Cited by 341Evolution and Genetic DynamicsChromosomal and Genetic VariationsGenomics and Phylogenetic Studies

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Evolution of primate gene expression

Khaitovich, Philipp, Enard, Wolfgang, Lachmann, Michael, Pääbo, Svante·2006·Nature Reviews Genetics

DOI 10.1038/nrg1940

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Abstract

It has been suggested that evolutionary changes in gene expression account for most phenotypic differences between species, in particular between humans and apes. What general rules can be described governing expression evolution? We find that a neutral model where negative selection and divergence time are the major factors is a useful null hypothesis for both transcriptome and genome evolution. Two tissues that stand out with regard to gene expression are the testes, where positive selection has exerted a substantial influence in both humans and chimpanzees, and the brain, where gene expression has changed less than in other organs but acceleration might have occurred in human ancestors.

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Evolutionary trees from DNA sequences: A maximum likelihood approach.
Felsenstein, J. (1981) · Journal of Molecular Evolution · doi:10.1007/bf01734359 · Cited by 14,571
Statistical method for testing the neutral mutation hypothesis by DNA polymorphism.
Tajima, F. (1989) · Genetics · doi:10.1093/genetics/123.3.585 · Cited by 14,056
Genome sequencing in microfabricated high-density picolitre reactors
Margulies, M., Egholm, M., Altman, W. E., Attiya, S., Bader, J. S., Bemben, L. A., Berka, J., Braverman, M. S., Chen, Y.-J., Chen, Z., et al. (2005) · Nature · doi:10.1038/nature03959 · Cited by 7,693
The Neutral Theory of Molecular Evolution
Kimura, M. (1979) · Scientific American · doi:10.1038/scientificamerican1179-98 · Cited by 7,687
The Neutral Theory of Molecular Evolution
Kimura, M. (1983) · Cambridge University Press eBooks · doi:10.1017/cbo9780511623486 · Cited by 6,300
A haplotype map of the human genome
The International HapMap Consortium (2005) · Nature · doi:10.1038/nature04226 · Cited by 5,858
On the Origin of Species by Means of Natural Selection
Livezey, R. L., & Darwin, C. R. (1953) · The American Midland Naturalist · doi:10.2307/2485224 · Cited by 5,431
The Design and Implementation of FFTW3
Frigo, M., & Johnson, S. G. (2005) · Proceedings of the IEEE · doi:10.1109/jproc.2004.840301 · Cited by 5,086
Statistical tests of neutrality of mutations.
Fu, Y., & Li, W. (1993) · Genetics · doi:10.1093/genetics/133.3.693 · Cited by 4,067
Evolutionary Rate at the Molecular Level
KIMURA, M. (1968) · Nature · doi:10.1038/217624a0 · Cited by 3,747

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Bertolero, M. A., Blevins, A. S., Baum, G. L., Gur, R. C., Gur, R. E., Roalf, D. R., Satterthwaite, T. D., & Bassett, D. S. (2019) · arXiv (Cornell University) · doi:10.48550/arxiv.1905.07606 · Cited by 14
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Authors: Khaitovich, P., Enard, W., Lachmann, M., & Pääbo, S.
Affiliations: Max Planck Society (DE)
Corresponding author: Pääbo, Svante
ORCID: Khaitovich, Philipp
Enard, Wolfgang
Lachmann, Michael
Pääbo, Svante
Venue: Nature Reviews Genetics
Publisher: Springer Science and Business Media LLC
Published: 2006-09
Volume: 7
Issue: 9
Pages: 693-702
ISSN: 1471-0056 (ISSN-L)
1471-0064
DOI: 10.1038/nrg1940
OpenAlex: W2099451735
Cited by: 341
References: 131
Citations by year: 2026: 7 · 2025: 9 · 2024: 23 · 2023: 12 · 2022: 9 · 2021: 12 · 2020: 12 · 2019: 11 · 2018: 13 · 2017: 13 · 2016: 17 · 2015: 13 · 2014: 21 · 2013: 24 · 2012: 27
FWCI: 2.51
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature Reviews Genetics (publishedVersion)
PubMed (publishedVersion)
Max Planck Institute for Plasma Physics (submittedVersion)
MPG.PuRe (Max Planck Society) (submittedVersion)
Funders: Bundesministerium für Bildung und Forschung
Max-Planck-Gesellschaft
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Evolution and Genetic Dynamics
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Chromosomal and Genetic Variations
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Phylogenetic Studies
Keywords: gene expression evolution, primate evolution, human-chimpanzee divergence, transcriptome evolution, genome evolution, positive selection, negative selection, divergence time, testis, brain, phenotypic evolution, neutral model
MeSH terms: Animals, Brain, Biological Evolution, Humans, Male, Mutation, Primates, Selection, Genetic, Species Specificity, Testis, Gene Expression, Genome, Human, Evolution, Molecular, Oligonucleotide Array Sequence Analysis

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