Human genetic variation and the gut microbiome in disease

Structure, function and diversity of the healthy human microbiome

The Human Microbiome Project Consortium (2012) · Nature · doi:10.1038/nature11234 · Cited by 11,726

Diet rapidly and reproducibly alters the human gut microbiome

David, L. A., Maurice, C. F., Carmody, R. N., Gootenberg, D. B., Button, J. E., Wolfe, B. E., Ling, A. V., Devlin, A. S., Varma, Y., Fischbach, M. A., et al. (2014) · Nature · doi:10.1038/nature12820 · Cited by 10,100

A core gut microbiome in obese and lean twins

Turnbaugh, P. J., Hamady, M., Yatsunenko, T., Cantarel, B. L., Duncan, A., Ley, R. E., Sogin, M. L., Jones, W. J., Roe, B. A., Affourtit, J. P., et al. (2009) · Nature · doi:10.1038/nature07540 · Cited by 7,823

Changes of Intestinal Functions in Liver Cirrhosis

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Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease

Hugot, J.-P., Chamaillard, M., Zouali, H., Lesage, S., Cézard, J.-P., Belaiche, J., Almer, S., Tysk, C., O'Morain, C. A., Gassull, M., et al. (2001) · Nature · doi:10.1038/35079107 · Cited by 5,591

Revised Estimates for the Number of Human and Bacteria Cells in the Body

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A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease

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Molecular-phylogenetic characterization of microbial community imbalances in human inflammatory bowel diseases

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Cross-talk between Akkermansia muciniphila and intestinal epithelium controls diet-induced obesity

Everard, A., Belzer, C., Geurts, L., Ouwerkerk, J. P., Druart, C., Bindels, L. B., Guiot, Y., Derrien, M., Muccioli, G. G., Delzenne, N. M., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1219451110 · Cited by 4,511

Applications of the Soil, Plant and Rumen Microbiomes in Pastoral Agriculture

Attwood, G. T., Wakelin, S. A., Leahy, S. C., Rowe, S. J., Clarke, S., Chapman, D. F., Muirhead, R. W., & Jacobs, J. M. E. (2019) · Frontiers in Nutrition · doi:10.3389/fnut.2019.00107 · Cited by 59

Tremella fuciformis polysaccharide reduces obesity in high-fat diet-fed mice by modulation of gut microbiota

He, G., Chen, T., Huang, L., Zhang, Y., Feng, Y., Qu, S., Yin, X., Liang, L., Yan, J., & Liu, W. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2022.1073350 · Cited by 59

The Human Microbiota in Endocrinology: Implications for Pathophysiology, Treatment, and Prognosis in Thyroid Diseases

Docimo, G., Cangiano, A., Romano, R. M., Pignatelli, M. F., Offi, C., Paglionico, V. A., Galdiero, M., Donnarumma, G., Nigro, V., Espósito, D., et al. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.586529 · Cited by 56

Concomitant analyses of intratumoral microbiota and genomic features reveal distinct racial differences in breast cancer

Parida, S., Siddharth, S., Xia, Y., & Sharma, D. (2023) · npj Breast Cancer · doi:10.1038/s41523-023-00505-6 · Cited by 52

Relative abundance data can misrepresent heritability of the microbiome

Bruijning, M., Ayroles, J. F., Henry, L. P., Koskella, B., Meyer, K., & Metcalf, C. J. E. (2023) · Microbiome · doi:10.1186/s40168-023-01669-w · Cited by 52

Of genes and microbes: solving the intricacies in host genomes

Wang, J., Chen, L., Zhao, N., Xu, X., Xu, Y., & Zhu, B. (2018) · Protein & Cell · doi:10.1007/s13238-018-0532-9 · Cited by 51

Microbiota Implications in Endocrine-Related Diseases: From Development to Novel Therapeutic Approaches

Clemente‐Suárez, V. J., Redondo-Flórez, L., Rubio-Zarapuz, A., Martín-Rodríguez, A., & Tornero-Aguilera, J. F. (2024) · Biomedicines · doi:10.3390/biomedicines12010221 · Cited by 59

Murine Genetic Background Has a Stronger Impact on the Composition of the Gut Microbiota than Maternal Inoculation or Exposure to Unlike Exogenous Microbiota

Korach-Rechtman, H., Freilich, S., Gerassy-Vainberg, S., Buhnik‐Rosenblau, K., Danin‐Poleg, Y., Bar, H., & Kashi, Y. (2019) · Applied and Environmental Microbiology · doi:10.1128/aem.00826-19 · Cited by 51

The Genetic Basis of Obesity and Related Metabolic Diseases in Humans and Companion Animals

Wallis, N. J., & Raffan, E. (2020) · Genes · doi:10.3390/genes11111378 · Cited by 57

Tissue-wide metabolomics reveals wide impact of gut microbiota on mice metabolite composition

Zarei, I., Koistinen, V., Kokla, M., Klåvus, A., Babu, A. F., Lehtonen, M., Auriola, S. O. K., & Hanhineva, K. (2022) · Scientific Reports · doi:10.1038/s41598-022-19327-w · Cited by 49

Diet Supplemented with Antioxidant and Anti-Inflammatory Probiotics Improves Sperm Quality after Only One Spermatogenic Cycle in Zebrafish Model

Valcarce, D. G., Riesco, M. F., Martínez, J. M., & Robles, V. (2019) · Nutrients · doi:10.3390/nu11040843 · Cited by 50

Gut Microbiota and Colorectal Cancer: A Balance Between Risk and Protection

Ionescu, V. A., Diaconu, C. C., Gheorghe, G., Mihai, M.-M., Diaconu, C. C., Bostan, M., & Bleoţu, C. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26083733 · Cited by 55

The metabolomic quest for a biomarker in chronic kidney disease

Davies, R. (2018) · Clinical Kidney Journal · doi:10.1093/ckj/sfy037 · Cited by 50

The anti-diabetic activity of polyphenols-rich vinegar extract in mice via regulating gut microbiota and liver inflammation

Xia, T., Zhang, Z., Zhao, Y., Kang, C., Zhang, X., Tian, Y., Yu, J., Cao, H., & Wang, M. (2022) · Food Chemistry · doi:10.1016/j.foodchem.2022.133443 · Cited by 52

The Microbiome in Patients With Inflammatory Diseases

Somineni, R. P., & Kugathasan, S. (2018) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2018.08.078 · Cited by 49

Inter-kingdom signaling between gut microbiota and their host

Li, Q., Ren, Y., & Fu, X. (2019) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-019-03076-7 · Cited by 48

The Future of Microbiome‐Based Therapeutics in Clinical Applications

Sharma, A., Das, P., Buschmann, M. M., & Gilbert, J. A. (2019) · Clinical Pharmacology & Therapeutics · doi:10.1002/cpt.1677 · Cited by 50

Microbial transmission from mother to child: improving infant intestinal microbiota development by identifying the obstacles

Daele, E. V., Knol, J., & Belzer, C. (2019) · Critical Reviews in Microbiology · doi:10.1080/1040841x.2019.1680601 · Cited by 49

The Computational Diet: A Review of Computational Methods Across Diet, Microbiome, and Health

Eetemadi, A., Rai, N., Pereira, B. M. P., Kim, M., Schmitz, H. H., & Tagkopoulos, I. (2020) · Frontiers in Microbiology · doi:10.3389/fmicb.2020.00393 · Cited by 51

SARS-CoV-2-Indigenous Microbiota Nexus: Does Gut Microbiota Contribute to Inflammation and Disease Severity in COVID-19?

Chattopadhyay, I., & Shankar, E. M. (2021) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2021.590874 · Cited by 46

Genetics and Genomics of Infectious Diseases in Key Aquaculture Species

Nguyen, N. H. (2024) · Biology · doi:10.3390/biology13010029 · Cited by 51

The Spanish gut microbiome reveals links between microorganisms and Mediterranean diet

Latorre‐Pérez, A., Hernández, M., Iglesias, J. R., Morán, J., Pascual, J., Porcar, M., Vilanova, C., & Yurrita, L. C. (2021) · Scientific Reports · doi:10.1038/s41598-021-01002-1 · Cited by 46

Heterogeneity of non-alcoholic fatty liver disease: Implications for clinical practice and research activity

Pal, P., Palui, R., & Ray, S. (2021) · World Journal of Hepatology · doi:10.4254/wjh.v13.i11.1584 · Cited by 51

The characteristics analysis of intestinal microecology on cerebral infarction patients and its correlation with apolipoprotein E

Wang, W., Xu, L., Yao, X., Cheng, X., & Zhu, Y. (2018) · Medicine · doi:10.1097/md.0000000000012805 · Cited by 45

Can intestinal microbiota and circulating microbial products contribute to pulmonary arterial hypertension?

Thenappan, T., Khoruts, A., Chen, Y., & Weir, Ε. K. (2019) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00416.2019 · Cited by 46

The intersect of genetics, environment, and microbiota in asthma-perspectives and challenges

Tang, H. H. F., Teo, S. M., Sly, P. D., Holt, P. G., & Inouye, M. (2021) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2020.08.026 · Cited by 43

Host genetics and microbiome associations through the lens of genome wide association studies

Weissbrod, O., Rothschild, D., Barkan, E., & Segal, E. (2018) · Current Opinion in Microbiology · doi:10.1016/j.mib.2018.05.003 · Cited by 45

Emerging evidence linking the gut microbiome to neurologic disorders

Griffiths, J. A., & Mazmanian, S. K. (2018) · Genome Medicine · doi:10.1186/s13073-018-0609-3 · Cited by 44

Bacterial Immunogenicity Is Critical for the Induction of Regulatory B Cells in Suppressing Inflammatory Immune Responses

Maerz, J. K., Trostel, C., Lange, A., Parusel, R., Michaelis, L., Schäfer, A., Yao, H., Löw, H.-C., & Frick, J.-S. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2019.03093 · Cited by 44

Investigating the Mechanistic Differences of Obesity-Inducing Lactobacillus kefiranofaciens M1 and Anti-obesity Lactobacillus mali APS1 by Microbolomics and Metabolomics

Lin, Y., Chen, Y., Li, K., & Chen, M. (2020) · Frontiers in Microbiology · doi:10.3389/fmicb.2020.01454 · Cited by 43

Gut dysbiosis associated with the rats' responses in methamphetamine‐induced conditioned place preference

Yang, C., Fu, X., Hao, W., Xiang, X., Liu, T., Yang, B., & Zhang, X. (2020) · Addiction Biology · doi:10.1111/adb.12975 · Cited by 45

Sensing Bacterial-Induced DNA Damaging Effects via Natural Killer Group 2 Member D Immune Receptor: From Dysbiosis to Autoimmunity and Carcinogenesis

Espinoza, J. L., & Minami, M. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00052 · Cited by 45

Does Malnutrition Have a Genetic Component?

Duggal, P., & Petri, W. A. (2018) · Annual Review of Genomics and Human Genetics · doi:10.1146/annurev-genom-083117-021340 · Cited by 41

Autoinducer-2 of gut microbiota, a potential novel marker for human colorectal cancer, is associated with the activation of TNFSF9 signaling in macrophages

Li, Q., Peng, W., Wu, J., Wang, X., Ren, Y., Li, H., Peng, Y., Tang, X., & Fu, X. (2019) · OncoImmunology · doi:10.1080/2162402x.2019.1626192 · Cited by 41

Microbiota in cerebrovascular disease: A key player and future therapeutic target

Tonomura, S., Ihara, M., & Friedland, R. P. (2020) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x20918031 · Cited by 41

Sex-Specific Associations between Gut Prevotellaceae and Host Genetics on Adiposity

Cuevas‐Sierra, A., Riezu‐Boj, J. I., Guruceaga, E., Milagro, F. I., & Martínez, J. A. (2020) · Microorganisms · doi:10.3390/microorganisms8060938 · Cited by 41

The Gut Microbiome in Psychosis From Mice to Men: A Systematic Review of Preclinical and Clinical Studies

Kraeuter, A.-K., Phillips, R., & Sarnyai, Z. (2020) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2020.00799 · Cited by 43

Progressive Shifts in the Gut Microbiome Reflect Prediabetes and Diabetes Development in a Treatment-Naive Mexican Cohort

Diener, C., Reyes‐Escogido, M. D. L., Jiménez-Ceja, L. M., Matus, M. G., Navarro, C. M. G., Chu, N. D., Zhong, V., Tejero, M. E., Alm, E. J., Reséndis-Antonio, O., et al. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.602326 · Cited by 39

Helicobacter pylori infection and other bacteria in pancreatic cancer and autoimmune pancreatitis

Kunovský, L., Dítě, P., Jabandžiev, P., Dolina, J., Vaculová, J., Blaho, M., Bojková, M., Dvořáčková, J., Uvírová, M., Kala, Z., et al. (2021) · World Journal of Gastrointestinal Oncology · doi:10.4251/wjgo.v13.i8.835 · Cited by 40

Using fish models to investigate the links between microbiome and social behaviour: The next step for translational microbiome research?

Soares, M. C., Cable, J., Lima, M. G., Maximino, C., & Xavier, R. (2019) · Fish and Fisheries · doi:10.1111/faf.12366 · Cited by 34

Oligosaccharides and Complex Carbohydrates: A New Paradigm for Cranberry Bioactivity

Coleman, C. M., & Ferreira, D. (2020) · Molecules · doi:10.3390/molecules25040881 · Cited by 40

The microbiome in pancreatic diseases: Recent advances and future perspectives

Ammer‐Herrmenau, C., Pfisterer, N., Weingarten, M. F., & Neeße, A. (2020) · United European Gastroenterology Journal · doi:10.1177/2050640620944720 · Cited by 39

Probiotic-Based Bacteriocin: Immunity Supplementation Against Viruses. An Updated Review

Umair, M., Jabbar, S., Zhaoxin, L., Zhang, J., Abid, M., Khan, K.-U.-R., Korma, S. A., Alghamdi, M. A., El‐Saadony, M. T., El-Hack, M. E. A., et al. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2022.876058 · Cited by 42

Microbiota alterations associated with vascular diseases: postbiotics as a next-generation magic bullet for gut-vascular axis

Flori, L., Benedetti, G., Martelli, A., & Calderone, V. (2024) · Pharmacological Research · doi:10.1016/j.phrs.2024.107334 · Cited by 40

Cellular Stress Responses and Gut Microbiota in Inflammatory Bowel Disease

Cao, S. “. (2018) · Gastroenterology Research and Practice · doi:10.1155/2018/7192646 · Cited by 37

Acceptive Immunity: The Role of Fucosylated Glycans in Human Host–Microbiome Interactions

Kononova, S., Litvinova, E. A., Vakhitov, T., Skalinskaya, M. I., & Sitkin, S. I. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22083854 · Cited by 41

Murine Adherent and InvasiveE. coliInduces Chronic Inflammation and Immune Responses in the Small and Large Intestines of Monoassociated IL-10-/- Mice Independent of Long Polar Fimbriae Adhesin A

Schmitz, J., Tonkonogy, S. L., Dogan, B., Leblond, A., Whitehead, K. J., Kim, S. C., Simpson, K. W., & Sartor, R. B. (2018) · Inflammatory Bowel Diseases · doi:10.1093/ibd/izy386 · Cited by 37

An orally administered magnoloside A ameliorates functional dyspepsia by modulating brain-gut peptides and gut microbiota

Xue, Z.-Z., Wu, C., Wei, J., Xian, M., Wang, T., Yang, B., & Chen, M. (2019) · Life Sciences · doi:10.1016/j.lfs.2019.116749 · Cited by 37

GIMICA: host genetic and immune factors shaping human microbiota

Tang, J., Wu, X., Mou, M., Wang, C., Wang, L., Li, F., Guo, M., Yin, J., Xie, W., Wang, X., et al. (2020) · Nucleic Acids Research · doi:10.1093/nar/gkaa851 · Cited by 37

A Distinct Microbiome Signature in Posttreatment Lyme Disease Patients

Morrissette, M., Pitt, N., González, A., Strandwitz, P., Caboni, M., Rebman, A. W., Knight, R. D., Donofrio, A. E., Aucott, J. N., Soloski, M. J., et al. (2020) · mBio · doi:10.1128/mbio.02310-20 · Cited by 38

Bifidobacterium Is Enriched in Gut Microbiome of Kashmiri Women with Polycystic Ovary Syndrome

Hassan, S., Kaakinen, M., Draisma, H. H. M., Zudina, L., Ganie, M. A., Rashid, A., Balkhiyarova, Z., Kiran, G. S., Vogazianos, P., Shammas, C., et al. (2022) · Genes · doi:10.3390/genes13020379 · Cited by 37

Intestinal dysbiosis in inflammatory bowel disease associated with primary immunodeficiency

Sokol, H., Mahlaoui, N., Aguilar, C., Bach, P., Join‐Lambert, O., Garraffo, A., Seksik, P., Danion, F., Jégou, S., Straube, M., et al. (2018) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2018.09.021 · Cited by 36

Epithelial immunity: priming defensive responses in the intestinal mucosa

Pardo‐Camacho, C., González-Castro, A. M., Rodiño‐Janeiro, B. K., Pigrau, M., & Vicario, M. (2017) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00215.2016 · Cited by 34

Relationship Between Oligosaccharides and Glycoconjugates Content in Human Milk and the Development of the Gut Barrier

Figueroa‐Lozano, S., & de Vos, P. (2018) · Comprehensive Reviews in Food Science and Food Safety · doi:10.1111/1541-4337.12400 · Cited by 33

Host Genetics and Gut Microbiome: Perspectives for Multiple Sclerosis

Maglione, A., Zuccalà, M., Tosi, M., Clerico, M., & Rolla, S. (2021) · Genes · doi:10.3390/genes12081181 · Cited by 34

Gut fungal mycobiome: A significant factor of tumor occurrence and development

Li, F., Gao, Y., Cheng, W., Su, L., & Yang, R. (2023) · Cancer Letters · doi:10.1016/j.canlet.2023.216302 · Cited by 36

Effect of radiotherapy on the gut microbiome in pediatric cancer patients: a pilot study

Sahly, N., Moustafa, A. M., Zaghloul, M. S., & Salem, T. Z. (2019) · PeerJ · doi:10.7717/peerj.7683 · Cited by 34

Shifting Climates, Foods, and Diseases: The Human Microbiome through Evolution

Amato, K. R., Jeyakumar, T., Poinar, H. N., & Gros, P. (2019) · BioEssays · doi:10.1002/bies.201900034 · Cited by 36

Cross-Regional View of Functional and Taxonomic Microbiota Composition in Obesity and Post-obesity Treatment Shows Country Specific Microbial Contribution

Medina, D. A., Li, T., Pamela Thomson, M., Artacho, A., Pérez‐Brocal, V., & Moyá, A. (2019) · Frontiers in Microbiology · doi:10.3389/fmicb.2019.02346 · Cited by 33

The gut microbiota can orchestrate the signaling pathways in colorectal cancer

Bennedsen, A. L. B., Furbo, S., Bjarnsholt, T., Raskov, H., Gögenür, I., & Kvich, L. (2022) · Apmis · doi:10.1111/apm.13206 · Cited by 30

Alterations in Gut Microbiota Composition in Patients with COVID-19: A Pilot Study of Whole Hypervariable 16S rRNA Gene Sequencing

Mańkowska‐Wierzbicka, D., Żuraszek-Szymańska, J., Wierzbicka, A., Gabryel, M., Mahadea, D., Baturo, A., Zakerska‐Banaszak, O., Słomski, R., Skrzypczak-Zielińska, M., & Dobrowolska, A. (2023) · Biomedicines · doi:10.3390/biomedicines11020367 · Cited by 32

Seven facts and five initiatives for gut microbiome research

Li, D., Gao, C., Zhang, F., Yang, R., Lan, C., Ma, Y., & Wang, J. (2020) · Protein & Cell · doi:10.1007/s13238-020-00697-8 · Cited by 36

Flavonoids and the gut microbiome: a powerful duo for brain health

Taherkhani, S., Ahmadi, P., Nasiraie, L. R., Janzadeh, A., Honardoost, M., & Esfahani, S. S. (2024) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2024.2435593 · Cited by 33

Organ transplantation and gut microbiota: current reviews and future challenges.

Xiao, J., Peng, Z., Liao, Y., Sun, H., Chen, W., Chen, X., Wei, Z., Yang, C., Nussler, A. K., Liu, J., et al. (2018) · Europe PMC (PubMed Central) · Cited by 31

On the Pathogenicity of the Oral Biofilm: A Critical Review from a Biological, Evolutionary, and Nutritional Point of View

Woelber, J. P., Al‐Ahmad, A., & Alt, K. W. (2022) · Nutrients · doi:10.3390/nu14102174 · Cited by 35

Progress of immune checkpoint therapy in the clinic (Review)

Fan, Y., Zhang, C., Jin, S., Gao, Z., Cao, J., Wang, A., Li, D., Wang, Q., Sun, X., & Bai, D. (2018) · Oncology Reports · doi:10.3892/or.2018.6819 · Cited by 30

Hepatic glycogen storage diseases are associated to microbial dysbiosis

Colonetti, K., dos Santos, B. B., Nalin, T., de Souza, C. F. M., Triplett, E. W., Dobbler, P. T., Schwartz, I. V. D., & Roesch, L. F. W. (2019) · PLoS ONE · doi:10.1371/journal.pone.0214582 · Cited by 30

Heme oxygenase-1 attenuates low-dose of deoxynivalenol-induced liver inflammation potentially associating with microbiota

Peng, Z., Liao, Y., Chen, L., Liu, S., Shan, Z., Nussler, A. K., Yao, P., Yan, H., Liu, L., & Yang, W. Q. (2019) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2019.04.020 · Cited by 30

Game of microbes: the battle within – gut microbiota and multiple sclerosis

Turner, T.-A. J., Lehman, P., Ghimire, S., Shahi, S. K., & Mangalam, A. K. (2024) · Gut Microbes · doi:10.1080/19490976.2024.2387794 · Cited by 33

The nasopharyngeal microbiome

Cleary, D. W., & Clarke, S. C. (2017) · Emerging Topics in Life Sciences · doi:10.1042/etls20170041 · Cited by 31

An alcohol-free beer enriched with isomaltulose and a resistant dextrin modulates gut microbiome in subjects with type 2 diabetes mellitus and overweight or obesity: a pilot study

Mateo‐Gállego, R., Moreno‐Indias, I., Bea, A. M., Sánchez‐Alcoholado, L., Fumanal, A. J., Quesada-Molina, M., Prieto-Martín, A., Gutiérrez‐Repiso, C., Civeira, F., & Tinahones, F. J. (2021) · Food & Function · doi:10.1039/d0fo03160g · Cited by 29

Microcystin-leucine arginine exposure induced intestinal lipid accumulation and MC-LR efflux disorder in Lithobates catesbeianus tadpoles

He, J., Shu, Y., Dai, Y., Gao, Y., Liu, S., Wang, W., Jiang, H., Zhang, H., Hong, P., & Wu, H. (2021) · Toxicology · doi:10.1016/j.tox.2021.153058 · Cited by 29

Role of Biological Sex in the Cardiovascular-Gut Microbiome Axis

Li, S., & Kararigas, G. (2022) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2021.759735 · Cited by 29

Maternal Phlorizin Intake Protects Offspring from Maternal Obesity-Induced Metabolic Disorders in Mice via Targeting Gut Microbiota to Activate the SCFA-GPR43 Pathway

Mei, X., Li, Y., Zhang, X., Zhai, X., Yang, Y., Li, Z., & Li, L. (2024) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.3c06370 · Cited by 30

The Core and Distinction of the Gut Microbiota in Chinese Populations across Geography and Ethnicity

Deng, L., Wang, R., Luo, J., Ren, F., Gu, Z., Zhao, Y., & Zhao, L. (2020) · Microorganisms · doi:10.3390/microorganisms8101579 · Cited by 30

Genome-wide multi-omics analysis reveals the nutrient-dependent metabolic features of mucin-degrading gut bacteria

Kim, K. S., Tiffany, E., Lee, J., Oh, A., Jin, H., Kim, J.-S., Lee, J., Nam, M. H., Hong, S., Park, S., et al. (2023) · Gut Microbes · doi:10.1080/19490976.2023.2221811 · Cited by 29

The Horse Gut Microbiome Responds in a Highly Individualized Manner to Forage Lignification

Gomez, A. M., Sharma, A. K., Grev, A. M., Sheaffer, C. C., & Martinson, K. L. (2020) · Journal of Equine Veterinary Science · doi:10.1016/j.jevs.2020.103306 · Cited by 28

Gene-Environmental Interactions as Metabolic Drivers of Nonalcoholic Steatohepatitis

Albhaisi, S. A. M., & Sanyal, A. J. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.665987 · Cited by 28

Contribution of the microbiota and their secretory products to inflammation and colorectal cancer pathogenesis: the role of toll-like receptors

Sheikh, A. A., Taube, J. H., & Greathouse, K. L. (2021) · Carcinogenesis · doi:10.1093/carcin/bgab060 · Cited by 26

A dual treatment blocks alcohol binge-drinking relapse: Microbiota as a new player

Ezquer, F. E., Quintanilla, M. E., Morales, P., Santapau, D., Munita, J. M., Moya‐Flores, F., Ezquer, M., Herrera‐Marschitz, M., & Israel, Y. (2022) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2022.109466 · Cited by 30

The gut microbiota – A vehicle for the prevention and treatment of hepatocellular carcinoma

Beyoğlu, D., & Idle, J. R. (2022) · Biochemical Pharmacology · doi:10.1016/j.bcp.2022.115225 · Cited by 28

Semen Microbiome, Male Infertility, and Reproductive Health

Chatzokou, D., Tsarna, E., Davouti, E., Siristatidis, C. S., Christopoulou, S., Spanakis, N., Tsakris, A., & Christopoulos, P. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26041446 · Cited by 28

Changes of Western honey bee Apis mellifera ligustica (Spinola, 1806) ventriculus microbial profile related to their in-hive tasks

Cilia, G., Fratini, F., Tafi, E., Mancini, S., Turchi, B., Sagona, S., Cerri, D., Felicioli, A., & Nanetti, A. (2020) · Journal of Apicultural Research · doi:10.1080/00218839.2020.1830259 · Cited by 27

Significance of African Diets in Biotherapeutic Modulation of the Gut Microbiome

Isibor, P. O., Akinduti, P. A., Aworunse, O. S., Oyewale, J., Oshamika, O. O., Ugboko, H. U., Taiwo, O., Ahuekwe, E. F., Obafemi, Y. D., Onibokun, E. A., et al. (2021) · Bioinformatics and Biology Insights · doi:10.1177/11779322211012697 · Cited by 30

Intergenerational Transmission of Characters Through Genetics, Epigenetics, Microbiota, and Learning in Livestock

David, I., Canario, L., Combes, S., & Demars, J. (2019) · Frontiers in Genetics · doi:10.3389/fgene.2019.01058 · Cited by 35

Inflammatory bowel disease increases the risk of hepatobiliary pancreatic cancer: A two‐sample Mendelian randomization analysis of European and East Asian populations

Huang, J., Li, X., Hong, J., Huang, L., Jiang, Q., Guo, S.-Q., Rong, Y., & Guo, G. (2023) · Cancer Medicine · doi:10.1002/cam4.6057 · Cited by 25

The human gut symbiont Ruminococcus gnavus shows specificity to blood group A antigen during mucin glycan foraging: Implication for niche colonisation in the gastrointestinal tract

Wu, H., Crost, E. H., Owen, C. D., van Bakel, W., Gascueña, A. M., Latousakis, D., Hicks, T., Walpole, S. J., Urbanowicz, P. A., Ndeh, D. A., et al. (2021) · PLoS Biology · doi:10.1371/journal.pbio.3001498 · Cited by 26

Host tp53 mutation induces gut dysbiosis eliciting inflammation through disturbed sialic acid metabolism

Lee, J.-G., Lee, S., Jeon, J., Kong, H. G., Cho, H.-J., Kim, J.-H., Kim, S.-Y., Oh, M. J., Lee, D., Seo, N., et al. (2022) · Microbiome · doi:10.1186/s40168-021-01191-x · Cited by 26

Mixture Effects of Tryptophan Intestinal Microbial Metabolites on Aryl Hydrocarbon Receptor Activity

Vrzalová, A., Pečinková, P., Illéš, P., Gurská, S., Džubák, P., Szotkowski, M., Hajdúch, M., Mani, S., & Dvořák, Z. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms231810825 · Cited by 26

Alteration in Gut Microbiota Composition of Older Adults Is Associated with Obesity and Its Indices: A Systematic Review

Tavassol, Z. H., Ejtahed, H., Atlasi, R., Saghafian, F., Khalagi, K., Hasani‐Ranjbar, S., Siadat, S. D., Nabipour, I., Ostovar, A., & Larijani, B. A. (2023) · The journal of nutrition health & aging · doi:10.1007/s12603-023-1988-8 · Cited by 30

The Low-Diversity Fecal Microbiota of the Critically Endangered Kākāpō Is Robust to Anthropogenic Dietary and Geographic Influences

Perry, E. K., Digby, A., & Taylor, M. W. (2017) · Frontiers in Microbiology · doi:10.3389/fmicb.2017.02033 · Cited by 25

Landscape of lipidomic metabolites in gut-liver axis of Sprague–Dawley rats after oral exposure to titanium dioxide nanoparticles

Chen, Z., Han, S., Zheng, P., Zhang, J., Zhou, S., & Jia, G. (2022) · Particle and Fibre Toxicology · doi:10.1186/s12989-022-00484-9 · Cited by 25

Effect of long-term temperature stress on the intestinal microbiome of an invasive snail

Li, S., Qian, Z., Gao, S., Shen, W., Li, X., Li, H., & Chen, L. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2022.961502 · Cited by 26

Biomolecular Mechanisms of Autoimmune Diseases and Their Relationship with the Resident Microbiota: Friend or Foe?

Topi, S., Bottalico, L., Charitos, I. A., Colella, M., Domenico, M. D., Palmirotta, R., & Santacroce, L. (2022) · Pathophysiology · doi:10.3390/pathophysiology29030041 · Cited by 26

SOD1 deficiency alters gastrointestinal microbiota and metabolites in mice

Haruka, S., Shibuya, S., Kato, T., Nakanishi, Y., Tsuboi, A., Moriya, S., Ohno, H., Miyamoto, H., Kodama, H., & Shimizu, T. (2019) · Experimental Gerontology · doi:10.1016/j.exger.2019.110795 · Cited by 24

Prakriti phenotypes as a stratifier of gut microbiome: A new frontier in personalized medicine?

Jnana, A., Murali, T. S., Guruprasad, K. P., & Satyamoorthy, K. (2020) · Journal of Ayurveda and Integrative Medicine · doi:10.1016/j.jaim.2020.05.013 · Cited by 29

Knowledge mapping of the links between the microbiota and allergic diseases: A bibliometric analysis (2002–2021)

Lv, H., Wang, Y., Gao, Z., Liu, P., Qin, D., Hua, Q., & Xu, Y. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1045795 · Cited by 24

Immune induction identified by TMT proteomics analysis in Fusobacterium nucleatum autoinducer-2 treated macrophages

Wu, J., Wang, Y., & Jiang, Z. (2020) · Expert Review of Proteomics · doi:10.1080/14789450.2020.1738223 · Cited by 23

Dietary Components, Microbial Metabolites and Human Health: Reading between the Lines

Guo, Y., Bian, X., Liu, J., Zhu, M. Q., Li, L., Yao, T., Tang, C., Ravichandran, V., Liao, P., Papadimitriou, K., et al. (2020) · Foods · doi:10.3390/foods9081045 · Cited by 23

Gastrointestinal Disease and COVID-19: A Review of Current Evidence

Chen, F., Dai, Z., Huang, C., Chen, H., Wang, X., & Li, X. (2021) · Digestive Diseases · doi:10.1159/000519412 · Cited by 23

THE EFFECT OF HOST GENETICS ON THE SECOND GENOME: THE GUT MICROBIOTA

(2021) · International Journal of Biology Pharmacy and Allied Sciences · doi:10.31032/ijbpas/2021/10.8.5592

Host genetic variation impacts microbiome composition across human body sites

Blekhman, R., Goodrich, J. K., Huang, K., Sun, Q., Bukowski, R., Bell, J. T., Spector, T. D., Keinan, A., Ley, R. E., Gevers, D., et al. (2015) · Genome Biology · doi:10.1186/s13059-015-0759-1 · Cited by 745

The gut microbiome as an effector of metabolic disease gene variants

Simpson, R. C., Cutler, H. B., James, D. E., & Masson, S. W. C. (2026) · Trends in Genetics · doi:10.1016/j.tig.2026.03.011

RESEARCH Open Access Host genetic variation impacts microbiome composition across human body sites

Blekhman, R., Goodrich, J. K., Huang, K. H., Sun, Q., Bukowski, R., Bell, J. T., Spector, T. D., Keinan, A., Ley, R. E., Gevers, D., et al. (2016)

GENETIC VARIATION IN INNATE IMMUNE GENES SHAPES GUT MICROBIOTA COMPOSITION AND HOST-MICROBE INTERACTIONS: A REVIEW

Majeed, M., Sajid, R., Sehar, A., & Akram, M. Z. (2026) · Kashf Journal of Multidisciplinary Research · doi:10.71146/kjmr809 · Cited by 2