The DOI matches its Crossref record; 131 of the 131 references it cites were found in a registry or an index.
Evolution of primate gene expression
Abstract
It has been suggested that evolutionary changes in gene expression account for most phenotypic differences between species, in particular between humans and apes. What general rules can be described governing expression evolution? We find that a neutral model where negative selection and divergence time are the major factors is a useful null hypothesis for both transcriptome and genome evolution. Two tissues that stand out with regard to gene expression are the testes, where positive selection has exerted a substantial influence in both humans and chimpanzees, and the brain, where gene expression has changed less than in other organs but acceleration might have occurred in human ancestors.
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“However, comparative microarray studies have shown a high degree of conservation across species in overall gene expression, although there is considerable upregulation of brain gene expression in humans compared to non-human primates (Khaitovich et al., 2006; Preuss et al., 2004; Vallender et al., 2008).”
From Large-Scale Cellular-Resolution Gene Profiling in Human Neocortex Reveals Species-Specific Molecular Signatures (2012) · cites this paper as Khaitovich et al., 2006
Citations
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Metadata
- Authors
- Khaitovich, P., Enard, W., Lachmann, M., & Pääbo, S.
- Affiliations
- Max Planck Society (DE)
- Corresponding author
- Pääbo, Svante
- Venue
- Nature Reviews Genetics
- Published
- 2006-09
- Volume
- 7
- Issue
- 9
- Pages
- 693-702
- ISSN
- 1471-0056 (ISSN-L)
- 1471-0064
- OpenAlex
- W2099451735
- Cited by
- 341
- References
- 131
- Citations by year
- 2026: 7 · 2025: 9 · 2024: 23 · 2023: 12 · 2022: 9 · 2021: 12 · 2020: 12 · 2019: 11 · 2018: 13 · 2017: 13 · 2016: 17 · 2015: 13 · 2014: 21 · 2013: 24 · 2012: 27
- FWCI
- 2.51
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Reviews Genetics (publishedVersion)
- PubMed (publishedVersion)
- Max Planck Institute for Plasma Physics (submittedVersion)
- MPG.PuRe (Max Planck Society) (submittedVersion)
- Funders
- Bundesministerium für Bildung und Forschung
- Max-Planck-Gesellschaft
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Evolution and Genetic Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Chromosomal and Genetic Variations
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Phylogenetic Studies
- Keywords
- gene expression evolution, primate evolution, human-chimpanzee divergence, transcriptome evolution, genome evolution, positive selection, negative selection, divergence time, testis, brain, phenotypic evolution, neutral model
- MeSH terms
- Animals, Brain, Biological Evolution, Humans, Male, Mutation, Primates, Selection, Genetic, Species Specificity, Testis, Gene Expression, Genome, Human, Evolution, Molecular, Oligonucleotide Array Sequence Analysis
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