Variable patterns of axonal projections of sensory neurons in the mouse vomeronasal system
Open accessAbstract
The vomeronasal system mediates pheromonal effects in mammals. We have employed gene targeting technology to introduce mutations in a putative pheromone receptor gene, VR2, in the germline of mice. By generating alleles differentially tagged with the histological markers taulacZ and tauGFP, we show that VR2 is monoallelically expressed in a given neuron. Axons of VR2-expressing neurons converge onto numerous glomeruli in the accessory olfactory bulb. The pattern of axonal projections is complex and variable. This wiring diagram is substantially different from that of the main olfactory system. The projection pattern is disrupted by deleting the coding region of VR2, but an unrelated seven-transmembrane protein, the odorant receptor M71, can partially substitute for VR2.
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Axons from VNO neurons expressing a given VR project to multiple glomeruli in the accessory olfactory bulb, where they form synaptic connections with AOB mitral/tufted cells, and AOB mitral cells form synapses within multiple glomeruli.
“In turn, axons from VNO neurons expressing a given VR project to multiple glomeruli in the accessory olfactory bulb (AOB) (Belluscio et al., 1999; Rodriguez et al., 1999), where they form synaptic connections with AOB mitral/tufted cells, and AOB mitral cells form synapses within multiple glomeruli (Wagner et al., 2006).”
From Neuronal Representation of Social Information in the Medial Amygdala of Awake Behaving Mice (2017) · cites this paper as Rodriguez et al., 1999
The distributed non-topographic representation of each stimulus type mirrors the distributed organization in the AOB and suggests that information sorting may further be accomplished through selective projection to downstream regions.
“Such distributed non-topographic representation of each stimulus type mirrors the distributed organization in the AOB (Belluscio et al., 1999; Rodriguez et al., 1999; Wagner et al., 2006) and suggests that information sorting may further be accomplished through selective projection to downstream regions.”
From Neuronal Representation of Social Information in the Medial Amygdala of Awake Behaving Mice (2017) · cites this paper as Rodriguez et al., 1999
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- Authors
- Rodriguez, I., Feinstein, P., & Mombaerts, P.
- Affiliations
- Rockefeller University (US)
- Corresponding author
- Mombaerts, Peter
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 1999-04
- Volume
- 97
- Issue
- 2
- Pages
- 199-208
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W1978331009
- Cited by
- 402
- References
- 48
- Citations by year
- 2026: 8 · 2025: 6 · 2024: 12 · 2023: 6 · 2022: 3 · 2021: 13 · 2020: 8 · 2019: 21 · 2018: 8 · 2017: 9 · 2016: 14 · 2015: 11 · 2014: 14 · 2013: 11 · 2012: 9
- FWCI
- 14.42
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- Funders
- McKnight Foundation
- National Institutes of Health
- Topics
- Life Sciences › Neuroscience › Sensory Systems › Olfactory and Sensory Function Studies
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Sensory Systems › Ion Channels and Receptors
- Keywords
- vomeronasal system, pheromone receptors, accessory olfactory bulb, axonal projections, glomeruli, monoallelic expression, seven-transmembrane proteins, pheromone signaling, mice
- MeSH terms
- Alleles, Animals, Axons, Base Sequence, Cell Count, Chemoreceptor Cells, Heterozygote, Homozygote, Lac Operon, Luminescent Proteins, Gene Expression, Mutagenesis, Site-Directed, DNA Primers, Olfactory Receptor Neurons, Germ-Line Mutation, Gene Targeting, Vomeronasal Organ, Green Fluorescent Proteins, Mice, Rats
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