Candidate-gene approaches for studying complex genetic traits: practical considerations

Initial sequencing and analysis of the human genome

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Molecular portraits of human breast tumours

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The sequence of the human genome

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Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease

Hugot, J.-P., Chamaillard, M., Zouali, H., Lesage, S., Cézard, J.-P., Belaiche, J., Almer, S., Tysk, C., O'Morain, C. A., Gassull, M., et al. (2001) · Nature · doi:10.1038/35079107 · Cited by 5,591

The Future of Genetic Studies of Complex Human Diseases

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A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease

Ogura, Y., Bonen, D. K., Inohara, N., Nicolae, D. L., Chen, F. F., Ramos, R., Britton, H., Moran, T., Karaliuskas, R., Duerr, R. H., et al. (2001) · Nature · doi:10.1038/35079114 · Cited by 5,030

A map of human genome sequence variation containing 1.42 million single nucleotide polymorphisms

The International SNP Map Working Group, Laboratories:, C. S. H., Sachidanandam, R., Weissman, D., Schmidt, S. C., Kakol, J. M., Stein, L. D., National Center for Biotechnology Information:, Marth, G., Sherry, S., et al. (2001) · Nature · doi:10.1038/35057149 · Cited by 2,977

Amino Acid Difference Formula to Help Explain Protein Evolution

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Epidemiology in Medicine

Hennekens, C. H., Buring, J. E., & Mayrent, S. L. (1987) · Medical Entomology and Zoology · Cited by 2,319

Listening to silence and understanding nonsense: exonic mutations that affect splicing

Cartegni, L., Chew, S. L., & Krainer, A. R. (2002) · Nature Reviews Genetics · doi:10.1038/nrg775 · Cited by 2,209

Lipoprotein Lipase Gene Polymorphisms and Blood Pressure Levels in the Northern Chinese Han Population

Biao, L. I., Ge, D., Wang, Y., Zhao, W., Zhou, X., Gu, D., & Chen, R. (2004) · Hypertension Research · doi:10.1291/hypres.27.373 · Cited by 17

HAB/LAB rats: an animal model of extremes in trait anxiety and depression

Landgraf, R. (2003) · Clinical Neuroscience Research · doi:10.1016/s1566-2772(03)00085-9 · Cited by 17

The genetics of cardiovascular disease

Delles, C., McBride, M., Padmanabhan, S., & Dominiczak, A. F. (2008) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2008.07.010 · Cited by 16

Replication of associations between LRP5 and ESRRA variants and bone density in premenopausal women

Giroux, S., Elfassihi, L., Cole, D. E. C., & Rousseau, F. (2008) · Osteoporosis International · doi:10.1007/s00198-008-0617-z · Cited by 17

Proper controls for SNP studies?

Hemminki, K., & Försti, A. (2002) · Carcinogenesis · doi:10.1093/carcin/23.8.1405 · Cited by 17

The Genetics of Obesity

Rodrigo Alonso, K., Farías, M., Àlvarez, V., & Cuevas, A. M. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-799961-6.00007-x · Cited by 17

Genetics of cognitive control: Implications for Nimh's research domain criteria initiative

Glahn, D. C., Knowles, E. E. M., & Pearlson, G. D. (2015) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.32345 · Cited by 16

Future possibilities in migraine genetics

Rudkjøbing, L. A., Esserlind, A.-L., & Olesen, J. (2012) · The Journal of Headache and Pain · doi:10.1007/s10194-012-0481-2 · Cited by 16

Genetic Susceptibility to Rhodococcus equi

McQueen, C. M., Dindot, S. V., Foster, M., & Cohen, N. D. (2015) · Journal of Veterinary Internal Medicine · doi:10.1111/jvim.13616 · Cited by 17

Low-Frequency Variants in HMGA1 Are Not Associated With Type 2 Diabetes Risk

Marquez, M., Huyvaert, M., Perry, J. R. B., Pearson, R. D., Falchi, M., Morris, A. P., Vivequin, S., Lobbens, S., Yengo, L., Gaget, S., et al. (2011) · Diabetes · doi:10.2337/db11-0728 · Cited by 17

Does refining the phenotype improve replication rates? A review and replication of candidate gene studies on Major Depressive Disorder and Chronic Major Depressive Disorder

Luo, X., Stavrakakis, N., Penninx, B. W. J. H., Bosker, F. J., Nolen, W. A., Boomsma, D. I., de Geus, E. J. C., Smit, J. H., Snieder, H., Nolte, I. M., et al. (2015) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.32396 · Cited by 16

Genetic Basis of Autism

Bonora, E., Monaco, A. P., Lamb, J. A., Bailey, A. J., & Barnby, G. (2006) · CRC Press eBooks · doi:10.1201/9781420004205.ch3 · Cited by 16

Genetic modifiers in rare disorders: the case of fragile X syndrome

Crawford, H., Scerif, G., Wilde, L., Beggs, A. D., Stockton, J., Sandhu, P., Shelley, L., Oliver, C., & McCleery, J. P. (2020) · European Journal of Human Genetics · doi:10.1038/s41431-020-00711-x · Cited by 16

Single Nucleotide Polymorphisms in Close Proximity to the Fibroblast Growth Factor 21 (FGF21) Gene Found to Be Associated with Sugar Intake in a Swedish Population

Janzi, S., González-Padilla, E., Najafi, K., Ramne, S., Ahlqvist, E., Borné, Y., & Sonestedt, E. (2021) · Nutrients · doi:10.3390/nu13113954 · Cited by 15

Single‐Feature Polymorphism Discovery in the Transcriptome of Tetraploid Alfalfa

Yang, S. S., Xu, W. W., Tesfaye, M., Lamb, J. F., Jung, H. G., Samac, D. A., Vance, C. P., & Gronwald, J. W. (2009) · The Plant Genome · doi:10.3835/plantgenome2009.03.0014 · Cited by 16

Genomic selection in loblolly pine - from lab to field

Işik, F., Whetten, R. W., Zapata-Valenzuela, J., Ogut, F., & McKeand, S. E. (2011) · BMC Proceedings · doi:10.1186/1753-6561-5-s7-i8 · Cited by 16

Genetic polymorphisms of phase I metabolizing enzyme genes, their interaction with lifetime grilled and smoked meat intake, and breast cancer incidence

Parada, H., Steck, S. E., Cleveland, R. J., Teitelbaum, S. L., Neugut, A. I., Santella, R. M., & Gammon, M. D. (2016) · Annals of Epidemiology · doi:10.1016/j.annepidem.2016.11.005 · Cited by 16

Genome-Wide Association Studies and Risk Scores for Coronary Artery Disease: Sex Biases

Byars, S., & Inouye, M. (2018) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-77932-4_38 · Cited by 16

Collaborative Design for Automated DNA Storage That Allows for Rapid, Accurate, Large-Scale Studies

Mahan, S. P., Ardlie, K., Krenitsky, K. F., Walsh, G., & Clough, G. (2004) · Assay and Drug Development Technologies · doi:10.1089/adt.2004.2.683 · Cited by 16

American Gastroenterological Association Future Trends Committee Report: The Application of Genomic and Proteomic Technologies to Digestive Disease Diagnosis and Treatment and Their Likely Impact on Gastroenterology Clinical Practice

Lazaridis, K. N., & Juran, B. D. (2005) · Gastroenterology · doi:10.1053/j.gastro.2005.06.047 · Cited by 16

Association between mannose-binding lectin levels and gene polymorphisms in chronic periodontitis and response to treatment

Özçaka, Ö., Bıçakçı, N., Nalbantsoy, A., Köse, T., & Berdeli, A. (2010) · Archives of Oral Biology · doi:10.1016/j.archoralbio.2009.12.006 · Cited by 16

Letter to the editor: A genetic-based algorithm for personalized resistance training

Karanikolou, A., Wang, G., & Pitsiladis, Y. P. (2017) · Biology of Sport · doi:10.5114/biolsport.2017.63385 · Cited by 16

Cytoskeletal transgelin 2 contributes to gender‐dependent adipose tissue expandability and immune function

Ortega, F. J., Moreno‐Navarrete, J. M., Mercader, J. M., Gómez‐Serrano, M., García‐Santos, E., Latorre, J., Lluch, A., Sabater, M., Caballano‐Infantes, E., Guzmán‐Ruiz, R., et al. (2019) · The FASEB Journal · doi:10.1096/fj.201900479r · Cited by 15

Effects in cattle of genetic variation within the IGF1R gene on the superovulation performance and pregnancy rates after embryo transfer

Yang, W.-C., Yang, L., Riaz, H., Tang, K., Chen, L., & Li, S. (2013) · Animal Reproduction Science · doi:10.1016/j.anireprosci.2013.10.008 · Cited by 15

Association of single nucleotide polymorphisms with form traits in three New Zealand populations of radiata pine in the presence of genotype by environment interactions

Li, Y., Wilcox, P., Telfer, E., Graham, N. J., & Stanbra, L. (2016) · Tree Genetics & Genomes · doi:10.1007/s11295-016-1019-6 · Cited by 15

Identification of muscle-specific candidate genes in Simmental beef cattle using imputed next generation sequencing

Bordbar, F., Jensen, J., Zhu, B., Wang, Z., Xu, L., Chang, T., Xu, L., Xu, L., Zhang, L., Gao, H., et al. (2019) · PLoS ONE · doi:10.1371/journal.pone.0223671 · Cited by 16

GASVeM: A New Machine Learning Methodology for Multi-SNP Analysis of GWAS Data Based on Genetic Algorithms and Support Vector Machines

Díaz, F. D., Lasheras, F. S., Moreno, V. R., Moratalla-Navarro, F., Molina, A. J., & Martín, V. (2021) · Mathematics · doi:10.3390/math9060654 · Cited by 16

Identification of a Novel Genetic Marker for Risk of Degenerative Rotator Cuff Disease Surgery in the UK Biobank

Yanik, E. L., Keener, J. D., Lin, S. J., Colditz, G. A., Wright, R. W., Evanoff, B., Jain, N. B., & Saccone, N. L. (2021) · Journal of Bone and Joint Surgery · doi:10.2106/jbjs.20.01474 · Cited by 15

Application of Gene Ontology to Gene Identification

Bastos, H. P., Tavares, B., Pesquita, C., Faria, D., & Couto, F. M. (2011) · Methods in molecular biology · doi:10.1007/978-1-61779-176-5_9 · Cited by 15

The Importance of Gene—Environment Interaction

North, K. E., & Martin, L. J. (2008) · Sociological Methods & Research · doi:10.1177/0049124108323538 · Cited by 16

Lack of association between common polymorphisms in the 17β-hydroxysteroid dehydrogenase type V gene (HSD17B5) and precocious pubarche

Petry, C. J., Ong, K. K., Wingate, D. L., de Zegher, F., Ibáñez, L., & Dunger, D. B. (2007) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2007.01.004 · Cited by 15

Applying Genomics to the Study of Complex Disease

Juran, B. D., & Lazaridis, K. N. (2007) · Seminars in Liver Disease · doi:10.1055/s-2006-960167 · Cited by 15

Genome-wide association scans identify multiple confirmed susceptibility loci for Crohnʼs disease: Lessons for study design

Tremelling, M., & Parkes, M. (2007) · Inflammatory Bowel Diseases · doi:10.1002/ibd.20239 · Cited by 15

The influence of genetics on intracranial aneurysm formation and rupture: current knowledge and its possible impact on future treatment

Krischek, B., & Tatagiba, M. S. (2008) · Advances and technical standards in neurosurgery · doi:10.1007/978-3-211-72283-1_3 · Cited by 14

Genetic and psychosocial predictors of alcohol use trajectories among disaster-exposed adolescents

Bountress, K. E., Danielson, C. K., Williamson, V. S., Vladmirov, V., Gelernter, J. E., Ruggiero, K. J., & Amstadter, A. B. (2017) · American Journal on Addictions · doi:10.1111/ajad.12575 · Cited by 14

Common variation in EMSYand risk of breast and ovarian cancer: a case-control study using HapMap tagging SNPs

Benusiglio, P. R., Lesueur, F., Luccarini, C., McIntosh, J., Luben, R., Smith, P. L., Dunning, A. M., Easton, D. F., Ponder, B. A. J., & Pharoah, P. D. P. (2005) · BMC Cancer · doi:10.1186/1471-2407-5-81 · Cited by 14

MALDI-TOF Mass Spectrometry

van den Boom, D., Wjst, M., & Everts, R. E. (2013) · Methods in molecular biology · doi:10.1007/978-1-62703-435-7_4 · Cited by 14

HLA ‐ DPB 1 variant rs3117242 is associated with anti‐neutrophil cytoplasmic antibody‐associated vasculitides in a Han Chinese population

Wu, Z., Wu, Q., Xu, J., Chen, S., Sun, F., Li, P., Bai, Y., Zheng, W., Chen, H., Zhang, F., et al. (2015) · International Journal of Rheumatic Diseases · doi:10.1111/1756-185x.12561 · Cited by 14

Genetic Research and Women’s Heart Disease: a Primer

Kavousi, M., Bielak, L. F., & Peyser, P. A. (2016) · Current Atherosclerosis Reports · doi:10.1007/s11883-016-0618-x · Cited by 14

Evidence for Genetic Risk Contributing to Long-Term Adverse Treatment Effects in Childhood Cancer Survivors

Gramatges, M. M., & Bhatia, S. (2017) · Annual Review of Medicine · doi:10.1146/annurev-med-041916-124328 · Cited by 14

Association of the promoter polymorphism −232C/G of the phosphoenolpyruvate carboxykinase gene (PCK1) with Type 2 diabetes mellitus

Gouni‐Berthold, I., Giannakidou, E., Faust, M., Berthold, H. K., & Krone, W. (2006) · Diabetic Medicine · doi:10.1111/j.1464-5491.2006.01819.x · Cited by 13

Multi-locus association study of schizophrenia susceptibility genes with a posterior probability method

Sun, X.-Q., Jia, Y.-B., Zhang, X.-G., Xu, Q., Shen, Y., & Li, Y.-D. (2005) · Science in China Series C Life Sciences · doi:10.1007/bf03183620 · Cited by 13

Genetics of Neurodegenerative Disorders

Caruso, C., Franceschi, C., & Licastro, F. (2003) · New England Journal of Medicine · doi:10.1056/nejm200307103490219 · Cited by 14

ANCA-Associated Vasculitis

Bonatti, F., Adorni, A., Percesepe, A., Vaglio, A., & Martorana, D. (2019) · Rare diseases of the immune system · doi:10.1007/978-3-030-03934-9_6 · Cited by 13

Pathophysiology of Primary Hypertension

Carey, R. M. (2008) · Elsevier eBooks · doi:10.1016/b978-0-12-374530-9.00020-6 · Cited by 13

Exceptional longevity and muscle and fitness related genotypes: a functional in vitro analysis and case-control association replication study with SNPs THRH rs7832552, IL6 rs1800795, and ACSL1 rs6552828

Fuku, N., eHe, Z.-H., Sanchis‐Gomar, F., Pareja-Galeano, H., Tian, Y., Arai, Y., Abe, Y., Murakami, H., Miyachi, M., Zempo, H., et al. (2015) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2015.00059 · Cited by 13

GenoWatch: a disease gene mining browser for association study

Chen, Y.-H., Liu, C.-K., Chang, S.-C., Lin, Y., Tsai, M., Chen, Y., & Yao, A. (2008) · Nucleic Acids Research · doi:10.1093/nar/gkn214 · Cited by 13

Degenerated intervertebral disc prolapse and its association of collagen I alpha 1 Spl gene polymorphism

Anjankar, S. D., Poornima, S., Raju, S., Jaleel, M. A., Bhiladvala, D., & Hasan, Q. A. (2015) · Indian Journal of Orthopaedics · doi:10.4103/0019-5413.168765 · Cited by 13

Gene expression profiling reveals candidate genes related to residual feed intake in duodenum of laying ducks1,2

Zeng, T., Huang, L., Ren, J., Chen, L., Tian, Y., Huang, Y., Zhang, H., Du, J., & Lu, L. (2017) · Journal of Animal Science · doi:10.2527/jas2017.1714 · Cited by 14

Advancing the Biobehavioral Research of Fatigue With Genetics and Genomics

Lyon, D., McCain, N. L., Pickler, R. H., Munro, C. L., & Elswick, R. K. (2011) · Journal of Nursing Scholarship · doi:10.1111/j.1547-5069.2011.01406.x · Cited by 13

Assessment of collagen genes involved in fragmented medial coronoid process development in Labrador Retrievers as determined by affected sibling-pair analysis

Salg, K. G., Temwichitr, J., Imholz, S., Hazewinkel, H. A. W., & Leegwater, P. A. J. (2006) · American Journal of Veterinary Research · doi:10.2460/ajvr.67.10.1713 · Cited by 13

The Pro387Leu variant of protein tyrosine phosphatase‐1B is not associated with diabetes mellitus type 2 in a German population

Gouni‐Berthold, I., Giannakidou, E., Müller‐Wieland, D., Faust, M., Kotzka, J., Berthold, H. K., & Krone, W. (2005) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2004.01446.x · Cited by 14

Genomics, genetic epidemiology, and genomic medicine

Lazaridis, K. N., & Petersen, G. M. (2005) · Clinical Gastroenterology and Hepatology · doi:10.1016/s1542-3565(05)00085-6 · Cited by 14

Statistical tools for linkage analysis and genetic association studies

Forabosco, P., Falchi, M., & Devoto, M. (2005) · Expert Review of Molecular Diagnostics · doi:10.1586/14737159.5.5.781 · Cited by 15

Polymorphisms of casein kinase I gamma 2 gene associated with simple febrile seizures in Chinese Han population

Ma, Y., Qi, Y., Zhiyue, C., Lu, J., Lie, H., Liping, Z., Jianhui, Z., Sun, F. Z., Dingfang, B., Qing, L., et al. (2004) · Neuroscience Letters · doi:10.1016/j.neulet.2004.06.054 · Cited by 13

Incorporating genetic analyses into birth defects cluster investigations: Strategies for identifying candidate genes

Green, R. F., & Moore, C. A. (2006) · Birth Defects Research Part A Clinical and Molecular Teratology · doi:10.1002/bdra.20280 · Cited by 13

Genetic Factors in Common Obstetric Disorders

Ward, K. J. (2008) · Clinical Obstetrics & Gynecology · doi:10.1097/grf.0b013e3181616545 · Cited by 13

Genes for asthma: much ado about nothing?

Whittaker, P. A. (2003) · Current Opinion in Pharmacology · doi:10.1016/s1471-4892(03)00035-3 · Cited by 13

Quality in epidemiological research: should we be submitting papers before we have the results and submitting more hypothesis-generating research?

Lawlor, D. A. (2007) · International Journal of Epidemiology · doi:10.1093/ije/dym168 · Cited by 13

Critical issues in the inclusion of genetic and epigenetic information in prevention and intervention trials

Latendresse, S. J., Musci, R., & Maher, B. S. (2018) · Prevention Science · doi:10.1007/s11121-017-0785-1 · Cited by 12

Variation in SLC1A1 is related to combat-related posttraumatic stress disorder

Zhang, J., Sheerin, C. M., Mandel, H., Banducci, A. N., Myrick, H., Acierno, R. E., Amstadter, A. B., & Wang, Z. (2014) · Journal of Anxiety Disorders · doi:10.1016/j.janxdis.2014.09.013 · Cited by 12

Investigation of CD24 and Its Expression in Iranian Relapsing-Remitting Multiple Sclerosis

Kollaee, A., Ghaffarpor, M., Pourmahmoudian, H., Shahbazi, M., & Zamani, M. (2011) · International Journal of Neuroscience · doi:10.3109/00207454.2011.610529 · Cited by 12

Association of LMX1A Genetic Polymorphisms With Susceptibility to Congenital Scoliosis in Chinese Han Population

Wu, N., Yuan, S., Liu, J., Chen, J., Fei, Q., Liu, S., Su, X., Wang, S., Zhang, J., Li, S., et al. (2014) · Spine · doi:10.1097/brs.0000000000000536 · Cited by 12

A Novel Link between the Oxytocin Receptor Gene and Impulsivity

Bozorgmehr, A., Moayedi, R., Sadeghi, B., Ghadirivasfi, M., Joghataei, M. T., & Shahbazi, A. (2020) · Neuroscience · doi:10.1016/j.neuroscience.2020.07.033 · Cited by 13

Overview of Behavioral Genetics Research for Family Researchers

Samek, D. R., Koh, B. D., & Rueter, M. A. (2013) · Journal of Family Theory & Review · doi:10.1111/jftr.12013 · Cited by 15

Cis‐regulatory sequence variation and association with Mycoplasma load in natural populations of the house finch (Carpodacus mexicanus)

Backström, N., Shipilina, D., Blom, M. P. K., & Edwards, S. V. (2013) · Ecology and Evolution · doi:10.1002/ece3.484 · Cited by 12

Hypertension genes and retinal vascular calibre: the Cardiovascular Health Study

Sun, C., Wang, J. J., Islam, A. F. M., Heckbert, S. R., Klein, R., Siscovick, D. S., Klein, B. E. K., & Wong, T. Y. (2009) · Journal of Human Hypertension · doi:10.1038/jhh.2008.168 · Cited by 12

Personalised Medicine: The Odyssey from Hope to Practice

Visvikis‐Siest, S., Gorenjak, V., & Stathopoulou, M. G. (2018) · Journal of Personalized Medicine · doi:10.3390/jpm8040031 · Cited by 13

COMT met allele differentially predicts risk versus severity of aberrant eating in a large community sample

Donofry, S. D., Roecklein, K. A., Wildes, J. E., Miller, M. A., Flory, J. D., & Manuck, S. B. (2014) · Psychiatry Research · doi:10.1016/j.psychres.2014.08.037 · Cited by 14

Association of Cadherin23 Single Nucleotide Polymorphism with Age‐Related Hearing Impairment in Han Chinese

Hwang, J.-H., Liu, K. S., Wu, C., & Liu, T. (2012) · Otolaryngology · doi:10.1177/0194599812446904 · Cited by 12

Single Nucleotide Polymorphisms (SNPs)

Batra, J., Srinivasan, S., & Clements, J. A. (2014) · Springer eBooks · doi:10.1007/978-1-4899-8050-2_5 · Cited by 12

Single-nucleotide polymorphisms in the RB1 gene and association with breast cancer in the British population

Lesueur, F., Song, H., Ahmed, S., Luccarini, C., Jordan, C., Luben, R., Easton, D. F., Dunning, A. M., Pharoah, P. D. P., & Ponder, B. A. J. (2006) · British Journal of Cancer · doi:10.1038/sj.bjc.6603160 · Cited by 12

Statistical geometry approach to the study of functional effects of human nonsynonymous SNPs

Barenboim, M., Jamison, D. C., & Vaisman, I. I. (2005) · Human Mutation · doi:10.1002/humu.20238 · Cited by 12

Genetic association studies in cancer: Good, bad or no longer ugly?

Savage, S. A., & Chanock, S. J. (2006) · Human Genomics · doi:10.1186/1479-7364-2-6-415 · Cited by 12

Genomics and the circulation

Podgoreanu, M. V., & Schwinn, D. A. (2004) · British Journal of Anaesthesia · doi:10.1093/bja/aeh168 · Cited by 12

Family‐Based Association

Dudbridge, F. (2007) · Wiley eBooks · doi:10.1002/9780470061619.ch38 · Cited by 11

To the Editor

Kornman, K. S., Duff, G. W., & Reilly, P. (2002) · Journal of Periodontology · doi:10.1902/jop.2002.73.12.1553 · Cited by 12

Meta‐analysis: Congruence of genomic and phenotypic differentiation across diverse natural study systems

Wood, Z. T., Wiegardt, A. K., Barton, K. L., Clark, J. D., Homola, J. J., Olsen, B. J., King, B. L., Kovach, A. I., & Kinnison, M. T. (2021) · Evolutionary Applications · doi:10.1111/eva.13264 · Cited by 9

Molecular Markers in Breeding of Crops: Recent Progress and Advancements

Dida, G. (2022) · Open Access Journal of Microbiology & Biotechnology · doi:10.23880/oajmb-16000244 · Cited by 11

Polymorphisms in the CTSH gene may influence the progression of diabetic retinopathy: a candidate-gene study in the Danish Cohort of Pediatric Diabetes 1987 (DCPD1987)

Thorsen, S. U., Sandahl, K. J., Nielsen, L. B., Broe, R., Rasmussen, M. L., Pető, T., Grauslund, J., Andersen, M. L. M., Mortensen, H. B., Pociot, F., et al. (2015) · Graefe s Archive for Clinical and Experimental Ophthalmology · doi:10.1007/s00417-015-3118-8 · Cited by 11

Statistical Optimization of Pharmacogenomics Association Studies: Key Considerations from Study Design to Analysis

Grady, B. J., & Ritchie, M. D. (2011) · Current pharmacogenomics and personalized medicine (Online)/Current pharmacogenomics and personalized medicine · doi:10.2174/187569211794728805 · Cited by 11

Individual differences in the processing of smoking-cessation video messages: An imaging genetics study

Shi, Z., Wang, A.-L., Aronowitz, C. A., Römer, D., & Langleben, D. D. (2017) · Biological Psychology · doi:10.1016/j.biopsycho.2017.07.019 · Cited by 13

Sex hormone-related polymorphisms in endometriosis and migraine: A narrative review

van der Vaart, J.-F., & Merki‐Feld, G. S. (2022) · Women s Health · doi:10.1177/17455057221111315 · Cited by 13

Genetics of antidepressant response and treatment-resistant depression

Chung, A.-N., Chen, T., & Lin, K. (2023) · Progress in brain research · doi:10.1016/bs.pbr.2023.01.002 · Cited by 11

Evaluation of 6 candidate genes on chromosome 11q23 for coeliac disease susceptibility: a case control study

Brophy, K., Ryan, A. W., Turner, G., Trimble, V., Patel, K. D., O'Morain, C. A., Kennedy, N. P., Egan, B., Close, E., Lawlor, G. O., et al. (2010) · BMC Medical Genetics · doi:10.1186/1471-2350-11-76 · Cited by 11

Associations of Polymorphisms in Four Candidate Genes with Carcass and/or Meat-Quality Traits in Two Meat-Type Chicken Lines

Sun, Y., Liu, R., Lu, X., Hu, Y., Zhao, G., Zheng, M., Chen, J., Wang, H., & Wen, J. (2013) · Animal Biotechnology · doi:10.1080/10495398.2012.742909 · Cited by 11

From genetic single candidate gene studies to complex genomics of GvHD

Bogunia‐Kubik, K., & Łacina, P. (2017) · British Journal of Haematology · doi:10.1111/bjh.14704 · Cited by 11

The Effects of Common Genetic Variation in 96 Genes Involved in Thyroid Hormone Regulation on TSH and FT4 Concentrations

Sterenborg, R. B. T. M., Galesloot, T. E., Teumer, A., Netea-Maier, R. T., Speed, D., Meima, M. E., Visser, W. E., Smit, J. W. A., Peeters, R. P., & Medici, M. (2022) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgac136 · Cited by 10

Construction of a Quantitative Genomic Map, Identification and Expression Analysis of Candidate Genes for Agronomic and Disease-Related Traits in Brassica napus

Raboanatahiry, N. H., Chao, H., He, J., Li, H., Yin, Y., & Li, M. (2022) · Frontiers in Plant Science · doi:10.3389/fpls.2022.862363 · Cited by 11

Relationship between cystathionine γ-lyase gene polymorphism and essential hypertension in Northern Chinese Han population

Li, Y., Zhao, Q., Xiao-li, L. I. U., Lai-yuan, W. A. N. G., Lu, X., Hong-fang, L. I., Shu-feng, C. H. E. N., Huang, J., & Gu, D. (2008) · Chinese Medical Journal · doi:10.1097/00029330-200804020-00011 · Cited by 11

SOD3 R231G polymorphism associated with coronary artery disease and myocardial infarction. The Ludwigshafen Risk and Cardiovascular Health (LURIC) study

Grammer, T. B., Renner, W., Hoffmann, M. M., Kleber, M. E., Winklhofer‐Roob, B. M., Boehm, B. O., & Maerz, W. (2009) · Free Radical Research · doi:10.1080/10715760902991763 · Cited by 11

Genetic Aspects of the Obstructive Sleep Apnoea–Hypopnoea Syndrome. Genetische Aspekte des obstruktiven Schlafapnoe-Hypopnoe-Syndroms

Riha, R. L. (2006) · Somnologie - Schlafforschung und Schlafmedizin · doi:10.1111/j.1439-054x.2006.00092.x · Cited by 11

Gold Nanoparticle Based Systems in Genetics

Gaspar, J., Baptista, P. V., & Rueff, J. (2007) · Current Pharmacogenomics · doi:10.2174/157016007780077185 · Cited by 11

Association between the arginine vasopressin receptor 1A (AVPR1A) gene and preschoolers’ executive functioning

Wade, M., Hoffmann, T. J., & Jenkins, J. M. (2014) · Brain and Cognition · doi:10.1016/j.bandc.2014.06.002 · Cited by 11

Approaches for the Identification of Genetic Modifiers of Nutrient Dependent Phenotypes: Examples from Folate

Zinck, J. W. R., & MacFarlane, A. J. (2014) · Frontiers in Nutrition · doi:10.3389/fnut.2014.00008 · Cited by 11

Sequence Variation in the Melanocortin-1 Receptor (MC1R) Does Not Explain Continent-wide Plumage Color Differences in the Australian Magpie (Cracticus tibicen)

Dobson, A. E., Schmidt, D. J., & Hughes, J. M. (2012) · Journal of Heredity · doi:10.1093/jhered/ess053 · Cited by 11

Interleukin-8 -251A/T polymorphism and periodontitis susceptibility: a meta-analysis

Yang, Z., Tang, X. P., Lai, Q. G., Jiang-bo, C., & Yuan, K. F. (2016) · Genetics and Molecular Research · doi:10.4238/gmr15047379 · Cited by 11

Application of genomic technologies to the improvement of meat quality in farm animals

Kharrati-Koopaee, H., & Koshkoiyeh, A. E. (2011) · Biotechnology and Molecular Biology Reviews · doi:10.5897/bmbr2011.0012 · Cited by 11

Genetic epidemiology: some special contributions of birth cohorts

Pembrey, M. E. (2004) · Paediatric and Perinatal Epidemiology · doi:10.1111/j.1365-3016.2004.00530.x · Cited by 12

Chicken fatness: from QTL to candidate gene

Jennen, D. G. J. (2004) · doi:10.18174/121559 · Cited by 11

Epidemiologic Considerations in Complex Disease Genetics: Figure 1.Preprint

Gallacher, J. (2011) · Cold Spring Harbor Protocols · doi:10.1101/pdb.top067512

Association study designs for complex diseases

Cardon, L. R., & Bell, J. I. (2001) · Nature Reviews Genetics · doi:10.1038/35052543 · Cited by 1,395

Genetic Approaches to Studying Common Diseases and Complex Traits

Hirschhorn, J. N. (2005) · Pediatric Research · doi:10.1203/01.pdr.0000159574.98964.87 · Cited by 96

A QUANTITATIVE ANALYSIS OF DISCREPANCIES BETWEEN CANDIDATE GENE AND GENOME-WIDE STUDIES OF COMPLEX TRAITS AND RELATED ENDOPHENOTYPES

Border, R., Johnson, E. C., Sullivan, P. F., Berley, N., & Keller, M. C. (2019) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2017.08.121

Genetic association studies.

Austin, M. A., Psaty, B. M., & Schwartz, S. (2013) · CABI eBooks · doi:10.1079/9781780641812.0068