The extracellular matrix and ciliary signaling

Ciliogenesis: building the cell's antenna

Ishikawa, H., & Marshall, W. F. (2011) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3085 · Cited by 956 · see citing works

Polycystic Kidney Disease

Wilson, P. D. (2004) · New England Journal of Medicine · doi:10.1056/nejmra022161 · Cited by 928 · see citing works

HEF1-Dependent Aurora A Activation Induces Disassembly of the Primary Cilium

Pugacheva, E. N., Jablonski, S. A., Hartman, T. R., Henske, E. P., & Golemis, E. A. (2007) · Cell · doi:10.1016/j.cell.2007.04.035 · Cited by 890 · see citing works

Polycystic Kidney Disease

Harris, P. C., & Torres, V. E. (2008) · Annual Review of Medicine · doi:10.1146/annurev.med.60.101707.125712 · Cited by 807 · see citing works

New Neurons Follow the Flow of Cerebrospinal Fluid in the Adult Brain

Sawamoto, K., Wichterle, H., González-Pérez, Ó., Cholfin, J. A., Yamada, M., Spassky, N., Murcia, N. S., García‐Verdugo, J. M., Marín, Ó., Rubenstein, J. L. R., et al. (2006) · Science · doi:10.1126/science.1119133 · Cited by 803 · see citing works

Inversin, the gene product mutated in nephronophthisis type II, functions as a molecular switch between Wnt signaling pathways

Simons, M., Gloy, J., Ganner, A., Bullerkotte, A., Bashkurov, M., Krönig, C., Schermer, B., Benzing, T., Cabello, O. A., Jenny, A., et al. (2005) · Nature Genetics · doi:10.1038/ng1552 · Cited by 767 · see citing works

A transition zone complex regulates mammalian ciliogenesis and ciliary membrane composition

García-Gonzalo, F. R., Corbit, K. C., Sirerol-Piquer, M. S., Ramaswami, G., Otto, E. A., Noriega, T. R., Seol, A. D., Robinson, J. F., Bennett, C., Josifova, D. J., et al. (2011) · Nature Genetics · doi:10.1038/ng.891 · Cited by 627 · see citing works

Mapping the NPHP-JBTS-MKS Protein Network Reveals Ciliopathy Disease Genes and Pathways

Sang, L., Miller, J. J., Corbit, K. C., Giles, R. H., Brauer, M. J., Otto, E. A., Baye, L. M., Wen, X., Scales, S. J., Kwong, M., et al. (2011) · Cell · doi:10.1016/j.cell.2011.04.019 · Cited by 606 · see citing works

Taking aim at the extracellular matrix: CCN proteins as emerging therapeutic targets

Jun, J.-I., & Lau, L. F. (2011) · Nature Reviews Drug Discovery · doi:10.1038/nrd3599 · Cited by 606 · see citing works

Mechanisms and functions of Hedgehog signalling across the metazoa

Ingham, P. W., Nakano, Y., & Seger, C. (2011) · Nature Reviews Genetics · doi:10.1038/nrg2984 · Cited by 605 · see citing works

Kidney-specific inactivation of the KIF3A subunit of kinesin-II inhibits renal ciliogenesis and produces polycystic kidney disease

Lin, F., Hiesberger, T., Cordes, K. R., Sinclair, A. M., Goldstein, L. S. B., Somlo, S., & Igarashi, P. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0836980100 · Cited by 588 · see citing works

Functional genomic screen for modulators of ciliogenesis and cilium length

Kim, J., Lee, J. E., Heynen‐Genel, S., Suyama, E., Ono, K., Lee, K., Ideker, T. E., Aza‐Blanc, P., & Gleeson, J. G. (2010) · Nature · doi:10.1038/nature08895 · Cited by 548 · see citing works

Cadherin 23 is a component of the tip link in hair-cell stereocilia

Siemens, J., Lillo, C., Dumont, R. A., Reynolds, A. J., Williams, D. S., Gillespie, P. G., & Müller, U. (2004) · Nature · doi:10.1038/nature02483 · Cited by 490 · see citing works

Primary cilia mediate mechanosensing in bone cells by a calcium-independent mechanism

Malone, A. M. D., Anderson, C. T., Tummala, P., Kwon, R. Y., Johnston, T. R., Stearns, T., & Jacobs, C. R. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0700636104 · Cited by 477 · see citing works

Coupling between hydrodynamic forces and planar cell polarity orients mammalian motile cilia

Guirao, B., Meunier, A., Mortaud, S., Aguilar, A., Corsi, J.-M., Strehl, L., Hirota, Y., Desoeuvre, A., Boutin, C., Han, Y.-G., et al. (2010) · Nature Cell Biology · doi:10.1038/ncb2040 · Cited by 418 · see citing works

Mutations in cadherin 23 affect tip links in zebrafish sensory hair cells

Söllner, C., Rauch, G.-J., Siemens, J., Geisler, R., Schuster, S. C., Müller, U., & Nicolson, T. A. (2004) · Nature · doi:10.1038/nature02484 · Cited by 337 · see citing works

Lack of cadherins Celsr2 and Celsr3 impairs ependymal ciliogenesis, leading to fatal hydrocephalus

Tissir, F., Qu, Y., Montcouquiol, M., Zhou, L., Komatsu, K., Shi, D., Fujimori, T., Labeau, J., Tyteca, D., Courtoy, P. J., et al. (2010) · Nature Neuroscience · doi:10.1038/nn.2555 · Cited by 333 · see citing works

Loss of Nephrocystin-3 Function Can Cause Embryonic Lethality, Meckel-Gruber-like Syndrome, Situs Inversus, and Renal-Hepatic-Pancreatic Dysplasia

Bergmann, C., Fliegauf, M., Brüchle, N. O., Frank, V., Olbrich, H., Kirschner, J., Schermer, B., Schmedding, I., Kispert, A., Kränzlin, B., et al. (2008) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2008.02.017 · Cited by 324 · see citing works

A Role for the Primary Cilium in Notch Signaling and Epidermal Differentiation during Skin Development

Ezratty, E. J., Stokes, N., Chai, S., Shah, A. S., Williams, S. E., & Fuchs, E. V. (2011) · Cell · doi:10.1016/j.cell.2011.05.030 · Cited by 314 · see citing works

Control of vertebrate multiciliogenesis by miR-449 through direct repression of the Delta/Notch pathway

Marcet, B., Chevalier, B., Luxardi, G., Coraux, C., Zaragosi, L., Cibois, M., Robbe-Sermesant, K., Jolly, T., Cardinaud, B., Moreilhon, C., et al. (2011) · Nature Cell Biology · doi:10.1038/ncb2241 · Cited by 298 · see citing works

The cell biology of polycystic kidney disease

Chapin, H. C., & Caplan, M. J. (2010) · The Journal of Cell Biology · doi:10.1083/jcb.201006173 · Cited by 282 · see citing works

Deletion of IFT20 in the mouse kidney causes misorientation of the mitotic spindle and cystic kidney disease

Jonassen, J. A., Agustin, J. T. S., Follit, J. A., & Pazour, G. J. (2008) · The Journal of Cell Biology · doi:10.1083/jcb.200808137 · Cited by 278 · see citing works

Directional Cell Migration and Chemotaxis in Wound Healing Response to PDGF-AA are Coordinated by the Primary Cilium in Fibroblasts

Schneider, L., Cammer, M., Lehman, J., Nielsen, S., Guerra, C., Veland, I., Stock, C., Hoffmann, E., Yoder, B., Schwab, A., et al. (2010) · Cellular Physiology and Biochemistry · doi:10.1159/000276562 · Cited by 250 · see citing works

Polycystin-1, the PKD1 gene product, is in a complex containing E-cadherin and the catenins

Huan, Y., & van Adelsberg, J. (1999) · Journal of Clinical Investigation · doi:10.1172/jci5111 · Cited by 248 · see citing works

Loss of GLIS2 causes nephronophthisis in humans and mice by increased apoptosis and fibrosis

Attanasio, M., Uhlenhaut, N. H., Sousa, V. H., O’Toole, J. F., Otto, E. A., Anlag, K., Klugmann, C., Treier, A.-C., Helou, J., Sayer, J. A., et al. (2007) · Nature Genetics · doi:10.1038/ng2072 · Cited by 240 · see citing works

pVHL and GSK3β are components of a primary cilium-maintenance signalling network

Thoma, C. R., Frew, I. J., Hoerner, C. R., Montani, M., Moch, H., & Krek, W. (2007) · Nature Cell Biology · doi:10.1038/ncb1579 · Cited by 238 · see citing works

Stages of ciliogenesis and regulation of ciliary length

Avasthi, P., & Marshall, W. F. (2012) · Differentiation · doi:10.1016/j.diff.2011.11.015 · Cited by 234 · see citing works

Cell shape and contractility regulate ciliogenesis in cell cycle–arrested cells

Pitaval, A., Tseng, Q., Bornens, M., & Théry, M. (2010) · The Journal of Cell Biology · doi:10.1083/jcb.201004003 · Cited by 213 · see citing works

Primary cilia mediate mechanotransduction through control of ATP‐induced Ca 2+ signaling in compressed chondrocytes

Wann, A. K. T., Zuo, N., Haycraft, C. J., Jensen, C. G., Poole, C. A., McGlashan, S. R., & Knight, M. M. (2012) · The FASEB Journal · doi:10.1096/fj.11-193649 · Cited by 206 · see citing works

Biochemical role of the collagen-rich tumour microenvironment in pancreatic cancer progression

Shields, M. A., Dangi-Garimella, S. Y., Redig, A. J., & Munshi, H. G. (2011) · Biochemical Journal · doi:10.1042/bj20111240 · Cited by 203 · see citing works

RhoA-mediated apical actin enrichment is required for ciliogenesis and promoted by Foxj1

Pan, J., You, Y., Huang, T., & Brody, S. L. (2007) · Journal of Cell Science · doi:10.1242/jcs.005306 · Cited by 203 · see citing works

Lack of Primary Cilia Primes Shear-Induced Endothelial-to-Mesenchymal Transition

Egorova, A. D., Khedoe, P. P. S. J., Goumans, M.-J. T. H., Yoder, B. K., Nauli, S. M., ten Dijke, P., Poelmann, R. E., & Hierck, B. P. (2011) · Circulation Research · doi:10.1161/circresaha.110.231860 · Cited by 195 · see citing works

Inhibition of neural crest migration underlies craniofacial dysmorphology and Hirschsprung's disease in Bardet–Biedl syndrome

Tobin, J. L., di Franco, M., Eichers, E. R., May‐Simera, H., Garcia, M., Yan, J., Quinlan, R., Justice, M. J., Hennekam, R. C. M., Briscoe, J., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0707057105 · Cited by 194 · see citing works

Localization of Extracellular Matrix Receptors on the Chondrocyte Primary Cilium

McGlashan, S. R., Jensen, C. G., & Poole, C. A. (2006) · Journal of Histochemistry & Cytochemistry · doi:10.1369/jhc.5a6866.2006 · Cited by 191 · see citing works

Collective Cell Migration Drives Morphogenesis of the Kidney Nephron

Vasilyev, A., Liu, Y., Mudumana, S. P., Mangos, S., Lam, P., Majumdar, Å., Zhao, J., Poon, K., Kondrychyn, I., Korzh, V. P., et al. (2008) · PLoS Biology · doi:10.1371/journal.pbio.1000009 · Cited by 188 · see citing works

CAS proteins in normal and pathological cell growth control

Tikhmyanova, N., Little, J. L., & Golemis, E. A. (2010) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-009-0213-1 · Cited by 187 · see citing works

Cilia in the nervous system: linking cilia function and neurodevelopmental disorders

Lee, J. E., & Gleeson, J. G. (2011) · Current Opinion in Neurology · doi:10.1097/wco.0b013e3283444d05 · Cited by 185 · see citing works

Nephronophthisis

Wolf, M. T. F., & Hildebrandt, F. (2010) · Pediatric Nephrology · doi:10.1007/s00467-010-1585-z · Cited by 183 · see citing works

PKD1/PKCμ promotes αvβ3 integrin recycling and delivery to nascent focal adhesions

Woods, A. J., White, D. P., Caswell, P. T., & Norman, J. C. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600267 · Cited by 182 · see citing works

Cadherin Adhesion, Tissue Tension, and Noncanonical Wnt Signaling Regulate Fibronectin Matrix Organization

Dzamba, B. J., Jakab, K., Marsden, M., Schwartz, M. A., & DeSimone, D. W. (2009) · Developmental Cell · doi:10.1016/j.devcel.2009.01.008 · Cited by 181 · see citing works

The PKD1 gene product, "polycystin-1," is a tyrosine-phosphorylated protein that colocalizes with alpha2beta1-integrin in focal clusters in adherent renal epithelia.

Wilson, P. D., Li, G., Li, X., & Burrow, C. R. (1999) · PubMed · Cited by 179 · see citing works

Cell Cycle–Dependent Ciliogenesis and Cancer

Plotnikova, O. V., Golemis, E. A., & Pugacheva, E. N. (2008) · Cancer Research · doi:10.1158/0008-5472.can-07-5838 · Cited by 172 · see citing works

Development of the post-natal growth plate requires intraflagellar transport proteins

Song, B., Haycraft, C. J., Seo, H., Yoder, B. K., & Serra, R. A. (2007) · Developmental Biology · doi:10.1016/j.ydbio.2007.02.003 · Cited by 171 · see citing works

Nephronophthisis

Salomon, R., Saunier, S., & Niaudet, P. (2008) · Pediatric Nephrology · doi:10.1007/s00467-008-0840-z · Cited by 169 · see citing works

Characterization of the nephrocystin/nephrocystin-4 complex and subcellular localization of nephrocystin-4 to primary cilia and centrosomes

Mollet, G., Silbermann, F., Delous, M., Salomon, R., Antignac, C., & Saunier, S. (2005) · Human Molecular Genetics · doi:10.1093/hmg/ddi061 · Cited by 165 · see citing works

Ultrastructural, tomographic and confocal imaging of the chondrocyte primary cilium in situ

Jensen, C. G., Poole, C. A., McGlashan, S. R., Marko, M., Issa, Z. I., Vujcich, K. V., & Bowser, S. S. (2004) · Cell Biology International · doi:10.1016/j.cellbi.2003.11.007 · Cited by 155 · see citing works

Calmodulin activation of Aurora-A kinase (AURKA) is required during ciliary disassembly and in mitosis

Plotnikova, O. V., Nikonova, A. S., Loskutov, Y. V., Kozyulina, P. Y., Pugacheva, E. N., & Golemis, E. A. (2012) · Molecular Biology of the Cell · doi:10.1091/mbc.e11-12-1056 · Cited by 155 · see citing works

Cilia and cell cycle re-entry

Kim, S., & Tsiokas, L. (2011) · Cell Cycle · doi:10.4161/cc.10.16.17009 · Cited by 150 · see citing works

The ADPKD genespkd1a/bandpkd2regulate extracellular matrix formation

Mangos, S., Lam, P., Zhao, A., Liu, Y., Mudumana, S. P., Vasilyev, A., Liu, A., & Drummond, I. A. S. (2010) · Disease Models & Mechanisms · doi:10.1242/dmm.003194 · Cited by 150 · see citing works

Fibrosis and progression of Autosomal Dominant Polycystic Kidney Disease (ADPKD)

Norman, J. T. (2011) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2011.06.012 · Cited by 145 · see citing works

C14ORF179 encoding IFT43 is mutated in Sensenbrenner syndrome

Arts, H. H., Bongers, E. M. H. F., Mans, D. A., van Beersum, S. E. C., Oud, M. M., Bolat, E., Spruijt, L., Cornelissen, E. A. M., Schuurs-Hoeijmakers, J. H. M., de Leeuw, N., et al. (2011) · Journal of Medical Genetics · doi:10.1136/jmg.2011.088864 · Cited by 144 · see citing works

Primary cilium‐dependent mechanosensing is mediated by adenylyl cyclase 6 and cyclic AMP in bone cells

Kwon, R. Y., Temiyasathit, S., Tummala, P., Quah, C. C., & Jacobs, C. R. (2010) · The FASEB Journal · doi:10.1096/fj.09-148007 · Cited by 144 · see citing works

Primary cilia in osteoarthritic chondrocytes: From chondrons to clusters

McGlashan, S. R., Cluett, E. C., Jensen, C. G., & Poole, C. (2008) · Developmental Dynamics · doi:10.1002/dvdy.21501 · Cited by 142 · see citing works

Nesprin-2 interacts with meckelin and mediates ciliogenesis via remodelling of the actin cytoskeleton

Dawe, H. R., Adams, M., Wheway, G., Szymańska, K., Logan, C. V., Noegel, A. A., Keith Gull, B., & Johnson, C. A. (2009) · Journal of Cell Science · doi:10.1242/jcs.043794 · Cited by 142 · see citing works

Primary Cilia Deletion in Pancreatic Epithelial Cells Results in Cyst Formation and Pancreatitis

Cano, D. A., Sekine, S., & Hebrok, M. (2006) · Gastroenterology · doi:10.1053/j.gastro.2006.10.050 · Cited by 141 · see citing works

MIM and Cortactin Antagonism Regulates Ciliogenesis and Hedgehog Signaling

Bershteyn, M., Atwood, S. X., Woo, W., Covington, M. L., & Oro, A. E. (2010) · Developmental Cell · doi:10.1016/j.devcel.2010.07.009 · Cited by 137 · see citing works

Loss of the Tg737 protein results in skeletal patterning defects

Zhang, Q., Murcia, N. S., Chittenden, L. R., Richards, W. G., Michaud, E. J., Woychik, R. P., & Yoder, B. K. (2003) · Developmental Dynamics · doi:10.1002/dvdy.10289 · Cited by 130 · see citing works

Nephrocystin interacts with Pyk2, p130 Cas , and tensin and triggers phosphorylation of Pyk2

Benzing, T. R., Gerke, P., Höpker, K., Hildebrandt, F., Kim, E., & Walz, G. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.171269898 · Cited by 122 · see citing works

A Hypomorphic Mutation in the Mouse Laminin α5 Gene Causes Polycystic Kidney Disease

Shannon, M. B., Patton, B. L., Harvey, S. J., & Miner, J. H. (2006) · Journal of the American Society of Nephrology · doi:10.1681/asn.2005121298 · Cited by 120 · see citing works

Laminin-511 is an epithelial message promoting dermal papilla development and function during early hair morphogenesisPreprint

Gao, J., DeRouen, M. C., Chen, C.-H., Nguyen, M., Nguyen, N. T., Ido, H., Harada, K., Sekiguchi, K., Morgan, B. A., Miner, J. H., et al. (2008) · Genes & Development · doi:10.1101/gad.1689908 · Cited by 119 · see citing works

Disruption of IFT Complex A Causes Cystic Kidneys without Mitotic Spindle Misorientation

Jonassen, J. A., SanAgustin, J. T., Baker, S. P., & Pazour, G. J. (2012) · Journal of the American Society of Nephrology · doi:10.1681/asn.2011080829 · Cited by 117 · see citing works

A role for the primary cilium in paracrine signaling between mechanically stimulated osteocytes and mesenchymal stem cells

Hoey, D. A., Kelly, D. J., & Jacobs, C. R. (2011) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2011.07.072 · Cited by 115 · see citing works

Nephrocystin-1 and nephrocystin-4 are required for epithelial morphogenesis and associate with PALS1/PATJ and Par6

Delous, M., Hellman, N. E., Gaudé, H.-M., Silbermann, F., Bivic, A. L., Salomon, R., Antignac, C., & Saunier, S. (2009) · Human Molecular Genetics · doi:10.1093/hmg/ddp434 · Cited by 114 · see citing works

Articular cartilage and growth plate defects are associated with chondrocyte cytoskeletal abnormalities in Tg737orpk mice lacking the primary cilia protein polaris

McGlashan, S. R., Haycraft, C. J., Jensen, C. G., Yoder, B. K., & Poole, C. A. (2006) · Matrix Biology · doi:10.1016/j.matbio.2006.12.003 · Cited by 112 · see citing works

Aberrant Regulation of Planar Cell Polarity in Polycystic Kidney Disease

Luyten, A., Su, X., Gondela, S., Chen, Y., Rompani, S. B., Takakura, A., & Zhou, J. (2010) · Journal of the American Society of Nephrology · doi:10.1681/asn.2010010127 · Cited by 110 · see citing works

A meckelin–filamin A interaction mediates ciliogenesis

Adams, M., Simms, R., Abdelhamed, Z., Dawe, H. R., Szymańska, K., Logan, C. V., Wheway, G., Pitt, E., Keith Gull, B., Knowles, M. A., et al. (2011) · Human Molecular Genetics · doi:10.1093/hmg/ddr557 · Cited by 106 · see citing works

Modification of the composition of polycystin-1 multiprotein complexes by calcium and tyrosine phosphorylation

Geng, L., Burrow, C. R., Li, H.-P., & Wilson, P. D. (2000) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/s0925-4439(00)00079-x · Cited by 104 · see citing works

Crk-Associated Substrate p130Cas Interacts with Nephrocystin and Both Proteins Localize to Cell–Cell Contacts of Polarized Epithelial Cells

Donaldson, J. C., Dempsey, P. J., Reddy, S., Bouton, A. H., Coffey, R. J., & Hanks, S. K. (2000) · Experimental Cell Research · doi:10.1006/excr.2000.4822 · Cited by 103 · see citing works

Depletion of primary cilia in articular chondrocytes results in reduced Gli3 repressor to activator ratio, increased Hedgehog signaling, and symptoms of early osteoarthritis

Chang, C., Ramaswamy, G., & Serra, R. A. (2011) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2011.11.009 · Cited by 101 · see citing works

Primary Cilia Regulate Branching Morphogenesis during Mammary Gland Development

McDermott, K. M., Liu, B. Y., Tlsty, T. D., & Pazour, G. J. (2010) · Current Biology · doi:10.1016/j.cub.2010.02.048 · Cited by 100 · see citing works

Dissection of HEF1-dependent functions in motility and transcriptional regulation

Fashena, S. J., Einarson, M. B., O’Neill, G. M., Patriotis, C., & Golemis, E. A. (2002) · Journal of Cell Science · doi:10.1242/jcs.115.1.99 · Cited by 96 · see citing works

The Na+/H+ exchanger NHE1 is required for directional migration stimulated via PDGFR-α in the primary cilium

Schneider, L., Stock, C.-M., Dieterich, P., Jensen, B. H., Pedersen, L. B., Satir, P., Schwab, A., Christensen, S. T., & Pedersen, S. F. (2009) · Journal of Cell Biology · doi:10.1083/jcb.200806019 · Cited by 94 · see citing works

β1-Integrins in the primary cilium of MDCK cells potentiate fibronectin-induced Ca2+signaling

Prætorius, H. A., Prætorius, J., Nielsen, S., Frøkiær, J., & Spring, K. R. (2004) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00096.2004 · Cited by 88 · see citing works

Biliary and Pancreatic Dysgenesis in Mice Harboring a Mutation in Pkhd1

Gallagher, A., Esquivel, E. L., Briere, T. S., Tian, X., Mitobe, M., Menezes, L. F., Markowitz, G. S., Jain, D., Onuchic², L. F., & Somlo, S. (2008) · American Journal Of Pathology · doi:10.2353/ajpath.2008.070381 · Cited by 87 · see citing works

Renal Tubular HIF-2α Expression Requires VHL Inactivation and Causes Fibrosis and Cysts

Schietke, R. E., Hackenbeck, T., Tran, M. G. B., Günther, R., Klanke, B., Warnecke, C., Knaup, K. X., Shukla, D., Rosenberger, C., Koesters, R., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0031034 · Cited by 87 · see citing works

Primary cilia modulate Ihh signal transduction in response to hydrostatic loading of growth plate chondrocytes

Shao, Y. Y., Wang, L., Welter, J. F., & Ballock, R. T. (2011) · Bone · doi:10.1016/j.bone.2011.08.033 · Cited by 84 · see citing works

The Nanomechanics of Polycystin-1 Extracellular Region

Qian, F., Wei, W., Germino, G. G., & Oberhauser, A. F. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m509650200 · Cited by 83 · see citing works

Gardner's syndrome (familial adenomatous polyposis): a cilia-related disorder

Gómez-García, E. B., & Knoers, N. V. A. M. (2009) · The Lancet Oncology · doi:10.1016/s1470-2045(09)70167-6 · Cited by 80 · see citing works

Non-Random Distribution and Sensory Functions of Primary Cilia in Vascular Smooth Muscle Cells

Lu, C. J., Du, H., Wu, J., Jansen, D. A., Jordan, K. L., Xu, N., Sieck, G. C., & Qian, Q. (2008) · Kidney & Blood Pressure Research · doi:10.1159/000132462 · Cited by 79 · see citing works

Effect of in vitro stress‐deprivation and cyclic loading on the length of tendon cell cilia in situ

Gardner, K. L., ARNOCZKY, S. P., & Lavagnino, M. (2010) · Journal of Orthopaedic Research® · doi:10.1002/jor.21271 · Cited by 78 · see citing works

Elevation of Serum Levels of Metalloproteinase-1, Tissue Inhibitor of Metalloproteinase-1 and Type IV Collagen, and Plasma Levels of Metalloproteinase-9 in Polycystic Kidney Disease

Nakamura, T., Ushiyama, C., Suzuki, S., Ebihara, I., Shimada, N., & Koide, H. (2000) · American Journal of Nephrology · doi:10.1159/000013552 · Cited by 78 · see citing works

NEDD9 and BCAR1 Negatively Regulate E-Cadherin Membrane Localization, and Promote E-Cadherin Degradation

Tikhmyanova, N., & Golemis, E. A. (2011) · PLoS ONE · doi:10.1371/journal.pone.0022102 · Cited by 77 · see citing works

The primary cilium as a dual sensor of mechanochemical signals in chondrocytes

Muhammad, H., Rais, Y., Miosge, N., & Ornan, E. M. (2012) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-011-0911-3 · Cited by 77 · see citing works

Rapid calcium-dependent activation of Aurora-A kinase

Plotnikova, O. V., Pugacheva, E. N., Dunbrack, R. L., & Golemis, E. A. (2010) · Nature Communications · doi:10.1038/ncomms1061 · Cited by 77 · see citing works

Polycystins, focal adhesions and extracellular matrix interactions

Drummond, I. A. S. (2011) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2011.03.003 · Cited by 75 · see citing works

Mechanisms of mammalian ciliary motility: Insights from primary ciliary dyskinesia genetics

Lee, L. (2010) · Gene · doi:10.1016/j.gene.2010.11.006 · Cited by 73 · see citing works

Primary cilia are highly oriented with respect to collagen direction and long axis of extensor tendon

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Simultaneous Measurement of Smoothened Entry Into and Exit From the Primary Cilium

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Exposure to 16 Hz Pulsed Electromagnetic Fields Protect the Structural Integrity of Primary Cilia and Associated TGF-β Signaling in Osteoprogenitor Cells Harmed by Cigarette Smoke

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Primary cilia suppress the fibrotic activity of atrial fibroblasts from patients with atrial fibrillation in vitro

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Methadone alters transcriptional programs associated with synapse formation in human cortical organoids

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Cortical interneurons migrating on a pure substrate of N-cadherin exhibit fast synchronous centrosomal and nuclear movements and reduced ciliogenesis

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Knockdown of Ift88 in fibroblasts causes extracellular matrix remodeling and decreases conduction velocity in cardiomyocyte monolayers

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A critique on the theory of homeostasis.

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The genetic background of hydrocephalus in a population-based cohort: implication of ciliary involvement

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Cystic Kidney Disease in a Patient With Systemic Toxicity From Long-term d-Penicillamine Use

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Microscopy-Based Automated Live Cell Screening for Small Molecules That Affect Ciliation

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Morphological and Functional Characterization of the Ciliary Pocket by Electron and Fluorescence Microscopy

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Quick, Single-Frequency Dielectric Characterization of Blood Samples of Pediatric Cancer Patients by a Cylindrical Capacitor: Pilot Study

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Depth and strain rate-dependent mechanical response of chondrocytes in reserve zone cartilage subjected to compressive loading

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Collagen VI Deficiency Impairs Tendon Fibroblasts Mechanoresponse in Ullrich Congenital Muscular Dystrophy

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Regulator of G protein signaling 12 drives inflammatory arthritis by activating synovial fibroblasts through MYCBP2/KIF2A signaling

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Hedgehog signaling regulates Wolffian duct development through the primary cilium

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RC/BTB2 is essential for formation of primary cilia in mammalian cells

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N6‐Methyladenosine Regulates Cilia Elongation in Cancer Cells by Modulating HDAC6 Expression

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Effects of pharmacological primary cilium disturbance in the context of in vitro 2D and 3D malignant pleura mesothelioma

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Islet cilia and glucose homeostasis

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TALPID3/KIAA0586 Regulates Multiple Aspects of Neuromuscular Patterning During Gastrointestinal Development in Animal Models and Human

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Extracellular matrix regulates morphogenesis and function of ciliated sensory organs in Caenorhabditis elegansPreprint

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Mechanisms underlying morphological and functional changes of cilia in fibroblasts derived from patients bearing ARL3 T31A and ARL3 T31A/C118F mutations

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Therapeutic opportunities in polycystic kidney and liver disease through extracellular matrix dynamics

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Exploring Ciliary Mechanisms in the Causation of Hydrocephalus in Humans—Similarities and Differences from Animal Models

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Chondrocyte and Pericellular Matrix Deformation and Strain in the Growth Plate Cartilage Reserve Zone Under Compressive Loading

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In-depth analysis of obesity-associated changes in adipose tissue-derived mesenchymal stromal/stem cells and primary cilia function

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Insight on the role of RKIP in cancer through key protein partners and cellular protrusions

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Mechanism of cystogenesis by Cd79a-driven, conditional mTOR activation in developing mouse nephrons

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Alström syndrome with a novel mutation of ALMS1 and Graves’ hyperthyroidism: A case report and review of the literature

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Cilia

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Genetic Landscape of Masticatory Muscle Tendon–Aponeurosis Hyperplasia

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Cilia and Flagella

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Alteration of primary cilia and intraflagellar transport 20 (IFT20) expression in oral squamous cell carcinoma (OSCC) cell lines

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Primary cilia and PTH1R interplay in the regulation of osteogenic actions

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Primary cilia: The central role in the electromagnetic field induced bone healing

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Extraciliary OFD1 Is Involved in Melanocyte Survival through Cell Adhesion to ECM via Paxillin

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Ruptured Sinus of Valsalva Aneurysm Associated with Situs Ambiguus, Isolated Levocardia, and Polysplenia

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Effects of Brain Injury on Primary Cilia of Glial Cells and Pericytes

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Imbalance of Ciliary Programs Drives Fibroblast Differentiation and Fibrotic Signaling in Systemic SclerosisPreprint

Nguyen, L. M. T., Córdova, C. E., Sapao, P., Vasquez-Hernandez, C., Klumpp, A., Nguyen, L. P. D., Dey, P., Gudjonsson, J. E., Ross, R. L., Galdo, F. D., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.02.25.707978 · Cited by 1 · see citing works

MSX1 in relation to clefting. hypodontia and hydrocephaly in humans

van den Boogaard, M. H. (2013) · Utrecht University Repository (Utrecht University)

Regulation of the Extracellular Matrix by Ciliary Machinery

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THE ROLE OF THE MECHANICAL PROPERTIES OF THE EXTRACELLULAR MATRIX IN CILIOGENESIS

Belova, E. (2021) · TUScholarShare (Temple University)

Extracellular matrix regulates morphogenesis and function of ciliated sensory organs

Vore, D. (2018) · doi:10.7282/t3c2512d

Extracellular matrix regulates morphogenesis and function of ciliated sensory organs in Caenorhabditis elegansPreprint

Vore, D., Knobel, K. M., Nguyen, K. C. Q., Hall, D. H., & Barr, M. M. (2018) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/376152 · Cited by 4 · see citing works

Primary cilia signalling at a glance

Wachten, D., & Christensen, S. T. (2025) · Journal of Cell Science · doi:10.1242/jcs.264187 · Cited by 12 · see citing works