Cited by 565MicroRNA in disease regulationExtracellular vesicles in diseasePancreatic function and diabetes

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Circulating microRNAs as novel biomarkers for diabetes mellitus

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Guay, Claudiane, Regazzi, Romano·2013·Nature Reviews Endocrinology

DOI 10.1038/nrendo.2013.86

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Abstract

Diabetes mellitus is characterized by insulin secretion from pancreatic β cells that is insufficient to maintain blood glucose homeostasis. Autoimmune destruction of β cells results in type 1 diabetes mellitus, whereas conditions that reduce insulin sensitivity and negatively affect β-cell activities result in type 2 diabetes mellitus. Without proper management, patients with diabetes mellitus develop serious complications that reduce their quality of life and life expectancy. Biomarkers for early detection of the disease and identification of individuals at risk of developing complications would greatly improve the care of these patients. Small non-coding RNAs called microRNAs (miRNAs) control gene expression and participate in many physiopathological processes. Hundreds of miRNAs are actively or passively released in the circulation and can be used to evaluate health status and disease progression. Both type 1 diabetes mellitus and type 2 diabetes mellitus are associated with distinct modifications in the profile of miRNAs in the blood, which are sometimes detectable several years before the disease manifests. Moreover, circulating levels of certain miRNAs seem to be predictive of long-term complications. Technical and scientific obstacles still exist that need to be overcome, but circulating miRNAs might soon become part of the diagnostic arsenal to identify individuals at risk of developing diabetes mellitus and its devastating complications.

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Authors: Guay, C., & Regazzi, R.
Affiliations: University of Lausanne (CH)
Corresponding author: Regazzi, Romano
ORCID: Guay, Claudiane
Regazzi, Romano
Venue: Nature Reviews Endocrinology
Publisher: Springer Science and Business Media LLC
Published: 2013-04-30
Volume: 9
Issue: 9
Pages: 513-521
ISSN: 1759-5029 (ISSN-L)
1759-5037
DOI: 10.1038/nrendo.2013.86
OpenAlex: W2061998727
Cited by: 563
References: 102
Citations by year: 2026: 6 · 2025: 20 · 2024: 20 · 2023: 41 · 2022: 28 · 2021: 55 · 2020: 54 · 2019: 57 · 2018: 71 · 2017: 72 · 2016: 49 · 2015: 54 · 2014: 32 · 2013: 3
FWCI: 3.81
Type: journal article
Language: en
Open access: green
iris.unil.ch
Licence: www.springer.com/tdm (tdm)
Locations: Nature Reviews Endocrinology (publishedVersion)
PubMed (publishedVersion)
IRIS (submittedVersion)
SERVAL (Université de Lausanne) (submittedVersion, other-oa)
Funders: National Science Foundation
European Foundation for the Study of Diabetes
Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
Société Francophone du Diabète
Servier
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pancreatic function and diabetes
Keywords: circulating microRNAs, diabetes mellitus, type 1 diabetes, type 2 diabetes, biomarkers, early diagnosis, disease complications, pancreatic beta cells, insulin secretion, non-coding RNA
MeSH terms: Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2, Humans, MicroRNAs

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Circulating microRNAs as novel biomarkers for diabetes mellitus

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