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Methods for the directed evolution of proteins
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Cites
Programming cells by multiplex genome engineering and accelerated evolution
Wang, H. H., Isaacs, F. J., Carr, P. A., Sun, Z. Z., Xu, G., Forest, C. R., & Church, G. M. (2009) · Nature · doi:10.1038/nature08187 · Cited by 1,529
Engineering Yeast Transcription Machinery for Improved Ethanol Tolerance and Production
Alper, H., Moxley, J., Nevoigt, E., Fink, G. R., & Stephanopoulos, G. (2006) · Science · doi:10.1126/science.1131969 · Cited by 823
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Alley, E. C., Khimulya, G., Biswas, S., AlQuraishi, M., & Church, G. M. (2019) · Nature Methods · doi:10.1038/s41592-019-0598-1 · Cited by 1,131
Low-N protein engineering with data-efficient deep learning
Biswas, S., Khimulya, G., Alley, E. C., Esvelt, K. M., & Church, G. M. (2021) · Nature Methods · doi:10.1038/s41592-021-01100-y · Cited by 422
Mason, D. M., Friedensohn, S., Weber, C. R., Jordi, C., Wagner, B., Meng, S. M., Ehling, R. A., Bonati, L., Dahinden, J., Gainza, P., et al. (2021) · Nature Biomedical Engineering · doi:10.1038/s41551-021-00699-9 · Cited by 308
Methods and Applications of CRISPR-Mediated Base Editing in Eukaryotic Genomes
Hess, G. T., Tycko, J., Yao, D., & Bassik, M. C. (2017) · Molecular Cell · doi:10.1016/j.molcel.2017.09.029 · Cited by 234
How DNA polymerases catalyse replication and repair with contrasting fidelity
Wu, W.-J., Yang, W., & Tsai, M.-D. (2017) · Nature Reviews Chemistry · doi:10.1038/s41570-017-0068 · Cited by 76
Recent advances in gene therapy for neurodevelopmental disorders with epilepsy
Turner, T. J., Zourray, C., Schorge, S., & Lignani, G. (2021) · Journal of Neurochemistry · doi:10.1111/jnc.15168 · Cited by 71
Molecular Evolution of Transition Metal Bioavailability at the Host–Pathogen Interface
Antelo, G. T., Vila, A. J., Giedroc, D. P., & Capdevila, D. A. (2021) · Trends in Microbiology · doi:10.1016/j.tim.2020.08.001 · Cited by 63
Directed Search: A New Operator in NSGA-II for Task Scheduling in IoT Based on Cloud-Fog Computing
Mousavi, S., Mood, S. E., Souri, A., & Javidi, M. M. (2023) · IEEE Transactions on Cloud Computing · doi:10.1109/tcc.2022.3188926 · Cited by 51
A combinatorially complete epistatic fitness landscape in an enzyme active site
Johnston, K. E., Almhjell, P. J., Watkins-Dulaney, E. J., Liu, G., Porter, N. J., Yang, J., & Arnold, F. H. (2024) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2400439121 · Cited by 44
Protein engineering by highly parallel screening of computationally designed variants
Sun, M. G. F., Seo, M.-H., Nim, S., Corbi-Verge, C., & Kim, P. M. (2016) · Science Advances · doi:10.1126/sciadv.1600692 · Cited by 41
Mutexa: A Computational Ecosystem for Intelligent Protein Engineering
Yang, Z. J., Shao, Q., Jiang, Y., Jurich, C., Ran, X., Juarez, R. J., Yan, B., Stull, S. L., Gollu, A., & Ding, N. (2023) · Journal of Chemical Theory and Computation · doi:10.1021/acs.jctc.3c00602 · Cited by 28
Selecting Better Biocatalysts by Complementing Recoded Bacteria**
Rubini, R., Jansen, S. C., Beekhuis, H., Rozeboom, H. J., & Mayer, C. (2023) · Angewandte Chemie International Edition · doi:10.1002/anie.202213942 · Cited by 15
Komp, E., Alanzi, H. N., Francis, R., Vuong, C., Roberts, L., Mosallanejad, A., & Beck, D. A. C. (2023) · Scientific Data · doi:10.1038/s41597-023-02553-w · Cited by 7
A chimeric viral platform for directed evolution in mammalian cells
Cole, A. J., Denes, C. E., Moreno, C. L., Hunault, L., Dobson, T., Hesselson, D., & Neely, G. G. (2025) · Nature Communications · doi:10.1038/s41467-025-59438-2 · Cited by 7
Exploring Evolution to Uncover Insights Into Protein Mutational Stability
Hermans, P., Tsishyn, M., Schwersensky, M., Rooman, M., & Pucci, F. (2025) · Molecular Biology and Evolution · doi:10.1093/molbev/msae267 · Cited by 6
Steady Out‐of‐Equilibrium Chemistry: What? Why? How?
Plasson, R., & Jullien, L. (2025) · ChemSystemsChem · doi:10.1002/syst.202500011 · Cited by 3
A high-throughput biocatalytic platform for screening isomeric kainoid natural products
Shepherd, R. A., Ramachandra, M., Hopiavuori, A. R., Jones, M. C., Fihn, C. A., Tabag, A. J., Manjunath, A., Gad, L. Y., Whipple, C. R., McKinnie, S. M. K., et al. (2026) · Cell Reports Physical Science · doi:10.1016/j.xcrp.2025.103092 · Cited by 2
Metadata
- Authors
- Packer, M. S., & Liu, D. R.
- Venue
- Nature Reviews Genetics
- Published
- 2015-06-09
- Volume
- 16
- Issue
- 7
- Pages
- 379-394
- ISSN
- 1471-0056 (ISSN-L)
- 1471-0064
- OpenAlex
- W1954202239
- Cited by
- 991
- References
- 2
- FWCI
- 5.39
- Type
- journal article
- Language
- en
- Open access
- closed
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
