Cited by 307Diabetes, Cardiovascular Risks, and LipoproteinsCholesterol and Lipid MetabolismAdipokines, Inflammation, and Metabolic Diseases

The DOI matches its Crossref record; 113 of the 114 references it cites were found in a registry or an index.

The emerging role of HDL in glucose metabolism

Drew, Brian G., Rye, Kerry-Anne, Duffy, Stephen J., Barter, Philip, Kingwell, Bronwyn A.·2012·Nature Reviews Endocrinology

DOI 10.1038/nrendo.2011.235

Open this paper in CoChat — free account

Abstract

A low plasma level of HDL cholesterol is an atherosclerotic risk factor; however, emerging evidence suggests that low HDL levels might also contribute to the pathophysiology of type 2 diabetes mellitus (T2DM) through direct effects on plasma glucose. In the past decade, animal and clinical studies have uncovered a previously undescribed spectrum of HDL actions, indicating that HDL may control glucose homeostasis through mechanisms including insulin secretion, direct glucose uptake by muscle via the AMP-activated protein kinase, and possibly enhanced insulin sensitivity. These effects are mediated by multiple cell types via mechanisms including preservation of cell function through cellular lipid removal and also via direct signaling events. We suggest a paradigm shift from HDL being a bystander to being an active player in diabetic pathophysiology, which raises the possibility that HDL elevation could be a novel therapeutic avenue for T2DM. The entry of HDL-raising agents of the cholesteryl ester transfer protein (CETP) inhibitor class into late-phase clinical trials creates potential for rapid clinical translation. This Review will discuss the emerging evidence for a role of HDL-mediated glucose regulation in the pathophysiology of T2DM, and will also outline the therapeutic potential for HDL elevation for the prevention and management of T2DM.

Integrity signals

Registry

Crossref · 10.1038/nrendo.2011.235

Cites

113 of 113 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Inflammation and metabolic disorders
Hotamisligil, G. S. (2006) · Nature · doi:10.1038/nature05485 · Cited by 9,199
Prevalence of the Metabolic Syndrome Among US Adults: Findings From the Third National Health and Nutrition Examination Survey
Ford, E. S., Giles, W. H., & Dietz, W. H. (2002) · JAMA · doi:10.1001/jama.287.3.356 · Cited by 6,698
Role of AMP-Activated Protein Kinase in Mechanism of Metformin Action
Zhou, G., Myers, R., Li, Y., Chen, Y., Shen, X., Fenyk-Melody, J., Wu, M., Ventre, J., Doebber, T., Fujii, N., et al. (2001) · Journal of Clinical Investigation · doi:10.1172/jci13505 · Cited by 5,652
Inflammation, stress, and diabetes
Wellen, K. E., & Hotamisligil, G. S. (2005) · Journal of Clinical Investigation · doi:10.1172/jci25102 · Cited by 4,143
Effects of long-term fenofibrate therapy on cardiovascular events in 9795 people with type 2 diabetes mellitus (the FIELD study): randomised controlled trial
(2005) · The Lancet · doi:10.1016/s0140-6736(05)67667-2 · Cited by 3,284
A genome-wide association study identifies novel risk loci for type 2 diabetes
Sladek, R., Rocheleau, G., Rung, J., Dina, C., Shen, L., Serre, D., Boutin, P., Vincent, D., Belisle, A., Hadjadj, S., et al. (2007) · Nature · doi:10.1038/nature05616 · Cited by 2,993
Effects of Combination Lipid Therapy in Type 2 Diabetes Mellitus
(2010) · New England Journal of Medicine · doi:10.1056/nejmoa1001282 · Cited by 2,837
Activation of oxidative stress by acute glucose fluctuations compared with sustained chronic hyperglycemia in patients with type 2 diabetes
Monnier, L., Mas, E., Ginet, C., Michel, F., Villon, L., Cristol, J.-P., & Colette, C. (2006) · JAMA · doi:10.1001/jama.295.14.1681 · Cited by 2,444
Statins and risk of incident diabetes: A collaborative meta-analysis of randomised statin trials
Sattar, N., Preiss, D., Murray, H. M., Welsh, P., Buckley, B. M., de Craen, A. J., Seshasai, S. R. K., McMurray, J. J., Freeman, D. J., Jukema, J. W., et al. (2010) · The Lancet · doi:10.1016/s0140-6736(09)61965-6 · Cited by 2,436
Cholesterol efflux capacity, high-density lipoprotein function, and atherosclerosis
Khera, A. V., Cuchel, M., de la Llera-Moya, M., Rodrigues, A., Burke, M. F., Jafri, K., French, B. C., Phillips, J. A., Mucksavage, M. L., Wilensky, R. L., et al. (2011) · New England Journal of Medicine · doi:10.1056/nejmoa1001689 · Cited by 1,943

Flagged first, then by citations

Show all 114 references

1 of the 114 references couldn’t be matched to a known paper.

Sorted by citations

Clinical Update: Cardiovascular Disease in Diabetes Mellitus
Wang, C. C. L., Hess, C. N., Hiatt, W. R., & Goldfine, A. B. (2016) · Circulation · doi:10.1161/circulationaha.116.022194 · Cited by 1,222
High-Density Lipoprotein Subfractions - What the Clinicians Need to Know
Pirillo, A., Norata, G. D., & Catapano, A. L. (2013) · Cardiology · doi:10.1159/000346463 · Cited by 754
Diabetic dyslipidemia
Li-ya, W., & Parhofer, K. G. (2014) · Metabolism · doi:10.1016/j.metabol.2014.08.010 · Cited by 543
Interaction between Glucose and Lipid Metabolism: More than Diabetic Dyslipidemia
Parhofer, K. G. (2015) · Diabetes & Metabolism Journal · doi:10.4093/dmj.2015.39.5.353 · Cited by 458
HDL-targeted therapies: progress, failures and future
Kingwell, B. A., Chapman, M. J., Kontush, A., & Miller, N. E. (2014) · Nature Reviews Drug Discovery · doi:10.1038/nrd4279 · Cited by 354
Self-citation
Prevalence of and risk factors for diabetic peripheral neuropathy in youth with type 1 and type 2 diabetes: SEARCH for Diabetes in Youth study
Jaiswal, M., Divers, J., Dabelea, D., Isom, S., Bell, R. A., Martin, C. L., Pettitt, D. J., Saydah, S., Pihoker, C., Standiford, D. A., et al. (2017) · Diabetes Care · doi:10.2337/dc17-0179 · Cited by 303
Cardioprotective functions of HDLs
Rye, K., & Barter, P. J. (2013) · Journal of Lipid Research · doi:10.1194/jlr.r039297 · Cited by 310
Self-citation
The role and function of HDL in patients with diabetes mellitus and the related cardiovascular risk
Femlak, M., Gluba-Brzózka, A., Ciałkowska-Rysz, A. D., & Rysz, J. (2017) · Lipids in Health and Disease · doi:10.1186/s12944-017-0594-3 · Cited by 226
Are hypertriglyceridemia and low HDL causal factors in the development of insulin resistance?
Li, N., Fu, J., Koonen, D. P. Y., Kuivenhoven, J. A., Snieder, H., & Hofker, M. H. (2014) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2013.12.013 · Cited by 179
HDL Cholesterol and Risk of Type 2 Diabetes: A Mendelian Randomization Study
Haase, C. L., Tybjærg‐Hansen, A., Nordestgaard, B. G., & Frikke‐Schmidt, R. (2015) · Diabetes · doi:10.2337/db14-1603 · Cited by 162
Lipoprotein Particles and Incident Type 2 Diabetes in the Multi-Ethnic Study of Atherosclerosis
Mackey, R. H., Mora, S., Bertoni, A. G., Wassel, C. L., Carnethon, M. R., Sibley, C. T., & Goff, D. C. (2015) · Diabetes Care · doi:10.2337/dc14-0645 · Cited by 156
HDL functionality
Soran, H., Hama, S., Yadav, R., & Durrington, P. N. (2012) · Current Opinion in Lipidology · doi:10.1097/mol.0b013e328355ca25 · Cited by 155
Lipidome as a predictive tool in progression to type 2 diabetes in Finnish men
Suvitaival, T., Bondia‐Pons, I., Yetukuri, L., Pöhö, P., Nolan, J. J., Hyötyläinen, T., Kuusisto, J., & Orešič, M. (2017) · Metabolism · doi:10.1016/j.metabol.2017.08.014 · Cited by 149
Interaction between high-density lipoproteins and inflammation: function matters more than concentration!
Nazir, S., Jankowski, V., Bender, G., Zewinger, S., Rye, K.-A., & van der Vorst, E. P. C. (2020) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2020.10.006 · Cited by 140
Self-citation
HDL in Atherosclerotic Cardiovascular Disease: In Search of a Role
Casula, M., Colpani, O., Xie, S., Catapano, A. L., & Baragetti, A. (2021) · Cells · doi:10.3390/cells10081869 · Cited by 149
High-density lipoprotein metabolism and reverse cholesterol transport: strategies for raising HDL cholesterol
Trajkovska, K. T. (2017) · The Anatolian Journal of Cardiology · doi:10.14744/anatoljcardiol.2017.7608 · Cited by 131
Role of HDL Cholesterol and Estimates of HDL Particle Composition in Future Development of Type 2 Diabetes in the General Population: The PREVEND Study
Abbasi, A., Corpeleijn, E., Gansevoort, R. T., Gans, R. O. B., Hillege, H. L., Stolk, R. P., Navis, G., Bakker, S. J. L., & Dullaart, R. P. F. (2013) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2013-1680 · Cited by 128
The evolution of domain arrangements in proteins and interaction networks
Bornberg‐Bauer, E., Beaussart, F., Kummerfeld, S., Teichmann, S. A., & Weiner, J. M. (2005) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-004-4416-1 · Cited by 127
Effect of pitavastatin on glucose, HbA1c and incident diabetes: A meta-analysis of randomized controlled clinical trials in individuals without diabetes
Vallejo‐Vaz, A. J., Seshasai, S. R. K., Kurogi, K., Michishita, I., Nozue, T., Sugiyama, S., Tsimikas, S., Yoshida, H., & Ray, K. K. (2015) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2015.06.001 · Cited by 124
Reverse Engineering and Evaluation of Prediction Models for Progression to Type 2 Diabetes
ANDERSON, J. P., Parikh, J. R., Shenfeld, D. K., Ivanov, V., Marks, C., Church, B. W., Laramie, J. M., Mardekian, J., Piper, B. A., Willke, R. J., et al. (2015) · Journal of Diabetes Science and Technology · doi:10.1177/1932296815620200 · Cited by 120
High-density lipoprotein, beta cells, and diabetes
von Eckardstein, A., & Widmann, C. (2014) · Cardiovascular Research · doi:10.1093/cvr/cvu143 · Cited by 105
Statins are diabetogenic – Myth or reality?
Sattar, N. A., & Taskinen, M. (2012) · Atherosclerosis Supplements · doi:10.1016/j.atherosclerosissup.2012.06.001 · Cited by 107
HDL endocytosis and resecretion
Röhrl, C., & Stangl, H. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2013.07.014 · Cited by 101
Type 2 diabetes mellitus unawareness, prevalence, trends and risk factors: National Health and Nutrition Examination Survey (NHANES) 1999–2010
Zhang, N., Yang, X. T., Zhu, X., Zhao, B., Huang, T., & Ji, Q. (2017) · Journal of International Medical Research · doi:10.1177/0300060517693178 · Cited by 109
Triglycerides to high-density lipoprotein–cholesterol ratio, glycemic control and cardiovascular risk in obese patients with type 2 diabetes
Quispe, R., Martin, S. S., & Jones, S. R. (2016) · Current Opinion in Endocrinology Diabetes and Obesity · doi:10.1097/med.0000000000000241 · Cited by 97
The Triglyceride/HDL Ratio and Triglyceride Glucose Index as Predictors of Glycemic Control in Patients with Diabetes Mellitus Type 2
Babić, N., Valjevac, A., Začiragić, A., Avdagić, N., Zukić, S., & Hasić, S. (2019) · Medical Archives · doi:10.5455/medarh.2019.73.163-168 · Cited by 97
Beginning to Understand High-Density Lipoproteins
Santos‐Gallego, C. G., Badimon, J. J., & Rosenson, R. S. (2014) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2014.08.001 · Cited by 96
Macrophage Polarization: Implications on Metabolic Diseases and the Role of Exercise
Silveira, L. S., Antunes, B. M., Minari, A. L. A., dos Santos, R. V. T., Neto, J. C. R., & Lira, F. S. (2016) · Critical Reviews in Eukaryotic Gene Expression · doi:10.1615/critreveukaryotgeneexpr.2016015920 · Cited by 96
HDL and glucose metabolism: current evidence and therapeutic potential
Siebel, A. L., Heywood, S. E., & Kingwell, B. A. (2015) · Frontiers in Pharmacology · doi:10.3389/fphar.2015.00258 · Cited by 97
Self-citation
HDL and type 2 diabetes: the chicken or the egg?
Xepapadaki, E., Nikdima, I., Sagiadinou, E. C., Zvintzou, E., & Kypreos, K. E. (2021) · Diabetologia · doi:10.1007/s00125-021-05509-0 · Cited by 89
The Role of High-Density Lipoproteins in Diabetes and Its Vascular Complications
Wong, N. K. P., Nicholls, S. J., Tan, J. T. M., & Bursill, C. A. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19061680 · Cited by 77
Insulin sensitivity across the lifespan from obese adolescents to obese adults with impaired glucose tolerance: Who is worse off?
Arslanian, S. A., Kim, J. Y., Nasr, A., Bacha, F. F., Tfayli, H. M., Lee, S., & Toledo, F. G. S. (2017) · Pediatric Diabetes · doi:10.1111/pedi.12562 · Cited by 82
Nonlinear relationship between untraditional lipid parameters and the risk of prediabetes: a large retrospective study based on Chinese adults
Li, M., Zhang, W., Zhang, M., Li, L., Wang, D., Yan, G., Qiao, Y., & Tang, C. (2024) · Cardiovascular Diabetology · doi:10.1186/s12933-023-02103-z · Cited by 80
The association between triglyceride-glucose index and the incidence of type 2 diabetes mellitus—a systematic review and dose–response meta-analysis of cohort studies
Pranata, R., Huang, I., Irvan, I., Lim, M. A., & Vania, R. (2021) · Endocrine · doi:10.1007/s12020-021-02780-4 · Cited by 76
Endoplasmic reticulum stress impairs cholesterol efflux and synthesis in hepatic cells
Röhrl, C., Eigner, K., Winter, K. S., Korbelius, M., Obrowsky, S., Kratky, D., Kovacs, W. J., & Stangl, H. (2013) · Journal of Lipid Research · doi:10.1194/jlr.m043299 · Cited by 73
HDL Cholesterol and Non-Cardiovascular Disease: A Narrative Review
Kjeldsen, E. W., Nordestgaard, L. T., & Frikke‐Schmidt, R. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22094547 · Cited by 76
Effects of High-Density Lipoprotein Elevation With Cholesteryl Ester Transfer Protein Inhibition on Insulin Secretion
Siebel, A. L., Natoli, A. K., Yap, F. Y. T., Carey, A. L., Reddy-Luthmoodoo, M., Sviridov, D., Weber, C. I. K., Meneses‐Lorente, G., Maugeais, C., Forbes, J. M., et al. (2013) · Circulation Research · doi:10.1161/circresaha.113.300689 · Cited by 71
Self-citation
Effect of Gum Arabic (Acacia Senegal) supplementation on visceral adiposity index (VAI) and blood pressure in patients with type 2 diabetes mellitus as indicators of cardiovascular disease (CVD): a randomized and placebo-controlled clinical trial
Babiker, R. A., Elmusharaf, K., Keogh, M. B., & Saeed, A. M. (2018) · Lipids in Health and Disease · doi:10.1186/s12944-018-0711-y · Cited by 69
Triglycerides/HDL cholesterol ratio and type 2 diabetes incidence: Panasonic Cohort Study 10
Yuge, H., Okada, H., Hamaguchi, M., Kurogi, K., Murata, H., Ito, M., & Fukui, M. (2023) · Cardiovascular Diabetology · doi:10.1186/s12933-023-02046-5 · Cited by 68
HDL-C and HDL-C/ApoA-I Predict Long-Term Progression of Glycemia in Established Type 2 Diabetes
Waldman, B., Jenkins, A. J., Davis, T. M. E., Taskinen, M., Scott, R. S., O'Connell, R. L., Gebski, V., Ng, M., & KEECH, A. C. (2014) · Diabetes Care · doi:10.2337/dc13-2738 · Cited by 69
Rethinking good cholesterol: a clinicians' guide to understanding HDL
Xiang, A. S., & Kingwell, B. A. (2019) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(19)30003-8 · Cited by 70
Self-citation
HDL-Cholesterol, Its Variability, and the Risk of Diabetes: A Nationwide Population-Based Study
Lee, S., Kim, H., Park, Y., Kwon, H., Yoon, K., Han, K., & Kim, M. K. (2019) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2019-01080 · Cited by 66
Triglyceride-rich lipoprotein and LDL particle subfractions and their association with incident type 2 diabetes: the PREVEND study
Sokooti, S., Flores-Guerrero, J. L., Heerspink, H. J. L., Connelly, M. A., Bakker, S. J. L., & Dullaart, R. P. F. (2021) · Cardiovascular Diabetology · doi:10.1186/s12933-021-01348-w · Cited by 69
Dietary guidelines for saturated fatty acids are not supported by the evidence
Parodi, P. W. (2015) · International Dairy Journal · doi:10.1016/j.idairyj.2015.08.007 · Cited by 69
Glucose and Lipid Dysmetabolism in a Rat Model of Prediabetes Induced by a High-Sucrose Diet
Burgeiro, A., Cerqueira, M., Varela-Rodríguez, B. M., Nunes, S., Neto, P., Pereira, F. C., Reis, F., & Carvalho, E. (2017) · Nutrients · doi:10.3390/nu9060638 · Cited by 73
Apolipoprotein A-I enhances insulin-dependent and insulin-independent glucose uptake by skeletal muscle
Tang, S., Tabet, F., Cochran, B. J., Torres, L., Wu, B. J., Barter, P. J., & Rye, K. (2019) · Scientific Reports · doi:10.1038/s41598-018-38014-3 · Cited by 70
Self-citation
HDL cholesterol and ASCVD risk stratification: A debate
Barter, P. J., & Genest, J. J. (2019) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2019.01.001 · Cited by 68
Self-citation
Metabolomics and Lipidomics Profiling Reveals Hypocholesterolemic and Hypolipidemic Effects of Arabinoxylan on Type 2 Diabetic Rats
Nie, Q., Xing, M., Chen, H., Hu, J., & Nie, S. (2019) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.9b03430 · Cited by 65
Apolipoprotein A-I Increases Insulin Secretion and Production From Pancreatic β-Cells via a G-Protein-cAMP-PKA-FoxO1–Dependent Mechanism
Cochran, B. J., Bisoendial, R. J., Hou, L., Glaros, E. N., Rossy, J., Thomas, S. R., Barter, P. J., & Rye, K.-A. (2014) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.114.304131 · Cited by 66
Self-citation
Evaluation of reconstituted high-density lipoprotein (rHDL) as a drug delivery platform – a detailed survey of rHDL particles ranging from biophysical properties to clinical implications
Simonsen, J. B. (2016) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2016.05.009 · Cited by 64
HDL Particle Subspecies and Their Association With Incident Type 2 Diabetes: The PREVEND Study
Sokooti, S., Flores-Guerrero, J. L., Kieneker, L. M., Heerspink, H. J. L., Connelly, M. A., Bakker, S. J. L., & Dullaart, R. P. F. (2021) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgab075 · Cited by 63
The effect of short‐term overfeeding on serum lipids in healthy humans
Heilbronn, L. K., Coster, A. C. F., Campbell, L. V., Greenfield, J. R., Lange, K. M., Christopher, M., Meikle, P. J., & Samocha‐Bonet, D. (2013) · Obesity · doi:10.1002/oby.20508 · Cited by 62
Future of High-Density Lipoprotein Infusion Therapies
Kingwell, B. A., & Chapman, M. J. (2013) · Circulation · doi:10.1161/circulationaha.113.002683 · Cited by 65
Self-citation
Dose–response association between the triglycerides: High‐density lipoprotein cholesterol ratio and type 2 diabetes mellitus risk: The rural Chinese cohort study and meta‐analysis
Cheng, C., Liu, Y., Sun, X., Yin, Z., Li, H., Zhang, M., Zhang, D., Wang, B., Ren, Y., Zhao, Y., et al. (2018) · Journal of Diabetes · doi:10.1111/1753-0407.12836 · Cited by 60
Potentialities of nanomaterials for the management and treatment of metabolic syndrome: A new insight
Adetunji, C. O., Michael, O. S., Rathee, S., Singh, K. R., Ajayi, O. O., Adetunji, J. B., Ojha, A., Singh, J., & Singh, R. P. (2021) · Materials Today Advances · doi:10.1016/j.mtadv.2021.100198 · Cited by 62
Association between the ratio of triglyceride to high‐density lipoprotein cholesterol and incident type 2 diabetes in Singapore Chinese men and women
Wang, Y., Koh, W., Talaei, M., Yuan, J., & Pan, A. (2016) · Journal of Diabetes · doi:10.1111/1753-0407.12477 · Cited by 57
Role of HDL in Those with Diabetes
Santos‐Gallego, C. G., & Rosenson, R. S. (2014) · Current Cardiology Reports · doi:10.1007/s11886-014-0512-5 · Cited by 59
HDLs, Diabetes, and Metabolic Syndrome
Vollenweider, P., von Eckardstein, A., & Widmann, C. (2014) · Handbook of experimental pharmacology · doi:10.1007/978-3-319-09665-0_12 · Cited by 55
Discoidal HDL and apoA-I-derived peptides improve glucose uptake in skeletal muscle
Dalla‐Riva, J., Stenkula, K. G., Petrlová, J., & Lagerstedt, J. O. (2013) · Journal of Lipid Research · doi:10.1194/jlr.m032904 · Cited by 54
HDL cholesterol concentration or HDL function: which matters?
Barter, P. J., & Rye, K. (2017) · European Heart Journal · doi:10.1093/eurheartj/ehx274 · Cited by 54
Self-citation
A Mendelian Randomization Study of Metabolite Profiles, Fasting Glucose, and Type 2 Diabetes
Liu, J., van Klinken, J. B., Semiz, S., van Dijk, K. W., Verhoeven, A., Hankemeier, T., Harms, A. C., Sijbrands, E. J. G., Sheehan, N. A., van Duijn, C. M., et al. (2017) · Diabetes · doi:10.2337/db17-0199 · Cited by 50
Advances in high-density lipoprotein physiology: surprises, overturns, and promises
Constantinou, C., Karavia, E. A., Xepapadaki, E., Πετροπούλου, Π.-Ι., Παπακώστα, Ε., Karavyraki, M., Zvintzou, E., Theodoropoulos, V., Filou, S., Hatziri, A., et al. (2015) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00429.2015 · Cited by 48
ApoA-1 improves glucose tolerance by increasing glucose uptake into heart and skeletal muscle independently of AMPKα2
Fritzen, A. M., Domingo‐Espín, J., Lundsgaard, A., Kleinert, M., Israelsen, I. M. E., Carl, C. S., Nicolaisen, T. S., Kjøbsted, R., Jeppesen, J. F., Wojtaszewski, J. F. P., et al. (2020) · Molecular Metabolism · doi:10.1016/j.molmet.2020.01.013 · Cited by 49
Association between triglyceride to HDL-C ratio and insulin resistance in indigenous Argentinean children
Hirschler, V., Maccallini, G., Sanchez, M. S., González, C. D., & Molinari, C. (2014) · Pediatric Diabetes · doi:10.1111/pedi.12228 · Cited by 48
Effects of the BET-inhibitor, RVX-208 on the HDL lipidome and glucose metabolism in individuals with prediabetes: A randomized controlled trial
Siebel, A. L., Trinh, S. K., Formosa, M. F., Mundra, P. A., Natoli, A. K., Reddy-Luthmoodoo, M., Huynh, K., Khan, A. A., Carey, A. L., van Hall, G., et al. (2016) · Metabolism · doi:10.1016/j.metabol.2016.03.002 · Cited by 47
Self-citation
Dysfunctional High-Density Lipoproteins in Type 2 Diabetes Mellitus: Molecular Mechanisms and Therapeutic Implications
Bonilha, I., Zimetti, F., Zanotti, I., Papotti, B., & Sposito, A. C. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10112233 · Cited by 48
High-density lipoprotein and inflammation in cardiovascular disease
Connelly, M. A., SHALAUROVA, I. Y., & Otvos, J. D. (2016) · Translational research · doi:10.1016/j.trsl.2016.01.006 · Cited by 46
Relationship Between HDL Functional Characteristics and Cardiovascular Health and Potential Impact of Dietary Patterns: A Narrative Review
Bardagjy, A. S., & Steinberg, F. M. (2019) · Nutrients · doi:10.3390/nu11061231 · Cited by 48
Progression of insulin resistance: A link between risk factors and the incidence of diabetes
Wu, W.-C., Wei, J., Chen, S., Fan, K., Lin, C., Yang, C., Lin, M., Shih, S., Hua, C., Hsein, Y.-C., et al. (2020) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2020.108050 · Cited by 47
Association between the triglyceride to high-density lipoprotein cholesterol ratio and the risk of type 2 diabetes mellitus among Chinese elderly: the Beijing Longitudinal Study of Aging
Zheng, D., Li, H., Ai, F., Sun, F., Singh, M., Cao, X., Jiang, J., He, Y., Tang, Z., & Guo, X. (2020) · BMJ Open Diabetes Research & Care · doi:10.1136/bmjdrc-2019-000811 · Cited by 45
Effect of high-dose pitavastatin on glucose homeostasis in patients at elevated risk of new-onset diabetes: insights from the CAPITAIN and PREVAIL-US studies
Chapman, M. J., Orsoni, A., Robillard, P., Hounslow, N. J., Sponseller, C. A., & Giral, P. (2013) · Current Medical Research and Opinion · doi:10.1185/03007995.2013.874989 · Cited by 44
The effect of CETP inhibitors on new-onset diabetes: a systematic review and meta-analysis
Dangas, K., Navar, A.-M., & Kastelein, J. J. P. (2022) · European Heart Journal - Cardiovascular Pharmacotherapy · doi:10.1093/ehjcvp/pvac025 · Cited by 44
HDL-Cholesterol and Triglycerides Dynamics: Essential Players in Metabolic Syndrome
Alcover, S., Ramos-Regalado, L., Girón, G., Muñoz‐García, N., & Vilahur, G. (2025) · Antioxidants · doi:10.3390/antiox14040434 · Cited by 50
Combined effect of metformin and gallic acid on inflammation, antioxidant status, endoplasmic reticulum (ER) stress and glucose metabolism in fructose-fed streptozotocin-induced diabetic rats
Obafemi, T. O., Jaiyesimi, K. F., Olomola, A. A., Olasehinde, O. R., Olaoye, O. A., Adewumi, F. D., Afolabi, B. A., Adewale, O. B., Akintayo, C. O., & Ojo, O. A. (2021) · Toxicology Reports · doi:10.1016/j.toxrep.2021.07.011 · Cited by 40
Apolipoprotein A-I Protects Against Pregnancy-Induced Insulin Resistance in Rats
Wu, B. J., Sun, Y., Ong, K. L., Li, Y., Tang, S., Barter, P. J., & Rye, K. (2019) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.118.312282 · Cited by 39
Self-citation
Anti-inflammatory Function of High-Density Lipoproteins via Autophagy of IκB Kinase
Gerster, R., Eloranta, J. J., Hausmann, M., Ruiz, P. A., Cosín‐Roger, J., Terhalle, A., Ziegler, U., Kullak-Ublick, G. A., von Eckardstein, A., & Rogler, G. (2014) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2014.12.006 · Cited by 45
Dietary patterns during pregnancy and risk of gestational diabetes: a prospective cohort study in Western China
Mak, J. K. L., Pham, N. M., Lee, A. H., Tang, L., Pan, X., Binns, C. W., & Sun, X. (2018) · Nutrition Journal · doi:10.1186/s12937-018-0413-3 · Cited by 44
Association between atherogenic index of plasma and gestational diabetes mellitus: a prospective cohort study based on the Korean population
Zhang, J., Suo, Y., Wang, L., Liu, D., Jia, Y. X., Fu, Y., Fan, W., & Jiang, Y. (2024) · Cardiovascular Diabetology · doi:10.1186/s12933-024-02341-9 · Cited by 37
Different inverse association of large high-density lipoprotein subclasses with exacerbation of insulin resistance and incidence of type 2 diabetes: The Nagahama study
Tabara, Y., Arai, H., Hirao, Y., Takahashi, Y., Setoh, K., Kawaguchi, T., Kosugi, S., Ito, Y., Nakayama, T., & Matsuda, F. (2017) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2017.03.018 · Cited by 37
Microvesicle-associated and circulating microRNAs in diabetic dyslipidemia: miR-218, miR-132, miR-143, and miR-21, miR-122, miR-155 have biomarker potential
Nemecz, M., Stefan, D. S., Comariţa, I. K., Constantin, A. L., Tanko, G., Guja, C., & Georgescu, A. (2023) · Cardiovascular Diabetology · doi:10.1186/s12933-023-01988-0 · Cited by 36
Conventional biomarkers for cardiovascular risks and their correlation with the castelli risk index-indices and tg/hdl-c
Salcedo-Cifuentes, M., Belalcazar, S., Acosta, E., & Medina-Murillo, J. J. (2019) · Archivos de Medicina (Manizales) · doi:10.30554/archmed.20.1.3534.2020 · Cited by 36
A Dietary Pattern Derived by Reduced Rank Regression is Associated with Type 2 Diabetes in An Urban Ghanaian Population
Frank, L. K., Jannasch, F., Kröger, J., Bedu‐Addo, G., Mockenhaupt, F. P., Schulze, M. B., & Danquah, I. (2015) · Nutrients · doi:10.3390/nu7075233 · Cited by 37
Therapeutic Approaches to the Regulation of Metabolism of High-Density Lipoprotein
Zhang, B., Kawachi, E., Miura, S.-I., Uehara, Y., Matsunaga, A., Kuroki, M., & Saku, K. (2013) · Circulation Journal · doi:10.1253/circj.cj-12-1584 · Cited by 34
Residual risks and evolving atherosclerotic plaques
Noothi, S. K., Ahmed, M. R., & Agrawal, D. K. (2023) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-023-04689-0 · Cited by 37
In vivo PET imaging with [18F]FDG to explain improved glucose uptake in an apolipoprotein A-I treated mouse model of diabetes
Cochran, B. J., Ryder, W. J., Parmar, A., Tang, S., Reilhac, A., Arthur, A., Charil, A., Hamze, H., Barter, P. J., Kritharides, L., et al. (2016) · Diabetologia · doi:10.1007/s00125-016-3993-5 · Cited by 34
Self-citation
Apolipoprotein C-III and High-Density Lipoprotein Subspecies Defined by Apolipoprotein C-III in Relation to Diabetes Risk
Aroner, S. A., Yang, M., Li, J., Furtado, J. D., Sacks, F. M., Tjønneland, A. M., Overvad, K., Cai, T., & Jensen, M. K. (2017) · American Journal of Epidemiology · doi:10.1093/aje/kwx143 · Cited by 34
HDL cholesterol is an independent predictor of β‐cell function decline and incident type 2 diabetes: A longitudinal study
Fiorentino, T. V., Succurro, E., Marini, M. A., Pedace, E., Andreozzi, F., Perticone, M., Sciacqua, A., Perticone, F., & Sesti, G. (2020) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.3289 · Cited by 33
The compensatory enrichment of sphingosine -1- phosphate harbored on glycated high-density lipoprotein restores endothelial protective function in type 2 diabetes mellitus
Tong, X., Lv, P., Mathew, A. V., Liu, D., Niu, C., Wang, Y., Liang, J., Li, J., Fu, Z., Pan, B., et al. (2014) · Cardiovascular Diabetology · doi:10.1186/1475-2840-13-82 · Cited by 33
Plasma lipid levels predict dysglycemia in a biracial cohort of nondiabetic subjects: Potential mechanisms
Owei, I., UMEKWE, N. A., Wan, J. Y., & Dagogo-Jack, S. E. (2016) · Experimental Biology and Medicine · doi:10.1177/1535370216659946 · Cited by 33
Association between the triglyceride to high-density lipoprotein cholesterol ratio and the risk of gestational diabetes mellitus: a second analysis based on data from a prospective cohort study
You, Y., Hu, H., Cao, C., Han, Y. Y., Tang, J., & Zhao, W. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1153072 · Cited by 34
Metabolic, hormonal characteristics and genetic variants of TCF7L2 associated with development of gestational diabetes mellitus in Mexican women
Reyes‐López, R., Pérez-Luque, E. L., & Malacara, J. M. (2014) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.2538 · Cited by 31
HDL particles incorporate into lipid bilayers – a combined AFM and single molecule fluorescence microscopy study
Plochberger, B., Röhrl, C., Preiner, J., Rankl, C., Brameshuber, M. O., Madl, J., Bittman, R., Ros, R., Sezgin, E., Eggeling, C., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-15949-7 · Cited by 32
Statins and New-Onset Diabetes
Barylski, M., Nikolić, D., Banach, M., Toth, P. P., Montalto, G., & Rizzo, M. (2014) · Current Pharmaceutical Design · doi:10.2174/13816128113196660678 · Cited by 30
Host Metabolic Changes during Mycobacterium Tuberculosis Infection Cause Insulin Resistance in Adult Mice
Oswal, N., Lizardo, K., Dhanyalayam, D., Ayyappan, J. P., Thangavel, H., Heysell, S. K., & Nagajyothi, J. F. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11061646 · Cited by 29
ABCA1 agonist peptides for the treatment of disease
Bielicki, J. K. (2015) · Current Opinion in Lipidology · doi:10.1097/mol.0000000000000258 · Cited by 29
Cholesterol reprograms glucose and lipid metabolism to promote proliferation in colon cancer cells
Mayengbam, S. S., Singh, A., Yaduvanshi, H., Bhati, F. K., Deshmukh, B., Athavale, D., Ramteke, P. L., & Bhat, M. K. (2023) · Cancer & Metabolism · doi:10.1186/s40170-023-00315-1 · Cited by 28
The evolving role of cholesteryl ester transfer protein inhibition beyond cardiovascular disease
Mehta, N. N., Dangas, K., Ditmarsch, M., Rensen, P. C. N., Dicklin, M. R., & Kastelein, J. J. P. (2023) · Pharmacological Research · doi:10.1016/j.phrs.2023.106972 · Cited by 28
Different relationship between ANGPTL3 and HDL components in female non-diabetic subjects and type-2 diabetic patients
Zhao, D., Yang, L., Wang, X., Yuan, S., Yu, C., Wang, Z., Lang, J., & Feng, Y. (2016) · Cardiovascular Diabetology · doi:10.1186/s12933-016-0450-1 · Cited by 28
Apolipoprotein Mimetic Peptides: An Emerging Therapy against Diabetic Inflammation and Dyslipidemia
Wolkowicz, P. E., White, C. R., & Anantharamaiah, G. M. (2021) · Biomolecules · doi:10.3390/biom11050627 · Cited by 29
Apolipoprotein C-III and its defined lipoprotein subspecies in relation to incident diabetes: the Multi-Ethnic Study of Atherosclerosis
Aroner, S. A., Furtado, J. D., Sacks, F. M., Tsai, M. Y., Mukamal, K. J., McClelland, R. L., & Jensen, M. K. (2019) · Diabetologia · doi:10.1007/s00125-019-4847-8 · Cited by 27

Authors: Drew, B. G., Rye, K.-A., Duffy, S. J., Barter, P., & Kingwell, B. A.
Affiliations: Baker Heart and Diabetes Institute (AU)
The Heart Research Institute (AU)
The Alfred Hospital (AU)
Corresponding author: Kingwell, Bronwyn A.
ORCID: Drew, Brian G.
Rye, Kerry-Anne
Duffy, Stephen J.
Kingwell, Bronwyn A.
Venue: Nature Reviews Endocrinology
Publisher: Springer Science and Business Media LLC
Published: 2012-01-24
Volume: 8
Issue: 4
Pages: 237-245
ISSN: 1759-5029 (ISSN-L)
1759-5037
DOI: 10.1038/nrendo.2011.235
OpenAlex: W1982981124
Cited by: 307
References: 114
Citations by year: 2026: 14 · 2025: 33 · 2024: 36 · 2023: 29 · 2022: 24 · 2021: 23 · 2020: 16 · 2019: 18 · 2018: 14 · 2017: 22 · 2016: 19 · 2015: 15 · 2014: 21 · 2013: 16 · 2012: 6
FWCI: 2.55
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Nature Reviews Endocrinology (publishedVersion)
PubMed (publishedVersion)
Funders: State Government of Victoria
National Health and Medical Research Council
National Medical Research Council
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Cholesterol and Lipid Metabolism
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Keywords: high-density lipoprotein, glucose metabolism, glucose homeostasis, type 2 diabetes, insulin secretion, AMPK, muscle glucose uptake, insulin sensitivity, CETP inhibitors, HDL-raising therapy, atherosclerosis, lipid removal
MeSH terms: Animals, Blood Glucose, Diabetes Mellitus, Type 2, Humans, Insulin, Lipoproteins, HDL, Cholesterol, HDL

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

The emerging role of HDL in glucose metabolism

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks