The DOI matches its Crossref record; 17 of the 17 references it cites were found in a registry or an index.
ChIP–seq and beyond: new and improved methodologies to detect and characterize protein–DNA interactions
Open accessAbstract
Chromatin immunoprecipitation experiments followed by sequencing (ChIP–seq) detect protein–DNA binding events and chemical modifications of histone proteins. Challenges in the standard ChIP–seq protocol have motivated recent enhancements in this approach, such as reducing the number of cells that are required and increasing the resolution. Complementary experimental approaches — for example, DNaseI hypersensitive site mapping and analysis of chromatin interactions that are mediated by particular proteins — provide additional information about DNA-binding proteins and their function. These data are now being used to identify variability in the functions of DNA-binding proteins across genomes and individuals. In this Review, I describe the latest advances in methods to detect and functionally characterize DNA-bound proteins.
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Cited by
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Metadata
- Authors
- Furey, T. S.
- Venue
- Nature Reviews Genetics
- Published
- 2012-10-23
- Volume
- 13
- Issue
- 12
- Pages
- 840-852
- ISSN
- 1471-0056 (ISSN-L)
- 1471-0064
- OpenAlex
- W2092988184
- Cited by
- 835
- References
- 17
- FWCI
- 4.14
- Type
- journal article
- Language
- en
- Open access
- green
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