Cited by 1,076Genetic Associations and EpidemiologyGenetic Mapping and Diversity in Plants and AnimalsHealth, Environment, Cognitive Aging

The DOI matches its Crossref record; 62 of the 63 references it cites were found in a registry or an index.

Candidate-gene approaches for studying complex genetic traits: practical considerations

Tabor, Holly K., Risch, Neil J., Myers, Richard M.·2002·Nature Reviews Genetics

DOI 10.1038/nrg796

Open this paper in CoChat — free account

Abstract

Association studies with candidate genes have been widely used for the study of complex diseases. However, this approach has been criticized because of non-replication of results and limits on its ability to include all possible causative genes and polymorphisms. These challenges have led to pessimism about the candidate-gene approach and about the genetic analysis of complex diseases in general. We believe that these criticisms can be usefully countered with an appeal to the principles of epidemiological investigation.

Integrity signals

Registry

Crossref · 10.1038/nrg796

Cites

62 of 62 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Initial sequencing and analysis of the human genome
International Human Genome Sequencing Consortium, Whitehead Institute for Biomedical Research, C. F. G. R., Lander, E. S., Linton, L. M., Birren, B., Nusbaum, C., Zody, M. C., Baldwin, J., Devon, K., Dewar, K., et al. (2001) · Nature · doi:10.1038/35057062 · Cited by 24,216
Molecular portraits of human breast tumours
Perou, C., Sørlie, T., Eisen, M., van de Rijn, M., Jeffrey, S., Rees, C. A., Pollack, J., Ross, D., Johnsen, H., Akslen, L., et al. (2000) · Nature · doi:10.1038/35021093 · Cited by 16,551
The sequence of the human genome
Venter, J. C., Adams, M. D., Myers, E. W., Li, P. W., Mural, R. J., Sutton, G. G., Smith, H. O., Yandell, M., Evans, C. A., Holt, R. A., et al. (2001) · Science · doi:10.1126/science.1058040 · Cited by 13,909
Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease
Hugot, J.-P., Chamaillard, M., Zouali, H., Lesage, S., Cézard, J.-P., Belaiche, J., Almer, S., Tysk, C., O'Morain, C. A., Gassull, M., et al. (2001) · Nature · doi:10.1038/35079107 · Cited by 5,591
The Future of Genetic Studies of Complex Human Diseases
Risch, N., & Merikangas, K. (1996) · Science · doi:10.1126/science.273.5281.1516 · Cited by 5,355
Self-citation
A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease
Ogura, Y., Bonen, D. K., Inohara, N., Nicolae, D. L., Chen, F. F., Ramos, R., Britton, H., Moran, T., Karaliuskas, R., Duerr, R. H., et al. (2001) · Nature · doi:10.1038/35079114 · Cited by 5,030
A map of human genome sequence variation containing 1.42 million single nucleotide polymorphisms
The International SNP Map Working Group, Laboratories:, C. S. H., Sachidanandam, R., Weissman, D., Schmidt, S. C., Kakol, J. M., Stein, L. D., National Center for Biotechnology Information:, Marth, G., Sherry, S., et al. (2001) · Nature · doi:10.1038/35057149 · Cited by 2,977
Amino Acid Difference Formula to Help Explain Protein Evolution
Grantham, R. L. (1974) · Science · doi:10.1126/science.185.4154.862 · Cited by 2,363
Epidemiology in Medicine
Hennekens, C. H., Buring, J. E., & Mayrent, S. L. (1987) · Medical Entomology and Zoology · Cited by 2,319
Listening to silence and understanding nonsense: exonic mutations that affect splicing
Cartegni, L., Chew, S. L., & Krainer, A. R. (2002) · Nature Reviews Genetics · doi:10.1038/nrg775 · Cited by 2,209

Flagged first, then by citations

Show all 63 references

1 of the 63 references couldn’t be matched to a known paper.

Research works printed but not linked: 1

Rothman, K. J. & Greenland, S. Modern Epidemiology, 2nd edn (Lippincott Raven, Philadelphia, 1998).

Sorted by citations

Items 201–300 of 1,000

Haplotype Analysis Improved Evidence for Candidate Genes for Intramuscular Fat Percentage from a Genome Wide Association Study of Cattle
Barendse, W. (2011) · PLoS ONE · doi:10.1371/journal.pone.0029601 · Cited by 61
DNA sequence polymorphisms in a panel of eight candidate bovine imprinted genes and their association with performance traits in Irish Holstein-Friesian cattle
Magee, D. A., Sikora, K. M., Berkowicz, E. W., Berry, D. P., Howard, D. J., Mullen, M. P., Evans, R. D., Spillane, C., & MacHugh, D. E. (2010) · BMC Genetics · doi:10.1186/1471-2156-11-93 · Cited by 60
Genetic variation in TP53 and risk of breast cancer in a population-based case–control study
Sprague, B. L., Trentham‐Dietz, A., García‐Closas, M., Newcomb, P. A., Titus-Ernstoff, L. T., Hampton, J. M., Chanock, S. J., Haines, J. L., & Egan, K. M. (2007) · Carcinogenesis · doi:10.1093/carcin/bgm097 · Cited by 60
Linkage and association with the NOS2A locus on chromosome 17q11 in multiple sclerosis
Barcellos, L. F., Begovich, A. B., Reynolds, R., Caillier, S. J., Brassat, D., Schmidt, S., Grams, S. E., Walker, K., Steiner, L. L., Cree, B., et al. (2004) · Annals of Neurology · doi:10.1002/ana.20092 · Cited by 60
The quest for quantitative trait loci associated with intelligence
Plomin, R. J., Kennedy, J. K. J., & Craig, I. (2006) · Intelligence · doi:10.1016/j.intell.2006.01.001 · Cited by 59
Identification of possible genetic polymorphisms involved in cancer cachexia: a systematic review
Tan, B. H. L., Ross, J. A., Kaasa, S., Skorpen, F., & Fearon, K. C. H. (2011) · Journal of Genetics · doi:10.1007/s12041-011-0027-4 · Cited by 57
Genetics of juvenile idiopathic arthritis: an update
Prahalad, S. (2004) · Current Opinion in Rheumatology · doi:10.1097/01.bor.0000134407.48586.b0 · Cited by 60
Bioinformatic Prediction of Leader Genes in Human Periodontitis
Covani, U., Marconcini, S., Giacomelli, L., Sivozhelevov, V., Barone, A. A., & Nicolini, C. A. (2008) · Journal of Periodontology · doi:10.1902/jop.2008.080062 · Cited by 59
Commentary: Nature–nurture interplay in emotional disorders
Rutter, M. L. (2003) · Journal of Child Psychology and Psychiatry · doi:10.1111/1469-7610.00178 · Cited by 61
Individual Differences in Intertemporal Choice
Keidel, K., Rramani, Q., Weber, B., Murawski, C., & Ettinger, U. (2021) · Frontiers in Psychology · doi:10.3389/fpsyg.2021.643670 · Cited by 66
Amphibian molecular ecology and how it has informed conservation
McCartney‐Melstad, E., & Shaffer, H. B. (2015) · Molecular Ecology · doi:10.1111/mec.13391 · Cited by 57
Replication of the association between the thrombospondin-4 A387P polymorphism and myocardial infarction
Wessel, J., Topol, E. J., Ji, M. H., Meyer, J. M., & McCarthy, J. J. (2004) · American Heart Journal · doi:10.1016/j.ahj.2003.12.013 · Cited by 58
Genetic basis of rheumatoid arthritis
Dieudé, P., & Cornélis, F. (2005) · Joint Bone Spine · doi:10.1016/j.jbspin.2005.09.001 · Cited by 57
The contribution of HLA genes to IBD susceptibility and phenotype
Yap, L. M., Ahmad, T., & Jewell, D. P. (2004) · Best Practice & Research Clinical Gastroenterology · doi:10.1016/j.bpg.2004.01.003 · Cited by 59
New Paradigms in Cardiovascular Medicine
Podgoreanu, M. V., & Schwinn, D. A. (2005) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2005.08.040 · Cited by 58
Matrix metalloproteinase circulating levels, genetic polymorphisms, and susceptibility to acute myocardial infarction among patients with coronary artery disease
Hlatky, M. A., Ashley, E. A., Quertermous, T., Boothroyd, D. B., Ridker, P. M., Southwick, A. M., Myers, R., Iribarren, C., Fortmann, S. P., & Go, A. S. (2007) · American Heart Journal · doi:10.1016/j.ahj.2007.06.042 · Cited by 57
Self-citation
Current status of understanding of the genetic etiology of coronary heart disease
Pranavchand, R., & Reddy, B. (2013) · Journal of Postgraduate Medicine · doi:10.4103/0022-3859.109492 · Cited by 58
Applications of the 1000 Genomes Project resources
Zheng-Bradley, X., & Flicek, P. (2016) · Briefings in Functional Genomics · doi:10.1093/bfgp/elw027 · Cited by 61
Genetics of Childhood Disorders: XLVII. Autism, Part 6: Duplication and Inherited Susceptibility of Chromosome 15q11-q13 Genes in Autism
Sutcliffe, J. S., & Nurmi, E. L. (2003) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-200302000-00021 · Cited by 57
Association between C1019T polymorphism of connexin37 and acute myocardial infarction: a study in patients from Sicily
Listı̀, F., Candore, G., Lio, D., Russo, M., Colonna‐Romano, G., Caruso, M., Hoffmann, E., & Caruso, C. (2004) · International Journal of Cardiology · doi:10.1016/j.ijcard.2004.05.031 · Cited by 56
Genetic mechanisms of parenting
Mileva‐Seitz, V. R., Bakermans‐Kranenburg, M. J., & van IJzendoorn, M. H. (2015) · Hormones and Behavior · doi:10.1016/j.yhbeh.2015.06.003 · Cited by 58
Methotrexate Pharmacogenetics in Rheumatoid Arthritis: a Status Report
Malik, F., & Ranganathan, P. (2013) · Pharmacogenomics · doi:10.2217/pgs.12.214 · Cited by 55
Unraveling the Genetic Basis of Seed Tocopherol Content and Composition in Rapeseed (Brassica napus L.)
Wang, X., Zhang, C., Li, L., Fritsche, S., Endrigkeit, J., Zhang, W., Yan, L., Jung, C., & Meng, J. (2012) · PLoS ONE · doi:10.1371/journal.pone.0050038 · Cited by 56
Mining Disease Susceptibility Genes through SNP Analyses and Expression Profiling Using MALDI-TOF Mass Spectrometry
Tang, K., Oeth, P. A., Kammerer, S., Denissenko, M. F., Ekblom, J., Jurinke, C., van den Boom, D., Braun, A. D., & Cantor, C. R. (2004) · Journal of Proteome Research · doi:10.1021/pr034080s · Cited by 54
ALDH1A2 (RALDH2) genetic variation in human congenital heart disease
Pavan, M., Ruiz, V. F., Silva, F. D., Sobreira, T. J. P., Cravo, R. M., Vasconcelos, M., Marques, L. P., Mesquita, S. M., Krieger, J. E., Lopes, A. A., et al. (2009) · BMC Medical Genetics · doi:10.1186/1471-2350-10-113 · Cited by 55
Linkage and association of myocilin (MYOC) polymorphisms with high myopia in a Chinese population.
Tang, W. C., Yip, S. P., Lo, K. K., Ng, P. W., Choi, P. S., Lee, S. Y., & Yap, M. K. H. (2007) · PubMed Central · Cited by 54
Genotyping of single nucleotide polymorphisms in cytokine genes using real-time PCR allelic discrimination technology*1
Johnson, V. J. (2004) · Cytokine · doi:10.1016/j.cyto.2004.05.002 · Cited by 53
Association of polymorphisms in platelet and hemostasis system genes with acute myocardial infarction
Knowles, J. W., Wang, H., Itakura, H., Southwick, A. M., Myers, R., Iribarren, C., Fortmann, S. P., Go, A. S., Quertermous, T., & Hlatky, M. A. (2007) · American Heart Journal · doi:10.1016/j.ahj.2007.05.021 · Cited by 53
Self-citation
Epigenetics in bipolar disorder: a critical review of the literature
Legrand, A., Iftimovici, A., Khayachi, A., & Chaumette, B. (2021) · Psychiatric Genetics · doi:10.1097/ypg.0000000000000267 · Cited by 48
Do Genomic Factors Play a Role in Diabetic Retinopathy?
Cabrera, A. P., Monickaraj, F., Rangasamy, S., Hobbs, S., McGuire, P. G., & Das, A. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9010216 · Cited by 74
Inferences of genetic architecture of bill morphology in house sparrow using a high‐density SNP array point to a polygenic basis
Lundregan, S. L., Hagen, I. J., Gohli, J., Niskanen, A. K., Kemppainen, P., Ringsby, T. H., Kvalnes, T., Pärn, H., Rønning, B., Holand, H., et al. (2018) · Molecular Ecology · doi:10.1111/mec.14811 · Cited by 54
The impact of a TSH receptor gene polymorphism on thyroid‐related phenotypes in a healthy Danish twin population
Hansen, P. S., van der Deure, W. M., Peeters, R. P., Iachine, I. A., Fenger, M., Sørensen, T. I. A., Kyvik, K. O., Visser, T. J., & Hegedűs, L. D. (2007) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2007.02820.x · Cited by 52
Association study of CARD8 (p.C10X) and NLRP3 (p.Q705K) variants with rheumatoid arthritis in French and Tunisian populations
Hamad, M. B., Cornélis, F., Marzouk, S., Chabchoub, G., Bahloul, Z., Rebaï, A., Fakhfakh, F., Ayadi, H., Petit, É., & Maalej, A. (2011) · International Journal of Immunogenetics · doi:10.1111/j.1744-313x.2011.01070.x · Cited by 50
Genetic polymorphisms of glutathione S-transferase genes and susceptibility to colorectal cancer: A case–control study in an Indian population
Wang, J., Jiang, J., Zhao, Y., Gajalakshmi, V., Kuriki, K., Suzuki, S., Nagaya, T., Nakamura, S., Akasaka, S., Ishikawa, H., et al. (2010) · Cancer Epidemiology · doi:10.1016/j.canep.2010.07.003 · Cited by 51
Keynote review: Disease-specific target selection: a critical first step down the right road
Roses, A. D., Burns, D. K., Chissoe, S. L., Middleton, L. T., & Jean, P. S. (2005) · Drug Discovery Today · doi:10.1016/s1359-6446(04)03321-5 · Cited by 51
Generalist genes and cognitive neuroscience
Butcher, L. M., Kennedy, J. K. J., & Plomin, R. J. (2006) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2006.03.004 · Cited by 51
Identification of Candidate Genes Regulating Carcass Depth and Hind Leg Circumference in Simmental Beef Cattle Using Illumina Bovine Beadchip and Next-Generation Sequencing Analyses
Bordbar, F., Mohammadabadi, M., Jensen, J., Xu, L., Li, J., & Zhang, L. (2022) · Animals · doi:10.3390/ani12091103 · Cited by 52
A Knowledge-Based Weighting Framework to Boost the Power of Genome-Wide Association Studies
Li, M., Sham, P. C., Cherny, S. S., & Song, Y. (2010) · PLoS ONE · doi:10.1371/journal.pone.0014480 · Cited by 51
The Molecular Basis of Congenital Heart Disease
Mitchell, M. E., Sander, T. L., Klinkner, D. B., & Tomita‐Mitchell, A. (2007) · Seminars in Thoracic and Cardiovascular Surgery · doi:10.1053/j.semtcvs.2007.07.013 · Cited by 49
Helicobacter pylori-related host gene polymorphisms associated with susceptibility of gastric carcinogenesis: a two-stage case-control study in Chinese
He, C., Tu, H., Sun, L. L., Xu, Q., Li, P., Gong, Y., Dong, N., & Yuan, Y. (2013) · Carcinogenesis · doi:10.1093/carcin/bgt079 · Cited by 50
Genome-Wide Association Study of Piglet Uniformity and Farrowing Interval
Wang, Y., Ding, X., Tan, Z., Ning, C., Xing, K., Yang, T., Pan, Y., Sun, D., & Wang, C. (2017) · Frontiers in Genetics · doi:10.3389/fgene.2017.00194 · Cited by 50
Intronic variants in the dopa decarboxylase ( DDC ) gene are associated with smoking behavior in European-Americans and African-Americans
Yu, Y., Panhuysen, C. I. M., Kranzler, H. R., HESSELBROCK, V. M., Rounsaville, B. J., Weiss, R. D., Brady, K. T., Farrer, L. A., & Gelernter, J. E. (2006) · Human Molecular Genetics · doi:10.1093/hmg/ddl144 · Cited by 49
The allele (A) -110 in the promoter region of the HSP70-1 gene is unfavorable to longevity in women
Altomare, K., Greco, V., Bellizzi, D., Berardelli, M., Dato, S., Rango, F. D., Garasto, S., Rose, G., Feraco, E., Mari, V., et al. (2003) · Biogerontology · doi:10.1023/a:1025182615693 · Cited by 50
TOBMI: trans-omics block missing data imputation using a k-nearest neighbor weighted approach
Dong, X., Lin, L., Zhang, R., Zhao, Y., Christiani, D. C., Wei, Y., & Chen, F. (2018) · Bioinformatics · doi:10.1093/bioinformatics/bty796 · Cited by 50
Low-Density Lipoprotein Cholesterol, Apolipoprotein B, and Risk of Coronary Heart Disease
Imes, C. C., & Austin, M. A. (2012) · Biological Research For Nursing · doi:10.1177/1099800412436967 · Cited by 51
A candidate gene survey of quantitative trait loci affecting chemical composition in tomato fruit
Bermúdez, L. F., Urias, Ú., Milstein, D., Kamenetzky, L., Asís, R., Fernie, A. R., Sluys, M. V., Carrari, F. O., & Rossi, M. (2008) · Journal of Experimental Botany · doi:10.1093/jxb/ern146 · Cited by 49
Candidate genes for male and female reproductive traits in Canchim beef cattle
Buzanskas, M. E., Grossi, D. D. A., Ventura, R. V., Schenkel, F. S., Chud, T. C. S., Stafuzza, N. B., Rola, L. D., Meirelles, S. L. C., Mokry, F. B., Mudadu, M. A., et al. (2017) · Journal of Animal Science and Biotechnology/Journal of animal science and biotechnology · doi:10.1186/s40104-017-0199-8 · Cited by 49
Gene–environment interactions between HPA-axis genes and stressful life events in depression: A systematic review
Normann, C., & Buttenschøn, H. N. (2019) · Acta Neuropsychiatrica · doi:10.1017/neu.2019.16 · Cited by 48
Genetic polymorphisms in immune- and inflammation-associated genes and their association with bovine mastitis resistance/susceptibility
Khan, M. Z., Wang, J., Ma, Y., Chen, T., Ma, M., Ullah, Q., Khan, I. M., Khan, A. A., Cao, Z., & Liu, S. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1082144 · Cited by 56
Search for informative polymorphisms in candidate genes: clock genes and circadian behaviour in blue tits
Steinmeyer, C., Mueller, J. C., & Kempenaers, B. (2008) · Genetica · doi:10.1007/s10709-008-9318-y · Cited by 49
The Genetics of Eating Disorders
Helder, S. G., & Collier, D. A. (2010) · Current topics in behavioral neurosciences · doi:10.1007/7854_2010_79 · Cited by 49
A Framework for Controlling False Discovery Rates and Minimizing the Amount of Genotyping in the Search for Disease Mutations
van den Oord, E. J. C. G., & Sullivan, P. F. (2003) · Human Heredity · doi:10.1159/000076393 · Cited by 47
The VNTR in complex disorders: The forgotten polymorphisms? A functional way forward?
Brookes, K. J. (2013) · Genomics · doi:10.1016/j.ygeno.2013.03.003 · Cited by 50
Susceptibility genes and modifiers for cardiac arrhythmias
Kääb, S., & Schulze‐Bahr, E. (2005) · Cardiovascular Research · doi:10.1016/j.cardiores.2005.04.005 · Cited by 47
Effect of Population Stratification on Case-Control Association Studies
Gorroochurn, P., Hodge, S. E., Heiman, G. A., & Greenberg, D. A. (2004) · Human Heredity · doi:10.1159/000081455 · Cited by 47
PTSD and dopaminergic genes, DRD2 and DAT, in multigenerational families exposed to the Spitak earthquake
Bailey, J. N., Goenjian, A. K., Noble, E. P., Walling, D. P., Ritchie, T. L., & Goenjian, H. A. (2010) · Psychiatry Research · doi:10.1016/j.psychres.2010.04.043 · Cited by 46
Association of twelve polymorphisms in three onco-lncRNA genes with hepatocellular cancer risk and prognosis: A case-control study
Wang, B., Xu, Q., Lv, Z., Fang, X., Ding, H.-X., Wen, J., & Yuan, Y. (2018) · World Journal of Gastroenterology · doi:10.3748/wjg.v24.i23.2482 · Cited by 46
Polymorphic variations in exon 10 of the luteinizing hormone receptor: Functional consequences and associations with breast cancer
Piersma, D., Verhoef‐Post, M., Look, M. P., Uitterlinden, A. G., Pols, H. A. P., Berns, E. M. J. J., & Themmen, A. P. N. (2007) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2007.06.007 · Cited by 45
Polymorphisms in KCNE1 or KCNE3 are not associated with Ménière disease in the Caucasian population
Campbell, C. A., Santina, C. C. D., Meyer, N. C., Smith, N. B., Myrie, O. A., Stone, E. M., Fukushima, K., Califano, J. A., Carey, J. P., Hansen, M. R., et al. (2009) · American Journal of Medical Genetics Part A · doi:10.1002/ajmg.a.33114 · Cited by 45
Polymeric immunoglobulin receptor polymorphisms and risk of nasopharyngeal cancer
Hirunsatit, R., Kongruttanachok, N., Shotelersuk, K., Supiyaphun, P., Voravud, N., Sakuntabhai, A., & Mutirangura, A. (2003) · BMC Genetics · doi:10.1186/1471-2156-4-3 · Cited by 45
Genetics, genes, genomics and g
Plomin, R. J. (2003) · Molecular Psychiatry · doi:10.1038/sj.mp.4001249 · Cited by 45
Genome‐Wide Association Studies
Morris, A. P., & Cardon, L. R. (2019) · Wiley eBooks · doi:10.1002/9781119487845.ch21 · Cited by 45
Osteoprotegerin Lys3Asn Polymorphism and the Risk of Fracture in Older Women
Moffett, S. P., Oakley, J. I., Cauley, J. A., Lui, L.-Y., Ensrud, K. E., Taylor, B. C., Hillier, T. A., Hochberg, M., Li, J., Cayabyab, S., et al. (2008) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2007-1019 · Cited by 44
Genetic Polymorphisms Associated with Overweight and Obesity in Uncontrolled Type 2 Diabetes Mellitus
Kasim, N. B., Huri, H. Z., Vethakkan, S. R., Ibrahim, L., & Abdullah, B. M. (2016) · Biomarkers in Medicine · doi:10.2217/bmm-2015-0037 · Cited by 44
Genetic risk factors for cerebrovascular disease in children with sickle cell disease: design of a case-control association study and genomewide screen
Adams, G. T., Snieder, H., McKie, V. C., Clair, B., Brambilla, D. J., Adams, R. J., Kutlar, F., & Kutlar, A. (2003) · BMC Medical Genetics · doi:10.1186/1471-2350-4-6 · Cited by 45
Mechanisms of Disease: genetics of functional gastrointestinal disorders—searching the genes that matter
Adam, B., Liebregts, T., & Holtmann, G. (2007) · Nature Clinical Practice Gastroenterology & Hepatology · doi:10.1038/ncpgasthep0717 · Cited by 44
LRP5 coding polymorphisms influence the variation of peak bone mass in a normal population of French-Canadian women
Giroux, S., Elfassihi, L., Cardinal, G., Laflamme, N., & Rousseau, F. (2007) · Bone · doi:10.1016/j.bone.2007.01.004 · Cited by 44
Effect of Population Stratification on Case-Control Association Studies
Heiman, G. A., Hodge, S. E., Gorroochurn, P., Zhang, J., & Greenberg, D. A. (2004) · Human Heredity · doi:10.1159/000081454 · Cited by 44
Backward Genotype-Trait Association (BGTA)-Based Dissection of Complex Traits in Case-Control Designs
Zheng, T., Wang, H., & Lo, S. (2006) · Human Heredity · doi:10.1159/000096995 · Cited by 44
Protein Tyrosine Phosphatase-1B Gene PTPN1
Spencer-Jones, N. J., Wang, X., Snieder, H., Spector, T. D., Carter, N. D., & O’Dell, S. D. (2005) · Diabetes · doi:10.2337/diabetes.54.11.3296 · Cited by 44
Genes for editing to improve economic traits in aquaculture fish species
Yang, Z., Fu, G., Lee, M., Yeo, S., & Yue, G. H. (2024) · Aquaculture and Fisheries · doi:10.1016/j.aaf.2024.05.005 · Cited by 43
Genetic basis of cranial cruciate ligament rupture (CCLR) in dogs
Baird, A., Carter, S. D., Innes, J., Ollier, W., & Short, A. D. (2014) · Connective Tissue Research · doi:10.3109/03008207.2014.910199 · Cited by 43
New approaches to investigating heterogeneity in complex traits
Bomprezzi, R., Kovanen, P. E., & Martin, R. (2003) · Journal of Medical Genetics · doi:10.1136/jmg.40.8.553 · Cited by 43
Bioinformatics and systems biology analysis of genes network involved in OLP (Oral Lichen Planus) pathogenesis
Orlando, B., Bragazzi, N. L., & Nicolini, C. A. (2013) · Archives of Oral Biology · doi:10.1016/j.archoralbio.2012.12.002 · Cited by 43
Detection of Methylated Circulating DNA as Noninvasive Biomarkers for Breast Cancer Diagnosis
Cheuk, I., Shin, V. Y., & Kwong, A. (2017) · Journal of Breast Cancer · doi:10.4048/jbc.2017.20.1.12 · Cited by 43
Lack of association of the vitamin D receptor gene with Graves’ disease in UK Caucasians
Collins, J. E., Heward, J. M., Nithiyananthan, R., Nejentsev, S., Todd, J. A., Franklyn, J. A., & Gough, S. C. L. (2004) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2004.02015.x · Cited by 45
Functional genetic polymorphisms in cytokines and metabolic genes as additional genetic markers for susceptibility to develop type 1 diabetes
Eerligh, P., Koeleman, B., Dudbridge, F., Bruining, G., Roep, B., & Giphart, M. (2004) · Genes and Immunity · doi:10.1038/sj.gene.6364036 · Cited by 50
Multiple hypothesis testing strategies for genetic case–control association studies
Rosenberg, P. S., Che, A., & Chen, B. E. (2005) · Statistics in Medicine · doi:10.1002/sim.2407 · Cited by 43
Evaluation of IL17A expression and of IL17A, IL17F and IL23R gene polymorphisms in Brazilian individuals with periodontitis
Saraiva, A. M., Silva, M. R. M. A. E., Silva, J. D. F. C., Costa, J. E., Gollob, K. J., Dutra, W. O., & Moreira, P. R. (2012) · Human Immunology · doi:10.1016/j.humimm.2012.10.026 · Cited by 42
Unlinked genetic loci control the reduced transcription of aminopeptidase N 1 and 3 in the European corn borer and determine tolerance to Bacillus thuringiensis Cry1Ab toxin
Coates, B. S., Sumerford, D. V., Siegfried, B. D., Hellmich, R. L., & Abel, C. A. (2013) · Insect Biochemistry and Molecular Biology · doi:10.1016/j.ibmb.2013.09.003 · Cited by 42
Insights into the Genetic Architecture of Diabetic Nephropathy
Palmer, N. D., & Freedman, B. I. (2012) · Current Diabetes Reports · doi:10.1007/s11892-012-0279-2 · Cited by 41
Dynamic Changes in Serum Soluble Triggering Receptor Expressed on Myeloid Cells-1 (sTREM-1) and its Gene Polymorphisms are Associated with Sepsis Prognosis
Su, L., Liu, C., Li, C., Jiang, Z., Xiao, K., Zhang, X., Li, M., Yan, P., Feng, D., & Xie, L. (2012) · Inflammation · doi:10.1007/s10753-012-9504-z · Cited by 41
“Soldier's Heart”: A Genetic Basis for Elevated Cardiovascular Disease Risk Associated with Post-traumatic Stress Disorder
Pollard, H. B., Shivakumar, C., Starr, J. M., Eidelman, O., Jacobowitz, D. M., Dalgard, C. L., Srivastava, M., Wilkerson, M. D., Stein, M. B., & Ursano, R. J. (2016) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2016.00087 · Cited by 41
Asthma phenotypes in childhood
Deliu, M., Belgrave, D. C. M., Sperrin, M., Buchan, I. E., & Čustović, A. (2016) · Expert Review of Clinical Immunology · doi:10.1080/1744666x.2017.1257940 · Cited by 41
Neuropeptides in Anxiety Modulation
Landgraf, R. (2005) · Handbook of experimental pharmacology · doi:10.1007/3-540-28082-0_12 · Cited by 41
HapMap-based study of the 17q21 ERBB2 amplicon in susceptibility to breast cancer
Benusiglio, P. R., Pharoah, P. D. P., Smith, P. L., Lesueur, F., Conroy, D. M., Luben, R., Dew, G., Jordan, C., Dunning, A. M., Easton, D. F., et al. (2006) · British Journal of Cancer · doi:10.1038/sj.bjc.6603473 · Cited by 41
Divergent patterns of linkage disequilibrium and haplotype structure across global populations at the interleukin-13 (IL13) locus
Tarazona‐Santos, E., & Tishkoff, S. A. (2004) · Genes and Immunity · doi:10.1038/sj.gene.6364149 · Cited by 41
Asthma Steroid Pharmacogenetics: A Study Strategy to Identify Replicated Treatment Responses
Weiss, S. T., Lake, S. L., Silverman, E. S., Silverman, E. K., Richter, B., Drazen, J. M., & Tantisira, K. G. (2004) · Proceedings of the American Thoracic Society · doi:10.1513/pats.200409-043ms · Cited by 41
Association analysis of the RGS4 gene in Han Chinese and Scottish populations with schizophrenia
Zhang, F., Clair, D. S., Liu, X., Sun, X., Sham, P. C., Crombie, C., Ma, X., Wang, Q., Meng, H., Deng, W., et al. (2005) · Genes Brain & Behavior · doi:10.1111/j.1601-183x.2005.00167.x · Cited by 41
Effects of common GRM5 genetic variants on cognition, hippocampal volume and mGluR5 protein levels in schizophrenia
Matosin, N., Newell, K. A., Quidé, Y., Andrews, J. L., Teroganova, N., Green, M. J., & Fernandez, F. (2017) · Brain Imaging and Behavior · doi:10.1007/s11682-017-9712-0 · Cited by 40
Haplotype-based breeding: A new insight in crop improvement
Sivabharathi, R. C., Rajagopalan, V. R., Suresh, R., Sudha, M., KARTHIKEYAN, G., Jayakanthan, M., & Raveendran, M. (2024) · Plant Science · doi:10.1016/j.plantsci.2024.112129 · Cited by 48
Inherited bradyarrhythmia: A diverse genetic background
Ishikawa, T., Tsuji, Y., & Makita, N. (2015) · Journal of Arrhythmia · doi:10.1016/j.joa.2015.09.009 · Cited by 40
Integrating candidate gene and quantitative genetic approaches to understand variation in timing of breeding in wild tit populations
Liedvogel, M., Cornwallis, C. K., & Sheldon, B. C. (2012) · Journal of Evolutionary Biology · doi:10.1111/j.1420-9101.2012.02480.x · Cited by 39
Dissection of complex traits in forest trees — opportunities for marker-assisted selection
Thavamanikumar, S., Southerton, S. G., Bossinger, G., & Thumma, B. R. (2013) · Tree Genetics & Genomes · doi:10.1007/s11295-013-0594-z · Cited by 39
Association between human African trypanosomiasis and the IL6 gene in a Congolese population
Courtin, D., Milet, J., Jamonneau, V., Sese, C., Kumeso, V. K. B., Bilenge, C. M. M., Bétard, C., & Garcia, A. (2006) · Infection Genetics and Evolution · doi:10.1016/j.meegid.2006.04.001 · Cited by 39
MICA-STR A.4 Is Associated With Slower Hearing Loss Progression in Patients With Ménière’s Disease
Gázquez, I., Moreno, A., Arán, I., Soto-Varela, A., Santos, S., Pérez-Garrigues, H., López‐Nevot, A., Requena, T., López‐Nevot, M. Á., & Lopez-Escamez, J. A. (2012) · Otology & Neurotology · doi:10.1097/mao.0b013e31824296c8 · Cited by 39
The search for genenotype/phenotype associations and the phenome scan
Jones, R. W., Pembrey, M. E., Golding, J., & Herrick, D. (2005) · Paediatric and Perinatal Epidemiology · doi:10.1111/j.1365-3016.2005.00664.x · Cited by 38
Genomic and physiological approaches to advancing forest tree improvement
Nelson, C. D., & Johnsen, K. H. (2008) · Tree Physiology · doi:10.1093/treephys/28.7.1135 · Cited by 39
The Role of Genetics in Preterm Birth
Mead, E., Wang, C. A., Phung, J., Fu, J. Y., Williams, S. M., Merialdi, M., Jacobsson, B., Lye, S. J., Menon, R., & Pennell, C. E. (2023) · Reproductive Sciences · doi:10.1007/s43032-023-01287-9 · Cited by 38
A comprehensive review on host genetic susceptibility to human papillomavirus infection and progression to cervical cancer
Chattopadhyay, K. (2011) · Indian journal of human genetics · doi:10.4103/0971-6866.92087 · Cited by 38

Authors: Tabor, H. K., Risch, N. J., & Myers, R. M.
Affiliations: Stanford Medicine (US)
Kaiser Permanente (US)
Corresponding author: Myers, Richard M.
ORCID: Tabor, Holly K.
Risch, Neil J.
Myers, Richard M.
Venue: Nature Reviews Genetics
Publisher: Springer Science and Business Media LLC
Published: 2002-05
Volume: 3
Issue: 5
Pages: 391-397
ISSN: 1471-0056 (ISSN-L)
1471-0064
DOI: 10.1038/nrg796
OpenAlex: W1969673534
Cited by: 1,076
References: 63
Citations by year: 2026: 5 · 2025: 12 · 2024: 26 · 2023: 21 · 2022: 24 · 2021: 28 · 2020: 34 · 2019: 36 · 2018: 37 · 2017: 47 · 2016: 40 · 2015: 57 · 2014: 39 · 2013: 54 · 2012: 53
FWCI: 8.17
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature Reviews Genetics (publishedVersion, public-domain)
PubMed (publishedVersion)
Funders: National Institutes of Health
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Mapping and Diversity in Plants and Animals
Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Health, Environment, Cognitive Aging
Keywords: candidate gene association, complex traits, complex diseases, replication of results, genetic polymorphism, causal genes, epidemiological principles, genetic epidemiology
MeSH terms: Animals, Humans, Reproducibility of Results, Linkage Disequilibrium, Molecular Epidemiology, Multifactorial Inheritance, Polymorphism, Single Nucleotide

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Candidate-gene approaches for studying complex genetic traits: practical considerations

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks