The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
RETRACTED: A Pleiotropically Acting MicroRNA, miR-31, Inhibits Breast Cancer Metastasis
Open accessAbstract
SUMMARY MicroRNAs are well-suited to regulate tumor metastasis due to their capacity to coordinately repress numerous target genes, thereby potentially enabling their intervention at multiple steps of the invasion-metastasis cascade. We identify a microRNA exemplifying these attributes, miR-31, whose expression correlates inversely with metastasis in human breast cancer patients. Overexpression of miR-31 in otherwise-aggressive breast tumor cells suppresses metastasis. We deploy a stable microRNA sponge strategy to stably inhibit miR-31 in vivo; this allows otherwise-non-aggressive breast cancer cells to metastasize. These phenotypes do not involve confounding influences on primary tumor development and are specifically attributable to miR-31-mediated inhibition of several steps of metastasis, including local invasion, extravasation or initial survival at a distant site, and metastatic colonization. Such pleiotropy is achieved via coordinate repression of a cohort of metastasis-promoting genes, including RhoA. Indeed, RhoA re-expression partially reverses miR-31-imposed metastasis-suppression. These findings indicate that miR-31 uses multiple mechanisms to oppose metastasis.
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InfluentialCombinatorial microRNA target predictions
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Cited by
Tumor Metastasis: Molecular Insights and Evolving Paradigms
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Targeting Mitochondrial Glutaminase Activity Inhibits Oncogenic Transformation
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Metadata
- Authors
- Valastyan, S., Reinhardt, F., Benaich, N., Calogrias, D., Szász, A. M., Wang, Z. C., Brock, J. E., Richardson, A. L., & Weinberg, R. A.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2009-06
- Volume
- 137
- Issue
- 6
- Pages
- 1032-1046
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W1978944350
- Cited by
- 820
- References
- 9
- FWCI
- 31.47
- Type
- journal article
- Language
- en
- Status
- Retracted
- Open access
- bronze
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- The paper
- Valastyan, S., Reinhardt, F., Benaich, N., Calogrias, D., Szász, A. M., Wang, Z. C., Brock, J. E., Richardson, A. L., & Weinberg, R. A. (2009). RETRACTED: A Pleiotropically Acting MicroRNA, miR-31, Inhibits Breast Cancer Metastasis. Cell. https://doi.org/10.1016/j.cell.2009.03.047
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