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Cited by 2,998

The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.

Causes and consequences of microRNA dysregulation in cancer

Open access
Croce, Carlo M.·2009·Nature Reviews Genetics

Abstract

Over the past several years it has become clear that alterations in the expression of microRNA (miRNA) genes contribute to the pathogenesis of most — if not all — human malignancies. These alterations can be caused by various mechanisms, including deletions, amplifications or mutations involving miRNA loci, epigenetic silencing or the dysregulation of transcription factors that target specific miRNAs. Because malignant cells show dependence on the dysregulated expression of miRNA genes, which in turn control or are controlled by the dysregulation of multiple protein-coding oncogenes or tumour suppressor genes, these small RNAs provide important opportunities for the development of future miRNA-based therapies.

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Metadata

Authors
Croce, C. M.
Venue
Nature Reviews Genetics
Published
2009-10
Volume
10
Issue
10
Pages
704-714
ISSN
  • 1471-0056 (ISSN-L)
  • 1471-0064
OpenAlex
W2008945738
Cited by
2,998
References
13
FWCI
8.58
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Causes and consequences of microRNA dysregulation in cancer. https://app.cochat.ai/papers/10.1038/nrg2634
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Croce, C. M. (2009). Causes and consequences of microRNA dysregulation in cancer. Nature Reviews Genetics. https://doi.org/10.1038/nrg2634

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.