Cited by 341Evolution and Genetic DynamicsChromosomal and Genetic VariationsGenomics and Phylogenetic Studies

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Evolution of primate gene expression

Khaitovich, Philipp, Enard, Wolfgang, Lachmann, Michael, Pääbo, Svante·2006·Nature Reviews Genetics

DOI 10.1038/nrg1940

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Abstract

It has been suggested that evolutionary changes in gene expression account for most phenotypic differences between species, in particular between humans and apes. What general rules can be described governing expression evolution? We find that a neutral model where negative selection and divergence time are the major factors is a useful null hypothesis for both transcriptome and genome evolution. Two tissues that stand out with regard to gene expression are the testes, where positive selection has exerted a substantial influence in both humans and chimpanzees, and the brain, where gene expression has changed less than in other organs but acceleration might have occurred in human ancestors.

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Evolutionary trees from DNA sequences: A maximum likelihood approach.
Felsenstein, J. (1981) · Journal of Molecular Evolution · doi:10.1007/bf01734359 · Cited by 14,571
Statistical method for testing the neutral mutation hypothesis by DNA polymorphism.
Tajima, F. (1989) · Genetics · doi:10.1093/genetics/123.3.585 · Cited by 14,056
Genome sequencing in microfabricated high-density picolitre reactors
Margulies, M., Egholm, M., Altman, W. E., Attiya, S., Bader, J. S., Bemben, L. A., Berka, J., Braverman, M. S., Chen, Y.-J., Chen, Z., et al. (2005) · Nature · doi:10.1038/nature03959 · Cited by 7,693
The Neutral Theory of Molecular Evolution
Kimura, M. (1979) · Scientific American · doi:10.1038/scientificamerican1179-98 · Cited by 7,687
The Neutral Theory of Molecular Evolution
Kimura, M. (1983) · Cambridge University Press eBooks · doi:10.1017/cbo9780511623486 · Cited by 6,300
A haplotype map of the human genome
The International HapMap Consortium (2005) · Nature · doi:10.1038/nature04226 · Cited by 5,858
On the Origin of Species by Means of Natural Selection
Livezey, R. L., & Darwin, C. R. (1953) · The American Midland Naturalist · doi:10.2307/2485224 · Cited by 5,431
The Design and Implementation of FFTW3
Frigo, M., & Johnson, S. G. (2005) · Proceedings of the IEEE · doi:10.1109/jproc.2004.840301 · Cited by 5,086
Statistical tests of neutrality of mutations.
Fu, Y., & Li, W. (1993) · Genetics · doi:10.1093/genetics/133.3.693 · Cited by 4,067
Evolutionary Rate at the Molecular Level
KIMURA, M. (1968) · Nature · doi:10.1038/217624a0 · Cited by 3,747
A gene atlas of the mouse and human protein-encoding transcriptomes
Su, A. I., Wiltshire, T., Batalov, S., Lapp, H., Ching, K. A., Block, D., Zhang, J., Soden, R., Hayakawa, M., Kreiman, G., et al. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0400782101 · Cited by 3,475
Adaptive protein evolution at the Adh locus in Drosophila
McDonald, J. H., & Kreitman, M. (1991) · Nature · doi:10.1038/351652a0 · Cited by 3,313
A Map of Recent Positive Selection in the Human Genome
Voight, B. F., Kudaravalli, S., Wen, X., & Pritchard, J. K. (2006) · PLoS Biology · doi:10.1371/journal.pbio.0040072 · Cited by 2,925
Evolution at Two Levels in Humans and Chimpanzees: Their macromolecules are so alike that regulatory mutations may account for their biological differences
King, M.-C., & Wilson, A. C. (1975) · Science · doi:10.1126/science.1090005 · Cited by 2,815
Genome sequence, comparative analysis and haplotype structure of the domestic dog
members, B. S. P., Lindblad-Toh, K., Wade, C. M., Mikkelsen, T. S., Karlsson, E. K., Jaffe, D. B., Kamal, M., Clamp, M., Chang, J. L., Kulbokas, E. J., et al. (2005) · Nature · doi:10.1038/nature04338 · Cited by 2,568
Initial sequence of the chimpanzee genome and comparison with the human genome
The Chimpanzee Sequencing and Analysis Consortium (2005) · Nature · doi:10.1038/nature04072 · Cited by 2,459
Cultures in chimpanzees
Whiten, A., Goodall, J., McGrew, W. C., Nishida, T., Reynolds, V., Sugiyama, Y., Tutin, C. E. G., Wrangham, R. W., & Boesch, C. (1999) · Nature · doi:10.1038/21415 · Cited by 2,448
Variance stabilization applied to microarray data calibration and to the quantification of differential expression
Huber, W., von Heydebreck, A., Sültmann, H., Poustka, A., & Vingron, M. (2002) · Bioinformatics · doi:10.1093/bioinformatics/18.suppl_1.s96 · Cited by 2,440
Natural selection and random genetic drift in phenotypic evolution
Lande, R. (1976) · Evolution · doi:10.1111/j.1558-5646.1976.tb00911.x · Cited by 1,828
Evolving gene/transcript definitions significantly alter the interpretation of GeneChip data
Dai, M. (2005) · Nucleic Acids Research · doi:10.1093/nar/gni179 · Cited by 1,807
A Test of Neutral Molecular Evolution Based on Nucleotide Data
Hudson, R. R., Kreitman, M., & Aguadé, M. (1987) · Genetics · doi:10.1093/genetics/116.1.153 · Cited by 1,759
Biological sequence analysis
Shukla, S., Mishra, B., Avashthi, H., & Chandra, M. (2021) · Elsevier eBooks · doi:10.1016/b978-0-323-89775-4.00003-1 · Cited by 1,514
Large-scale analysis of the human and mouse transcriptomes
Su, A. I., Cooke, M. P., Ching, K. A., Hakak, Y., Walker, J. R., Wiltshire, T., Orth, A. P., Vega, R. G., Sapinoso, L. M., Moqrich, A., et al. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.012025199 · Cited by 1,466
The rapid evolution of reproductive proteins
Swanson, W. J., & Vacquier, V. D. (2002) · Nature Reviews Genetics · doi:10.1038/nrg733 · Cited by 1,316
A MOLECULAR APPROACH TO THE STUDY OF GENIC HETEROZYGOSITY IN NATURAL POPULATIONS. II. AMOUNT OF VARIATION AND DEGREE OF HETEROZYGOSITY IN NATURAL POPULATIONS OF DROSOPHILA PSEUDOOBSCURA
Lewontin, R. C., & Hubby, J. L. (1966) · Genetics · doi:10.1093/genetics/54.2.595 · Cited by 1,221
SEX CHROMOSOMES AND THE EVOLUTION OF SEXUAL DIMORPHISM
Rice, W. R. (1984) · Evolution · doi:10.1111/j.1558-5646.1984.tb00346.x · Cited by 1,174
The Origin of Species, by Means of Natural Selection, or the Preservation of Favored Races in the Struggle for Life
Darwin, C. R. (1860) · The Crayon · doi:10.2307/25528056 · Cited by 1,168
Slightly Deleterious Mutant Substitutions in Evolution
OHTA, T. (1973) · Nature · doi:10.1038/246096a0 · Cited by 1,104
The major evolutionary transitions
Szathmáry, E., & Smith, J. M. (1995) · Nature · doi:10.1038/374227a0 · Cited by 1,095
A Scan for Positively Selected Genes in the Genomes of Humans and Chimpanzees
Nielsen, R., Bustamante, C. D., Clark, A. G., Glanowski, S., Sackton, T. B., Hubisz, M. J., Fledel-Alon, A., Tanenbaum, D. M., Civello, D., White, T. J., et al. (2005) · PLoS Biology · doi:10.1371/journal.pbio.0030170 · Cited by 998
Orangutan Cultures and the Evolution of Material Culture
van Schaik, C. P., Ancrenaz, M., Borgen, G., Galdikas, B. M. F., Knott, C. D., Singleton, I., Suzuki, A. K., Utami-Atmoko, S. S., & Merrill, M. Y. (2003) · Science · doi:10.1126/science.1078004 · Cited by 960
Evolutionary Rate in the Protein Interaction Network
Fraser, H. B., Hirsh, A. E., Steinmetz, L. M., Scharfe, C., & Feldman, M. W. (2002) · Science · doi:10.1126/science.1068696 · Cited by 869
Intra- and Interspecific Variation in Primate Gene Expression Patterns
Enard, W., Khaitovich, P., Klose, J., Zöllner, S. K., Heißig, F., Giavalisco, P., Nieselt, K., Muchmore, E. A., Varki, A. P., Ravid, R., et al. (2002) · Science · doi:10.1126/science.1068996 · Cited by 845
Self-citation
Variation in gene expression within and among natural populations
Oleksiak, M. F., Churchill, G. A., & Crawford, D. L. (2002) · Nature Genetics · doi:10.1038/ng983 · Cited by 736
Maximum-likelihood estimation of evolutionary trees from continuous characters.
(1973) · Europe PMC (PubMed Central) · Cited by 700
Postcopulatory sexual selection
Birkhead, T. R., & Pizzari, T. (2002) · Nature Reviews Genetics · doi:10.1038/nrg774 · Cited by 698
Adaptive protein evolution in Drosophila
Smith, N. G. C., & Eyre‐Walker, A. (2002) · Nature · doi:10.1038/4151022a · Cited by 677
Tool Use and Tool Making in Wild Chimpanzees
Boesch, C., & Boesch, H. (1990) · Folia Primatologica · doi:10.1159/000156428 · Cited by 671
Sex-Dependent Gene Expression and Evolution of the Drosophila Transcriptome
Ranz, J. M., Castillo-Davis, C. I., Meiklejohn, C. D., & Hartl, D. L. (2003) · Science · doi:10.1126/science.1085881 · Cited by 617
Parallel Patterns of Evolution in the Genomes and Transcriptomes of Humans and Chimpanzees
Khaitovich, P., Hellmann, I., Enard, W., Nowick, K., Leinweber, M., Franz, H., Weiß, G., Lachmann, M., & Pääbo, S. (2005) · Science · doi:10.1126/science.1108296 · Cited by 590
Self-citation
The origin of species by means of natural selection, or, The preservation of favored races in the struggle for life /
Darwin, C. R., & Darwin, C. R. (1894) · A.L. Burt eBooks · doi:10.5962/bhl.title.56969 · Cited by 575
Rapid evolution of male reproductive genes in the descent of man
Wyckoff, G. J., Wang, W., & Wu, C. (2000) · Nature · doi:10.1038/35002070 · Cited by 560
The Signature of Positive Selection at Randomly Chosen Loci
Przeworski, M. (2002) · Genetics · doi:10.1093/genetics/160.3.1179 · Cited by 509
An integrated view of protein evolution
Pál, C., Papp, B., & Lercher, M. J. (2006) · Nature Reviews Genetics · doi:10.1038/nrg1838 · Cited by 508
Microcephalin , a Gene Regulating Brain Size, Continues to Evolve Adaptively in Humans
Evans, P. D., Gilbert, S. L., Mekel-Bobrov, N., Vallender, E. J., Anderson, J. R., Vaezazizi, L. M., Tishkoff, S. A., Hudson, R. R., & Lahn, B. T. (2005) · Science · doi:10.1126/science.1113722 · Cited by 506
Elevated gene expression levels distinguish human from non-human primate brains
Cáceres, M., Lachuer, J., Zapala, M. A., Redmond, J. C., Kudo, L., Geschwind, D. H., Lockhart, D. J., Preuss, T. M., & Barlow, C. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2135499100 · Cited by 491
Evolution of Transcription Factor Binding Sites in Mammalian Gene Regulatory Regions: Conservation and Turnover
Dermitzakis, E. T., & Clark, A. G. (2002) · Molecular Biology and Evolution · doi:10.1093/oxfordjournals.molbev.a004169 · Cited by 463
Accelerated Evolution of Nervous System Genes in the Origin of Homo sapiens
Dorus, S., Vallender, E. J., Evans, P. D., Anderson, J. R., Gilbert, S. L., Mahowald, M. A., Wyckoff, G. J., Malcom, C. M., & Lahn, B. T. (2004) · Cell · doi:10.1016/j.cell.2004.11.040 · Cited by 429
Neutral and adaptive variation in gene expression
Whitehead, A., & Crawford, D. L. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0507648103 · Cited by 414
PHENOTYPIC EVOLUTION BY NEUTRAL MUTATION
Lynch, M., & Hill, W. G. (1986) · Evolution · doi:10.1111/j.1558-5646.1986.tb00561.x · Cited by 403
An expressed pseudogene regulates the messenger-RNA stability of its homologous coding gene
Hirotsune, S., Yoshida, N., Chen, A. Y.-C., Garrett, L. J., Sugiyama, F., Takahashi, S., Yagami, K.-I., Wynshaw-Boris, A. J., & Yoshiki, A. (2003) · Nature · doi:10.1038/nature01535 · Cited by 393
Estimation of Divergence Times for Major Lineages of Primate Species
Glazko, G. V. (2003) · Molecular Biology and Evolution · doi:10.1093/molbev/msg050 · Cited by 391
Structural and transcriptional features of the mouse spermatid genome.
Kierszenbaum, A. L., & Tres, L. L. (1975) · The Journal of Cell Biology · doi:10.1083/jcb.65.2.258 · Cited by 383
Testing the neutral theory of molecular evolution with genomic data from Drosophila
Fay, J. C., Wyckoff, G. J., & Wu, C. (2002) · Nature · doi:10.1038/4151024a · Cited by 357
Evolution of gene expression in the Drosophila melanogaster subgroup
Rifkin, S. A., Kim, J., & White, K. P. (2003) · Nature Genetics · doi:10.1038/ng1086 · Cited by 351
The quantitative genetics of transcription
Gibson, G. C., & Weir, B. S. (2005) · Trends in Genetics · doi:10.1016/j.tig.2005.08.010 · Cited by 350
A Neutral Model of Transcriptome Evolution
Khaitovich, P., Weiß, G., Lachmann, M., Hellmann, I., Enard, W., Muetzel, B., Wirkner, U., Ansorge, W. J., & Pääbo, S. (2004) · PLoS Biology · doi:10.1371/journal.pbio.0020132 · Cited by 344
Self-citation
Variation within and among species in gene expression: raw material for evolution
Whitehead, A., & Crawford, D. L. (2006) · Molecular Ecology · doi:10.1111/j.1365-294x.2006.02868.x · Cited by 341
Comparing the human and chimpanzee genomes: Searching for needles in a haystackPreprint
Varki, A. P., & Altheide, T. K. (2005) · Genome Research · doi:10.1101/gr.3737405 · Cited by 339
Animal traditions: behavioural inheritance in evolution
(2001) · Choice Reviews Online · doi:10.5860/choice.39-0310 · Cited by 334
Near-neutrality in evolution of genes and gene regulation
Ohta, T. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.252626899 · Cited by 333
Effect of agonal and postmortem factors on gene expression profile: quality control in microarray analyses of postmortem human brain
Tomita, H., Vawter, M. P., Walsh, D. M., Evans, S. J., Choudary, P. V., Li, J., Overman, K. M., Atz, M. E., Myers, R. M., Jones, E. G., et al. (2004) · Biological Psychiatry · doi:10.1016/j.biopsych.2003.10.013 · Cited by 331
The second inheritance system of chimpanzees and humans
Whiten, A. (2005) · Nature · doi:10.1038/nature04023 · Cited by 328
Expression profiling in primates reveals a rapid evolution of human transcription factors
Gilad, Y., Oshlack, A., Smyth, G. K., Speed, T. P., & White, K. P. (2006) · Nature · doi:10.1038/nature04559 · Cited by 323
Regional Patterns of Gene Expression in Human and Chimpanzee BrainsPreprint
Khaitovich, P., Muetzel, B., She, X., Lachmann, M., Hellmann, I., Dietzsch, J., Steigele, S., Do, H.-H., Weiß, G., Enard, W., et al. (2004) · Genome Research · doi:10.1101/gr.2538704 · Cited by 310
Self-citation
Rapid evolution of male-biased gene expression in Drosophila
Meiklejohn, C. D., Parsch, J., Ranz, J. M., & Hartl, D. L. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1630690100 · Cited by 302
Reconstruction of evolutionary trees
Winther, R. G. (2018) · Cambridge University Press eBooks · doi:10.1017/9781316276259.003 · Cited by 299
Sequence Divergence, Functional Constraint, and Selection in Protein Evolution
Fay, J. C., & Wu, C. (2003) · Annual Review of Genomics and Human Genetics · doi:10.1146/annurev.genom.4.020303.162528 · Cited by 298
Neuronal Expression of Neural Nitric Oxide Synthase (nNOS) Protein Is Suppressed by an Antisense RNA Transcribed from an NOS Pseudogene
Korneev, S. A., Park, J. H., & O’Shea, M. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-18-07711.1999 · Cited by 278
Sperm competition games: sperm size and sperm number under adult control
Parker, G. A. (1993) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.1993.0110 · Cited by 278
Common Pattern of Evolution of Gene Expression Level and Protein Sequence in Drosophila
Nuzhdin, S. V., Wayne, M. L., Harmon, K. L., & McIntyre, L. M. (2004) · Molecular Biology and Evolution · doi:10.1093/molbev/msh128 · Cited by 264
Systematic changes in gene expression in postmortem human brains associated with tissue pH and terminal medical conditions
Li, J. Z., Vawter, M. P., Walsh, D. M., Tomita, H., Evans, S. J., Choudary, P. V., Lopez, J. F., Avelar, A., Shokoohi, V., Chung, T., et al. (2004) · Human Molecular Genetics · doi:10.1093/hmg/ddh065 · Cited by 261
Large-Scale Turnover of Functional Transcription Factor Binding Sites in Drosophila
Moses, A. M., Pollard, D. A., Nix, D. A., Iyer, V. N., Li, X., Biggin, M. D., & Eisen, M. B. (2006) · PLoS Computational Biology · doi:10.1371/journal.pcbi.0020130 · Cited by 260
Animal Traditions: Behavioural Inheritance in Evolution
Avital, E., & Jablonka, E. (2000) · doi:10.1017/cbo9780511542251 · Cited by 254
Evolution of Proteins and Gene Expression Levels are Coupled in Drosophila and are Independently Associated with mRNA Abundance, Protein Length, and Number of Protein-Protein Interactions
Lemos, B. (2005) · Molecular Biology and Evolution · doi:10.1093/molbev/msi122 · Cited by 252
The transcriptional consequences of mutation and natural selection in Caenorhabditis elegans
Denver, D. R., Morris, K., Streelman, J. T., Kim, S. K., Lynch, M., & Thomas, W. K. (2005) · Nature Genetics · doi:10.1038/ng1554 · Cited by 248
Sister grouping of chimpanzees and humans as revealed by genome-wide phylogenetic analysis of brain gene expression profiles.
Uddin, M., Wildman, D. E., Liu, G., Xu, W., Johnson, R. M., Hof, P. R., Kapatos, G., Grossman, L. I., & Goodman, M. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0308725100 · Cited by 238
First Observation of Tool Use in Wild Gorillas
Breuer, T., Ndoundou‐Hockemba, M., & Fishlock, V. (2005) · PLoS Biology · doi:10.1371/journal.pbio.0030380 · Cited by 224
Evolutionary Conservation of Expression Profiles Between Human and Mouse Orthologous Genes
Liao, B., & Zhang, J. (2005) · Molecular Biology and Evolution · doi:10.1093/molbev/msj054 · Cited by 220
A possible meiotic function of the peculiar patterns of gene expression in mammalian spermatogenic cells
Kleene, K. C. (2001) · Mechanisms of Development · doi:10.1016/s0925-4773(01)00413-0 · Cited by 216
Human brain evolution: insights from microarrays
Preuss, T. M., Cáceres, M., Oldham, M. C., & Geschwind, D. H. (2004) · Nature Reviews Genetics · doi:10.1038/nrg1469 · Cited by 215
The microcephaly ASPM gene is expressed in proliferating tissues and encodes for a mitotic spindle protein
Kouprina, N., Pavlı́ček, A., Collins, N. K., Nakano, M., Noskov, V. N., Ohzeki, J., Mochida, G. H., Risinger, J. I., Goldsmith, P. K., Gunsior, M., et al. (2005) · Human Molecular Genetics · doi:10.1093/hmg/ddi220 · Cited by 210
Population genetic variation in gene expression is associated with phenotypic variation in Saccharomyces cerevisiae
Fay, J. C., McCullough, H. L., Sniegowski, P., & Eisen, M. B. (2004) · Genome biology · doi:10.1186/gb-2004-5-4-r26 · Cited by 203
Evidence for Widespread Degradation of Gene Control Regions in Hominid Genomes
Keightley, P. D., Lercher, M. J., & Eyre‐Walker, A. (2005) · PLoS Biology · doi:10.1371/journal.pbio.0030042 · Cited by 198
Accelerated Evolution of the ASPM Gene Controlling Brain Size Begins Prior to Human Brain Expansion
Kouprina, N., Pavlíček, A., Mochida, G. H., Solomon, G. G., Gersch, W., Yoon, Y.-H., Collura, R. V., Ruvolo, M., Barrett, J. C., Woods, C. G., et al. (2004) · PLoS Biology · doi:10.1371/journal.pbio.0020126 · Cited by 195
Conservation and Coevolution in the Scale-Free Human Gene Coexpression Network
Jordan, I. K., Mariño‐Ramírez, L., Wolf, Y. I., & Koonin, E. V. (2004) · Molecular Biology and Evolution · doi:10.1093/molbev/msh222 · Cited by 194
Pervasive Adaptive Evolution in Primate Seminal Proteins
Clark, N. L., & Swanson, W. J. (2005) · PLoS Genetics · doi:10.1371/journal.pgen.0010035 · Cited by 192
Molecular Evolution of Sex-Biased Genes in Drosophila
Zhang, Z., Hambuch, T. M., & Parsch, J. (2004) · Molecular Biology and Evolution · doi:10.1093/molbev/msh223 · Cited by 189
A mutation accumulation assay reveals a broad capacity for rapid evolution of gene expression
Rifkin, S. A., Houle, D., Kim, J., & White, K. P. (2005) · Nature · doi:10.1038/nature04114 · Cited by 187
Cheaters sometimes prosper: distortion of mendelian segregation by meiotic drive
Lyttle, T. W. (1993) · Trends in Genetics · doi:10.1016/0168-9525(93)90120-7 · Cited by 182
Social structure and life‐history patterns in western gorillas (Gorilla gorilla gorilla)
Robbins, M. M., Bermejo, M., Cipolletta, C., Magliocca, F., Parnell, R. J., & Stokes, E. J. (2004) · American Journal of Primatology · doi:10.1002/ajp.20069 · Cited by 179
Genetic links between brain development and brain evolution
Gilbert, S. L., Dobyns, W. B., & Lahn, B. T. (2005) · Nature Reviews Genetics · doi:10.1038/nrg1634 · Cited by 174
Human recombination hot spots hidden in regions of strong marker association
Jeffreys, A. J., Neumann, R., Panayi, M., Myers, S., & Donnelly, P. (2005) · Nature Genetics · doi:10.1038/ng1565 · Cited by 174
Multi-species microarrays reveal the effect of sequence divergence on gene expression profilesPreprint
Gilad, Y., Rifkin, S. A., Bertone, P., Gerstein, M., & White, K. P. (2005) · Genome Research · doi:10.1101/gr.3335705 · Cited by 171
Variation in tissue-specific gene expression among natural populations
Whitehead, A., & Crawford, D. L. (2005) · Genome biology · doi:10.1186/gb-2005-6-2-r13 · Cited by 162
RATES OF DIVERGENCE IN GENE EXPRESSION PROFILES OF PRIMATES, MICE, AND FLIES: STABILIZING SELECTION AND VARIABILITY AMONG FUNCTIONAL CATEGORIES
Lemos, B., Meiklejohn, C. D., Cáceres, M., & Hartl, D. L. (2005) · Evolution · doi:10.1111/j.0014-3820.2005.tb00900.x · Cited by 162
Sperm competition games: sperm size and number under gametic control
Parker, G. A., & Begon, M. E. (1993) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.1993.0111 · Cited by 152
Evolutionary significance of gene expression divergence
Jordan, I. K., Mariño‐Ramírez, L., & Koonin, E. V. (2004) · Gene · doi:10.1016/j.gene.2004.11.034 · Cited by 151
Natural selection as the process of accumulating genetic information in adaptive evolution
Kimura, M. (1961) · Genetics Research · doi:10.1017/s0016672300000616 · Cited by 147
Gain-of-function amino acid substitutions drive positive selection of FGFR2 mutations in human spermatogonia
Goriely, A., McVean, G. A. T., van Pelt, A. M. M., O'Rourke, A. W., Wall, S. A., de Rooij, D. G., & Wilkie, A. O. M. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0500267102 · Cited by 146
Multiple mating, sperm competition and meiotic drive
Haig, D., & Bergstrom, C. T. (1995) · Journal of Evolutionary Biology · doi:10.1046/j.1420-9101.1995.8030265.x · Cited by 145
Patterns, mechanisms, and functions of translation regulation in mammalian spermatogenic cells
Kleene, K. C. (2003) · Cytogenetic and Genome Research · doi:10.1159/000076807 · Cited by 138
Laser Capture Microdissection-Generated Target Sample for High-Density Oligonucleotide Array Hybridization
Ohyama, H., Zhang, X., Ohno, S., Alevizos, I., Posner, M. R., Wong, D. T., & Todd, R. (2000) · BioTechniques · doi:10.2144/00293st05 · Cited by 138
RATE TESTS FOR SELECTION ON QUANTITATIVE CHARACTERS DURING MACROEVOLUTION AND MICROEVOLUTION
Turelli, M., Gillespie, J. H., & Lande, R. (1988) · Evolution · doi:10.1111/j.1558-5646.1988.tb02526.x · Cited by 137
Mixed-Model Reanalysis of Primate Data Suggests Tissue and Species Biases in Oligonucleotide-Based Gene Expression Profiles
Hsieh, W., Chu, T., Wolfinger, R. D., & Gibson, G. C. (2003) · Genetics · doi:10.1093/genetics/165.2.747 · Cited by 135
Neutral theory of molecular evolution
Takahata, N. (1996) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(96)80034-7 · Cited by 134
Incongruent Expression Profiles between Human and Mouse Orthologous Genes Suggest Widespread Neutral Evolution of Transcription Control
Yanai, I., Graur, D., & Ophir, R. (2004) · OMICS A Journal of Integrative Biology · doi:10.1089/153623104773547462 · Cited by 132
Uncovering evolutionary patterns of gene expression using microarrays
Ranz, J. M., & Machado, C. A. (2005) · Trends in Ecology & Evolution · doi:10.1016/j.tree.2005.09.002 · Cited by 125
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Authors: Khaitovich, P., Enard, W., Lachmann, M., & Pääbo, S.
Affiliations: Max Planck Society (DE)
Corresponding author: Pääbo, Svante
ORCID: Khaitovich, Philipp
Enard, Wolfgang
Lachmann, Michael
Pääbo, Svante
Venue: Nature Reviews Genetics
Publisher: Springer Science and Business Media LLC
Published: 2006-09
Volume: 7
Issue: 9
Pages: 693-702
ISSN: 1471-0056 (ISSN-L)
1471-0064
DOI: 10.1038/nrg1940
OpenAlex: W2099451735
Cited by: 341
References: 131
Citations by year: 2026: 7 · 2025: 9 · 2024: 23 · 2023: 12 · 2022: 9 · 2021: 12 · 2020: 12 · 2019: 11 · 2018: 13 · 2017: 13 · 2016: 17 · 2015: 13 · 2014: 21 · 2013: 24 · 2012: 27
FWCI: 2.51
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature Reviews Genetics (publishedVersion)
PubMed (publishedVersion)
Max Planck Institute for Plasma Physics (submittedVersion)
MPG.PuRe (Max Planck Society) (submittedVersion)
Funders: Bundesministerium für Bildung und Forschung
Max-Planck-Gesellschaft
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Evolution and Genetic Dynamics
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Chromosomal and Genetic Variations
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Phylogenetic Studies
Keywords: gene expression evolution, primate evolution, human-chimpanzee divergence, transcriptome evolution, genome evolution, positive selection, negative selection, divergence time, testis, brain, phenotypic evolution, neutral model
MeSH terms: Animals, Brain, Biological Evolution, Humans, Male, Mutation, Primates, Selection, Genetic, Species Specificity, Testis, Gene Expression, Genome, Human, Evolution, Molecular, Oligonucleotide Array Sequence Analysis

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