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Circulating microRNAs as novel biomarkers for diabetes mellitus
Open accessAbstract
Diabetes mellitus is characterized by insulin secretion from pancreatic β cells that is insufficient to maintain blood glucose homeostasis. Autoimmune destruction of β cells results in type 1 diabetes mellitus, whereas conditions that reduce insulin sensitivity and negatively affect β-cell activities result in type 2 diabetes mellitus. Without proper management, patients with diabetes mellitus develop serious complications that reduce their quality of life and life expectancy. Biomarkers for early detection of the disease and identification of individuals at risk of developing complications would greatly improve the care of these patients. Small non-coding RNAs called microRNAs (miRNAs) control gene expression and participate in many physiopathological processes. Hundreds of miRNAs are actively or passively released in the circulation and can be used to evaluate health status and disease progression. Both type 1 diabetes mellitus and type 2 diabetes mellitus are associated with distinct modifications in the profile of miRNAs in the blood, which are sometimes detectable several years before the disease manifests. Moreover, circulating levels of certain miRNAs seem to be predictive of long-term complications. Technical and scientific obstacles still exist that need to be overcome, but circulating miRNAs might soon become part of the diagnostic arsenal to identify individuals at risk of developing diabetes mellitus and its devastating complications.
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Wang, N., Zhou, Y., Jiang, L., Li, D., Yang, J., Zhang, C., & Zen, K. (2012) · PLoS ONE · doi:10.1371/journal.pone.0051140 · Cited by 99
Circulating miRNAs: Reflecting or Affecting Cardiovascular Disease?
van Empel, V. P. M., Windt, L. J. D., & Martins, P. A. D. C. (2012) · Current Hypertension Reports · doi:10.1007/s11906-012-0310-7 · Cited by 87
MicroRNAs: a new ray of hope for diabetes mellitus
Kumar, M., Nath, S., Prasad, H. K., Sharma, G., & Li, Y. (2012) · Protein & Cell · doi:10.1007/s13238-012-2055-0 · Cited by 66
Characterization of Vesicles Secreted from Insulinoma NIT-1 Cells
Lee, H. S., Jeong, J., & Lee, K. (2009) · Journal of Proteome Research · doi:10.1021/pr900009y · Cited by 58
Towards understanding the inherited susceptibility for nephropathy in diabetes
Thomas, M. C., Groop, P., & Tryggvason, K. (2012) · Current Opinion in Nephrology & Hypertension · doi:10.1097/mnh.0b013e328350313e · Cited by 58
Type 1 Diabetes Islet Autoantibody Markers
Winter, W. E., Harris, N., & Schatz, D. (2002) · Diabetes Technology & Therapeutics · doi:10.1089/152091502321118838 · Cited by 53
Circulating MicroRNAs Are Not Eliminated by Hemodialysis
Martino, F., Lorenzen, J. M., Schmidt, J. J., Schmidt, M., Broll, M., Görzig, Y., Kielstein, J. T., & Thum, T. (2012) · PLoS ONE · doi:10.1371/journal.pone.0038269 · Cited by 52
Analysis of urinary microRNAs in chronic kidney disease
Beltrami, C., Clayton, A., Phillips, A. O., Fraser, D. J., & Bowen, T. (2012) · Biochemical Society Transactions · doi:10.1042/bst20120090 · Cited by 48
Biomarkers for type 1 diabetes.
Purohit, S. B., & She, J. (2008) · PubMed Central · Cited by 44
microRNA expression fingerprint in serum of type 1 diabetic patients
Sebastiani, G., Spagnuolo, I., Patti, A., Grieco, F. A., Cataldo, D., Ferretti, E., Tiberti, C., & Dotta, F. (2012) · Dépôt institutionnel de l'Université libre de Bruxelles (Université Libre de Bruxelles) · Cited by 16
Flagged first, then by citations
Research works printed but not linked: 1
- Guay, C., Menoud, V., Gattesco, S. & Regazzi, R. MicroRNA transfer as a new cell-to-cell communication mode between pancreatic β cells. Diabetologia 55, S95 (2012).
Cited by
Sorted by citations
Ying, W., Riopel, M., Bandyopadhyay, G., Dong, Y., Birmingham, A., Seo, J. B., Ofrecio, J. M., Wollam, J., Hernandez-Carretero, A., Fu, W., et al. (2017) · Cell · doi:10.1016/j.cell.2017.08.035 · Cited by 1,191
Aptamer-Based Detection of Circulating Targets for Precision Medicine
Wu, L., Wang, Y., Xu, X., Liu, Y., Lin, B., Zhang, M., Zhang, J., Wan, S., Yang, C. J., & Tan, W. (2021) · Chemical Reviews · doi:10.1021/acs.chemrev.0c01140 · Cited by 706
Polycystic Ovary Syndrome: Etiology, Current Management, and Future Therapeutics
Singh, S., Pal, N., Shubham, S., Sarma, D. K., Verma, V., Marotta, F., & Kumar, M. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12041454 · Cited by 521
β-Cell Failure in Type 2 Diabetes: Postulated Mechanisms and Prospects for Prevention and Treatment
Halban, P. A., Polonsky, K. S., Bowden, D. W., Hawkins, M. A., Ling, C., Mather, K. J., Powers, A. C., Rhodes, C. J., Sussel, L., & Weir, G. C. (2014) · Diabetes Care · doi:10.2337/dc14-0396 · Cited by 460
“It has been suggested that altered miRNA expression may contribute toward b-cell failure in T2D and that these molecules may serve as biomarkers for the disease (30).”
BackgroundMicroRNA regulatory networks in human adipose tissue and obesity
Arner, P., & Kulyté, A. (2015) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2015.25 · Cited by 461
Metadata
- Authors
- Guay, C., & Regazzi, R.
- Affiliations
- University of Lausanne (CH)
- Corresponding author
- Regazzi, Romano
- Venue
- Nature Reviews Endocrinology
- Published
- 2013-04-30
- Volume
- 9
- Issue
- 9
- Pages
- 513-521
- ISSN
- 1759-5029 (ISSN-L)
- 1759-5037
- OpenAlex
- W2061998727
- Cited by
- 563
- References
- 102
- Citations by year
- 2026: 6 · 2025: 20 · 2024: 20 · 2023: 41 · 2022: 28 · 2021: 55 · 2020: 54 · 2019: 57 · 2018: 71 · 2017: 72 · 2016: 49 · 2015: 54 · 2014: 32 · 2013: 3
- FWCI
- 3.81
- Type
- journal article
- Language
- en
- Open access
- green
- iris.unil.ch
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Reviews Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- IRIS (submittedVersion)
- SERVAL (Université de Lausanne) (submittedVersion, other-oa)
- Funders
- National Science Foundation
- European Foundation for the Study of Diabetes
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
- Société Francophone du Diabète
- Servier
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pancreatic function and diabetes
- Keywords
- circulating microRNAs, diabetes mellitus, type 1 diabetes, type 2 diabetes, biomarkers, early diagnosis, disease complications, pancreatic beta cells, insulin secretion, non-coding RNA
- MeSH terms
- Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2, Humans, MicroRNAs
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