The DOI matches its Crossref record; 95 of the 96 references it cites were found in a registry or an index.
Synthetic biology
Open accessAbstract
Synthetic biologists come in two broad classes. One uses unnatural molecules to reproduce emergent behaviours from natural biology, with the goal of creating artificial life. The other seeks interchangeable parts from natural biology to assemble into systems that function unnaturally. Either way, a synthetic goal forces scientists to cross uncharted ground to encounter and solve problems that are not easily encountered through analysis. This drives the emergence of new paradigms in ways that analysis cannot easily do. Synthetic biology has generated diagnostic tools that improve the care of patients with infectious diseases, as well as devices that oscillate, creep and play tic-tac-toe.
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“For example, the amino acids used by life show little correlation with abiotic synthesis of amino acids (Ward and Benner, 2007), and only four bases are used in nucleic acids when others are also possible (Benner and Sismour, 2005; Yang et al., 2006).”
From The Astrobiology Primer v2.0 (2016) · cites this paper as Benner and Sismour, 2005
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Citations
Cites
1 retracted
Computational Design of a Biologically Active Enzyme
Dwyer, M. A., Looger, L. L., & Hellinga, H. W. (2004) · Science · doi:10.1126/science.1098432 · Cited by 295
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Flagged first, then by citations
1 of the 96 references couldn’t be matched to a known paper.
Research works printed but not linked: 5
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Cited by
Sorted by citations
Items 801–831 of 831
Towards democratization of nucleic acid detection
Aidelberg, G. (2021) · theses.fr (ABES) · doi:10.70675/d5303232z2b0cz4c63za6d7zd2e750551996
Abukar, A. A. (2023) · theses.fr (ABES) · doi:10.70675/500c7118z10f4z4d35zb23dz5a4d0cbc4e59
Alternative paths to proliferation
Ryan, J. C. (2022) · theses.fr (ABES) · doi:10.70675/1a5dc998z2b46z4252z90e2z1575eef7081f
Technical challenges and innovations in moving HMMs forward
Yu, K., & Bian, G. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-31402-5.00003-7
Construction et évolution dirigée de consortia synthétiques mutualistes de Bacillus subtilis
Laforge, N. (2024) · theses.fr (ABES) · doi:10.70675/1a5f75e4zc59cz4b16z9ca2ze4f157bfa6d0
Revealing the link between cell volume and evolution
García‐Ruano, D. (2023) · theses.fr (ABES) · doi:10.70675/7df2b48az59e1z4bebzbdb4z10c070f0fc1c
Synthetic biological toolbox in auxin signaling research
Liu, Z., Yu, W., Li, W., Yang, Z., & Qi, L. (2025) · Critical Insights in Plant Science · doi:10.1080/29932297.2026.2651613
Plant Synthetic Biology Takes Off: Bryophytes Onboard with New Tools, Systems, and Opportunities
Frangedakis, E. (2026) · ACS Synthetic Biology · doi:10.1021/acssynbio.6c00092
Wong, A. A. W. L., Bénard, F., & Perrin, D. M. (2026) · Angewandte Chemie · doi:10.1002/ange.1429706
Aptamer-based enantioselective biosensors: a review of strategies for chiral biomolecule detection
Shovey, A. F., Zahraee, H., Mahroughi, S., Felletti, S., Catani, M., Cavazzini, A., Abnous, K., & Taghdisi, S. M. (2026) · Microchemical journal (Print) · doi:10.1016/j.microc.2026.118335
Synthetic Biology as a Major Biothreat Enhancer
Kambouris, M. E. (2026) · Advanced sciences and technologies for security applications · doi:10.1007/978-3-032-25690-4_4
Synthetic Biology Patents and Technology
Tiwari, I. M., Badgotya, B., Pawar, J., & Kiran, K. (2026) · Springer eBooks · doi:10.1007/978-981-95-3957-4_45
Murjani, K., & Singh, V. (2026) · Springer eBooks · doi:10.1007/978-981-95-3957-4_13
Synthetic Biology for Treatment of Metabolic Disorders
Yasam, S. K., Joseph, J. K., & Rajagopal, S. (2026) · Springer eBooks · doi:10.1007/978-981-95-3957-4_41
Metal-Resilient Crops: Agronomic Innovations and Biotechnological Breakthroughs
Sameena, P. P., Anjitha, K. S., Raj, K. P. A., Veena, M., & Puthur, J. T. (2026) · Sustainability Sciences in Asia and Africa · doi:10.1007/978-981-95-7746-0_17
Bioengineering of plant natural products: Concepts and processes in synthetic biology
Malik, J., Jain, A., & Verma, S. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-34129-8.00027-4
Biosafety concerns and ethical aspects of synthetic biology
Kumar, K., Abed, M. F., Ahmad, A., Hussein, H. Y., Raj, U., Ileena, & Wahi, N. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-34129-8.00010-9
SynBioGPT2: A dynamic reasoning framework enables high-fidelity design of microbial cell factories
Mao, Z., Du, J., Guan, J., Wang, W., Wang, R., Li, H., Shi, Z., Yuan, Q., Liao, X., & Ma, H. (2026) · BioDesign Research · doi:10.1016/j.bidere.2026.100093
Hooda, P., Malik, R., Raheja, I., & Chaudhary, H. (2026) · Elsevier eBooks · doi:10.1016/b978-0-12-817534-7.00004-5
The Impact of Cognition-Based Biology on Synthetic Biology
Miller, W. B., Baluška, F., Slijepčević, P., & Reber, A. S. (2026) · Springer eBooks · doi:10.1007/978-3-032-23779-8_17
Scalable Syntheses of Pseudouridine and N 1 -Methylpseudouridine
Jiao, Y., Yang, Y., Zhou, B., & Yu, S. (2026) · The Journal of Organic Chemistry · doi:10.1021/acs.joc.6c00751
Design of Conditional Guide RNAs for the Logical Regulation of Gene Expression
Park, D., Shin, W., Kang, H., & Kim, J. (2026) · Methods in molecular biology · doi:10.1007/978-1-0716-5304-3_5
Genetically Engineered Microbes in Environmental Biotechnology
Ayangbenro, A. S., & Kutu, F. R. (2026) · IGI Global eBooks · doi:10.4018/979-8-2600-2998-5.ch003
Protein Design and Synthetic Biology
Wipat, A., & Hallinan, J. S. (2026) · Springer eBooks · doi:10.1007/978-3-032-11023-7_5
Yuan, F., Zhou, J., Kuang, Z., Zhang, M., Xu, J., Qin, L., Yuan, R., Ouyang, Y., & Zhang, P. (2026) · ACS Nano · doi:10.1021/acsnano.6c05486
The Collective Power of Bacteria as a Blueprint for Emergent Intelligence
Blee, J. A., Gorochowski, T. E., & Hauert, S. (2026) · Advanced Intelligent Systems · doi:10.1002/aisy.70534
Bidirectional photoriboswitch for translational regulation in mammalian cells
Hu, Y., Li, C. Y., Fu, L., 孙熠昂, Zhang, M., Yau, T. M., Xiong, C., Shi, P., & Kuang, Y. (2026) · iScience · doi:10.1016/j.isci.2026.117671
BindingDB Entry 50004534: Platensimycin and platencin congeners from Streptomyces platensis.
BindingDB (2020) · UC San Diego · doi:10.7270/q2j67ksn
Metadata
- Authors
- Benner, S. A., & Sismour, A. M.
- Affiliations
- University of Florida (US)
- Corresponding author
- Benner, Steven A.
- ORCID
- Benner, Steven A.
- Venue
- Nature Reviews Genetics
- Published
- 2005-07-01
- Volume
- 6
- Issue
- 7
- Pages
- 533-543
- ISSN
- 1471-0056 (ISSN-L)
- 1471-0064
- PMC
- PMC7097405
- OpenAlex
- W4211125927
- Cited by
- 834
- References
- 96
- Citations by year
- 2026: 43 · 2025: 54 · 2024: 48 · 2023: 48 · 2022: 31 · 2021: 28 · 2020: 38 · 2019: 18 · 2018: 27 · 2017: 26 · 2016: 39 · 2015: 36 · 2014: 47 · 2013: 49 · 2012: 44
- FWCI
- 2.93
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Nature Reviews Genetics (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gene Regulatory Network Analysis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Microbial Metabolic Engineering and Bioproduction
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
- Keywords
- synthetic biology, artificial life, synthetic gene circuits, diagnostic tools, infectious diseases, synthetic oscillators
- MeSH terms
- Biology, DNA, Genetic Engineering, Humans, Proteins, Templates, Genetic, Protein Folding, Genome Components
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