The DOI matches its Crossref record; 85 of the 85 references it cites were found in a registry or an index.
Human brain evolution: insights from microarrays
Abstract
Several recent microarray studies have compared gene-expression patterns n humans, chimpanzees and other non-human primates to identify evolutionary changes that contribute to the distinctive cognitive and behavioural characteristics of humans. These studies support the surprising conclusion that the evolution of the human brain involved an upregulation of gene expression relative to non-human primates, a finding that could be relevant to understanding human cerebral physiology and function. These results show how genetic and genomic methods can shed light on the basis of human neural and cognitive specializations, and have important implications for neuroscience, anthropology and medicine.
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“However, comparative microarray studies have shown a high degree of conservation across species in overall gene expression, although there is considerable upregulation of brain gene expression in humans compared to non-human primates (Khaitovich et al., 2006; Preuss et al., 2004; Vallender et al., 2008).”
From Large-Scale Cellular-Resolution Gene Profiling in Human Neocortex Reveals Species-Specific Molecular Signatures (2012) · cites this paper as Preuss et al., 2004
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Evolution of Gene Expression in Human and Chimpanzee Brains
Osada, N., Sugano, S., & Suzuki, Y. (2008) · Wiley eBooks · doi:10.1002/9780470015902.a0020748
Манолова, А. О., & Gulyaeva, N. V. (2023) · Российский физиологический журнал им И М Сеченова · doi:10.31857/s0869813923090078 · Cited by 1
The Birth of Our Free Imagination
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Tse, P. U. (2024) · Oxford University Press eBooks · doi:10.1093/oso/9780198901181.002.0003
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Additional file 1 of Evolutionary conservation and divergence of the human brain transcriptome
Pembroke, W. G., Hartl, C., & Geschwind, D. H. (2021) · Figshare · doi:10.6084/m9.figshare.13667952
Self-citationAdditional file 13 of Evolutionary conservation and divergence of the human brain transcriptome
Pembroke, W. G., Hartl, C., & Geschwind, D. H. (2021) · Figshare · doi:10.6084/m9.figshare.13667949
Self-citationMa, Y., Yuan, J., & Wang, J. (2026) · Frontiers in Neuroscience · doi:10.3389/fnins.2026.1866277
Metadata
- Authors
- Preuss, T. M., Cáceres, M., Oldham, M. C., & Geschwind, D. H.
- Affiliations
- Emory University (US)
- University of California, Los Angeles (US)
- Corresponding author
- Preuss, Todd M.
- Geschwind, Daniel H.
- Venue
- Nature Reviews Genetics
- Published
- 2004-11
- Volume
- 5
- Issue
- 11
- Pages
- 850-860
- ISSN
- 1471-0056 (ISSN-L)
- 1471-0064
- OpenAlex
- W2062073165
- Cited by
- 215
- References
- 85
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 12 · 2023: 6 · 2022: 1 · 2021: 8 · 2020: 5 · 2019: 2 · 2018: 3 · 2017: 6 · 2016: 6 · 2015: 7 · 2014: 6 · 2013: 13 · 2012: 14
- FWCI
- 3.35
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Reviews Genetics (publishedVersion)
- PubMed (publishedVersion)
- Funders
- James S. McDonnell Foundation
- National Institutes of Health
- National Institute of Mental Health
- Topics
- Life Sciences › Agricultural and Biological Sciences › Ecology, Evolution, Behavior and Systematics › Primate Behavior and Ecology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genomic variations and chromosomal abnormalities
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Keywords
- human brain evolution, gene expression, comparative genomics, chimpanzees, non-human primates, neural specialization
- MeSH terms
- Animals, Brain, Biological Evolution, Humans, Species Specificity, Gene Expression, Oligonucleotide Array Sequence Analysis
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