polybrominated diphenyl ethers, and perfluoroalkyl compounds: an important exposure pathway for people? Environ Sci Technol 2010 44 3221 31 20387882
  9. [9]Cooper JE Kendig EL Belcher SM Assessment of bisphenol A released from reusable plastic, aluminium and stainless steel water bottles Chemosphere 2011 in press PMC3210908 21741673
  10. [10]Yang CZ Yaniger SI Jordan VC Klein DJ Bittner GD Most plastic products release estrogenic chemicals: a potential health problem that can be solved Environ Health Perspect 2011 119 989 96 21367689 PMC3222987
  11. [11]Wolff MS Occupational exposure to polychlorinated biphenyls (PCBs) Environ Health Perspect 1985 60 133 8 3928344 PMC1568557
  12. [12]Nash JP Kime DE Van der Ven LTM Wester PW Brion F Maack G Stahlschmidt-Allner P Tyler CR Long-Term exposure to environmental concentrations of the pharmaceutical ethynylestradiol causes reproductive failure in fish Environ Health Perspect 2004 112 1725 33 15579420 PMC1253666
  13. [13]Diamanti-Kandarakis E Bourguignon JP Giudice LC Hauser R Prins GS Soto AM Zoeller RT Gore AC Endocrine-disrupting chemicals: an Endocrine Society scientific statement Endocr Rev 2009 30 293 342 19502515 PMC2726844
  14. [14]Singleton DW Khan SA Xenoestrogen exposure and mechanisms of endocrine disruption Front Biosci 2003 8 s110 8 12456297
  15. [16]Gray LE Jr Ostby J Ferrell J Sigmon R Cooper R Linder R Rehnberg G Goldman J Laskey J Correlation of sperm and endocrine measures with reproductive success in rodents Prog Clin Biol Res 1989 302 193 209 2666989
  16. [17]Gray LE Jr Ostby J Sigmon R Ferrell J Rehnberg G Linder R Cooper R Goldman J Laskey J The development of a protocol to assess reproductive effects of toxicants in the rat Reprod Toxicol 1988 2 3-4 281 7 2485184
  17. [19]Aksglaede L Sorensen K Petersen JH Skakkebaek NE Juul A Recent decline in age at breast development: the Copenhagen Puberty Study Pediatrics 2009 123 e932 39 19403485
  18. [20]Massart F Parrino R Seppia P Federico G Saggese G How do environmental estrogen disruptors induce precocious puberty? Minerva Pediatr 2006 58 247 254 16832329
  19. [21]Roy JR Chakraborty S Chakraborty TR Estrogen-like endocrine disrupting chemicals affecting puberty in humans--a review Med Sci Monit 2009 15 RA137 145 19478717
  20. [22]Denham M Schell LM Deane G Gallo MV Ravenscroft J DeCaprio AP Relationship of lead, mercury, mirex, dichlorodiphenyldichloroethylene, hexachlorobenzene, and polychlorinated biphenyls to timing of menarche among Akwesasne Mohawk girls Pediatrics 2005 115 e127 34 15653789
  21. [23]Den Hond E Roels HA Hoppenbrouwers K Nawrot T Thijs L Vandermeulen C Winneke G Vanderschueren D Staessen JA Sexual maturation in relation to polychlorinated aromatic hydrocarbons: Sharpe and Skakkebaek’s hypothesis revisited Environ Health Perspect 2002 110 771 6 12153757 PMC1240947
  22. [24]Kendig EL Le HH Belcher SM Defining hormesis: evaluation of a complex concentration response phenomenon Int J Toxicol 2010 29 235 46 20448256
  23. [25]Vandenberg LN Maffini MV Sonnenschein C Rubin BS Soto AM Bisphenol-A and the great divide: a review of controversies in the field of endocrine disruption Endocr Rev 2009 30 75 95 19074586 PMC2647705
  24. [26]vom Saal FS Akingbemi BT Belcher SM Birnbaum LS Crain DA Eriksen M Farabollini F Guillette LJ Jr Hauser R Heindel JJ Ho SM Hunt PA Iguchi T Jobling S Kanno J Keri RA Knudsen KE Laufer H LeBlanc GA Marcus M McLachlan JA Myers JP Nadal A Newbold RR Olea N Prins GS Richter CA Rubin BS Sonnenschein C Soto AM Talsness CE Vandenbergh JG Vandenberg LN Walser-Kuntz DR Watson CS Welshons WV Wetherill Y Zoeller RT Chapel Hill bisphenol A expert panel consensus statement: integration of mechanisms, effects in animals and potential to impact human health at current levels of exposure Reprod Toxicol 2007 24 131 8 17768031 PMC2967230
  25. [27]Walker DM Gore AC Transgenerational neuroendocrine disruption of reproduction Nat Rev Endocrinol 2011 7 197 207 21263448 PMC3976559
  26. [28]Gore AC Neuroendocrine targets of endocrine disruptors Hormones (Athens) 2010 9 16 27 20363718 PMC2896297
  27. [29]Ottinger MA vom Saal FS Impact of environmental endocrine disruptors on sexual differentiation in birds and mammals Pfaff D Arnold A Etgen AM Rubin R Hormones and Behavior in Higher Vertebrates New York Academic Press 2002 325 83
  28. [30]Ottinger MA Lavoie ET Abdelnabi M Quinn MJ Jr Marcell A Dean K An overview of dioxin-like compounds, PCB, and pesticide exposures associated with sexual differentiation of neuroendocrine systems, fluctuating asymmetry, and behavioral effects in birds J Environ Sci Health C Environ Carcinog Ecotoxicol Rev 2009 27 286 300 19953400
  29. [31]Ottinger MA Lavoie ET Thompson N Bohannon M Dean K Quinn MJ Jr Is the gonadotropin releasing hormone system vulnerable to endocrine disruption in birds? Gen Comp Endocrinol 2009 163 104 8 19457435
  30. [32]Sager DB Effect of postnatal exposure to polychlorinated biphenyls on adult male reproductive function Environ Res 1983 31 76 94 6406218
  31. [33]Sager DB Girard DM Long-term effects on reproductive parameters in female rats after translactational exposure to PCBs Environ Res 1994 66 52 76 8013438
  32. [34]Chung YW Nunez AA Clemens LG Effects of neonatal polychlorinated biphenyl exposure on female sexual behavior Physiol Behav 2001 74 363 70 11714501
  33. [35]Fusani L Della Seta D Dessi-Fulgheri F Farabollini F Altered reproductive success in rat pairs after environmental-like exposure to xenoestrogen Proc R Soc Lond B Biol Sci 2007 274 1631 6 PMC2169273 17456458
  34. [37]Mura E Barale C Quinn MJ Jr Panzica GC Ottinger MA Viglietti Panzica C Organizational Effects of DDE on Brain Vasotocin System in Male Japanese Quail Neurotoxicology 2009 30 479 84 19442834
  35. [38]Viglietti-Panzica C Montoncello B Mura E Pessatti M Panzica GC Organizational effects of diethylstilbestrol on brain vasotocin and sexual behavior in male quail Brain Res Bull 2005 65 225 33 15811585
  36. [40]Parmigiani S Palanza P vom Saal FS Ethotoxicology: an evolutionary approach to the study of environmental endocrine-disrupting chemicals Toxicol Ind Health 1998 14 333 9 9460184
  37. [41]Schettler T Toxic threats to neurologic development of children Environ Health Perspect 2001 109 Suppl 6 813 6 11744499 PMC1240616
  38. [43]Bale TL Baram TZ Brown AS Goldstein JM Insel TR McCarthy MM Nemeroff CB Reyes TM Simerly RB Susser ES Nestler EJ Early life programming and neurodevelopmental disorders Biol Psychiatry 2010 68 314 9 20674602 PMC3168778
  39. [44]Henningsson S Jonsson L Ljunggren E Westberg L Gillberg C Rastam M Anckarsater H Nygren G Landen M Thuresson K Betancur C Leboyer M Eriksson E Melke J Possible association between the androgen receptor gene and autism spectrum disorder Psychoneuroendocrinology 2009 34 752 61 19167832
  40. [45]Martel MM Klump K Nigg JT Breedlove SM Sisk CL Potential hormonal mechanisms of attention-deficit/hyperactivity disorder and major depressive disorder: a new perspective Horm Behav 2009 55 465 79 19265696 PMC3616481
  41. [46]Swan SH Liu F Hines M Kruse RL Wang C Redmon JB Sparks A Weiss B Prenatal phthalate exposure and reduced masculine play in boys Int J Androl 2010 33 259 69 19919614 PMC2874619
  42. [47]Richter CA Birnbaum LS Farabollini F Newbold RR Rubin BS Talsness CE Vandenbergh JG Walser-Kuntz DR vom Saal FS In vivo effects of bisphenol A in laboratory rodent studies Reprod Toxicol 2007 24 199 224 17683900 PMC2151845
  43. [48]Carvill S Sensory impairments, intellectual disability and psychiatry J Intellect Disabil Res 2001 45 467 83 11737534
  44. [49]Reynolds S Lane SJ Diagnostic validity of sensory over-responsivity: a review of the literature and case reports J Autism Dev Disord 2008 38 516 29 17917804
  45. [50]Tyrer F McGrother CW Thorp CF Donaldson M Bhaumik S Watson JM Hollin C Physical aggression towards others in adults with learning disabilities: prevalence and associated factors J Intellect Disabil Res 2006 50 295 304 16507034
  46. [51]Rosas LG Eskenazi B Pesticides and child neurodevelopment Curr Opin Pediatr 2008 20 191 7 18332717
  47. [53]Slotkin TA Levin ED Seidler FJ Comparative developmental neurotoxicity of organophosphate insecticides: effects on brain development are separable from systemic toxicity Environ Health Perspect 2006 114 746 51 16675431 PMC1459930
  48. [54]Slotkin TA Seidler FJ Comparative developmental neurotoxicity of organophosphates in vivo: transcriptional responses of pathways for brain cell development, cell signaling, cytotoxicity and neurotransmitter systems Brain Res Bull 2007 72 232 74 17452286 PMC1945108
  49. [55]Slotkin TA Seidler FJ Prenatal chlorpyrifos exposure elicits presynaptic serotonergic and dopaminergic hyperactivity at adolescence: critical periods for regional and sex-selective effects Reprod Toxicol 2007 23 421 7 17267174
  50. [56]Ricceri L Markina N Valanzano A Fortuna S Cometa MF Meneguz A Calamandrei G Developmental exposure to chlorpyrifos alters reactivity to environmental and social cues in adolescent mice Toxicol Appl Pharmacol 2003 191 189 201 13678652
  51. [57]Ricceri L Venerosi A Capone F Cometa MF Lorenzini P Fortuna S Calamandrei G Developmental neurotoxicity of organophosphorous pesticides: fetal and neonatal exposure to chlorpyrifos alters sex-specific behaviors at adulthood in mice Toxicol Sci 2006 93 105 13 16760416
  52. [58]Venerosi A Calamandrei G Ricceri L A social recognition test for female mice reveals behavioral effects of developmental chlorpyrifos exposure Neurotoxicol Teratol 2006 28 466 71 16814983
  53. [59]Venerosi A Cutuli D Colonnello V Cardona D Ricceri L Calamandrei G Neonatal exposure to chlorpyrifos affects maternal responses and maternal aggression of female mice in adulthood Neurotoxicol Teratol 2008 30 468 74 18674613
  54. [60]Venerosi A Ricceri L Rungi A Sanghez V Calamandrei G Gestational exposure to the organophosphate chlorpyrifos alters social-emotional behaviour and impairs responsiveness to the serotonin transporter inhibitor fluvoxamine in mice Psychopharmacology (Berl) 2010 208 99 107 19921154
  55. [62]Choleris E Clipperton-Allen AE Phan A Kavaliers M Neuroendocrinology of social information processing in rats and mice Front Neuroendocrinol 2009 30 442 59 19442683
  56. [63]Guo Y Lai T Chen S Hsu C Gender-related decrease in Raven’s progressive matrices scores in children prenatally exposed to polychlorinated bophenyis and related contaminants Environ Contam Toxicol 1995 8 13 7663094
  57. [64]Schantz SL Widholm JJ Cognitive effects of endocrine-disrupting chemicals in animals Environ Health Perspect 2001 109 1197 206 11748026 PMC1240501
  58. [65]Schantz SL Moshtaghian J Ness DK Spatial learning deficits in adult rats exposed to ortho-substituted PCB congeners during gestation and lactation Fundam Appl Toxicol 1995 26 117 26 7657055
  59. [66]Roegge CS Seo BW Crofton KM Schantz SL Gestational-lactational exposure to Aroclor 1254 impairs radial-arm maze performance in male rats Toxicol Sci 2000 57 121 30 10966518
  60. [67]Widholm JJ Clarkson GB Strupp BJ Crofton KM Seegal RF Schantz SL Spatial reversal learning in Aroclor 1254-exposed rats: sex-specific deficits in associative ability and inhibitory control Toxicol Appl Pharmacol 2001 174 188 98 11446834
  61. [69]Stein J Schettler T Wallinga D Valenti M In harm’s way: toxic threats to child development J Dev Behav Pediatr 2002 23 S13 22 11875286
  62. [70]Winneke G Developmental aspects of environmental neurotoxicology: Lessons from lead and polychlorinated biphenyls J Neurol Sci 2011 308 9 15 21679971
  63. [71]Yu ML Hsu CC Guo YL Lai TJ Chen SJ Luo JM Disordered behavior in the early-born Taiwan Yucheng children Chemosphere 1994 29 2413 22 7850390
  64. [72]Hwang L Environmental stressors and violence: lead and polychlorinated biphenyls Rev Environ Health 2007 22 313 28 18351230
  65. [73]Braun JM Yolton K Dietrich KN Hornung R Ye X Calafat AM Lanphear BP Prenatal bisphenol A exposure and early childhood behavior Environ Health Perspect 2009 117 1945 52 20049216 PMC2799471
  66. [74]Miodovnik A Engel SM Zhu C Ye X Soorya LV Silva MJ Calafat AM Wolff MS Endocrine disruptors and childhood social impairment Neurotoxicology 2011 32 261 67 21182865 PMC3057338
  67. [75]Viberg H Fredriksson A Eriksson P Changes in spontaneous behaviour and altered response to nicotine in the adult rat, after neonatal exposure to the brominated flame retardant, decabrominated diphenyl ether (PBDE 209) Neurotoxicology 2007 28 136 42 17030062
  68. [76]Ishido M Yonemoto J Morita M Mesencephalic neurodegeneration in the orally administered bisphenol A-caused hyperactive rats Toxicol Lett 2007 173 66 72 17689037
  69. [77]Gioiosa L Fissore E Ghirardelli G Parmigiani S Palanza P Developmental exposure to low-dose estrogenic endocrine disruptors alters sex differences in exploration and emotional responses in mice Horm Behav 2007 52 307 16 17568585
  70. [78]Palanza P Morellini F Parmigiani S vom Saal FS Ethological methods to study the effects of maternal exposure to estrogenic endocrine disrupters. A study with methoxychlor Neurotoxicol Teratol 2002 24 55 69 11836072
  71. [79]Xu X Tian D Hong X Chen L Xie L Sex-specific influence of exposure to bisphenol-A between adolescence and young adulthood on mouse behaviors Neuropharmacology 2011 61 565 573 21570416
  72. [80]Jasarevic E Sieli PT Twellman EE Welsh TH Jr Schachtman TR Roberts RM Geary DC Rosenfeld CS Disruption of adult expression of sexually selected traits by developmental exposure to bisphenol A Proc Natl Acad Sci U S A 2011 108 11715 11720 21709224 PMC3136312
  73. [81]Bateman HL Patisaul HB Disrupted female reproductive physiology following neonatal exposure to phytoestrogens or estrogen specific ligands is associated with decreased GnRH activation and kisspeptin fiber density in the hypothalamus Neurotoxicology 2008 29 988 97 18656497 PMC2647326
  74. [82]Cox KH Gatewood JD Howeth C Rissman EF Gestational exposure to bisphenol A and cross-fostering affect behaviors in juvenile mice Horm Behav 2010 58 754 61 20691692 PMC2982867
  75. [83]Hoffman DJ Eagles-Smith CA Ackerman JT Adelsbach TL Stebbins KR Oxidative stress response of Forster’s terns (Sterna forsteri) and Caspian terns (Hydroprogne caspia) to mercury and selenium bioaccumulation in liver, kidney, and brain Environ Toxicol Chem 2011 30 920 9 21194179
  76. [84]Salama J Chakraborty TR Ng L Gore AC Effects of polychlorinated biphenyls on estrogen receptor-beta expression in the anteroventral periventricular nucleus Environ Health Perspect 2003 111 1278 82 12896846 PMC1241606
  77. [85]Khurana S Ranmal S Ben-Jonathan N Exposure of newborn male and female rats to environmental estrogens: delayed and sustained hyperprolactinemia and alterations in estrogen receptor expression Endocrinology 2000 141 4512 7 11108262
  78. [86]Aloisi AM Della Seta D Ceccarelli I Farabollini F Bisphenol-A differently affects estrogen receptors-α in estrous-cycling and lactating female rats Neurosci Lett 2001 310 49 52 11524155
  79. [87]Rubin BS Lenkowski JR Schaeberle CM Vandenberg LN Ronsheim PM Soto AM Evidence of altered brain sexual differentiation in mice exposed perinatally to low, environmentally relevant levels of Bisphenol A Endocrinology 2006 147 3681 91 16675520
  80. [88]Patisaul HB Fortino AE Polston EK Neonatal genistein or bisphenol-A exposure alters sexual differentiation of the AVPV Neurotoxicol Teratol 2006 28 111 118 16427766
  81. [89]Kubo K Arai O Ogata R Omura M Hori T Aou S Exposure to bisphenol A during the fetal and suckling periods disrupts sexual differentiation of the locus coeruleus and of behavior in the rat Neurosci Lett 2001 304 73 6 11335058
  82. [90]Kubo K Arai O Omura M Watanabe R Ogata R Aou S Low dose effects of bisphenol A on sexual differentiation of the brain and behavior in rats Neurosci Res 2003 45 345 56 12631470
  83. [91]Martini M Miceli D Gotti S Viglietti-Panzica C Fissore E Palanza P Panzica GC Effects of perinatal administration of bisphenol A on the neuronal nitric oxide synthase expressing system in the hypothalamus and limbic system of CD1 mice J Neuroendocrinol 2010 22 1004 12 20561153
  84. [92]Miceli D Martini M Franceschini I Palanza P Panzica GC Organizational effects of bisphenol-A on kisspeptin expression in the hypothalamus of CD1 mouse Abstracts of 1st World conference on Kisspeptin Cordoba, Spain 2008 52
  85. [93]Patisaul HB Todd KL Mickens JA Adewale HB Impact of neonatal exposure to the ERalpha agonist PPT, bisphenol-A or phytoestrogens on hypothalamic kisspeptin fiber density in male and female rats Neurotoxicology 2009 30 350 7 19442818 PMC3691558
  86. [94]Goodson JL Bass AH Social behavior functions and related anatomical characteristics of vasotocin/vasopressin systems in vertebrates Brain Res Rev 2001 35 246 65 11423156
  87. [96]Jurkevich A Barth SW Aste N Panzica GC Grossmann R Intracerebral sex differences in the vasotocin system in birds: possible implication on behavioral and autonomic functions Horm Behav 1996 30 673 81 9047289
  88. [97]Panzica GC Aste N Castagna C Viglietti-Panzica C Balthazart J Steroid-induced plasticity in the sexually dimorphic vasotocinergic innervation of the avian brain: behavioral implications Brain Res Rev 2001 37 178 200 11744086
  89. [99]Panzica GC Castagna C Viglietti-Panzica C Russo C Tlemçani O Balthazart J Organizational effects of estrogens on brain vasotocin and sexual behavior in quail J Neurobiol 1998 37 684 99 9858268
  90. [100]Han TM De Vries GJ Organizational Effects of Testosterone, Estradiol, and Dihydrotestosterone on Vasopressin mRNA Expression in the Bed Nucleus of the Stria Terminalis J Neurobiol 2003 54 502 10 12532400
  91. [101]Plumari L Viglietti Panzica C Allieri F Honda S Harada N Absil P Balthazar J Panzica GC Changes in the Arginine-Vasopressin Immunoreactive systems in male mice lacking a functional aromatase gene J Neuroendocrinol 2002 14 971 8 12472878
  92. [103]Pierman S Sica M Allieri F Viglietti-Panzica C Panzica GC Bakker J Activational effects of estradiol and dihydrotestosterone on social recognition and the arginine-vasopressin immunoreactive system in male mice lacking a functional aromatase gene Horm Behav 2008 54 98 106 18346740 PMC2706693
  93. [104]Boyd SK Gonadal steroid modulation of vasotocin concentrations in the bullfrog brain Neuroendocrinol 1994 60 150 6 7969772
  94. [105]De Vries GJ Buijs RM Sluiter AA Gonadal hormone actions on the morphology of the vasopressinergic innervation of the adult rat brain Brain Res 1984 298 141 5 6722551
  95. [106]Viglietti-Panzica C Aste N Balthazart J Panzica GC Vasotocinergic innervation of sexually dimorphic medial preoptic nucleus of the male Japanese quail: influence of testosterone Brain Res 1994 657 171 84 7820616
  96. [107]Grassi D Amorim MA Garcia-Segura LM Panzica G Estrogen receptor alpha is involved in the estrogenic regulation of arginine vasopressin immunoreactivity in the supraoptic and paraventricular nuclei of ovariectomized rats Neurosci Lett 2010 474 135 9 20298751
  97. [108]Kodavanti PR Curras-Collazo MC Neuroendocrine actions of organohalogens: Thyroid hormones, Arginine Vasopressin, and neuroplasticity Front Neuroendocrinol 2010 20609372
  98. [109]Panzica GC Balthazart J Pessatti M Viglietti-Panzica C The parvocellular vasotocin system of Japanese quail: a developmental and adult model for the study of influences of gonadal hormones on sexually differentiated and behaviorally relevant neural circuits Environ Health Perspect 2002 110 423 8 12060839 PMC1241193
  99. [110]Mattsson A Mura E Brunstrom B Panzica G Halldin K Selective activation of estrogen receptor alpha in Japanese quail embryos affects reproductive organ differentiation but not the male sexual behavior or the parvocellular vasotocin system Gen Comp Endocrinol 2008 159 150 7 18805421
  100. [111]Axelsson J Mattsson A Brunström B Halldin K Expression of estrogen receptor alpha and -beta mRNA in the brain of Japanese quail embryos Dev Neurobiol 2007 67 1742 50 17638389
  101. [112]Roy BN Reid RL Van Vugt DA The effects of estrogen and progesterone on corticotropin-releasing hormone and arginine vasopressin messenger ribonucleic acid levels in the paraventricular nucleus and supraoptic nucleus of the rhesus monkey Endocrinology 1999 140 2191 8 10218971
  102. [113]Scallet AC Wofford M Meredith JC Allaben WT Ferguson SA Dietary exposure to genistein increases vasopressin but does not alter beta-endorphin in the rat hypothalamus Toxicol Sci 2003 72 296 300 12660364
  103. [115]Coburn CG Gillard ER Curras-Collazo MC Dietary exposure to aroclor 1254 alters central and peripheral vasopressin release in response to dehydration in the rat Toxicol Sci 2005 84 149 56 15574674
  104. [118]Adewale HB Todd KL Mickens JA Patisaul HB The impact of neonatal bisphenol-A exposure on sexually dimorphic hypothalamic nuclei in the female rat Neurotoxicology 2010 PMC3030630 20696184
  105. [119]Bale TL Dorsa DM Sex differences in and effects of estrogen on oxytocin receptor messenger ribonucleic acid expression in the ventromedial hypothalamus Endocrinology 1995 136 27 32 7828541
  106. [121]Panzica GC Bo E Martini MA Miceli D Mura E Viglietti-Panzica C Gotti S Neuropeptides and enzymes are targets for the action of endocrine disrupting chemicals in the vertebrate brain J Toxicol Environ Health B Crit Rev 2011 14 449 72 21790321
  107. [122]Fernandez M Paradisi M D’Intino G Del Vecchio G Sivilia S Giardino L Calza L A single prenatal exposure to the endocrine disruptor 2,3,7,8-tetrachlorodibenzo-p-dioxin alters developmental myelination and remyelination potential in the rat brain J Neurochem 2010 115 897 909 20807317
  108. [123]Head JA Hahn ME Kennedy SW Key amino acids in the aryl hydrocarbon receptor predict dioxin sensitivity in avian species Environ Sci Technol 2008 42 7535 41 18939598
  109. [124]Bell DR Clode S Fan MQ Fernandes A Foster PM Jiang T Loizou G MacNicoll A Miller BG Rose M Tran L White S Toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin in the developing male Wistar(Han) rat. I: No decrease in epididymal sperm count after a single acute dose Toxicol Sci 2007 99 214 23 17545212
  110. [125]Bell DR Clode S Fan MQ Fernandes A Foster PM Jiang T Loizou G MacNicoll A Miller BG Rose M Tran L White S Interpretation of studies on the developmental reproductive toxicology of 2,3,7,8-tetrachlorodibenzo-p-dioxin in male offspring Food Chem Toxicol 2010 48 1439 47 20388530 PMC2923583
  111. [126]Ishihara K Warita K Tanida T Sugawara T Kitagawa H Hoshi N Does paternal exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) affect the sex ratio of offspring? J Vet Med Sci 2007 69 347 52 17485921
  112. [127]Hurst CH DeVito MJ Setzer RW Birnbaum LS Acute administration of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in pregnant Long Evans rats: association of measured tissue concentrations with developmental effects Toxicol Sci 2000 53 411 20 10696789
  113. [128]Nagayama J Kohno H Kunisue T Kataoka K Shimomura H Tanabe S Konishi S Concentrations of organochlorine pollutants in mothers who gave birth to neonates with congenital hypothyroidism Chemosphere 2007 68 972 6 17307219
  114. [129]Bernal J Thyroid hormones and brain development Vitam Horm 2005 71 95 122 16112266
  115. [130]Hugla JL Thome JP Effects of polychlorinated biphenyls on liver ultrastructure, hepatic monooxygenases, and reproductive success in the barbel Ecotoxicol Environ Saf 1999 42 265 73 10090815
  116. [131]Adewale HB Jefferson WN Newbold RR Patisaul HB Neonatal Bisphenol-A exposure alters rat reproductive development and ovarian morphology without impairing activation of gonadotropin releasing hormone neurons Biol Reprod 2009 81 690 9 19535786 PMC2754884
  117. [133]Crews D Gore AC Life Imprints: Living in a contaminated world Environ Health Perspect 2011 119 1208 10 21571618 PMC3230404
  118. [134]Welshons WV Thayer KA Judy BM Taylor JA Curran EM vom Saal FS Large effects from small exposures. I. Mechanisms for endocrine-disrupting chemicals with estrogenic activity Environ Health Perspect 2003 111 994 1006 12826473 PMC1241550
  119. [135]Weltje L vom Saal FS Oehlmann J Reproductive stimulation by low doses of xenoestrogens contrasts with the view of hormesis as an adaptive response Hum Exp Toxicol 2005 24 431 7 16235731
  120. [138]Tena-Sempere M Roles of Kisspeptins in the control of hypothalamic-gonadotropic function: Focus on sexual differentiation and puberty onset Endocr Dev 2010 17 52 62 19955756
  121. [139]Cooke B Hegstrom CD Villeneuve LS Breedlove SM Sexual differentiation of the vertebrate brain: principles and mechanisms Front Neuroendocrinol 1998 19 323 62 9799588
  122. [140]Gorski RA Sexual dimorphisms of the brain J Anim Sci 1985 61 Suppl 3 38 61 3908433
  123. [141]Simerly RB Organization and regulation of sexually dimorphic neuroendocrine pathways Behav Brain Res 1998 92 195 203 9638961
  124. [142]Simerly RB Wired for reproduction: organization and development of sexually dimorphic circuits in the mammalian forebrain Annu Rev Neurosci 2002 25 507 36 12052919
  125. [143]Bakker J Baum MJ Role for estradiol in female-typical brain and behavioral sexual differentiation Front Neuroendocrinol 2008 29 1 16 17720235 PMC2373265
  126. [144]Bateman HL Patisaul HB Disrupted female reproductive physiology following neonatal exposure to phytoestrogens or estrogen specific ligands is associated with decreased GnRH activation and kisspeptin fiber density in the hypothalamus Neurotoxicology 2008 29 988 97 18656497 PMC2647326
  127. [145]Fernandez M Bianchi M Lux-Lantos V Libertun C Neonatal exposure to bisphenol a alters reproductive parameters and gonadotropin releasing hormone signaling in female rats Environ Health Perspect 2009 117 757 62 19479018 PMC2685838
  128. [147]Navarro VM Sanchez-Garrido MA Castellano JM Roa J Garcia-Galiano D Pineda R Aguilar E Pinilla L Tena-Sempere M Persistent impairment of hypothalamic KiSS-1 system following exposures to estrogenic compounds at critical periods of brain sex differentiation Endocrinology 2009 150 2359 67 19106226
  129. [148]Losa SM Todd KL Sullivan AW Cao J Mickens JA Patisaul HB Neonatal exposure to genistein adversely impacts the ontogeny of hypothalamic kisspeptin signaling pathways and ovarian development in the peripubertal female rat Reprod Toxicol 2010 PMC3034101 20951797
  130. [149]Pines A Cucos S Ever-Handani P Ron M Some organochlorine insecticide and polychlorinated biphenyl blood residues in infertile males in the general Israeli population of the middle 1980’s Arch Environ Contam Toxicol 1987 16 587 97 3115197
  131. [150]Bloom MS Parsons PJ Steuerwald AJ Schisterman EF Browne RW Kim K Coccaro GA Conti GC Narayan N Fujimoto VY Toxic trace metals and human oocytes during in vitro fertilization (IVF) Reprod Toxicol 2010 29 298 305 20096775 PMC2882801
  132. [151]Telisman S Cvitkovic P Jurasovic J Pizent A Gavella M Rocic B Semen quality and reproductive endocrine function in relation to biomarkers of lead, cadmium, zinc, and copper in men Environ Health Perspect 2000 108 45 53 10620523 PMC1637869
  133. [152]Chung YW Clemens LG Effects of perinatal exposure to polychlorinated biphenyls on development of female sexual behavior Bull Environ Contam Toxicol 1999 62 664 70 10353990
  134. [153]Chandrareddy A Muneyyirci-Delale O McFarlane SI Murad OM 2008 Adverse effects of phytoestrogens on reproductive health: a report of three cases Complement Ther Clin Pract 14 132 135 18396257
  135. [154]Bitman J Cecil HC Estrogenic activity of DDT analogs and polychlorinated biphenyls J Agric Food Chem 1970 18 1108 12 5483049
  136. [155]Andric SA Kostic TS Dragisic SM Andric NL Stojilkovic SS Kovacevic RZ Acute effects of polychlorinated biphenyl-containing and -free transformer fluids on rat testicular steroidogenesis Environ Health Perspect 2000 108 955 9 11049815 PMC1240128
  137. [156]Hays LE Carpenter CD Petersen SL Evidence that GABAergic neurons in the preoptic area of the rat brain are targets of 2,3,7,8-tetrachlorodibenzo-p-dioxin during development Environ Health Perspect 2002 110 Suppl 3 369 76 12060831 PMC1241185
  138. [157]Eriksson P Talts U Neonatal exposure to neurotoxic pesticides increases adult susceptibility: a review of current findings Neurotoxicology 2000 21 37 47 10794383
  139. [159]Nayyar T Zawia NH Hood DB Transplacental effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on the temporal modulation of Sp1 DNA binding in the developing cerebral cortex and cerebellum Exp Toxicol Pathol 2002 53 461 8 11926288
  140. [160]Kuchiiwa S Cheng SB Nagatomo I Akasaki Y Uchida M Tominaga M Hashiguchi W Kuchiiwa T In utero and lactational exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin decreases serotonin-immunoreactive neurons in raphe nuclei of male mouse offspring Neurosci Lett 2002 317 73 6 11755243
  141. [161]Cho SJ Jung JS Jin I Jung YW Ko BH Nam KS Park IK Moon IS Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on the expression of synaptic proteins in dissociated rat cortical cells Mol Cells 2002 14 238 44 12442896
  142. [162]Kakeyama M Sone H Tohyama C Changes in expression of NMDA receptor subunit mRNA by perinatal exposure to dioxin Neuroreport 2001 12 4009 12 11742229
  143. [163]Tillitt DE Papoulias DM 2,3,7,8-Tetrachlorodibenzo-p-dioxin toxicity in the zebrafish embryo: local circulation failure in the dorsal midbrain is associated with increased apoptosis Toxicol Sci 2002 69 1 2 12215654
  144. [164]Dong W Teraoka H Tsujimoto Y Stegeman JJ Hiraga T Role of aryl hydrocarbon receptor in mesencephalic circulation failure and apoptosis in zebrafish embryos exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin Toxicol Sci 2004 77 109 16 14657521
  145. [165]Kajta M Wojtowicz AK Mackowiak M Lason W Aryl hydrocarbon receptor-mediated apoptosis of neuronal cells: a possible interaction with estrogen receptor signaling Neuroscience 2009 158 811 22 19027052
  146. [166]Kawajiri K Fujii-Kuriyama Y Cytochrome P450 gene regulation and physiological functions mediated by the aryl hydrocarbon receptor Arch Biochem Biophys 2007 464 207 12 17481570
  147. [167]Hayes CL Spink DC Spink BC Cao JQ Walker NJ Sutter TR 17 beta-estradiol hydroxylation catalyzed by human cytochrome P450 1B1 Proc Natl Acad Sci U S A 1996 93 9776 81 8790407 PMC38505
  148. [169]Wormke M Stoner M Saville B Walker K Abdelrahim M Burghardt R Safe S The aryl hydrocarbon receptor mediates degradation of estrogen receptor alpha through activation of proteasomes Mol Cell Biol 2003 23 1843 55 12612060 PMC149455
  149. [170]Ruegg J Swedenborg E Wahlstrom D Escande A Balaguer P Pettersson K Pongratz I The transcription factor aryl hydrocarbon receptor nuclear translocator functions as an estrogen receptor beta-selective coactivator, and its recruitment to alternative pathways mediates antiestrogenic effects of dioxin Mol Endocrinol 2008 22 304 16 17991765 PMC5419643
  150. [171]Namkung MJ Porubek DJ Nelson SD Juchau MR Regulation of aromatic oxidation of estradiol-17 beta in maternal hepatic, fetal hepatic and placental tissues: comparative effects of a series of inducing agents J Steroid Biochem 1985 22 563 7 3999749
  151. [172]Watanabe MX Jones SP Iwata H Kim EY Kennedy SW Effects of co-exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin and perfluorooctane sulfonate or perfluorooctanoic acid on expression of cytochrome P450 isoforms in chicken (Gallus gallus) embryo hepatocyte cultures Comp Biochem Physiol C Toxicol Pharmacol 2009 149 605 12 19167519
  152. [173]Spink DC Hayes CL Young NR Christou M Sutter TR Jefcoate CR Gierthy JF The effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on estrogen metabolism in MCF-7 breast cancer cells: evidence for induction of a novel 17 beta-estradiol 4-hydroxylase J Steroid Biochem Mol Biol 1994 51 251 8 7826886
  153. [174]Machala M Neca J Drabek P Ulrich R Sabatova V Nezveda K Raszyk J Gajduskova V Effects of chronic exposure to PCBs on cytochrome P450 systems and steroidogenesis in liver and testis of bulls (Bos taurus) Comp Biochem Physiol A Mol Integr Physiol 1998 120 65 70 9773499
  154. [175]Haake-McMillan JM Safe SH Neonatal exposure to Aroclor 1254: effects on adult hepatic testosterone hydroxylase activities Xenobiotica 1991 21 481 9 1897248
  155. [176]Moore RW Potter CL Theobald HM Robinson JA Peterson RE Androgenic deficiency in male rats treated with 2,3,7,8-tetrachlorodibenzo-p-dioxin Toxicol Appl Pharmacol 1985 79 99 111 4049410
  156. [177]Yoshihara S Nagata K Wada I Yoshimura H Kuroki H Masuda Y A unique change of steroid metabolism in rat liver microsomes induced with highly toxic polychlorinated biphenyl(PCB) and polychlorinated dibenzofuran(PCDF) J Pharmacobiodyn 1982 5 994 1004 6820382
  157. [178]Diotel N Le Page Y Mouriec K Tong SK Pellegrini E Vaillant C Anglade I Brion F Pakdel F Chung BC Kah O Aromatase in the brain of teleost fish: expression, regulation and putative functions Front Neuroendocrinol 2010 31 172 92 20116395
  158. [179]Pellegrini E Mouriec K Anglade I Menuet A Le Page Y Gueguen MM Marmignon MH Brion F Pakdel F Kah O Identification of aromatase-positive radial glial cells as progenitor cells in the ventricular layer of the forebrain in zebrafish J Comp Neurol 2007 501 150 67 17206614
  159. [180]Menuet A Pellegrini E Brion F Gueguen MM Anglade I Pakdel F Kah O Expression and estrogen-dependent regulation of the zebrafish brain aromatase gene J Comp Neurol 2005 485 304 20 15803511
  160. [181]Tong SK Mouriec K Kuo MW Pellegrini E Gueguen MM Brion F Kah O Chung BC A cyp19a1b-gfp (aromatase B) transgenic zebrafish line that expresses GFP in radial glial cells Genesis 2009 47 67 73 19101983
  161. [182]Le Page Y Scholze M Kah O Pakdel F Assessment of xenoestrogens using three distinct estrogen receptors and the zebrafish brain aromatase gene in a highly responsive glial cell system Environ Health Perspect 2006 114 752 8 16675432 PMC1459931
  162. [183]Menuet A Pellegrini E Anglade I Blaise O Laudet V Kah O Pakdel F Molecular characterization of three estrogen receptor forms in zebrafish: binding characteristics, transactivation properties, and tissue distributions Biol Reprod 2002 66 1881 92 12021076
  163. [184]Mouriec K Gueguen MM Manuel C Percevault F Thieulant ML Pakdel F Kah O Androgens upregulate cyp19a1b (aromatase B) gene expression in the brain of zebrafish (Danio rerio) through estrogen receptors Biol Reprod 2009 80 889 96 19129512
  164. [185]Mouriec K Lareyre JJ Tong SK Le Page Y Vaillant C Pellegrini E Pakdel F Chung BC Kah O Anglade I Early regulation of brain aromatase (cyp19a1b) by estrogen receptors during zebrafish development Dev Dyn 2009 238 2641 51 19718764
  165. [186]Lephart ED A review of brain aromatase cytochrome P450 Brain Res Rev 1996 22 1 26 8871783
  166. [187]Boon WC Chow JD Simpson ER The multiple roles of estrogens and the enzyme aromatase Prog Brain Res 2010 181 209 32 20478440
  167. [188]Waters EM Simerly RB Estrogen induces caspase-dependent cell death during hypothalamic development J Neurosci 2009 29 9714 8 19657024 PMC6428191
  168. [189]Wright CL Schwarz JS Dean SL McCarthy MM Cellular mechanisms of estradiol-mediated sexual differentiation of the brain Trends Endocrinol Metab 2010 21 553 61 20813326 PMC2941875
  169. [190]Le Page Y Diotel N Vaillant C Pellegrini E Anglade I Merot Y Kah O Aromatase, brain sexualization and plasticity: the fish paradigm Eur J Neurosci 2010 32 2105 15 21143665
  170. [192]Newbold RR Impact of environmental endocrine disrupting chemicals on the development of obesity Hormones (Athens) 2010 9 206 17 20688618
  171. [193]Newbold RR Padilla-Banks E Jefferson WN Environmental estrogens and obesity Mol Cell Endocrinol 2009 304 84 89 19433252 PMC2682588
  172. [194]Janesick A Blumberg B Endocrine disrupting chemicals and the developmental programming of adipogenesis and obesity Birth Defects Res C Embryo Today 2011 93 34 50 21425440 PMC4919125
  173. [195]Newbold Prenatal exposure to diethylstilbestrol (DES) Fertil Steril 2008 89 e55 56 18308064
  174. [196]Palmlund I Exposure to a xenoestrogen before birth: the diethylstilbestrol experience Journal of Psychosomatic Obstetrics and Gynaecology 1996 17 71 84 8819018
  175. [197]Rubin MM Antenatal exposure to DES: lessons learned…future concerns Obstetrical and Gynecological Survey 2007 62 548 555 17634156
  176. [198]Zuo Z Chen S Wu T Zhang J Su Y Chen Y Wang C Tributyltin causes obesity and hepatic steatosis in male mice Environ Toxicol 2009 26 79 85 19760618
  177. [199]Cooke GM Forsyth DS Bondy GS Tachon R Tague B Coady L Organotin speciation and tissue distribution in rat dams, fetuses, and neonates following oral administration of tributyltin chloride J Toxicol Environ Health A 2008 71 384 95 18246498
  178. [200]Bailey SK Davies IM Tributyltin contamination in the Firth of Forth (1975-87) Sci Total Environ 1988 76 185 92 3238424
  179. [201]Morcillo Y Porte C Evidence of endocrine disruption in clams--Ruditapes decussata--transplanted to a tributyltin-polluted environment Environ Pollut 2000 107 47 52 15093007
  180. [202]Kanayama T Kobayashi N Mamiya S Nakanishi T Nishikawa J Organotin compounds promote adipocyte differentiation as agonists of the peroxisome proliferator-activated receptor gamma/retinoid X receptor pathway Mol Pharmacol 2005 67 766 74 15611480
  181. [203]Grun F Blumberg B Environmental obesogens: organotins and endocrine disruption via nuclear receptor signaling Endocrinology 2006 147 S50 5 16690801
  182. [204]Si J Wu X Wan C Zeng T Zhang M Xie K Li J Peripubertal exposure to low doses of tributyltin chloride affects the homeostasis of serum T, E2, LH, and body weight of male mice Environ Toxicol 2011 26 307 14 20052771
  183. [205]Bo E Viglietti-Panzica C Panzica GC Acute exposure to tributyltin induces c-fos activation in the hypothalamic arcuate nucleus of adult male mice Neurotoxicology 2011 32 277 80 21185327
  184. [208]Wei P Zhang J Dowhan DH Han Y Moore DD Specific and overlapping functions of the nuclear hormone receptors CAR and PXR in xenobiotic response Pharmacogenomics J 2002 2 117 26 12049174
  185. [209]Toran-Allerand CD Guan X MacLusky NJ Horvath TL Diano S Singh M Connolly ES Jr Nethrapalli IS Tinnikov AA ER-X: a novel, plasma membrane-associated, putative estrogen receptor that is regulated during development and after ischemic brain injury J Neurosci 2002 22 8391 401 12351713 PMC6757764
  186. [210]Frye CA Walf AA Membrane actions of progestins at dopamine type 1-like and GABAA receptors involve downstream signal transduction pathways Steroids 2008 73 906 13 18342351 PMC2492830
  187. [211]Roepke TA Ronnekleiv OK Kelly MJ Physiological consequences of membrane-initiated estrogen signaling in the brain Front Biosci 2011 16 1560 73 21196248 PMC3094271

Cited by

Sorted by citations

Authors
Frye, C., Bo, E., Calamandrei, G., Calzà, L., Dessì‐Fulgheri, F., Fernández, M., Fusani, L., Kah, O., Kajta, M., Le Page, Y., Patisaul, H. B., Venerosi, A., Wojtowicz, A. K., & Panzica, G. C.
Affiliations
  • University at Albany, State University of New York (US)
  • Neuroscience Institute Cavalieri Ottolenghi (IT)
  • Istituto Superiore di Sanità (IT)
  • University of Bologna (IT)
  • University of Florence (IT)
  • University of Ferrara (IT)
  • Centre National de la Recherche Scientifique (FR)
  • Maj Institute of Pharmacology (PL)
  • North Carolina State University (US)
  • Politecnico di Torino (IT)
Corresponding author
Frye, C.
ORCID
Venue
Journal of Neuroendocrinology
Publisher
Wiley
Published
2011-12-20
Volume
24
Issue
1
Pages
144-159
ISSN
  • 0953-8194 (ISSN-L)
  • 1365-2826
DOI
10.1111/j.1365-2826.2011.02229.x
PMC
PMC3245362
OpenAlex
W2158159969
Cited by
431
References
19
Citations by year
2026: 8 · 2025: 19 · 2024: 22 · 2023: 20 · 2022: 13 · 2021: 44 · 2020: 24 · 2019: 31 · 2018: 37 · 2017: 43 · 2016: 41 · 2015: 41 · 2014: 39 · 2013: 31 · 2012: 16
FWCI
2.82
Type
journal article
Language
en
Open access
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Journal of Neuroendocrinology (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
  • HAL (submittedVersion)
  • Archivio istituzionale della ricerca (Alma Mater Studiorum Università di Bologna) (submittedVersion)
  • Florence Research (University of Florence) (submittedVersion)
  • Institutional Research Information System University of Turin (University of Turin) (submittedVersion, other-oa)
  • Institutional Research Information System University of Ferrara (University of Ferrara) (submittedVersion, other-oa)
Funders
  • U.S. Public Health Service (067698)
  • National Institute of Mental Health (MH-067698, R01MH067698)
Topics
  • Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Effects and risks of endocrine disrupting chemicals
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Sexual Differentiation and Disorders
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
Keywords
endocrine disruptors, neuroendocrine system, behavioral effects, brain development, sexual dimorphism, xenoestrogens, steroid hormone receptors, aryl hydrocarbon receptor, peroxisome proliferator-activated receptors, retinoid X receptor, pesticide exposure, bisphenol A, phytoestrogens, estradiol, reproductive behavior, plastic contaminants, pharmaceuticals
MeSH terms
Bisphenol A Compounds, Animals, Behavior, Animal, Benzhydryl Compounds, Brain, Environmental Pollutants, Humans, Phenols, Puberty, Reproduction, Phytoestrogens, Endocrine Disruptors

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review