Cited by 1,345Liver physiology and pathologyNF-κB Signaling PathwaysHepatocellular Carcinoma Treatment and Prognosis

The DOI matches its Crossref record; 135 of the 137 references it cites were found in a registry or an index.

NF-κB in the liver—linking injury, fibrosis and hepatocellular carcinoma

Open access

Luedde, Tom, Schwabe, Robert F.·2011·Nature Reviews Gastroenterology & Hepatology

DOI 10.1038/nrgastro.2010.213PMC PMC3295539

Open this paper in CoChat — free account

Abstract

Hepatic cirrhosis and hepatocellular carcinoma (HCC) are the most common causes of death in patients with chronic liver disease. Chronic liver injury of virtually any etiology triggers inflammatory and wound-healing responses that in the long run promote the development of hepatic fibrosis and HCC. Here, we review the role of the transcription factor nuclear factor-κB (NF-κB), a master regulator of inflammation and cell death, in the development of hepatocellular injury, liver fibrosis and HCC, with a particular focus on the role of NF-κB in different cellular compartments of the liver. We propose that NF-κB acts as a central link between hepatic injury, fibrosis and HCC, and that it may represent a target for the prevention or treatment of liver fibrosis and HCC. However, NF-κB acts as a two-edged sword and inhibition of NF-κB may not only exert beneficial effects but also negatively impact hepatocyte viability, especially when NF-κB inhibition is pronounced. Finding appropriate targets or identifying drugs that either exert only a moderate effect on NF-κB activity or that can be specifically delivered to nonparenchymal cells will be essential to avoid the increase in liver injury associated with complete NF-κB blockade in hepatocytes.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1038/nrgastro.2010.213

Cites

135 of 135 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Sorafenib in advanced hepatocellular carcinoma
Llovet, J. M., Ricci, S., Mazzaferro, V., Hilgard, P., Gane, E., Blanc, J.-F., de Oliveira, A. C., Santoro, A., Raoul, J.-L., Forner, A., et al. (2008) · New England Journal of Medicine · doi:10.1056/nejmoa0708857 · Cited by 13,097
Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. Adults
Calle, E. E., Rodriguez, C., Walker-Thurmond, K., & Thun, M. J. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa021423 · Cited by 7,696
Sorafenib in Advanced Hepatocellular Carcinoma
정, 재. (2008) · Cited by 5,586
Liver fibrosis
Bataller, R., & Brenner, D. A. (2005) · Journal of Clinical Investigation · doi:10.1172/jci24282 · Cited by 4,958
Phosphorylation meets ubiquitination: the control of NF-κB activity
Karin, M., & Ben-Neriah, Y. (2000) · Annual Review of Immunology · doi:10.1146/annurev.immunol.18.1.621 · Cited by 4,766
Activators and target genes of Rel/NF-κB transcription factors
Pahl, H. L. (1999) · Oncogene · doi:10.1038/sj.onc.1203239 · Cited by 3,727
TLR4 links innate immunity and fatty acid-induced insulin resistance
Shi, H., Kokoeva, M. V., Inouye, K., Tzameli, I., Yin, H., & Flier, J. S. (2006) · Journal of Clinical Investigation · doi:10.1172/jci28898 · Cited by 3,690
Missing Pieces in the NF-κB Puzzle
Ghosh, S., & Karin, M. (2002) · Cell · doi:10.1016/s0092-8674(02)00703-1 · Cited by 3,638
Activators and Target Genes of Rel/NF-кB Transcription Factors
Loop, T., & Pahl, H. L. (2003) · Springer eBooks · doi:10.1007/978-94-010-0163-2_1 · Cited by 3,179
An Essential Role for NF-κB in Preventing TNF-α-Induced Cell Death
Beg, A. A., & Baltimore, D. (1996) · Science · doi:10.1126/science.274.5288.782 · Cited by 3,047

Show all 137 references

Sorted by citations

Items 101–200 of 999

Lycium barbarum polysaccharides improve CCl4-induced liver fibrosis, inflammatory response and TLRs/NF-kB signaling pathway expression in wistar rats
Gan, F., Liu, Q., Liu, Y., Huang, D. W., Pan, C., Song, S., & Huang, K. (2017) · Life Sciences · doi:10.1016/j.lfs.2017.11.047 · Cited by 113
Lutein decreases oxidative stress and inflammation in liver and eyes of guinea pigs fed a hypercholesterolemic diet
Kim, J. E., Clark, R. M., Park, Y., Lee, J., & Fernández, M. L. (2012) · Nutrition Research and Practice · doi:10.4162/nrp.2012.6.2.113 · Cited by 112
Puerarin mediates hepatoprotection against CCl4-induced hepatic fibrosis rats through attenuation of inflammation response and amelioration of metabolic function
Li, R., Xu, L., Liang, T., Li, Y., Zhang, S., & Duan, X. (2012) · Food and Chemical Toxicology · doi:10.1016/j.fct.2012.10.059 · Cited by 111
GDF15 deficiency exacerbates chronic alcohol- and carbon tetrachloride-induced liver injury
Chung, H. K., Kim, J. T., Kim, H.-W., Kwon, M., Kim, S. Y., Shong, M., Kim, K. S., & Yi, H. (2017) · Scientific Reports · doi:10.1038/s41598-017-17574-w · Cited by 111
CCN1 induces hepatic ductular reaction through integrin αvβ5–mediated activation of NF-κB
Kim, K.-H., Chen, C.-C., Alpini, G., & Lau, L. F. (2015) · Journal of Clinical Investigation · doi:10.1172/jci79327 · Cited by 109
Protein complex scaffolding predicted as a prevalent function of long non-coding RNAs
Ribeiro, D. M., Zanzoni, A., Cipriano, A., Ponti, R. D., Spinelli, L., Ballarino, M., Bozzoni, I., Tartaglia, G. G., & Brun, C. (2017) · Nucleic Acids Research · doi:10.1093/nar/gkx1169 · Cited by 112
Protective effect of a polysaccharide from Anoectochilus roxburghii against carbon tetrachloride-induced acute liver injury in mice
Biyu, Z., Su, M., Chen, Q., Chang, Q., Wang, W., & Li, H. (2017) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2017.02.018 · Cited by 107
Chlorogenic Acid Inhibits Liver Fibrosis by Blocking the miR-21-Regulated TGF-β1/Smad7 Signaling Pathway in Vitro and in Vivo
Yang, F., Luo, L., Zhu, Z., Zhou, X., Wang, Y., Xue, J., Zhang, J., Cai, X., Chen, Z.-L., Ma, Q., et al. (2017) · Frontiers in Pharmacology · doi:10.3389/fphar.2017.00929 · Cited by 107
The Impact of Acute or Chronic Alcohol Intake on the NF-κB Signaling Pathway in Alcohol-Related Liver Disease
Nowak, A. J., & Relja, B. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21249407 · Cited by 112
Role of Oxidative Stress in Liver Disorders
Conde de la Rosa, L., Goicoechea, L., Torres, S., Garcia-Ruiz, C., & Fernandez-Checa, J. C. (2022) · Livers · doi:10.3390/livers2040023 · Cited by 107
Micro-RNA Profiling in Human Serum Reveals Compartment-Specific Roles of miR-571 and miR-652 in Liver Cirrhosis
Roderburg, C., Mollnow, T., Bongaerts, B. W. C., Elfimova, N., Cardenas, D. V., Janssen, K., Zimmermann, H. W., Koch, A. H., Vucur, M., Luedde, M., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0032999 · Cited by 105
Self-citation
Physiological and Immune Functions of Punicalagin
Venusová, E., Kolesárová, A., Horký, P., & Sláma, P. (2021) · Nutrients · doi:10.3390/nu13072150 · Cited by 110
Protective Effects of Polydatin from Polygonum cuspidatum against Carbon Tetrachloride-Induced Liver Injury in Mice
Zhang, H., Yu, C., Jiang, Y.-P., Peng, C. Y., He, K., Tang, J., & Xin, H. (2012) · PLoS ONE · doi:10.1371/journal.pone.0046574 · Cited by 103
Hepatitis C Virus and Hepatocellular Carcinoma: When the Host Loses Its Grip
Goto, K., Suarez, A. A. R., Wrensch, F., Baumert, T. F., & Lupberger, J. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21093057 · Cited by 108
Hepatic stellate cells: central modulators of hepatic carcinogenesis
Thompson, A., Conroy, K. P., & Henderson, N. C. (2015) · BMC Gastroenterology · doi:10.1186/s12876-015-0291-5 · Cited by 103
Hepatoprotective effect of quercetin against LPS/ d -GalN induced acute liver injury in mice by inhibiting the IKK/NF-κB and MAPK signal pathways
Peng, Z., Gong, X., Yang, Y., Huang, L., Zhang, Q., Zhang, P., Wan, R., & Zhang, B. (2017) · International Immunopharmacology · doi:10.1016/j.intimp.2017.09.022 · Cited by 101
Pharmacological activities and pharmacokinetics of liquiritin: A review
Qin, J., Chen, J., Peng, F., Sun, C., Lei, Y., Chen, G., Li, G., Yin, Y., Lin, Z., Wu, L., et al. (2022) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2022.115257 · Cited by 101
Combined delivery of sorafenib and a MEK inhibitor using CXCR4-targeted nanoparticles reduces hepatic fibrosis and prevents tumor development
Sung, Y., Liu, Y.-C., Chao, P., Chang, C.-C., Jin, P.-R., Lin, T.-T., Lin, J.-A., Cheng, H., Wang, J., Lai, C. P., et al. (2017) · Theranostics · doi:10.7150/thno.21168 · Cited by 102
Creatine Alleviates Doxorubicin-Induced Liver Damage by Inhibiting Liver Fibrosis, Inflammation, Oxidative Stress, and Cellular Senescence
Aljobaily, N. A., Viereckl, M. J., Hydock, D. S., Aljobaily, H., Wu, T.-Y., Busekrus, R. B., Jones, B., Alberson, J., & Han, Y. (2020) · Nutrients · doi:10.3390/nu13010041 · Cited by 101
Inhibition of Neddylation Represses Lipopolysaccharide-induced Proinflammatory Cytokine Production in Macrophage Cells
Chang, F.-M., Reyna, S. M., Granados, J. C., Wei, S., Innis‐Whitehouse, W., Maffi, S. K., Rodriguez, E., Slaga, T. J., & Short, J. D. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.397703 · Cited by 99
Hepatitis C Virus Infection of Cultured Human Hepatoma Cells Causes Apoptosis and Pyroptosis in Both Infected and Bystander Cells
Kofahi, H. M., Taylor, N., Hirasawa, K., Grant, M. D., & Russell, R. S. (2016) · Scientific Reports · doi:10.1038/srep37433 · Cited by 99
Preventive and therapeutic effects of oleuropein against carbon tetrachloride-induced liver damage in mice
Domitrović, R., Jakovac, H., Vasiljev, V., Šain, I., Romić, Ž., & Rahelić, D. (2011) · Pharmacological Research · doi:10.1016/j.phrs.2011.12.005 · Cited by 99
Involvement of DNA Damage Response Pathways in Hepatocellular Carcinoma
Yang, S., Chang, C.-W., Wei, R., Shiue, Y., Wang, S., & Yeh, Y. (2014) · BioMed Research International · doi:10.1155/2014/153867 · Cited by 101
From overnutrition to liver injury: AMP-activated protein kinase in nonalcoholic fatty liver diseases
Zhao, P., & Saltiel, A. R. (2020) · Journal of Biological Chemistry · doi:10.1074/jbc.rev120.011356 · Cited by 106
Synergistic gene expression during the acute phase response is characterized by transcription factor assisted loading
Goldstein, I., Paakinaho, V., Baek, S., Sung, M.-H., & Hager, G. L. (2017) · Nature Communications · doi:10.1038/s41467-017-02055-5 · Cited by 97
Oncogenic Effects of HIV-1 Proteins, Mechanisms Behind
Isaguliants, M. G., Олеговна, Б. Е., Avdoshina, D., Kondrashova, A., Chiodi, F., & Palefsky, J. M. (2021) · Cancers · doi:10.3390/cancers13020305 · Cited by 100
Anti-oxidative, anti-inflammatory and hepatoprotective effects of Radix Bupleuri extract against oxidative damage in tilapia (Oreochromis niloticus) via Nrf2 and TLRs signaling pathway
Jia, R., Gu, Z., He, Q., Du, J., Cao, L., Jeney, G., Xu, P., & Yin, G. (2019) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2019.07.080 · Cited by 94
Effects of Sorafenib and Quercetin Alone or in Combination in Treating Hepatocellular Carcinoma: In Vitro and In Vivo Approaches
Abdu, S. B. S., Juaid, N., Amin, A., Moulay, M., & Miled, N. (2022) · Molecules · doi:10.3390/molecules27228082 · Cited by 98
FXR and liver carcinogenesis
Huang, X., Zhao, W., & Huang, W. (2014) · Acta Pharmacologica Sinica · doi:10.1038/aps.2014.117 · Cited by 98
Fibroblast growth factor 21 attenuates hepatic fibrogenesis through TGF-β/smad2/3 and NF-κB signaling pathways
Xu, P., Zhang, Y., Liu, Y., Yuan, Q., Song, L., Liu, M., Liu, Z., Yang, Y., Li, J., Li, D., et al. (2016) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2015.11.012 · Cited by 97
Inducible nitric oxide synthase (iNOS) in muscle wasting syndrome, sarcopenia, and cachexia
Hall, D. T., Ma, J. F., Marco, S. D., & Gallouzi, I. (2011) · Aging · doi:10.18632/aging.100358 · Cited by 98
Hepatocyte-specific PPARA expression exclusively promotes agonist-induced cell proliferation without influence from nonparenchymal cells
Brocker, C. N., Yue, J., Kim, D., Qu, A., Bonzo, J. A., & Gonzalez, F. J. (2017) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00205.2016 · Cited by 93
Immunity and Fibrogenesis: The Role of Th17/IL-17 Axis in HBV and HCV-induced Chronic Hepatitis and Progression to Cirrhosis
Paquissi, F. C. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01195 · Cited by 95
Association between obstructive sleep apnea and non-alcoholic fatty liver disease: a systematic review and meta-analysis
Jin, S., Jiang, S., & Hu, A. (2018) · Sleep And Breathing · doi:10.1007/s11325-018-1625-7 · Cited by 96
Chemokines and Chemokine Receptors in the Development of NAFLD
Roh, Y., & Seki, E. (2018) · Advances in experimental medicine and biology · doi:10.1007/978-981-10-8684-7_4 · Cited by 94
MicroRNA-140 acts as a liver tumor suppressor by controlling NF-κB activity by directly targeting DNA methyltransferase 1 (Dnmt1) expression
Takata, A., Otsuka, M., Yoshikawa, T., Kishikawa, T., Hikiba, Y., Obi, S., Goto, T., Kang, Y. J., Maeda, S., Yoshida, H., et al. (2012) · Hepatology · doi:10.1002/hep.26011 · Cited by 92
Molecular characterization of the grape seeds extract’s effect against chemically induced liver cancer: In vivo and in vitro analyses
Hamza, A. A., Heeba, G. H., Elwy, H. M., Murali, C., El‐Awady, R., & Amin, A. (2018) · Scientific Reports · doi:10.1038/s41598-018-19492-x · Cited by 92
Hepatoprotective and anti-inflammatory effects of total flavonoids of Qu Zhi Ke (peel of Citrus changshan-huyou) on non-alcoholic fatty liver disease in rats via modulation of NF-κB and MAPKs
Jiang, J., Li, Y., Shi, Z., Wang, L., Shan, L., & Efferth, T. (2019) · Phytomedicine · doi:10.1016/j.phymed.2019.153082 · Cited by 92
Hepatocellular Carcinoma in Chronic Viral Hepatitis: Where Do We Stand?
Russo, F. P., Zanetto, A., Pinto, E., Battistella, S., Penzo, B., Burra, P., & Farinati, F. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23010500 · Cited by 92
Vanillic acid attenuates obesity via activation of the AMPK pathway and thermogenic factors in vivo and in vitro
Jung, Y., Park, J., Kim, H., Sim, J., Youn, D., Kang, J., Lim, S., Jeong, M., Yang, W. M., Lee, S., et al. (2017) · The FASEB Journal · doi:10.1096/fj.201700231rr · Cited by 91
Gastroesophageal and Laryngopharyngeal Reflux Associated With Laryngeal Malignancy: A Systematic Review and Meta-analysis
Parsel, S. M., Wu, E. L., Riley, C. A., & McCoul, E. D. (2018) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2018.10.028 · Cited by 91
Long noncoding RNA CASC11 promotes hepatocarcinogenesis and HCC progression through EIF4A3‐mediated E2F1 activation
Song, H., Liu, Y., Li, X., Chen, S., Xie, R., Chen, D., Gao, H., Wang, G., Cai, B., & Yang, X. (2020) · Clinical and Translational Medicine · doi:10.1002/ctm2.220 · Cited by 91
Molecular mechanisms in the pathogenesis of N-nitrosodimethylamine induced hepatic fibrosis
George, J., Tsuchishima, M., & Tsutsumi, M. (2019) · Cell Death and Disease · doi:10.1038/s41419-018-1272-8 · Cited by 90
Perspectives in liver redox imbalance: Toxicological and pharmacological aspects underlying iron overloading, nonalcoholic fatty liver disease, and thyroid hormone action
Videla, L. A., & Valenzuela, R. (2021) · BioFactors · doi:10.1002/biof.1797 · Cited by 91
Oxidative Stress in Non-Alcoholic Fatty Liver Disease
Smirne, C., Croce, E., Benedetto, D. D., Cantaluppi, V., Comi, C., Sainaghi, P. P., Minisini, R., Grossini, E., & Pirisi, M. (2022) · Livers · doi:10.3390/livers2010003 · Cited by 100
Mangiferin relieves CCl4-induced liver fibrosis in mice
Zhang, L., Liu, C., Yin, L., Huang, C., & Fan, S. (2023) · Scientific Reports · doi:10.1038/s41598-023-30582-3 · Cited by 101
Inhibition of Adenosine Monophosphate–Activated Protein Kinase–3‐Hydroxy‐3‐Methylglutaryl Coenzyme A Reductase Signaling Leads to Hypercholesterolemia and Promotes Hepatic Steatosis and Insulin Resistance
Loh, K., Tam, S., Murray‐Segal, L., Huynh, K., Meikle, P. J., Scott, J. W., van Denderen, B., Chen, Z., Steel, R., LeBlond, N. D., et al. (2018) · Hepatology Communications · doi:10.1002/hep4.1279 · Cited by 89
Selective IKK2 inhibitor IMD0354 disrupts NF-κB signaling to suppress corneal inflammation and angiogenesis
Lennikov, A., Mirabelli, P., Mukwaya, A., Schaupper, M., Thangavelu, M., Lachota, M., Ali, Z., Jensen, L. D., & Lagali, N. (2018) · Angiogenesis · doi:10.1007/s10456-018-9594-9 · Cited by 88
Free radicals, antioxidants, nuclear factor‐E2‐related factor‐2 and liver damage
Ramos‐Tovar, E., & Muriel, P. (2019) · Journal of Applied Toxicology · doi:10.1002/jat.3880 · Cited by 91
IL-1β and TNFα Differentially Influence NF-κB Activity and FasL-Induced Apoptosis in Primary Murine Hepatocytes During LPS-Induced Inflammation
Rex, J., Lutz, A., Faletti, L. E., Albrecht, U., Thomas, M., Bode, J. G., Borner, C., Sawodny, O., & Merfort, I. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2019.00117 · Cited by 87
Chronic hepatitis C virus infection and pathogenesis of hepatocellular carcinoma
Bandiera, S., Bian, C. B., Hoshida, Y., Baumert, T. F., & Zeisel, M. B. (2016) · Current Opinion in Virology · doi:10.1016/j.coviro.2016.09.010 · Cited by 86
The oncogenic role of hepatitis delta virus in hepatocellular carcinoma
Puigvehí, M., Moctezuma‐Velázquez, C., Villanueva, A., & Llovet, J. M. (2019) · JHEP Reports · doi:10.1016/j.jhepr.2019.05.001 · Cited by 86
Oxidative stress in obesity-associated hepatocellular carcinoma: sources, signaling and therapeutic challenges
Brahma, M. K., Gilglioni, E. H., Zhou, L., Trépo, E., Chen, P., & Gurzov, E. N. (2021) · Oncogene · doi:10.1038/s41388-021-01950-y · Cited by 85
Andrographolide Ameliorates Inflammation and Fibrogenesis and Attenuates Inflammasome Activation in Experimental Non-Alcoholic Steatohepatitis
Cabrera, D., Wree, A., Povero, D., Solı́s, N., Hernández, A., Pizarro, M., Moshage, H. J., Torres, J., Feldstein, A. E., Cabello‐Verrugio, C., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-03675-z · Cited by 86
Magnesium isoglycyrrhizinate suppresses LPS-induced inflammation and oxidative stress through inhibiting NF-κB and MAPK pathways in RAW264.7 cells
Xie, C., Li, X., Zhu, J., Wu, J., Geng, S., & Zhong, C. (2018) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2018.12.033 · Cited by 85
Beyond the X Factor: Relevance of Sex Hormones in NAFLD Pathophysiology
Torre, S. D. (2021) · Cells · doi:10.3390/cells10092502 · Cited by 91
Gut epithelial barrier damage caused by dishwasher detergents and rinse aids
Öğülür, İ., Pat, Y., Aydın, T., Yazıcı, D., Rückert, B., Peng, Y., Kim, J., Radzikowska, U., Westermann, P., Sokołowska, M., et al. (2022) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2022.10.020 · Cited by 84
Tumor regulation of the tissue environment in the liver
Eggert, T., & Greten, T. F. (2017) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2017.02.005 · Cited by 86
Review article: emerging role of the gut microbiome in the progression of nonalcoholic fatty liver disease and potential therapeutic implications
Jayakumar, S., & Loomba, R. S. (2019) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.15314 · Cited by 87
NLRP3 inflammasome activation from Kupffer cells is involved in liver fibrosis of Schistosoma japonicum-infected mice via NF-κB
Zhang, W., Fang, Z., & Liu, W. (2019) · Parasites & Vectors · doi:10.1186/s13071-018-3223-8 · Cited by 86
Alleviation of Liver Dysfunction, Oxidative Stress and Inflammation Underlies the Protective Effect of Ferulic Acid in Methotrexate-Induced Hepatotoxicity
Roghani, M., Kalantari‬, H., Khodayar, M. J., Khorsandi, L., Kalantar, M., Goudarzi, M., & Kalantar, H. (2020) · Drug Design Development and Therapy · doi:10.2147/dddt.s237107 · Cited by 84
Endoplasmic reticulum stress in nonalcoholic (metabolic associated) fatty liver disease (NAFLD/MAFLD)
Flessa, C., Kyrou, I., Ansari, N. N., Kaltsas, G., Kassi, E. N., & Randeva, H. S. (2022) · Journal of Cellular Biochemistry · doi:10.1002/jcb.30247 · Cited by 87
Loss of PDK4 switches the hepatic NF‐κB/TNF pathway from pro‐survival to pro‐apoptosis
Wu, J., Zhao, Y., Park, Y., Lee, J., Gao, L., Zhao, J., & Wang, L. (2018) · Hepatology · doi:10.1002/hep.29902 · Cited by 83
Dietary Stevioside Supplementation Alleviates Lipopolysaccharide-Induced Intestinal Mucosal Damage through Anti-Inflammatory and Antioxidant Effects in Broiler Chickens
Jiang, J., Qi, L., Lv, Z., Jin, S. H., Wei, X., & Shi, F. (2019) · Antioxidants · doi:10.3390/antiox8120575 · Cited by 83
Beta-Catenin–NF-κB Interactions in Murine Hepatocytes: A Complex to Die for
Nejak‐Bowen, K. N., Kikuchi, A., & Monga, S. P. (2012) · Hepatology · doi:10.1002/hep.26042 · Cited by 83
Role of lymphocytes in liver cancer
Mossanen, J. C., & Tacke, F. (2013) · OncoImmunology · doi:10.4161/onci.26468 · Cited by 83
Reversal of myofibroblast differentiation: A review
Yang, X., Chen, B., Liu, T., & Chen, X. (2014) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2014.04.007 · Cited by 82
TLR4 signaling promotes a COX-2/PGE2/STAT3 positive feedback loop in hepatocellular carcinoma (HCC) cells
Lin, A., Wang, G., Zhao, H., Zhang, Y., Han, Q., Zhang, C., Tian, Z., & Zhang, J. (2015) · OncoImmunology · doi:10.1080/2162402x.2015.1074376 · Cited by 82
Anthocyanin-rich Riceberry bran extract attenuates gentamicin-induced hepatotoxicity by reducing oxidative stress, inflammation and apoptosis in rats
Arjinajarn, P., Chueakula, N., Pongchaidecha, A., Jaikumkao, K., Chatsudthipong, V., Mahatheeranont, S., Norkaew, O., Chattipakorn, N., & Lungkaphin, A. (2017) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2017.05.100 · Cited by 82
Endoplasmic Reticulum Stress and Autophagy in the Pathogenesis of Non-alcoholic Fatty Liver Disease (NAFLD): Current Evidence and Perspectives
Flessa, C., Kyrou, I., Ansari, N. N., Kaltsas, G., Papavassiliou, A. G., Kassi, E. N., & Randeva, H. S. (2021) · Current Obesity Reports · doi:10.1007/s13679-021-00431-3 · Cited by 81
Chlorogenic acid ameliorates alcohol-induced liver injuries through scavenging reactive oxygen species
Kim, H., Pan, J. H., Kim, S. H., Lee, J. H., & Park, J. (2018) · Biochimie · doi:10.1016/j.biochi.2018.05.008 · Cited by 81
Antioxidative, inflammatory and immune responses in hydrogen peroxide-induced liver injury of tilapia (GIFT, Oreochromis niloticus)
Jia, R., Du, J., Cao, L., Li, Y., Johnson, O., Gu, Z., Jeney, G., Xu, P., & Yin, G. (2018) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2018.10.084 · Cited by 80
Pro-inflammation NF-κB signaling triggers a positive feedback via enhancing cholesterol accumulation in liver cancer cells
He, M., Zhang, W., Dong, Y., Wang, L., Fang, T., Tang, W., Lv, B., Chen, G., Yang, B., Huang, P., et al. (2017) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-017-0490-8 · Cited by 80
OTULIN protects the liver against cell death, inflammation, fibrosis, and cancer
Damgaard, R. B., Jolin, H. E., Allison, M., Davies, S. E., Titheradge, H. L., McKenzie, A. N. J., & Komander, D. (2020) · Cell Death and Differentiation · doi:10.1038/s41418-020-0532-1 · Cited by 80
Role of α-lipoic acid in dextran sulfate sodium-induced ulcerative colitis in mice: Studies on inflammation, oxidative stress, DNA damage and fibrosis
Trivedi, P. P., & Jena, G. (2013) · Food and Chemical Toxicology · doi:10.1016/j.fct.2013.06.019 · Cited by 80
Context-Dependent Role of NF-κB Signaling in Primary Liver Cancer—from Tumor Development to Therapeutic Implications
Czauderna, C., Castven, D., Mahn, F. L., & Marquardt, J. U. (2019) · Cancers · doi:10.3390/cancers11081053 · Cited by 83
Inhibitory effects of Scutellaria baicalensis extract on hepatic stellate cells through inducing G2/M cell cycle arrest and activating ERK-dependent apoptosis via Bax and caspase pathway
Pan, T., Wang, P.-W., Leu, Y., Wu, T.-H., & Wu, T.-S. (2011) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2011.12.028 · Cited by 79
Iron, Oxidative Stress, and Metabolic Dysfunction—Associated Steatotic Liver Disease
Gensluckner, S., Wernly, B., Datz, C., & Aigner, E. S. (2024) · Antioxidants · doi:10.3390/antiox13020208 · Cited by 82
Melatonin attenuates carbon tetrachloride–induced liver fibrosis via inhibition of necroptosis
Choi, H., Kang, J., & Lee, S. (2015) · Translational research · doi:10.1016/j.trsl.2015.04.002 · Cited by 79
The hepatocyte IKK:NF-κB axis promotes liver steatosis by stimulating de novo lipogenesis and cholesterol synthesis
Heida, A., Gruben, N., Catrysse, L., Koehorst, M., Koster, M., Kloosterhuis, N. J., Gerding, A., Havinga, R., Bloks, V. W., Bongiovanni, L., et al. (2021) · Molecular Metabolism · doi:10.1016/j.molmet.2021.101349 · Cited by 78
Case study on the utility of hepatic global gene expression profiling in the risk assessment of the carcinogen furan
Jackson, A. F., Williams, A., Recio, L., Waters, M. D., Lambert, I. B., & Yauk, C. L. (2013) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2013.10.019 · Cited by 78
Direct AMPK Activation Corrects NASH in Rodents Through Metabolic Effects and Direct Action on Inflammation and Fibrogenesis
Dagorn, P. G., Foretz, M., Steinberg, G. R., Batchuluun, B., Zawistowska‐Deniziak, A., Lambooij, J. M., Guigas, B., Carling, D., Monternier, P., Moller, D. E., et al. (2021) · Hepatology Communications · doi:10.1002/hep4.1799 · Cited by 78
Delivery of siRNA Using CXCR4-targeted Nanoparticles Modulates Tumor Microenvironment and Achieves a Potent Antitumor Response in Liver Cancer
Liu, J.-Y., Chiang, T., Liu, C.-H., Chern, G.-G., Lin, T.-T., Gao, D.-Y., & Chen, Y. (2015) · Molecular Therapy · doi:10.1038/mt.2015.147 · Cited by 80
Tanshinol ameliorates CCl4-induced liver fibrosis in rats through the regulation of Nrf2/HO-1 and NF-κB/IκBα signaling pathway
Wang, R., Wang, J., Song, F., Li, S., & Yuan, Y. (2018) · Drug Design Development and Therapy · doi:10.2147/dddt.s159546 · Cited by 78
Cysteine cathepsins control hepatic NF-κB-dependent inflammation via sirtuin-1 regulation
Pulido, Á. D. M., de Gregorio, E., Moles, A., Tarrats, N., Tutusaus, A., Colell, A., Fernández-Checa, J. C., Morales, A., & Marı́, M. (2016) · Cell Death and Disease · doi:10.1038/cddis.2016.368 · Cited by 78
Clinical Practice Guidelines of the Russian Scientific Liver Society, Russian Gastroenterological Association, Russian Association of Endocrinologists, Russian Association of Gerontologists and Geriatricians and National Society for Preventive Cardiology on Diagnosis and Treatment of Non-Alcoholic Liver Disease
Ivashkin, V. T., Maevskaya, M. V., Жаркова, М. С., Kotovskaya, Y. V., Ткачева, О. Н., Troshina, E. A., Shestakova, M. V., Maev, I. V., Breder, V. V., Geyvandova, N. I., et al. (2022) · Russian Journal of Gastroenterology Hepatology Coloproctology · doi:10.22416/1382-4376-2022-32-4-104-140 · Cited by 86
Anti-inflammatory activities of green tea catechins along the gut–liver axis in nonalcoholic fatty liver disease: lessons learned from preclinical and human studies
Hodges, J. K., Sasaki, G. Y., & Bruno, R. S. (2020) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2020.108478 · Cited by 80
NF-κB signaling relieves negative regulation by miR-194 in hepatocellular carcinoma by suppressing the transcription factor HNF-1α
Bao, C., Li, Y., Huan, L., Zhang, Y., Zhao, F., Wang, Q., Liang, L., Ding, J., Liu, L., Chen, T., et al. (2015) · Science Signaling · doi:10.1126/scisignal.aaa8441 · Cited by 79
Novel Investigations of Flavonoids as Chemopreventive Agents for Hepatocellular Carcinoma
Liao, C.-Y., Lee, C.-C., Tsai, C., Hsueh, C.-W., Wang, C.-C., Chen, I.-H., Tsai, M.-K., Liu, M., Hsieh, A.-T., Su, K.-J., et al. (2015) · BioMed Research International · doi:10.1155/2015/840542 · Cited by 76
Forskolin, a hedgehog signalling inhibitor, attenuates carbon tetrachloride‐induced liver fibrosis in rats
El-Agroudy, N. N., El‐Naga, R. N., El‐Razeq, R. A., & El‐Demerdash, E. (2016) · British Journal of Pharmacology · doi:10.1111/bph.13611 · Cited by 76
The Role of the Transsulfuration Pathway in Non-Alcoholic Fatty Liver Disease
Werge, M. P., McCann, A., Galsgaard, E. D., Holst, D., Bugge, A. K., Albrechtsen, N. J. W., & Gluud, L. L. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10051081 · Cited by 78
Quercetin attenuates the activation of hepatic stellate cells and liver fibrosis in mice through modulation of HMGB1-TLR2/4-NF-κB signaling pathways
Li, X., Jin, Q., Yao, Q., Xu, B., Li, Z., & Tu, C. (2016) · Toxicology Letters · doi:10.1016/j.toxlet.2016.09.002 · Cited by 77
Inflammation‐Induced Long Intergenic Noncoding RNA (LINC00665) Increases Malignancy Through Activating the Double‐Stranded RNA–Activated Protein Kinase/Nuclear Factor Kappa B Pathway in Hepatocellular Carcinoma
Ding, J., Zhao, J., Huan, L., Liu, Y., Qiao, Y., Wang, Z., Chen, Z., Huang, S., Zhao, Y., & He, X. (2020) · Hepatology · doi:10.1002/hep.31195 · Cited by 74
Smyd3-associated regulatory pathways in cancer
Giakountis, A., Moulos, P., Sarris, M. E., Hatzis, P., & Talianidis, I. (2016) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2016.08.008 · Cited by 76
Liraglutide improves liver microvascular dysfunction in cirrhosis: Evidence from translational studies
de Mesquita, F. C., Guixé‐Muntet, S., Fernández‐Iglesias, A., Maeso‐Díaz, R., Vila, S., Hide, D., Ortega‐Ribera, M., Rosa, J. L., García‐Pagán, J. C., Bosch, J., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-02866-y · Cited by 78
Perturbation of MicroRNA-370/Lin-28 homolog A/nuclear factor kappa B regulatory circuit contributes to the development of hepatocellular carcinoma
Xu, W., Yi, M., Li, Q., Zhou, W., Cong, W., Yang, Y., Ning, B., Yin, C., Huang, Z., Wang, J., et al. (2013) · Hepatology · doi:10.1002/hep.26541 · Cited by 73
A20 prevents chronic liver inflammation and cancer by protecting hepatocytes from death
Catrysse, L., Ghahremani, M., Vereecke, L., Youssef, S., Guire, C. M., Sze, M., Weber, A., Heikenwalder, M., de Bruin, A., Beyaert, R., et al. (2016) · Cell Death and Disease · doi:10.1038/cddis.2016.154 · Cited by 71
Lycium barbarum polysaccharides improve hepatic injury through NFkappa-B and NLRP3/6 pathways in a methionine choline deficient diet steatohepatitis mouse model
Xiao, J., Wang, F., Liong, E. C., So, K., & Tipoe, G. L. (2018) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2018.09.151 · Cited by 73
Tumor-Associated Macrophages in Hepatocellular Carcinoma: Friend or Foe?
Zhou, D., Luan, J., Huang, C., & Li, J. (2020) · Gut and Liver · doi:10.5009/gnl20223 · Cited by 74
Liver Injury and Disease Pathogenesis in Chronic Hepatitis C
Yamane, D., McGivern, D. R., Masaki, T., & Lemon, S. M. (2013) · Current topics in microbiology and immunology · doi:10.1007/978-3-642-27340-7_11 · Cited by 73

Authors: Luedde, T., & Schwabe, R. F.
Affiliations: Universitätsklinikum Aachen (DE)
Columbia University Irving Medical Center (US)
Corresponding author: Luedde, Tom
Schwabe, Robert F.
ORCID: Luedde, Tom
Schwabe, Robert F.
Venue: Nature Reviews Gastroenterology & Hepatology
Publisher: Springer Science and Business Media LLC
Published: 2011-02
Volume: 8
Issue: 2
Pages: 108-118
ISSN: 1759-5045 (ISSN-L)
1759-5053
DOI: 10.1038/nrgastro.2010.213
PMC: PMC3295539
OpenAlex: W1976777085
Cited by: 1,345
References: 137
Citations by year: 2026: 97 · 2025: 99 · 2024: 119 · 2023: 109 · 2022: 122 · 2021: 156 · 2020: 120 · 2019: 95 · 2018: 79 · 2017: 76 · 2016: 66 · 2015: 68 · 2014: 51 · 2013: 38 · 2012: 42
FWCI: 5.65
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
Locations: Nature Reviews Gastroenterology & Hepatology (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health (5u54ca126513-03)
National Institute on Alcohol Abuse and Alcoholism (R01AA020211)
National Cancer Institute (U54 CA126513.)
National Institute of Diabetes and Digestive and Kidney Diseases (R01DK076920)
National Center for Complementary and Integrative Health (R21AT003878)
Topics: Health Sciences › Medicine › Hepatology › Liver physiology and pathology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
Health Sciences › Medicine › Hepatology › Hepatocellular Carcinoma Treatment and Prognosis
Keywords: NF-κB, liver fibrosis, hepatocellular carcinoma, chronic liver disease, liver cirrhosis, chronic liver injury, liver inflammation, hepatocytes, non-parenchymal liver cells, NF-κB inhibition, hepatocyte viability
MeSH terms: Cell Survival, Fibrosis, Carcinoma, Hepatocellular, Homeostasis, Humans, Liver, Liver Neoplasms, NF-kappa B, Hepatocytes

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

NF-κB in the liver—linking injury, fibrosis and hepatocellular carcinoma

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks