Mapping complex disease traits with global gene expression

Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls

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Genetics of Food Intake Self-Regulation in Childhood: Literature Review and Research Opportunities

Faith, M. S., Carnell, S., & Kral, T. V. E. (2013) · Human Heredity · doi:10.1159/000353879 · Cited by 7,633

A General Framework for Weighted Gene Co-Expression Network Analysis

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Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease

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The Connectivity Map: Using Gene-Expression Signatures to Connect Small Molecules, Genes, and Disease

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The human disease network

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Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis

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Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease

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Heritability in the genomics era — concepts and misconceptions

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An Oncogene-Induced DNA Damage Model for Cancer Development

Halazonetis, T. D., Gorgoulis, V. G., & Bartek, J. (2008) · Science · doi:10.1126/science.1140735 · Cited by 1,851

Relative Impact of Nucleotide and Copy Number Variation on Gene Expression Phenotypes

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Six new loci associated with body mass index highlight a neuronal influence on body weight regulation

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Genetic variants regulating ORMDL3 expression contribute to the risk of childhood asthma

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Genetics of gene expression surveyed in maize, mouse and man

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Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes

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Genetic Dissection of Transcriptional Regulation in Budding Yeast

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DNA methylation profiling of human chromosomes 6, 20 and 22

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Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants

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Common variants at 30 loci contribute to polygenic dyslipidemia

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Expression profiling using microarrays fabricated by an ink-jet oligonucleotide synthesizer

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Genetics of gene expression and its effect on disease

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Gene map of the extended human MHC

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Genetic analysis of genome-wide variation in human gene expression

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Inferring Genetic Networks and Identifying Compound Mode of Action via Expression Profiling

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A genome-wide association study of global gene expression

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Association of Systemic Lupus Erythematosus with C8orf13–BLK and ITGAM–ITGAX

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Mapping the Genetic Architecture of Gene Expression in Human Liver

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Variations in DNA elucidate molecular networks that cause disease

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Genome-wide association analysis identifies 20 loci that influence adult height

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TRAF1–C5 as a Risk Locus for Rheumatoid Arthritis — A Genomewide Study

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Molecular interactions on microarrays

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Genetic variation in the 5q31 cytokine gene cluster confers susceptibility to Crohn disease

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Many sequence variants affecting diversity of adult human height

Gudbjartsson, D. F., Walters, G. B., Þorleifsson, G., Stefánsson, H., Halldórsson, B. V., Zusmanovich, P., Sulem, P., Thorlacius, S., Gylfason, A., Steinberg, S., et al. (2008) · Nature Genetics · doi:10.1038/ng.122 · Cited by 675

Genetics of global gene expression

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Analysis of oncogenic signaling networks in glioblastoma identifies ASPM as a molecular target

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Trans-acting regulatory variation in Saccharomyces cerevisiae and the role of transcription factors

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Allelic Variation in Human Gene Expression

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The landscape of genetic complexity across 5,700 gene expression traits in yeast

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Localization of type 1 diabetes susceptibility to the MHC class I genes HLA-B and HLA-A

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Novel Crohn Disease Locus Identified by Genome-Wide Association Maps to a Gene Desert on 5p13.1 and Modulates Expression of PTGER4

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The gene encoding phosphodiesterase 4D confers risk of ischemic stroke

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Revealing the architecture of gene regulation: the promise of eQTL studies

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Natural variation in human gene expression assessed in lymphoblastoid cells

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High-Resolution Mapping of Expression-QTLs Yields Insight into Human Gene Regulation

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Common genetic variants account for differences in gene expression among ethnic groups

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Integrated transcriptional profiling and linkage analysis for identification of genes underlying disease

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Discovery of expression QTLs using large-scale transcriptional profiling in human lymphocytes

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A survey of genetic human cortical gene expression

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The prostaglandin receptor EP4 suppresses colitis, mucosal damage and CD4 cell activation in the gut

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Gene–Environment Interaction in Yeast Gene Expression

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The prostaglandin receptor EP4 suppresses colitis, mucosal damage and CD4 cell activation in the gut

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Effect of 17q21 Variants and Smoking Exposure in Early-Onset Asthma

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Differences in Risk of Insulin-Dependent Diabetes in Offspring of Diabetic Mothers and Diabetic Fathers

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The Genetics of Asthma

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Genetic Inheritance of Gene Expression in Human Cell Lines

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A genome-wide association study identifies six susceptibility loci for chronic lymphocytic leukemia

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Regulatory network construction in Arabidopsis by using genome-wide gene expression quantitative trait loci

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Intergenic variants of HBS1L-MYB are responsible for a major quantitative trait locus on chromosome 6q23 influencing fetal hemoglobin levels in adults

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The expanding world of small RNAs

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HUMAN TYPE 1 DIABETES AND THE INSULIN GENE: Principles of Mapping Polygenes

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Discovery of tissue-specific exons using comprehensive human exon microarrays

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Cis -acting expression quantitative trait loci in mice

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Mapping Determinants of Gene Expression Plasticity by Genetical Genomics in C. elegans

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Sequence census methods for functional genomics

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Experimental comparison and cross-validation of the Affymetrix and Illumina gene expression analysis platforms

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ORMDL3 Gene Is Associated with Asthma in Three Ethnically Diverse Populations

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The environmental contribution to gene expression profiles

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Heritability and Tissue Specificity of Expression Quantitative Trait Loci

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Moving toward a system genetics view of disease

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A genome-wide approach to identify genetic variants that contribute to etoposide-induced cytotoxicity

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Integration of global SNP-based mapping and expression arrays reveals key regions, mechanisms, and genes important in the pathogenesis of multiple myeloma

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Inferring dynamic architecture of cellular networks using time series of gene expression, protein and metabolite data

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Microarrays for an Integrative Genomics

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Genetics of Psoriasis: Paternal Inheritance and a Locus on Chromosome 6p

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A polymorphism controlling ORMDL3 expression is associated with asthma that is poorly controlled by current medications

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Statistical Methods for Expression Quantitative Trait Loci (eQTL) Mapping

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A Novel Susceptibility Locus for Type 1 Diabetes on Chr12q13 Identified by a Genome-Wide Association Study

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Sequence Polymorphisms Cause Many False cis eQTLs

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A thematic review series: systems biology approaches to metabolic and cardiovascular disorders

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Redefinition of Affymetrix probe sets by sequence overlap with cDNA microarray probes reduces cross-platform inconsistencies in cancer-associated gene expression measurements

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Genetic Architecture of Transcript-Level Variation in Humans

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On the design and analysis of gene expression studies in human populations

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Genetic Linkage of IgA Deficiency to the Major Histocompatibility Complex: Evidence for Allele Segregation Distortion, Parent-of-Origin Penetrance Differences, and the Role of Anti-IgA Antibodies in Disease Predisposition

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Exon arrays provide accurate assessments of gene expression

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Non-Overlapping and Non–Cell-Type–Specific Gene Expression Signatures Predict Lung Cancer Survival

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A Genome-Wide Gene Expression Signature of Environmental Geography in Leukocytes of Moroccan Amazighs

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Maternal effects in atopic disease

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Small-scale copy number variation and large-scale changes in gene expression

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Thematic review series: Systems Biology Approaches to Metabolic and Cardiovascular Disorders. Reverse engineering gene networks to identify key drivers of complex disease phenotypes

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