Cited by 619

The DOI matches its Crossref record; 141 of the 141 references it cites were found in a registry or an index.

Chromatin modifiers and remodellers: regulators of cellular differentiation

Chen, Taiping, Dent, Sharon Y. R.·2014·Nature Reviews Genetics

Open this paper in CoChat — free account

Abstract

Cellular differentiation is, by definition, epigenetic. Genome-wide profiling of pluripotent cells and differentiated cells suggests global chromatin remodelling during differentiation, which results in a progressive transition from a fairly open chromatin configuration to a more compact state. Genetic studies in mouse models show major roles for a variety of histone modifiers and chromatin remodellers in key developmental transitions, such as the segregation of embryonic and extra-embryonic lineages in blastocyst stage embryos, the formation of the three germ layers during gastrulation and the differentiation of adult stem cells. Furthermore, rather than merely stabilizing the gene expression changes that are driven by developmental transcription factors, there is emerging evidence that chromatin regulators have multifaceted roles in cell fate decisions.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1038/nrg3607

Cites

141 of 141 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

1 retracted

RETRACTED: Protein Kinase A Determines Timing of Early Differentiation through Epigenetic Regulation with G9a
Yamamizu, K., Fujihara, M., Tachibana, M., Katayama, S., Takahashi, A., Hara, E., Imai, H., Shinkai, Y., & Yamashita, J. K. (2012) · Cell stem cell · doi:10.1016/j.stem.2012.02.022 · Cited by 36
Retracted
A bivalent chromatin structure marks key developmental genes in embryonic stem cells
Bernstein, B. E., Mikkelsen, T. S., Xie, X., Kamal, M., Huebert, D. J., Cuff, J., Fry, B., Meissner, A., Wernig, M., Plath, K., et al. (2006) · Cell · doi:10.1016/j.cell.2006.02.041 · Cited by 5,361
Human DNA methylomes at base resolution show widespread epigenomic differences
Lister, R., Pelizzola, M., Dowen, R. H., Hawkins, R. D., Hon, G., Tonti-Filippini, J., Nery, J. R., Lee, L., Ye, Z., Ngo, Q.-M., et al. (2009) · Nature · doi:10.1038/nature08514 · Cited by 4,673
Histone H3K27ac separates active from poised enhancers and predicts developmental state
Creyghton, M. P., Cheng, A. W., Welstead, G. G., Kooistra, T., Carey, B. W., Steine, E. J., Hanna, J., Lodato, M. A., Frampton, G. M., Sharp, P. A., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1016071107 · Cited by 4,302
Genome-wide maps of chromatin state in pluripotent and lineage-committed cells
Mikkelsen, T. S., Ku, M., Jaffe, D. B., Issac, B., Lieberman, E., Giannoukos, G., Alvarez, P., Brockman, W., Kim, T.-K., Koche, R. P., et al. (2007) · Nature · doi:10.1038/nature06008 · Cited by 4,129
Formation of Pluripotent Stem Cells in the Mammalian Embryo Depends on the POU Transcription Factor Oct4
Nichols, J., Zevnik, B., Anastassiadis, K., Niwa, H., Klewe-Nebenius, D., Chambers, I., Schöler, H., & Smith, A. (1998) · Cell · doi:10.1016/s0092-8674(00)81769-9 · Cited by 3,392
Cancer epigenetics: from mechanism to therapy
Dawson, M. A., & Kouzarides, T. (2012) · Cell · doi:10.1016/j.cell.2012.06.013 · Cited by 3,203
DNA methylation: roles in mammalian development
Smith, Z. D., & Meissner, A. (2013) · Nature Reviews Genetics · doi:10.1038/nrg3354 · Cited by 3,045
Long non-coding RNAs: new players in cell differentiation and development
Fatica, A., & Bozzoni, I. (2014) · Nature Reviews Genetics · doi:10.1038/nrg3606 · Cited by 2,980
Polycomb complexes repress developmental regulators in murine embryonic stem cells
Boyer, L., Plath, K., Zeitlinger, J., Brambrink, T., Medeiros, L. A., Lee, T., Levine, S., Wernig, M., Tajonar, A., Ray, M. K., et al. (2006) · Nature · doi:10.1038/nature04733 · Cited by 2,738
Genome-scale DNA methylation maps of pluripotent and differentiated cells
Meissner, A., Mikkelsen, T. S., Gu, H., Wernig, M., Hanna, J., Sivachenko, A., Zhang, X., Bernstein, B. E., Nusbaum, C., Jaffe, D. B., et al. (2008) · Nature · doi:10.1038/nature07107 · Cited by 2,536
A unique chromatin signature uncovers early developmental enhancers in humans
Rada-Iglesias, A., Bajpai, R., Swigut, T., Brugmann, S. A., Flynn, R. A., & Wysocka, J. (2011) · Nature · doi:10.1038/nature09692 · Cited by 2,233
New cell lines from mouse epiblast share defining features with human embryonic stem cells
Tesar, P. J., Chenoweth, J. G., Brook, F. A., Davies, T. J., Evans, E. P., Mack, D. L., Gardner, R. L., & McKay, R. D. G. (2007) · Nature · doi:10.1038/nature05972 · Cited by 2,187
A Chromatin Landmark and Transcription Initiation at Most Promoters in Human Cells
Guenther, M. G., Levine, S. S., Boyer, L. A., Jaenisch, R., & Young, R. A. (2007) · Cell · doi:10.1016/j.cell.2007.05.042 · Cited by 2,002
Identification of 67 Histone Marks and Histone Lysine Crotonylation as a New Type of Histone Modification
Tan, M., Luo, H., Lee, S., Jin, F., Yang, J. S., Montellier, E., Buchou, T., Cheng, Z., Rousseaux, S., Rajagopal, N., et al. (2011) · Cell · doi:10.1016/j.cell.2011.08.008 · Cited by 1,902
Naive and Primed Pluripotent States
Nichols, J., & Smith, A. (2009) · Cell Stem Cell · doi:10.1016/j.stem.2009.05.015 · Cited by 1,859
Pioneer transcription factors: establishing competence for gene expression
Zaret, K. S., & Carroll, J. S. (2011) · Genes & Development · doi:10.1101/gad.176826.111 · Cited by 1,589
Dissecting direct reprogramming through integrative genomic analysis
Mikkelsen, T. S., Hanna, J. H., Zhang, X., Ku, M., Wernig, M., Schorderet, P., Bernstein, B., Jaenisch, R., Lander, E. S., & Meissner, A. (2008) · Nature · doi:10.1038/nature07056 · Cited by 1,515
Chromatin signatures of pluripotent cell lines
Azuara, V., Perry, P., Sauer, S., Spivakov, M., Jørgensen, H. F., John, R. M., Gouti, M., Casanova, M., Warnes, G., Merkenschlager, M., et al. (2006) · Nature Cell Biology · doi:10.1038/ncb1403 · Cited by 1,353
Genome-wide mapping of HATs and HDACs reveals distinct functions in active and inactive genes
Wang, Z., Zang, C., Cui, K., Schones, D. E., Barski, A., Peng, W., & Zhao, K. (2009) · Cell · doi:10.1016/j.cell.2009.06.049 · Cited by 1,344
G9a histone methyltransferase plays a dominant role in euchromatic histone H3 lysine 9 methylation and is essential for early embryogenesis
Tachibana, M., Sugimoto, K., Nozaki, M., Ueda, J., Ohta, T., Ohki, M., Fukuda, M., Takeda, N., Niida, H., Kato, H., et al. (2002) · Genes & Development · doi:10.1101/gad.989402 · Cited by 1,253
Interaction between Oct3/4 and Cdx2 Determines Trophectoderm Differentiation
Niwa, H., Toyooka, Y., Shimosato, D., Strumpf, D., Takahashi, K., Yagi, R., & Rossant, J. (2005) · Cell · doi:10.1016/j.cell.2005.08.040 · Cited by 1,190
Cdx2 is required for correct cell fate specification and differentiation of trophectoderm in the mouse blastocyst
Strumpf, D., Mao, C.-A., Yamanaka, Y., Ralston, A., Chawengsaksophak, K., Beck, F., & Rossant, J. (2005) · Development · doi:10.1242/dev.01801 · Cited by 1,123
Chromatin remodelling during development
Ho, L., & Crabtree, G. R. (2010) · Nature · doi:10.1038/nature08911 · Cited by 1,114
EZH1 mediates methylation on histone H3 lysine 27 and complements EZH2 in maintaining stem cell identity and executing pluripotency
Shen, X., Liu, Y., Hsu, Y.-J., Fujiwara, Y., Kim, J., Mao, X., Yuan, G.-C., & Orkin, S. H. (2008) · Molecular Cell · doi:10.1016/j.molcel.2008.10.016 · Cited by 1,021
Hyperdynamic Plasticity of Chromatin Proteins in Pluripotent Embryonic Stem Cells
Meshorer, E., Yellajoshula, D., George, E., Scambler, P. J., Brown, D. T., & Misteli, T. (2006) · Developmental Cell · doi:10.1016/j.devcel.2005.10.017 · Cited by 1,008
Lineage-Specific Polycomb Targets and De Novo DNA Methylation Define Restriction and Potential of Neuronal Progenitors
Mohn, F., Weber, M., Rebhan, M., Roloff, T. C., Richter, J., Stadler, M. B., Bibel, M., & Schübeler, D. (2008) · Molecular Cell · doi:10.1016/j.molcel.2008.05.007 · Cited by 974
Facilitators and Impediments of the Pluripotency Reprogramming Factors' Initial Engagement with the Genome
Soufi, A., Donahue, G., & Zaret, K. S. (2012) · Cell · doi:10.1016/j.cell.2012.09.045 · Cited by 933
Suz12 is essential for mouse development and for EZH2 histone methyltransferase activity
Pasini, D., Bracken, A. P., Jensen, M. R., Denchi, E. L., & Helin, K. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600402 · Cited by 916
The Polycomb-Group Gene Ezh2 Is Required for Early Mouse Development
O'Carroll, D., Erhardt, S., Pagani, M., Barton, S. C., Surani, M. A., & Jenuwein, T. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.13.4330-4336.2001 · Cited by 912
TETonic shift: biological roles of TET proteins in DNA demethylation and transcription
Pastor, W. A., Aravind, L., & Rao, A. (2013) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3589 · Cited by 897
PCGF Homologs, CBX Proteins, and RYBP Define Functionally Distinct PRC1 Family Complexes
Gao, Z., Zhang, J., Bonasio, R., Strino, F., Sawai, A., Parisi, F., Kluger, Y., & Reinberg, D. (2012) · Molecular Cell · doi:10.1016/j.molcel.2012.01.002 · Cited by 848
A Brg1 Null Mutation in the Mouse Reveals Functional Differences among Mammalian SWI/SNF Complexes
Bultman, S. J., Gebuhr, T., Yee, D., LaMantia, C., Nicholson, J., Gilliam, A. C., Randazzo, F. M., METZGER, D., Chambon, P., Crabtree, G. R., et al. (2000) · Molecular Cell · doi:10.1016/s1097-2765(00)00127-1 · Cited by 845
The Transcriptional and Epigenomic Foundations of Ground State Pluripotency
Marks, H., Kalkan, T., Menafra, R., Denissov, S., Jones, K., Hofemeister, H., Nichols, J., Kranz, A., Francis Stewart, A., Smith, A., et al. (2012) · Cell · doi:10.1016/j.cell.2012.03.026 · Cited by 835
Epigenomic Analysis of Multilineage Differentiation of Human Embryonic Stem Cells
Xie, W., Schultz, M. D., Lister, R., Hou, Z., Rajagopal, N., Ray, P. R., Whitaker, J. W., Tian, S., Hawkins, R. D., Leung, D., et al. (2013) · Cell · doi:10.1016/j.cell.2013.04.022 · Cited by 750
Whole-Genome Analysis of Histone H3 Lysine 4 and Lysine 27 Methylation in Human Embryonic Stem Cells
Pan, G., Tian, S., Nie, J., Yang, C., Ruotti, V., Wei, H., Jonsdottir, G. A., Stewart, R., & Thomson, J. A. (2007) · Cell Stem Cell · doi:10.1016/j.stem.2007.08.003 · Cited by 711
Global Transcription in Pluripotent Embryonic Stem Cells
Efroni, S., Duttagupta, R., Cheng, J., Dehghani, H., Hoeppner, D. J., Dash, C., Bazett-Jones, D. P., Le Grice, S., McKay, R. D. G., Buetow, K. H., et al. (2008) · Cell Stem Cell · doi:10.1016/j.stem.2008.03.021 · Cited by 698
The Polycomb Group Protein Suz12 Is Required for Embryonic Stem Cell Differentiation
Pasini, D., Bracken, A. P., Hansen, J. B., Capillo, M., & Helin, K. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.01432-06 · Cited by 696
G9a-mediated irreversible epigenetic inactivation of Oct-3/4 during early embryogenesis
Feldman, N., Gerson, A., Fang, J., Li, E., Zhang, Y., Shinkai, Y., Cedar, H., & Bergman, Y. (2006) · Nature Cell Biology · doi:10.1038/ncb1353 · Cited by 651
Chromatin-modifying enzymes as modulators of reprogramming
Önder, T. T., Kara, N., Cherry, A. B. C., Sinha, A. U., Zhu, N., Bernt, K. M., Cahan, P., Mancarci, B. O., Unternaehrer, J., Gupta, P. B., et al. (2012) · Nature · doi:10.1038/nature10953 · Cited by 650
Dynamic Equilibrium and Heterogeneity of Mouse Pluripotent Stem Cells with Distinct Functional and Epigenetic States
Hayashi, K., Lopes, S. M. C. D. S., Tang, F., & Surani, M. A. (2008) · Cell Stem Cell · doi:10.1016/j.stem.2008.07.027 · Cited by 649
Chromatin Signatures in Multipotent Human Hematopoietic Stem Cells Indicate the Fate of Bivalent Genes during Differentiation
Cui, K., Zang, C., Roh, T., Schones, D. E., Childs, R. W., Peng, W., & Zhao, K. (2009) · Cell stem cell · doi:10.1016/j.stem.2008.11.011 · Cited by 649
Dynamic and Coordinated Epigenetic Regulation of Developmental Transitions in the Cardiac Lineage
Wamstad, J. A., Alexander, J. M., Truty, R., Shrikumar, A., Li, F., Eilertson, K. E., Ding, H., Wylie, J. N., Pico, A. R., Capra, J. A., et al. (2012) · Cell · doi:10.1016/j.cell.2012.07.035 · Cited by 627
Whole-Genome Mapping of Histone H3 Lys4 and 27 Trimethylations Reveals Distinct Genomic Compartments in Human Embryonic Stem Cells
Zhao, X. D., Han, X., Chew, J. L., Liu, J., Chiu, K. P., Choo, A., Orlov, Y. L., Sung, W.-K., Shahab, A., Kuznetsov, V. A., et al. (2007) · Cell Stem Cell · doi:10.1016/j.stem.2007.08.004 · Cited by 615
Large histone H3 lysine 9 dimethylated chromatin blocks distinguish differentiated from embryonic stem cells
Wen, B., Wu, H., Shinkai, Y., Irizarry, R. A., & Feinberg, A. P. (2009) · Nature Genetics · doi:10.1038/ng.297 · Cited by 614
An embryonic stem cell chromatin remodeling complex, esBAF, is essential for embryonic stem cell self-renewal and pluripotency
Ho, L., Ronan, J. L., Wu, J., Staahl, B. T., Chen, L., Kuo, A., Lessard, J., Nesvizhskii, A. I., Ranish, J., & Crabtree, G. R. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0812889106 · Cited by 566
Wdr5 Mediates Self-Renewal and Reprogramming via the Embryonic Stem Cell Core Transcriptional Network
Ang, Y.-S., Tsai, S., Lee, D., Monk, J. M., Su, J., Ratnakumar, K., Ding, J., Ge, Y., Darr, H., Chang, B., et al. (2011) · Cell · doi:10.1016/j.cell.2011.03.003 · Cited by 564
Genome-wide Chromatin State Transitions Associated with Developmental and Environmental Cues
Zhu, J., Adli, M., Zou, J., Verstappen, G., Coyne, M. J., Zhang, X., Durham, T., Miri, M., Deshpande, V., Jager, P. L. D., et al. (2013) · Cell · doi:10.1016/j.cell.2012.12.033 · Cited by 559
RYBP-PRC1 Complexes Mediate H2A Ubiquitylation at Polycomb Target Sites Independently of PRC2 and H3K27me3
Tavares, L., Dimitrova, E., Oxley, D., Webster, J., Poot, R., Demmers, J., Bezstarosti, K., Taylor, S., Ura, H., Koide, H., et al. (2012) · Cell · doi:10.1016/j.cell.2011.12.029 · Cited by 555
Comparative Epigenomic Analysis of Murine and Human Adipogenesis
Mikkelsen, T. S., Xu, Z., Zhang, X., Wang, L., Gimble, J. M., Lander, E. S., & Rosen, E. D. (2010) · Cell · doi:10.1016/j.cell.2010.09.006 · Cited by 526
Identification and characterization of subpopulations in undifferentiated ES cell culture
Toyooka, Y., Shimosato, D., Murakami, K., Takahashi, K., & Niwa, H. (2008) · Development · doi:10.1242/dev.017400 · Cited by 525
Deterministic direct reprogramming of somatic cells to pluripotency
Rais, Y., Zviran, A., Geula, S., Gafni, O., Chomsky, E., Viukov, S., Mansour, A. A., Caspi, I., Krupalnik, V., Zerbib, M., et al. (2013) · Nature · doi:10.1038/nature12587 · Cited by 522
Tet1 is dispensable for maintaining pluripotency and its loss is compatible with embryonic and postnatal development
Dawlaty, M. M., Ganz, K., Powell, B. E., Hu, Y.-C., Markoulaki, S., Cheng, A. W., Gao, Q., Kim, J., Choi, S.-W., Page, D. C., et al. (2011) · Cell stem cell · doi:10.1016/j.stem.2011.07.010 · Cited by 508
The genomic landscape of histone modifications in human T cells
Roh, T.-Y., Cuddapah, S., Cui, K., & Zhao, K. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0607617103 · Cited by 496
Asymmetrically Modified Nucleosomes
Voigt, P., LeRoy, G., Drury, W. J., Zee, B. M., Son, J., Beck, D. B., Young, N. L., Garcia, B. A., & Reinberg, D. (2012) · Cell · doi:10.1016/j.cell.2012.09.002 · Cited by 488
De novo DNA methylation promoted by G9a prevents reprogramming of embryonically silenced genes
Epsztejn‐Litman, S., Feldman, N., Abu-Remaileh, M., Shufaro, Y., Gerson, A., Ueda, J., Deplus, R., Fuks, F., Shinkai, Y., Cedar, H., et al. (2008) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.1476 · Cited by 480
H3K9 methylation is a barrier during somatic cell reprogramming into iPSCs
Chen, J., Liu, H., Liu, J., Qi, J., Wei, B., Yang, J., Liang, H., Chen, Y., Chen, J., Wu, Y., et al. (2013) · Nature Genetics · doi:10.1038/ng.2491 · Cited by 462
Mbd3/NURD Complex Regulates Expression of 5-Hydroxymethylcytosine Marked Genes in Embryonic Stem Cells
Yildirim, O., Li, R., Hung, J.-H., Chen, P. B., Dong, X., Ee, L.-S., Weng, Z., Rando, O. J., & Fazzio, T. G. (2011) · Cell · doi:10.1016/j.cell.2011.11.054 · Cited by 450
An RNAi Screen of Chromatin Proteins Identifies Tip60-p400 as a Regulator of Embryonic Stem Cell Identity
Fazzio, T. G., Huff, J. T., & Panning, B. (2008) · Cell · doi:10.1016/j.cell.2008.05.031 · Cited by 450
G9a/GLP complexes independently mediate H3K9 and DNA methylation to silence transcription
Tachibana, M., Matsumura, Y., Fukuda, M., Kimura, H., & Shinkai, Y. (2008) · The EMBO Journal · doi:10.1038/emboj.2008.192 · Cited by 439
Transcriptional and Epigenetic Dynamics during Specification of Human Embryonic Stem Cells
Gifford, C. A., Ziller, M. J., Gu, H., Trapnell, C., Donaghey, J., Tsankov, A., Shalek, A. K., Kelley, D. R., Shishkin, A. A., Issner, R., et al. (2013) · Cell · doi:10.1016/j.cell.2013.04.037 · Cited by 435
An embryonic stem cell chromatin remodeling complex, esBAF, is an essential component of the core pluripotency transcriptional network
Ho, L., Jothi, R., Ronan, J. L., Cui, K., Zhao, K., & Crabtree, G. R. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0812888106 · Cited by 429
The murine SNF5/INI1 chromatin remodeling factor is essential for embryonic development and tumor suppression
Klochendler‐Yeivin, A., Fiette, L., Barra, J., Muchardt, C., Babinet, C., & Yaniv, M. (2000) · EMBO reports · doi:10.1093/embo-reports/kvd129 · Cited by 406
Histone H3-K9 Methyltransferase ESET Is Essential for Early Development
Dodge, J. E., Kang, Y.-K., Beppu, H., Lei, H., & Li, E. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.6.2478-2486.2004 · Cited by 391
DNA Methylation Dynamics during In Vivo Differentiation of Blood and Skin Stem Cells
Bock, C., Beerman, I., Lien, W., Smith, Z. D., Gu, H., Boyle, P., Gnirke, A., Fuchs, E. V., Rossi, D. J., & Meissner, A. (2012) · Molecular Cell · doi:10.1016/j.molcel.2012.06.019 · Cited by 390
Chromatin-Remodeling Components of the BAF Complex Facilitate Reprogramming
Singhal, N., Graumann, J., Wu, G., Araúzo-Bravo, M. J., Han, D. W., Greber, B., Gentile, L., Mann, M., & Schöler, H. R. (2010) · Cell · doi:10.1016/j.cell.2010.04.037 · Cited by 378
The NuRD component Mbd3 is required for pluripotency of embryonic stem cells
Kaji, K., Caballero, I. M., MacLeod, R., Nichols, J., Wilson, V. A., & Hendrich, B. (2006) · Nature Cell Biology · doi:10.1038/ncb1372 · Cited by 375
Fbxl10/Kdm2b Recruits Polycomb Repressive Complex 1 to CpG Islands and Regulates H2A Ubiquitylation
Wu, X., Johansen, J. V., & Helin, K. (2013) · Molecular Cell · doi:10.1016/j.molcel.2013.01.016 · Cited by 373
Chromatin signature of embryonic pluripotency is established during genome activation
Vastenhouw, N. L., Zhang, Y., Woods, I. G., Imam, F., Regev, A., Liu, X. S., Rinn, J., & Schier, A. F. (2010) · Nature · doi:10.1038/nature08866 · Cited by 373
Tet1 Regulates Adult Hippocampal Neurogenesis and Cognition
Zhang, R.-R., Cui, Q., Murai, K., Lim, Y. C., Smith, Z. D., Jin, S., Ye, P., Rosa, L., Lee, Y. K., Wu, H.-P., et al. (2013) · Cell stem cell · doi:10.1016/j.stem.2013.05.006 · Cited by 367
Rnf2 ( Ring1b ) deficiency causes gastrulation arrest and cell cycle inhibition
Voncken, J. W., Roelen, B. A. J., Roefs, M., de Vries, S., Verhoeven, E., Marino, S., Deschamps, J., & van Lohuizen, M. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0434312100 · Cited by 363
SetDB1 contributes to repression of genes encoding developmental regulators and maintenance of ES cell state
Bilodeau, S., Kagey, M. H., Frampton, G. M., Rahl, P. B., & Young, R. A. (2009) · Genes & Development · doi:10.1101/gad.1837309 · Cited by 356
Nonoverlapping Functions of the Polycomb Group Cbx Family of Proteins in Embryonic Stem Cells
Morey, L., Pascual, G., Cozzuto, L., Roma, G., Wutz, A., Benitah, S. A., & Croce, L. D. (2012) · Cell stem cell · doi:10.1016/j.stem.2011.12.006 · Cited by 347
Functional Anatomy of Polycomb and Trithorax Chromatin Landscapes in Drosophila Embryos
Schuettengruber, B., Ganapathi, M., Leblanc, B., Portoso, M., Jaschek, R., Tolhuis, B., van Lohuizen, M., Tanay, A., & Cavalli, G. (2009) · PLoS Biology · doi:10.1371/journal.pbio.1000013 · Cited by 338
Maternal BRG1 regulates zygotic genome activation in the mousePreprint
Bultman, S. J., Gebuhr, T. C., Pan, H., Svoboda, P., Schultz, R. M., & Magnuson, T. (2006) · Genes & Development · doi:10.1101/gad.1435106 · Cited by 338
Polycomb complexes act redundantly to repress genomic repeats and genes
Leeb, M., Pasini, D., Novatchkova, M., Jaritz, M., Helin, K., & Wutz, A. (2010) · Genes & Development · doi:10.1101/gad.544410 · Cited by 335
A Temporal Chromatin Signature in Human Embryonic Stem Cells Identifies Regulators of Cardiac Development
Paige, S. L., Thomas, S., Stoick-Cooper, C. L., Wang, H., Maves, L., Sandstrom, R. S., Pabon, L., Reinecke, H., Pratt, G. A., Keller, G. M., et al. (2012) · Cell · doi:10.1016/j.cell.2012.08.027 · Cited by 334
Epigenomic annotation of enhancers predicts transcriptional regulators of human neural crest
Rada-Iglesias, A., Bajpai, R., Prescott, S., Brugmann, S. A., Swigut, T., & Wysocka, J. (2012) · Cell stem cell · doi:10.1016/j.stem.2012.07.006 · Cited by 314
Kdm2b maintains murine embryonic stem cell status by recruiting PRC1 complex to CpG islands of developmental genes
He, J., Shen, L., Wan, M., Taranova, O., Wu, H., & Zhang, Y. (2013) · Nature Cell Biology · doi:10.1038/ncb2702 · Cited by 314
Combined Action of PHD and Chromo Domains Directs the Rpd3S HDAC to Transcribed Chromatin
Li, B., Gogol, M., Carey, M., Lee, D., Seidel, C. W., & Workman, J. L. (2007) · Science · doi:10.1126/science.1139004 · Cited by 309
Epigenetics of Reprogramming to Induced Pluripotency
Papp, B., & Plath, K. (2013) · Cell · doi:10.1016/j.cell.2013.02.043 · Cited by 307
The eed mutation disrupts anterior mesoderm production in mice
Faust, C., Schumacher, A., Holdener, B., & Magnuson, T. (1995) · Development · doi:10.1242/dev.121.2.273 · Cited by 294
esBAF facilitates pluripotency by conditioning the genome for LIF/STAT3 signalling and by regulating polycomb function
Ho, L., Miller, E. L., Ronan, J. L., Ho, W. Q., Jothi, R., & Crabtree, G. R. (2011) · Nature Cell Biology · doi:10.1038/ncb2285 · Cited by 273
NuRD‐mediated deacetylation of H3K27 facilitates recruitment of Polycomb Repressive Complex 2 to direct gene repression
Reynolds, N., Salmon‐Divon, M., Dvinge, H., Hynes-Allen, A. M., Balasooriya, G. I., Leaford, D., Behrens, A., Bertone, P., & Hendrich, B. (2011) · The EMBO Journal · doi:10.1038/emboj.2011.431 · Cited by 271
Loss of Gcn5l2 leads to increased apoptosis and mesodermal defects during mouse development
Xu, W., Edmondson, D. G., Evrard, Y. A., Wakamiya, M., Behringer, R. R., & Roth, S. Y. (2000) · Nature Genetics · doi:10.1038/79973 · Cited by 269
H3K27me3 forms BLOCs over silent genes and intergenic regions and specifies a histone banding pattern on a mouse autosomal chromosomePreprint
Pauler, F. M., Sloane, M. A., Huang, R., Regha, K., Koerner, M. V., Tamir, I., Sommer, A., Aszódi, A., Jenuwein, T., & Barlow, D. P. (2008) · Genome Research · doi:10.1101/gr.080861.108 · Cited by 264
Eset partners with Oct4 to restrict extraembryonic trophoblast lineage potential in embryonic stem cellsPreprint
Yuan, P., Han, J., Guo, G., Orlov, Y. L., Huss, M., Loh, Y., Yaw, L. P., Robson, P., Lim, B., & Ng, H. (2009) · Genes & Development · doi:10.1101/gad.1831909 · Cited by 261
A Hierarchy of H3K4me3 and H3K27me3 Acquisition in Spatial Gene Regulation in Xenopus Embryos
Akkers, R. C., van Heeringen, S. J., Jacobi, U. G., Janssen‐Megens, E. M., Françoijs, K., Stunnenberg, H. G., & Veenstra, G. J. C. (2009) · Developmental Cell · doi:10.1016/j.devcel.2009.08.005 · Cited by 255
DNA methylation in ES cells requires the lysine methyltransferase G9a but not its catalytic activity
Dong, K., Maksakova, I. A., Mohn, F., Leung, D., Appanah, R., Lee, S., Yang, H. C., Lam, L. L. C., Mager, D. L., Schübeler, D., et al. (2008) · The EMBO Journal · doi:10.1038/emboj.2008.193 · Cited by 253
TrxG and PcG Proteins but Not Methylated Histones Remain Associated with DNA through Replication
Petruk, S., Sedkov, Y., Johnston, D. M., Hodgson, J. W., Black, K. L., Kovermann, S. K., Beck, S., Canaani, E., Brock, H. W., & Mazo, A. (2012) · Cell · doi:10.1016/j.cell.2012.06.046 · Cited by 251
Synergistic Function of DNA Methyltransferases Dnmt3a and Dnmt3b in the Methylation of Oct4 and Nanog
Li, J., Pu, M., Hirasawa, R., Li, B.-Z., Huang, Y.-N., Zeng, R., Jing, N.-H., Chen, T., Li, E., Sasaki, H., et al. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.01380-07 · Cited by 248
Self-citation
Dynamic Chromatin Remodeling Mediated by Polycomb Proteins Orchestrates Pancreatic Differentiation of Human Embryonic Stem Cells
Xie, R., Everett, L. J., Lim, H., Patel, N. A., Schug, J., KROON, E. J., Kelly, O., Wang, A., D’Amour, K. A., Robins, A. J., et al. (2013) · Cell stem cell · doi:10.1016/j.stem.2012.11.023 · Cited by 246
SWI/SNF-Brg1 Regulates Self-Renewal and Occupies Core Pluripotency-Related Genes in Embryonic Stem Cells
Kidder, B. L., Palmer, S. S., & Knott, J. G. (2008) · Stem Cells · doi:10.1634/stemcells.2008-0710 · Cited by 245
Distinct histone modifications in stem cell lines and tissue lineages from the early mouse embryo
Rugg‐Gunn, P. J., Cox, B., Ralston, A., & Rossant, J. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0914507107 · Cited by 244
NuRD suppresses pluripotency gene expression to promote transcriptional heterogeneity and lineage commitment
Reynolds, N., Latos, P., Hynes-Allen, A., Loos, R., Leaford, D., O'Shaughnessy, A., Mosaku, O., Signolet, J., Brennecke, P., Kalkan, T., et al. (2012) · Cell Stem Cell · doi:10.1016/j.stem.2012.02.020 · Cited by 236
Distinct but overlapping roles of histone acetylase PCAF and of the closely related PCAF-B/GCN5 in mouse embryogenesis
Yamauchi, T., Yamauchi, J., Kuwata, T., Tamura, T., Yamashita, T., Bae, N. S., Westphal, H., Ozato, K., & Nakatani, Y. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.21.11303 · Cited by 236
Genome-wide Chromatin Interactions of the Nanog Locus in Pluripotency, Differentiation, and Reprogramming
Apostolou, E., Ferrari, F., Walsh, R. M., Bar‐Nur, O., Stadtfeld, M., Cheloufi, S., Stuart, H. T., Polo, J. M., Ohsumi, T. K., Borowsky, M. L., et al. (2013) · Cell stem cell · doi:10.1016/j.stem.2013.04.013 · Cited by 223
The Mammalian Ortholog of Drosophila MOF That Acetylates Histone H4 Lysine 16 Is Essential for Embryogenesis and Oncogenesis
Gupta, A. K. D., Guerin-Peyrou, T. G., Sharma, G. G., Park, C., Agarwal, M., Ganju, R. K., Pandita, S., Choi, K., Sukumar, S. V., PANDITA, R. K., et al. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.01045-07 · Cited by 223
RNF20 and USP44 Regulate Stem Cell Differentiation by Modulating H2B Monoubiquitylation
Fuchs, G., Shema, E., Vesterman, R., Kotler, E., Wolchinsky, Z., Wilder, S., Golomb, L., Pribluda, A., Zhang, F., Haj‐Yahya, M., et al. (2012) · Molecular Cell · doi:10.1016/j.molcel.2012.05.023 · Cited by 220
MicroRNA Regulation of Cbx7 Mediates a Switch of Polycomb Orthologs during ESC Differentiation
O’Loghlen, A., Muñoz-Cabello, A. M., Gaspar‐Maia, A., Wu, H., Banito, A., Kunowska, N., Racek, T., Pemberton, H. N., Beolchi, P., Lavial, F., et al. (2012) · Cell stem cell · doi:10.1016/j.stem.2011.12.004 · Cited by 219
Klf4 Organizes Long-Range Chromosomal Interactions with the Oct4 Locus in Reprogramming and Pluripotency
Wei, Z., Gao, F., Kim, S., Yang, H., Lyu, J., An, W., Wang, K., & Lu, W. (2013) · Cell Stem Cell · doi:10.1016/j.stem.2013.05.010 · Cited by 214
Chromatin “Prepattern” and Histone Modifiers in a Fate Choice for Liver and Pancreas
Xu, C., Cole, P. A., Meyers, D. J., Kormish, J. D., Dent, S., & Zaret, K. S. (2011) · Science · doi:10.1126/science.1202845 · Cited by 210
Self-citation
Srg3, a Mouse Homolog of Yeast SWI3, Is Essential for Early Embryogenesis and Involved in Brain Development
Kim, J. K., Huh, S., Choi, H., Lee, K.-S., Shin, D., Lee, C., Nam, J., Kim, H., Chung, H., Lee, H. W., et al. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.22.7787-7795.2001 · Cited by 201
Genome-wide Maps of Histone Modifications Unwind In Vivo Chromatin States of the Hair Follicle Lineage
Lien, W.-H., Guo, X., Polak, L., Lawton, L. N., Young, R. A., Zheng, D., & Fuchs, E. (2011) · Cell Stem Cell · doi:10.1016/j.stem.2011.07.015 · Cited by 199
The Histone Acetyltransferase MOF Is a Key Regulator of the Embryonic Stem Cell Core Transcriptional Network
Li, X., Li, L., Pandey, R., Byun, J. S., Gardner, K., Qin, Z. S., & Dou, Y. (2012) · Cell stem cell · doi:10.1016/j.stem.2012.04.023 · Cited by 192
Gcn5 and SAGA Regulate Shelterin Protein Turnover and Telomere Maintenance
Atanassov, B. S., Evrard, Y. A., Multani, A. S., Zhang, Z., Tora, L., Devys, D., Chang, S. S., & Dent, S. (2009) · Molecular Cell · doi:10.1016/j.molcel.2009.06.015 · Cited by 188
Self-citation
Mof (MYST1 or KAT8) Is Essential for Progression of Embryonic Development Past the Blastocyst Stage and Required for Normal Chromatin Architecture
Thomas, T., Dixon, M. P., Kueh, A. J., & Voss, A. K. (2008) · Molecular and Cellular Biology · doi:10.1128/mcb.02202-07 · Cited by 185
Polycomb Proteins Remain Bound to Chromatin and DNA during DNA Replication In Vitro
Francis, N. J., Follmer, N. E., Simon, M. D., Aghia, G., & Butler, J. D. (2009) · Cell · doi:10.1016/j.cell.2009.02.017 · Cited by 183
Mbd3, a component of the NuRD co-repressor complex, is required for development of pluripotent cells
Kaji, K., Nichols, J., & Hendrich, B. (2007) · Development · doi:10.1242/dev.02802 · Cited by 180
Histone variants in pluripotency and disease
Skene, P. J., & Henikoff, S. (2013) · Development · doi:10.1242/dev.091439 · Cited by 164
L3MBTL2 Protein Acts in Concert with PcG Protein-Mediated Monoubiquitination of H2A to Establish a Repressive Chromatin Structure
Trojer, P., Cao, A. R., Gao, Z., Li, Y., Zhang, J., Xu, X., Li, G., Losson, R., Erdjument‐Bromage, H., Tempst, P., et al. (2011) · Molecular Cell · doi:10.1016/j.molcel.2011.04.004 · Cited by 159
Making copies of chromatin: the challenge of nucleosomal organization and epigenetic information
Corpet, A., & Almouzni, G. (2008) · Trends in Cell Biology · doi:10.1016/j.tcb.2008.10.002 · Cited by 158
The Histone H2B Monoubiquitination Regulatory Pathway Is Required for Differentiation of Multipotent Stem Cells
Karpiuk, O., Najafova, Z., Krämer, F., Hennion, M., Galonska, C., König, A., Snaidero, N., Vogel, T., Shchebet, A., Begus‐Nahrmann, Y., et al. (2012) · Molecular Cell · doi:10.1016/j.molcel.2012.05.022 · Cited by 155
Genomic Prevalence of Heterochromatic H3K9me2 and Transcription Do Not Discriminate Pluripotent from Terminally Differentiated Cells
Lienert, F., Mohn, F., Tiwari, V. K., Baubec, T., Roloff, T. C., Gaidatzis, D., Stadler, M. B., & Schübeler, D. (2011) · PLoS Genetics · doi:10.1371/journal.pgen.1002090 · Cited by 149
Disruption of Trrap causes early embryonic lethality and defects in cell cycle progression
Herceg, Z., Hulla, W., Gell, D. A., Cuenin, C., LLeonart, M. E., Jackson, S. P., & Wang, Z. (2001) · Nature Genetics · doi:10.1038/ng725 · Cited by 148
Loss of Gcn5 Acetyltransferase Activity Leads to Neural Tube Closure Defects and Exencephaly in Mouse Embryos
Bu, P., Evrard, Y. A., Lozano, G., & Dent, S. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.00066-07 · Cited by 146
Self-citation
USP22 regulates cell proliferation by deubiquitinating the transcriptional regulator FBP1
Atanassov, B. S., & Dent, S. Y. R. (2011) · The EMBO Reports · doi:10.1038/embor.2011.140 · Cited by 144
Self-citation
The Polycomb Group Protein L3mbtl2 Assembles an Atypical PRC1-Family Complex that Is Essential in Pluripotent Stem Cells and Early Development
Qin, J., Whyte, W. A., Anderssen, E., Apostolou, E., Chen, H.-H., Akbarian, S., Bronson, R. T., Hochedlinger, K., Ramaswamy, S., Young, R. A., et al. (2012) · Cell stem cell · doi:10.1016/j.stem.2012.06.002 · Cited by 134
Formation of an Active Tissue-Specific Chromatin Domain Initiated by Epigenetic Marking at the Embryonic Stem Cell Stage
Szutorisz, H., Canzonetta, C., Georgiou, A., Chow, C.-M., Tora, L., & Dillon, N. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.5.1804-1820.2005 · Cited by 131
ERG-associated protein with SET domain (ESET)-Oct4 interaction regulates pluripotency and represses the trophectoderm lineage
Yeap, L.-S., Hayashi, K., & Surani, M. A. (2009) · Epigenetics & Chromatin · doi:10.1186/1756-8935-2-12 · Cited by 126
Ring1B and Suv39h1 delineate distinct chromatin states at bivalent genes during early mouse lineage commitment
Alder, O., Lavial, F., Helness, A., Brookes, E., Pinho, S., Chandrashekran, A., Arnaúd, P., Pombo, A., O’Neill, L. P., & Azuara, V. (2010) · Development · doi:10.1242/dev.048363 · Cited by 122
Homozygous disruption of the tip60 gene causes early embryonic lethality
Hu, Y., Fisher, J. B., Koprowski, S. L., McAllister, D. M., Kim, M., & Lough, J. (2009) · Developmental Dynamics · doi:10.1002/dvdy.22110 · Cited by 121
Histone H3 Lysine 27 Methylation Asymmetry on Developmentally-Regulated Promoters Distinguish the First Two Lineages in Mouse Preimplantation Embryos
Dahl, J. A., Reiner, A. H., Klungland, A., Wakayama, T., & Collas, P. (2010) · PLoS ONE · doi:10.1371/journal.pone.0009150 · Cited by 113
Rybp/DEDAF Is Required for Early Postimplantation and for Central Nervous System Development
Pirity, M. K., Locker, J. D., & Schreiber‐Agus, N. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.16.7193-7202.2005 · Cited by 102
Cell Fate Potential of Human Pluripotent Stem Cells Is Encoded by Histone Modifications
Hong, S., Rampalli, S., Lee, J. B., McNicol, J. D., Collins, T., Draper, J. S., & Bhatia, M. (2011) · Cell stem cell · doi:10.1016/j.stem.2011.06.002 · Cited by 98
RYBP Represses Endogenous Retroviruses and Preimplantation- and Germ Line-Specific Genes in Mouse Embryonic Stem Cells
Hisada, K., Sánchez, C., Endo, T. A., Endoh, M., Román-Trufero, M., Sharif, J., Koseki, H., & Vidal, M. (2012) · Molecular and Cellular Biology · doi:10.1128/mcb.06441-11 · Cited by 93
KMT1E Mediated H3K9 Methylation Is Required for the Maintenance of Embryonic Stem Cells by Repressing Trophectoderm Differentiation
Lohmann, F., Loureiro, J., Su, H., Fang, Q., Lei, H., Lewis, T., Yang, Y., Labow, M., Li, E., Chen, T., et al. (2009) · Stem Cells · doi:10.1002/stem.278 · Cited by 93
Self-citation
Promoter DNA Methylation Patterns of Differentiated Cells Are Largely Programmed at the Progenitor Stage
Sørensen, A. L., Jacobsen, B. M., Reiner, A. H., Andersen, I. S., & Collas, P. (2010) · Molecular Biology of the Cell · doi:10.1091/mbc.e10-01-0018 · Cited by 83
Genome-wide map of quantified epigenetic changes during in vitro chondrogenic differentiation of primary human mesenchymal stem cells
Herlofsen, S. R., Bryne, J. C., Høiby, T., Wang, L., Issner, R., Zhang, X., Coyne, M. J., Boyle, P., Gu, H., Meza‐Zepeda, L. A., et al. (2013) · BMC Genomics · doi:10.1186/1471-2164-14-105 · Cited by 79
Dnmt3a regulates both proliferation and differentiation of mouse neural stem cells
Wu, Z., Huang, K. Y., Yu, J., Le, T. T., Namihira, M., Liu, Y., Zhang, J., Xue, Z., Cheng, L., & Fan, G. (2012) · Journal of Neuroscience Research · doi:10.1002/jnr.23077 · Cited by 76
Differential preimplantation regulation of two mouse homologues of the yeast SWI2 protein
Legouy, E., Thompson, E. M., Muchardt, C., & Renard, J. P. J. P. (1998) · Developmental Dynamics · Cited by 72
Chromatin: Receiver and Quarterback for Cellular Signals
Johnson, D. G., & Dent, S. (2013) · Cell · doi:10.1016/j.cell.2013.01.017 · Cited by 71
Self-citation
Ultrastructure of Human Embryonic Stem Cells and Spontaneous and Retinoic Acid-Induced Differentiating Cells
Park, S., Park, S. H., Kook, M., Kim, E., Park, S., & Lim, J. H. (2004) · Ultrastructural Pathology · doi:10.1080/01913120490515595 · Cited by 64
Developmental potential of Gcn5−/− embryonic stem cells in vivo and in vitro
Lin, W., Srajer, G., Evrard, Y. A., et al. (2007) · Developmental Dynamics · doi:10.1002/dvdy.21160 · Cited by 63
Brg1 Governs a Positive Feedback Circuit in the Hair Follicle for Tissue Regeneration and Repair
Xiong, Y., Li, W., Shang, C., Chen, R. M., Han, P., Yang, J., Stankunas, K., Wu, B., Pan, M., Zhou, B., et al. (2013) · Developmental Cell · doi:10.1016/j.devcel.2013.03.015 · Cited by 61
Histone ubiquitylation and chromatin dynamics
Wright, D. E. (2011) · Frontiers in bioscience · doi:10.2741/3973 · Cited by 56
Mbd3, a Component of NuRD/Mi-2 Complex, Helps Maintain Pluripotency of Mouse Embryonic Stem Cells by Repressing Trophectoderm Differentiation
Zhu, D., Fang, J., Li, Y., & Zhang, J. (2009) · PLoS ONE · doi:10.1371/journal.pone.0007684 · Cited by 53
Switching cell fate, ncRNAs coming to play
Guan, D., Zhang, W., Zhang, W., Liu, G.-H., & Belmonte, J. C. I. (2013) · Cell Death and Disease · doi:10.1038/cddis.2012.196 · Cited by 52
Histone H2B lysine 120 monoubiquitination is required for embryonic stem cell differentiation
Chen, S., Li, J., Wang, D.-L., & Sun, F.-L. (2012) · Cell Research · doi:10.1038/cr.2012.114 · Cited by 52
Histone Acetyltransferase Cofactor Trrap Maintains Self-Renewal and Restricts Differentiation of Embryonic Stem Cells
Sawan, C., Hernández‐Vargas, H., Murr, R., Lopez, F., Vaissière, T., Ghantous, A., Cuenin, C., Imbert, J., Wang, Z., Ren, B., et al. (2013) · Stem Cells · doi:10.1002/stem.1341 · Cited by 32
NuRD-dependent DNA methylation prevents ES cells from accessing a trophectoderm fate
Latos, P. A., Helliwell, C., Mosaku, O., Dudzińska, D., Stubbs, B. A., Berdasco, M., Esteller, M., & Hendrich, B. (2012) · Biology Open · doi:10.1242/bio.2012513 · Cited by 23

ATAC-seq: a method for assaying chromatin accessibility genome-wide
Buenrostro, J. D., Wu, B., Chang, H. Y., & Greenleaf, W. J. (2015) · Current Protocols in Molecular Biology · doi:10.1002/0471142727.mb2129s109 · Cited by 3,289
Advancing the understanding of autism disease mechanisms through genetics
de la Torre-Ubieta, L., Won, H., Stein, J. L., & Geschwind, D. H. (2016) · Nature Medicine · doi:10.1038/nm.4071 · Cited by 827
Tet2 is required to resolve inflammation by recruiting Hdac2 to specifically repress IL-6
Zhang, Q., Zhao, K., Shen, Q., Han, Y., Gu, Y., Li, X., Zhao, D., Liu, Y., Wang, C., Zhang, X., et al. (2015) · Nature · doi:10.1038/nature15252 · Cited by 807
Establishing neural crest identity: a gene regulatory recipe
Simões-Costa, M., & Bronner, M. E. (2015) · Development · doi:10.1242/dev.105445 · Cited by 649
The IBD interactome: an integrated view of aetiology, pathogenesis and therapy
de Souza, H. S. P., Fiocchi, C., & Iliopoulos, D. (2017) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2017.110 · Cited by 447

See all 619

Authors: Chen, T., & Dent, S. Y. R.
Venue: Nature Reviews Genetics
Publisher: Springer Science and Business Media LLC
Published: 2013-12-24
Volume: 15
Issue: 2
Pages: 93-106
ISSN: 1471-0056
1471-0064
DOI: 10.1038/nrg3607
PMC: PMC3999985
Cited by: 619
References: 141
Language: en
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.

Chromatin modifiers and remodellers: regulators of cellular differentiation

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Metadata

Record

About these checks

Data sources