Cited by 307Diabetes, Cardiovascular Risks, and LipoproteinsCholesterol and Lipid MetabolismAdipokines, Inflammation, and Metabolic Diseases

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The emerging role of HDL in glucose metabolism

Drew, Brian G., Rye, Kerry-Anne, Duffy, Stephen J., Barter, Philip, Kingwell, Bronwyn A.·2012·Nature Reviews Endocrinology

DOI 10.1038/nrendo.2011.235

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Abstract

A low plasma level of HDL cholesterol is an atherosclerotic risk factor; however, emerging evidence suggests that low HDL levels might also contribute to the pathophysiology of type 2 diabetes mellitus (T2DM) through direct effects on plasma glucose. In the past decade, animal and clinical studies have uncovered a previously undescribed spectrum of HDL actions, indicating that HDL may control glucose homeostasis through mechanisms including insulin secretion, direct glucose uptake by muscle via the AMP-activated protein kinase, and possibly enhanced insulin sensitivity. These effects are mediated by multiple cell types via mechanisms including preservation of cell function through cellular lipid removal and also via direct signaling events. We suggest a paradigm shift from HDL being a bystander to being an active player in diabetic pathophysiology, which raises the possibility that HDL elevation could be a novel therapeutic avenue for T2DM. The entry of HDL-raising agents of the cholesteryl ester transfer protein (CETP) inhibitor class into late-phase clinical trials creates potential for rapid clinical translation. This Review will discuss the emerging evidence for a role of HDL-mediated glucose regulation in the pathophysiology of T2DM, and will also outline the therapeutic potential for HDL elevation for the prevention and management of T2DM.

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Clinical Update: Cardiovascular Disease in Diabetes Mellitus
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Diabetic dyslipidemia
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Interaction between Glucose and Lipid Metabolism: More than Diabetic Dyslipidemia
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Authors: Drew, B. G., Rye, K.-A., Duffy, S. J., Barter, P., & Kingwell, B. A.
Affiliations: Baker Heart and Diabetes Institute (AU)
The Heart Research Institute (AU)
The Alfred Hospital (AU)
Corresponding author: Kingwell, Bronwyn A.
ORCID: Drew, Brian G.
Rye, Kerry-Anne
Duffy, Stephen J.
Kingwell, Bronwyn A.
Venue: Nature Reviews Endocrinology
Publisher: Springer Science and Business Media LLC
Published: 2012-01-24
Volume: 8
Issue: 4
Pages: 237-245
ISSN: 1759-5029 (ISSN-L)
1759-5037
DOI: 10.1038/nrendo.2011.235
OpenAlex: W1982981124
Cited by: 307
References: 114
Citations by year: 2026: 14 · 2025: 33 · 2024: 36 · 2023: 29 · 2022: 24 · 2021: 23 · 2020: 16 · 2019: 18 · 2018: 14 · 2017: 22 · 2016: 19 · 2015: 15 · 2014: 21 · 2013: 16 · 2012: 6
FWCI: 2.55
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Nature Reviews Endocrinology (publishedVersion)
PubMed (publishedVersion)
Funders: State Government of Victoria
National Health and Medical Research Council
National Medical Research Council
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Cholesterol and Lipid Metabolism
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Keywords: high-density lipoprotein, glucose metabolism, glucose homeostasis, type 2 diabetes, insulin secretion, AMPK, muscle glucose uptake, insulin sensitivity, CETP inhibitors, HDL-raising therapy, atherosclerosis, lipid removal
MeSH terms: Animals, Blood Glucose, Diabetes Mellitus, Type 2, Humans, Insulin, Lipoproteins, HDL, Cholesterol, HDL

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The emerging role of HDL in glucose metabolism

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