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Cited by 757

The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.

Micronutrient deficiencies in pregnancy worldwide: health effects and prevention

Open access
Gernand, Alison D., Schulze, Kerry J., Stewart, Christine P., West, Keith P., Christian, Parul·2016·Nature Reviews Endocrinology
DOI 10.1038/nrendo.2016.37
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Abstract

Micronutrients, vitamins and minerals accessible from the diet, are essential for biologic activity. Micronutrient status varies widely throughout pregnancy and across populations. Women in low-income countries often enter pregnancy malnourished, and the demands of gestation can exacerbate micronutrient deficiencies with health consequences for the fetus. Examples of efficacious single micronutrient interventions include folic acid to prevent neural tube defects, iodine to prevent cretinism, zinc to reduce risk of preterm birth, and iron to reduce the risk of low birth weight. Folic acid and vitamin D might also increase birth weight. While extensive mechanistic and association research links multiple antenatal micronutrients with plausible materno–fetal health advantages, hypothesized benefits have often been absent, minimal or unexpected in trials. These findings suggest a role for population context in determining health responses and filling extensive gaps in knowledge. Multiple micronutrient supplements reduce the risks of being born with low birth weight, small for gestational age or stillborn in undernourished settings, and justify micronutrient interventions with antenatal care. Measurable health effects of gestational micronutrient exposure might persist into childhood but few data exists on potential long-term benefits. In this Review, we discuss micronutrient intake recommendations, risks and consequences of deficiencies, and the effects of interventions with a particular emphasis on offspring.

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Metadata

Authors
Gernand, A. D., Schulze, K. J., Stewart, C. P., West, K. P., & Christian, P.
Venue
Nature Reviews Endocrinology
Publisher
Springer Science and Business Media LLC
Published
2016-04-01
Volume
12
Issue
5
Pages
274-289
ISSN
  • 1759-5029 (ISSN-L)
  • 1759-5037
DOI
10.1038/nrendo.2016.37
OpenAlex
W2325817714
Cited by
757
References
7
FWCI
9.71
Type
journal article
Language
en
Open access
green

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