Cited by 834Gene Regulatory Network AnalysisMicrobial Metabolic Engineering and BioproductionRNA and protein synthesis mechanisms

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Synthetic biology

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Benner, Steven A., Sismour, A. Michael·2005·Nature Reviews Genetics

DOI 10.1038/nrg1637PMC PMC7097405

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Abstract

Synthetic biologists come in two broad classes. One uses unnatural molecules to reproduce emergent behaviours from natural biology, with the goal of creating artificial life. The other seeks interchangeable parts from natural biology to assemble into systems that function unnaturally. Either way, a synthetic goal forces scientists to cross uncharted ground to encounter and solve problems that are not easily encountered through analysis. This drives the emergence of new paradigms in ways that analysis cannot easily do. Synthetic biology has generated diagnostic tools that improve the care of patients with infectious diseases, as well as devices that oscillate, creep and play tic-tac-toe.

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Mathematical modeling of translation initiation for the estimation of its efficiency to computationally design mRNA sequences with desired expression levels in prokaryotes
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Authors: Benner, S. A., & Sismour, A. M.
Affiliations: University of Florida (US)
Corresponding author: Benner, Steven A.
ORCID: Benner, Steven A.
Venue: Nature Reviews Genetics
Publisher: Springer Science and Business Media LLC
Published: 2005-07-01
Volume: 6
Issue: 7
Pages: 533-543
ISSN: 1471-0056 (ISSN-L)
1471-0064
DOI: 10.1038/nrg1637
PMC: PMC7097405
OpenAlex: W4211125927
Cited by: 834
References: 96
Citations by year: 2026: 43 · 2025: 54 · 2024: 48 · 2023: 48 · 2022: 31 · 2021: 28 · 2020: 38 · 2019: 18 · 2018: 27 · 2017: 26 · 2016: 39 · 2015: 36 · 2014: 47 · 2013: 49 · 2012: 44
FWCI: 2.93
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.springernature.com/gp/researchers/text-and-data-mining (tdm)
www.springernature.com/gp/researchers/text-and-data-mining (vor)
www.springer.com/tdm (tdm)
Locations: Nature Reviews Genetics (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gene Regulatory Network Analysis
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Microbial Metabolic Engineering and Bioproduction
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
Keywords: synthetic biology, artificial life, synthetic gene circuits, diagnostic tools, infectious diseases, synthetic oscillators
MeSH terms: Biology, DNA, Genetic Engineering, Humans, Proteins, Templates, Genetic, Protein Folding, Genome Components

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