Cited by 1,345Liver physiology and pathologyNF-κB Signaling PathwaysHepatocellular Carcinoma Treatment and Prognosis

The DOI matches its Crossref record; 135 of the 137 references it cites were found in a registry or an index.

NF-κB in the liver—linking injury, fibrosis and hepatocellular carcinoma

Open access

Luedde, Tom, Schwabe, Robert F.·2011·Nature Reviews Gastroenterology & Hepatology

DOI 10.1038/nrgastro.2010.213PMC PMC3295539

Open this paper in CoChat — free account

Abstract

Hepatic cirrhosis and hepatocellular carcinoma (HCC) are the most common causes of death in patients with chronic liver disease. Chronic liver injury of virtually any etiology triggers inflammatory and wound-healing responses that in the long run promote the development of hepatic fibrosis and HCC. Here, we review the role of the transcription factor nuclear factor-κB (NF-κB), a master regulator of inflammation and cell death, in the development of hepatocellular injury, liver fibrosis and HCC, with a particular focus on the role of NF-κB in different cellular compartments of the liver. We propose that NF-κB acts as a central link between hepatic injury, fibrosis and HCC, and that it may represent a target for the prevention or treatment of liver fibrosis and HCC. However, NF-κB acts as a two-edged sword and inhibition of NF-κB may not only exert beneficial effects but also negatively impact hepatocyte viability, especially when NF-κB inhibition is pronounced. Finding appropriate targets or identifying drugs that either exert only a moderate effect on NF-κB activity or that can be specifically delivered to nonparenchymal cells will be essential to avoid the increase in liver injury associated with complete NF-κB blockade in hepatocytes.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1038/nrgastro.2010.213

Cites

135 of 135 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Sorafenib in advanced hepatocellular carcinoma
Llovet, J. M., Ricci, S., Mazzaferro, V., Hilgard, P., Gane, E., Blanc, J.-F., de Oliveira, A. C., Santoro, A., Raoul, J.-L., Forner, A., et al. (2008) · New England Journal of Medicine · doi:10.1056/nejmoa0708857 · Cited by 13,097
Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. Adults
Calle, E. E., Rodriguez, C., Walker-Thurmond, K., & Thun, M. J. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa021423 · Cited by 7,696
Sorafenib in Advanced Hepatocellular Carcinoma
정, 재. (2008) · Cited by 5,586
Liver fibrosis
Bataller, R., & Brenner, D. A. (2005) · Journal of Clinical Investigation · doi:10.1172/jci24282 · Cited by 4,958
Phosphorylation meets ubiquitination: the control of NF-κB activity
Karin, M., & Ben-Neriah, Y. (2000) · Annual Review of Immunology · doi:10.1146/annurev.immunol.18.1.621 · Cited by 4,766
Activators and target genes of Rel/NF-κB transcription factors
Pahl, H. L. (1999) · Oncogene · doi:10.1038/sj.onc.1203239 · Cited by 3,727
TLR4 links innate immunity and fatty acid-induced insulin resistance
Shi, H., Kokoeva, M. V., Inouye, K., Tzameli, I., Yin, H., & Flier, J. S. (2006) · Journal of Clinical Investigation · doi:10.1172/jci28898 · Cited by 3,690
Missing Pieces in the NF-κB Puzzle
Ghosh, S., & Karin, M. (2002) · Cell · doi:10.1016/s0092-8674(02)00703-1 · Cited by 3,638
Activators and Target Genes of Rel/NF-кB Transcription Factors
Loop, T., & Pahl, H. L. (2003) · Springer eBooks · doi:10.1007/978-94-010-0163-2_1 · Cited by 3,179
An Essential Role for NF-κB in Preventing TNF-α-Induced Cell Death
Beg, A. A., & Baltimore, D. (1996) · Science · doi:10.1126/science.274.5288.782 · Cited by 3,047
NF-κB at the crossroads of life and death
Karin, M., & Lin, A. (2002) · Nature Immunology · doi:10.1038/ni0302-221 · Cited by 2,709
Hepatocellular carcinoma in cirrhosis: Incidence and risk factors
Fattovich, G., Stroffolini, T., Zagni, I., & Donato, F. (2004) · Gastroenterology · doi:10.1053/j.gastro.2004.09.014 · Cited by 2,587
NF-κB functions as a tumour promoter in inflammation-associated cancer
Pikarsky, E., Porat, R. M., Stein, I., Abramovitch, R., Amit, S., Kasem, S., Gutkovich-Pyest, E., Urieli-Shoval, S., Galun, E., & Ben‐Neriah, Y. (2004) · Nature · doi:10.1038/nature02924 · Cited by 2,423
Local and systemic insulin resistance resulting from hepatic activation of IKK-β and NF-κB
Cai, D., Yuan, M., Frantz, D. F., Melendez, P. A., Hansen, L., Lee, J., & Shoelson, S. E. (2005) · Nature Medicine · doi:10.1038/nm1166 · Cited by 2,245
IKK-1 and IKK-2: Cytokine-Activated IκB Kinases Essential for NF-κB Activation
Mercurio, F., Zhu, H., Murray, B. W., Shevchenko, A., Bennett, B. L., Li, J. W., Young, D. B., Barbosa, M. S., Mann, M., Manning, A. M., et al. (1997) · Science · doi:10.1126/science.278.5339.860 · Cited by 2,042
TLR4 enhances TGF-β signaling and hepatic fibrosis
Seki, E., De Minicis, S., Österreicher, C. H., Kluwe, J., Osawa, Y., Brenner, D. A., & Schwabe, R. F. (2007) · Nature Medicine · doi:10.1038/nm1663 · Cited by 1,942
Self-citation
MicroRNA-155 is induced during the macrophage inflammatory response
O'Connell, R. M., Taganov, K. D., Boldin, M. P., Cheng, G., & Baltimore, D. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0610731104 · Cited by 1,866
The IκB Kinase Complex (IKK) Contains Two Kinase Subunits, IKKα and IKKβ, Necessary for IκB Phosphorylation and NF-κB Activation
Zandi, E., Rothwarf, D. M., Delhase, M., Hayakawa, M., & Karin, M. (1997) · Cell · doi:10.1016/s0092-8674(00)80406-7 · Cited by 1,814
Reactive Oxygen Species Promote TNFα-Induced Death and Sustained JNK Activation by Inhibiting MAP Kinase Phosphatases
Kamata, H., Honda, S.-I., Maeda, S., Chang, L., Hirata, H., & Karin, M. (2005) · Cell · doi:10.1016/j.cell.2004.12.041 · Cited by 1,792
IKK-β links inflammation to obesity-induced insulin resistance
Arkan, M. C., Hevener, A. L., Greten, F. R., Maeda, S., Li, Z.-W., Long, J. M., Wynshaw-Boris, A., Poli, G., Olefsky, J., & Karin, M. (2005) · Nature Medicine · doi:10.1038/nm1185 · Cited by 1,773
Dietary and Genetic Obesity Promote Liver Inflammation and Tumorigenesis by Enhancing IL-6 and TNF Expression
Park, E. J., Lee, J. H., Yu, G.-Y., He, G., Ali, S. R., Holzer, R. G., Österreicher, C. H., Takahashi, H., & Karin, M. (2010) · Cell · doi:10.1016/j.cell.2009.12.052 · Cited by 1,764
Selective depletion of macrophages reveals distinct, opposing roles during liver injury and repair
Duffield, J. S., Forbes, S. J., Constandinou, C. M., Clay, S., Partolina, M., Vuthoori, S., Wu, S., Lang, R., & Iredale, J. P. (2005) · Journal of Clinical Investigation · doi:10.1172/jci200522675 · Cited by 1,649
Liver fibrosis
Bataller, R. A. (2005) · Journal of Clinical Investigation · doi:10.1172/jci200524282c1 · Cited by 1,480
Activation by IKKα of a Second, Evolutionary Conserved, NF-κB Signaling Pathway
Senftleben, U., Cao, Y., Xiao, G., Greten, F. R., Krähn, G. M., Bonizzi, G., Chen, Y., Hu, Y., Fong, A., Sun, S., et al. (2001) · Science · doi:10.1126/science.1062677 · Cited by 1,361
Diabetes increases the risk of chronic liver disease and hepatocellular carcinoma
El‐Serag, H. B., Tran, T., & Everhart, J. E. (2004) · Gastroenterology · doi:10.1053/j.gastro.2003.10.065 · Cited by 1,242
IκB Kinase-β: NF-κB Activation and Complex Formation with IκB Kinase-α and NIK
Woronicz, J. D., Gao, X., Cao, Z., Rothe, M., & Goeddel, D. V. (1997) · Science · doi:10.1126/science.278.5339.866 · Cited by 1,183
IKKβ Couples Hepatocyte Death to Cytokine-Driven Compensatory Proliferation that Promotes Chemical Hepatocarcinogenesis
Maeda, S., Kamata, H., Luo, J., Leffert, H. L., & Karin, M. (2005) · Cell · doi:10.1016/j.cell.2005.04.014 · Cited by 1,160
Mechanisms of spontaneous resolution of rat liver fibrosis. Hepatic stellate cell apoptosis and reduced hepatic expression of metalloproteinase inhibitors
Iredale, J. P., Benyon, R. C., Pickering, J., McCullen, M., Northrop, M., Pawley, S., Hovell, C., & Arthur, M. J. (1998) · Journal of Clinical Investigation · doi:10.1172/jci1018 · Cited by 1,075
Fasting Serum Glucose Level and Cancer Risk in Korean Men and Women
Jee, S. H. (2005) · JAMA · doi:10.1001/jama.293.2.194 · Cited by 989
Severe Liver Degeneration in Mice Lacking the IκB Kinase 2 Gene
Li, Q., Antwerp, D. V., Mercurio, F., Lee, K., & Verma, I. M. (1999) · Science · doi:10.1126/science.284.5412.321 · Cited by 963
The IKKβ Subunit of IκB Kinase (IKK) is Essential for Nuclear Factor κB Activation and Prevention of Apoptosis
Li, Z., Chu, W., Hu, Y., Delhase, M., Deerinck, T. J., Ellisman, M. H., Johnson, R. S., & Karin, M. (1999) · The Journal of Experimental Medicine · doi:10.1084/jem.189.11.1839 · Cited by 927
Lipid Metabolism and Liver Inflammation. II. Fatty liver disease and fatty acid oxidation
Reddy, J. K., & Rao, M. S. (2006) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00521.2005 · Cited by 872
IκB Kinase Promotes Tumorigenesis through Inhibition of Forkhead FOXO3a
Hu, M. C.-T., Lee, D.-F., Xia, W., Golfman, L. S., Ou-Yang, F., Yang, J.-Y., Zou, Y., Bao, S., Hanada, N., Saso, H., et al. (2004) · Cell · doi:10.1016/s0092-8674(04)00302-2 · Cited by 868
Positive and Negative Regulation of IκB Kinase Activity Through IKKβ Subunit Phosphorylation
Delhase, M., Hayakawa, M., Chen, Y., & Karin, M. (1999) · Science · doi:10.1126/science.284.5412.309 · Cited by 852
NF- B as a Critical Link Between Inflammation and CancerPreprint
Karin, M. (2009) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a000141 · Cited by 841
STAT3 Activation of miR-21 and miR-181b-1 via PTEN and CYLD Are Part of the Epigenetic Switch Linking Inflammation to Cancer
Iliopoulos, D., Jaeger, S. A., Hirsch, H. A., Bulyk, M. L., & Struhl, K. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.07.023 · Cited by 830
Abnormal Morphogenesis But Intact IKK Activation in Mice Lacking the IKKα Subunit of IκB Kinase
Hu, Y., Baud, V., Delhase, M., Zhang, P., Deerinck, T. J., Ellisman, M. H., Johnson, R. S., & Karin, M. (1999) · Science · doi:10.1126/science.284.5412.316 · Cited by 822
Micro-RNA profiling reveals a role for miR-29 in human and murine liver fibrosis
Roderburg, C., Urban, G.-W., Bettermann, K., Vucur, M., Zimmermann, H. W., Schmidt, S., Janssen, J., Koppe, C., Knolle, P. A., Castoldi, M., et al. (2010) · Hepatology · doi:10.1002/hep.23922 · Cited by 821
Self-citation
The p65 subunit is responsible for the strong transcription activating potential of NF‐kappa B.
Schmitz, M. L., & Baeuerle, P. A. (1991) · The EMBO Journal · doi:10.1002/j.1460-2075.1991.tb04950.x · Cited by 796
Toll-Like Receptor 9 Promotes Steatohepatitis by Induction of Interleukin-1β in Mice
Miura, K., Kodama, Y., Inokuchi, S., Schnabl, B., Aoyama, T., Ohnishi, H., Olefsky, J. M., Brenner, D. A., & Seki, E. (2010) · Gastroenterology · doi:10.1053/j.gastro.2010.03.052 · Cited by 741
Recognition and Signaling by Toll-Like Receptors
West, A. P., Koblansky, A. A., & Ghosh, S. (2006) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.21.122303.115827 · Cited by 736
Induction of gadd45β by NF-κB downregulates pro-apoptotic JNK signalling
De Smaele, E., Zazzeroni, F., Papa, S., Nguyen, D. U., Jin, R., Jones, J., Cong, R., & Franzoso, G. (2001) · Nature · doi:10.1038/35104560 · Cited by 732
Histologic Improvement of Fibrosis in Patients with Hepatitis C Who Have Sustained Response to Interferon Therapy
Shiratori, Y., Imazeki, F., Moriyama, M., Yano, M., Arakawa, Y., Yokosuka, O., Kuroki, T., Nishiguchi, S., Sata, M., Yamada, G., et al. (2000) · Annals of Internal Medicine · doi:10.7326/0003-4819-132-7-200004040-00002 · Cited by 732
The wolf in sheep's clothing: the role of interleukin-6 in immunity, inflammation and cancer
Naugler, W. E., & Karin, M. (2008) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2007.12.007 · Cited by 730
Inhibition of JNK activation through NF-κB target genes
Tang, G., Minemoto, Y., Dibling, B., Purcell, N. H., Li, Z., Karin, M., & Lin, A. (2001) · Nature · doi:10.1038/35104568 · Cited by 721
The E3 Ubiquitin Ligase Itch Couples JNK Activation to TNFα-induced Cell Death by Inducing c-FLIPL Turnover
Chang, L., Kamata, H., Solinas, G., Luo, J.-L., Maeda, S., Venuprasad, K., Liu, Y.-C., & Karin, M. (2006) · Cell · doi:10.1016/j.cell.2006.01.021 · Cited by 706
Identification of the receptor component of the IκBα–ubiquitin ligase
Yaron, A., Hatzubai, A., Davis, M., Lavon, I., Amit, S., Manning, A. M., Andersen, J., Mann, M., Mercurio, F., & Ben‐Neriah, Y. (1998) · Nature · doi:10.1038/25159 · Cited by 654
Toll-Like Receptor 4 Mediates Inflammatory Signaling by Bacterial Lipopolysaccharide in Human Hepatic Stellate Cells
Paik, Y.-H., Schwabe, R. F., Bataller, R., Russo, M. P., Jobin, C., & Brenner, D. A. (2003) · Hepatology · doi:10.1053/jhep.2003.50182 · Cited by 651
Self-citation
Transcriptional regulation via the NF-κB signaling module
Hoffmann, A., Natoli, G., & Ghosh, G. (2006) · Oncogene · doi:10.1038/sj.onc.1209933 · Cited by 649
Limb and Skin Abnormalities in Mice Lacking IKKα
Takeda, K., Takeuchi, O., Tsujimura, T., Itami, S., Adachi, O., Kawai, T., Sanjo, H., Yoshikawa, K., Terada, N., & Akira, S. (1999) · Science · doi:10.1126/science.284.5412.313 · Cited by 606
Deletion of NEMO/IKKγ in Liver Parenchymal Cells Causes Steatohepatitis and Hepatocellular Carcinoma
Luedde, T., Beraza, N., Kotsikoris, V., Loo, G., Nenci, A., Vos, R. D., Roskams, T., Trautwein, C., & Pasparakis, M. (2007) · Cancer Cell · doi:10.1016/j.ccr.2006.12.016 · Cited by 603
Self-citation
Inflammation and Cancer: IL-6 and STAT3 Complete the Link
Bromberg, J., & Wang, T. C. (2009) · Cancer Cell · doi:10.1016/j.ccr.2009.01.009 · Cited by 570
Embryonic Lethality, Liver Degeneration, and Impaired NF-κB Activation in IKK-β-Deficient Mice
Tanaka, M., Fuentes, M. E., Yamaguchi, T., Durnin, M., Dalrymple, S. A., Hardy, K. L., & Goeddel, D. V. (1999) · Immunity · doi:10.1016/s1074-7613(00)80042-4 · Cited by 569
Lethal toxicity of lipopolysaccharide and tumor necrosis factor in normal and D-galactosamine-treated mice.
Lehmann, V., Freudenberg, M. A., & Galanos, C. (1987) · The Journal of Experimental Medicine · doi:10.1084/jem.165.3.657 · Cited by 547
The changing pattern of epidemiology in hepatocellular carcinoma
Nordenstedt, H., White, D. L., & El‐Serag, H. B. (2010) · Digestive and Liver Disease · doi:10.1016/s1590-8658(10)60507-5 · Cited by 545
A nucleosomal function for IκB kinase-α in NF-κB-dependent gene expression
Anest, V., Ostrander, J. H., Cogswell, P. C., Steinbrecher, K. A., Strahl, B. D., & Baldwin, A. S. (2003) · Nature · doi:10.1038/nature01648 · Cited by 522
Severe liver degeneration and lack of NF-kappaB activation in NEMO/IKKgamma-deficient mice.
Rudolph, D., Yeh, W., Wakeham, A. C., Rudolph, B., Nallainathan, D., Potter, J., Elia, A., & Mak, T. W. (2000) · PubMed Central · Cited by 518
Mechanisms of Disease: mechanisms of hepatic fibrosis and therapeutic implications
Friedman, S. L. (2004) · Nature Clinical Practice Gastroenterology & Hepatology · doi:10.1038/ncpgasthep0055 · Cited by 508
Signalling pathways in alcohol-induced liver inflammation
Mandrekar, P., & Szabó, G. (2009) · Journal of Hepatology · doi:10.1016/j.jhep.2009.03.007 · Cited by 500
Murine hepatocyte apoptosis induced in vitro and in vivo by TNF- alpha requires transcriptional arrest.
Leist, M., Gantner, F., Bohlinger, I., Germann, P., Tiegs, G., & Wendel, A. (1994) · The Journal of Immunology · doi:10.4049/jimmunol.153.4.1778 · Cited by 490
Severe liver degeneration and lack of NF-κ B activation in NEMO/IKKγ-deficient mice
Rudolph, D., Yeh, W.-C., Wakeham, A., Rudolph, B., Nallainathan, D., Potter, J., Elia, A. J., & Mak, T. W. (2000) · Genes & Development · doi:10.1101/gad.14.7.854 · Cited by 479
NFkappaB prevents apoptosis and liver dysfunction during liver regeneration.
Iimuro, Y., Nishiura, T., Hellerbrand, C., Behrns, K. E., Schoonhoven, R., Grisham, J. W., & Brenner, D. A. (1998) · Journal of Clinical Investigation · doi:10.1172/jci483 · Cited by 447
Hepatocellular carcinoma
Okuda, K. (2000) · Journal of Hepatology · doi:10.1016/s0168-8278(00)80428-6 · Cited by 444
CCR1 and CCR5 promote hepatic fibrosis in mice
Seki, E., De Minicis, S., Gwak, G.-Y., Kluwe, J., Inokuchi, S., Bursill, C. A., Llovet, J. M., Brenner, D. A., & Schwabe, R. F. (2009) · Journal of Clinical Investigation · doi:10.1172/jci37444 · Cited by 431
Self-citation
Gene Expression Profiles During Hepatic Stellate Cell Activation in Culture and In Vivo
Minicis, S. D., Seki, E., Uchinami, H., Kluwe, J., Zhang, Y., Brenner, D. A., & Schwabe, R. F. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.02.033 · Cited by 427
Self-citation
Hepatocyte IKKβ/NF-κB Inhibits Tumor Promotion and Progression by Preventing Oxidative Stress-Driven STAT3 Activation
He, G., Yu, G.-Y., Temkin, V., Ogata, H., Kuntzen, C., Sakurai, T., Sieghart, W., Peck-Radosavljevic, M., Leffert, H. L., & Karin, M. (2010) · Cancer Cell · doi:10.1016/j.ccr.2009.12.048 · Cited by 427
Regression of liver fibrosis after biliary drainage in patients with chronic pancreatitis and stenosis of the common bile duct
Hammel, P., Couvelard, A., O'Toole, D., Ratouis, A., Sauvanet, A., Fléjou, J. F., Degott, C., Belghiti, J., Bernades, P., Valla, D., et al. (2001) · New England Journal of Medicine · doi:10.1056/nejm200102083440604 · Cited by 427
Toll-Like Receptor Signaling in the Liver
Schwabe, R. F., Seki, E., & Brenner, D. A. (2006) · Gastroenterology · doi:10.1053/j.gastro.2006.01.038 · Cited by 411
Self-citation
A Fourth IκB Protein within the NF-κB Signaling Module
Basak, S., Kim, H., Kearns, J. D., Tergaonkar, V., O'Dea, E. L., Werner, S. L., Benedict, C. A., Ware, C. F., Ghosh, G., Verma, I. M., et al. (2007) · Cell · doi:10.1016/j.cell.2006.12.033 · Cited by 404
Loss of hepatic NF-κB activity enhances chemical hepatocarcinogenesis through sustained c-Jun N-terminal kinase 1 activation
Sakurai, T., Maeda, S., Chang, L., & Karin, M. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0603499103 · Cited by 403
Nuclear localization of IκBα promotes active transport of NF-κB from the nucleus to the cytoplasm
Arenzana‐Seisdedos, F., Turpin, P., Rodríguez, M. S., Thomas, D., Hay, R. T., Virelizier, J., & Dargemont, C. (1997) · Journal of Cell Science · doi:10.1242/jcs.110.3.369 · Cited by 399
Hepatocyte Apoptosis, Expression of Death Receptors, and Activation of NF-κB in the Liver of Nonalcoholic and Alcoholic Steatohepatitis Patients
Ribeiro, P. S., Cortez‐Pinto, H., Solá, S., Castro, R. E., Ramalho, R. M., Baptista, A., de Moura, M. C., Camilo, M., & Rodrigues, C. M. (2004) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2004.40009.x · Cited by 392
A Lymphotoxin-Driven Pathway to Hepatocellular Carcinoma
Haybaeck, J., Zeller, N., Wolf, M. J., Weber, A., Wagner, U., Kurrer, M. O., Bremer, J., Iezzi, G., Graf, R., Clavien, P., et al. (2009) · Cancer Cell · doi:10.1016/j.ccr.2009.08.021 · Cited by 381
The alternative NF-κB pathway from biochemistry to biology: Pitfalls and promises for future drug development
Dejardin, E. (2006) · Biochemical Pharmacology · doi:10.1016/j.bcp.2006.08.007 · Cited by 361
Not interferon, but interleukin‐6 controls early gene expression in hepatitis B virus infection
Hösel, M., Quasdorff, M., Wiegmann, K., Webb, D., Zedler, U., Broxtermann, M., Tedjokusumo, R., Esser, K., Arzberger, S., Kirschning, C. J., et al. (2009) · Hepatology · doi:10.1002/hep.23226 · Cited by 360
Toll-like receptors as targets in chronic liver diseases
Mencin, A. M., Kluwe, J., & Schwabe, R. F. (2009) · Gut · doi:10.1136/gut.2008.156307 · Cited by 340
Self-citation
The NEMO adaptor bridges the nuclear factor-κB and interferon regulatory factor signaling pathways
Zhao, T., Yang, L., Sun, Q., Arguello, M., Ballard, D. W., Hiscott, J. B., & Lin, R. (2007) · Nature Immunology · doi:10.1038/ni1465 · Cited by 317
Absence of tumor necrosis factor rescues RelA-deficient mice from embryonic lethality
Doi, T. S., Marino, M. W., Takahashi, T., Yoshida, T., Sakakura, T., Old, L. J., & Obata, Y. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.6.2994 · Cited by 299
IKKβ Is Required for Prevention of Apoptosis Mediated by Cell-Bound but Not by Circulating TNFα
Maeda, S., Chang, L., Li, Z.-W., Luo, J.-L., Leffert, H., & Karin, M. (2003) · Immunity · doi:10.1016/s1074-7613(03)00301-7 · Cited by 286
Disruption of TAK1 in hepatocytes causes hepatic injury, inflammation, fibrosis, and carcinogenesis
Inokuchi, S., Aoyama, T., Miura, K., Österreicher, C. H., Kodama, Y., Miyai, K. N., Akira, S., Brenner, D. A., & Seki, E. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0909781107 · Cited by 283
Inhibition of inhibitor of κB kinases stimulates hepatic stellate cell apoptosis and accelerated recovery from rat liver fibrosis
Oakley, F., Meso, M., Iredale, J. P., Green, K., Marek, C. J., Zhou, X., May, M. J., Millward‐Sadler, H., Wright, M. C., & Mann, D. A. (2005) · Gastroenterology · doi:10.1053/j.gastro.2004.10.003 · Cited by 265
Apoptotic hepatocyte DNA inhibits hepatic stellate cell chemotaxis via toll-like receptor 9
Watanabe, A., Hashmi, A., Gomes, D. A., Town, T., Badou, A., Flavell, R. A., & Mehal, W. Z. (2007) · Hepatology · doi:10.1002/hep.21867 · Cited by 262
NF‐κB: A Multifaceted Transcription Factor Regulated at Several Levels
Schmitz, M. L., Mattioli, I., Buss, H., & Kracht, M. (2004) · ChemBioChem · doi:10.1002/cbic.200400144 · Cited by 245
Hepatic Expression of CXC Chemokines Predicts Portal Hypertension and Survival in Patients With Alcoholic Hepatitis
Dominguez, M., Miquel, R., Colmenero, J., Moreno, M., García–Pagán, J., Bosch, J., Arroyo, V., Ginès, P., Caballería, J., & Bataller, R. (2009) · Gastroenterology · doi:10.1053/j.gastro.2009.01.056 · Cited by 238
Tumor necrosis factor in the pathogenesis of infectious diseases
Beutler, B., & Grau, G. E. (1993) · Critical Care Medicine · doi:10.1097/00003246-199310001-00003 · Cited by 236
New insights into the antifibrotic effects of sorafenib on hepatic stellate cells and liver fibrosis
Wang, Y., Gao, J., Zhang, D., Zhang, J., Ma, J., & Jiang, H. (2010) · Journal of Hepatology · doi:10.1016/j.jhep.2010.02.027 · Cited by 233
TAK1 Suppresses a NEMO-Dependent but NF-κB-Independent Pathway to Liver Cancer
Bettermann, K., Vucur, M., Haybaeck, J., Koppe, C., Janssen, J., Heymann, F., Weber, A., Weiskirchen, R., Liedtke, C., Gaßler, N., et al. (2010) · Cancer Cell · doi:10.1016/j.ccr.2010.03.021 · Cited by 219
Self-citation
Functional Linkage of Cirrhosis-Predictive Single Nucleotide Polymorphisms of Toll-Like Receptor 4 to Hepatic Stellate Cell Responses
Guo, J., Loke, J., Zheng, F., Hong, F., Yea, S., Fukata, M., Tarocchi, M., Abar, O. T., Huang, H., Sninsky, J. J., et al. (2009) · Hepatology · doi:10.1002/hep.22697 · Cited by 217
Modulation of Hepatic Fibrosis by c-Jun-N-Terminal Kinase Inhibition
Kluwe, J., Pradere, J., Gwak, G., Mencin, A., De Minicis, S., Österreicher, C. H., Colmenero, J., Bataller, R., & Schwabe, R. F. (2010) · Gastroenterology · doi:10.1053/j.gastro.2009.09.015 · Cited by 217
Self-citation
Rapid DNA binding by nuclear factor kappa B in hepatocytes at the start of liver regeneration.
Fitzgerald, M. J., Webber, E. M., Donovan, J. R., & Fausto, N. (1995) · PubMed · Cited by 213
The Role of Inflammation in Cholestasis: Clinical and Basic Aspects
Kosters, A., & Karpen, S. J. (2010) · Seminars in Liver Disease · doi:10.1055/s-0030-1253227 · Cited by 208
Tumor necrosis factor-induced apoptosis during the poisoning of mice with hepatotoxins
Leist, M., Gantner, F., Naumann, H., Bluethmann, H., Vogt, K., Brigelius‐Flohé, R., Nicotera, P., Volk, H., & Wendel, A. (1997) · Gastroenterology · doi:10.1053/gast.1997.v112.pm9041255 · Cited by 202
Activation of nuclear factor κB in hepatitis C virus infection: Implications for pathogenesis and hepatocarcinogenesis
Tai, D., Tsai, S., Chen, Y.-M., Chuang, Y.-L., Peng, C., Sheen, I., Yeh, C., Chang, K. S. S., Huang, S.-N., Kuo, G. C., et al. (2000) · Hepatology · doi:10.1002/hep.510310316 · Cited by 192
IκBβ acts to inhibit and activate gene expression during the inflammatory response
Rao, P., Hayden, M. S., Long, M., Scott, M. L., West, A. P., Zhang, D., Oeckinghaus, A., Lynch, C., Hoffmann, A., Baltimore, D., et al. (2010) · Nature · doi:10.1038/nature09283 · Cited by 188
NF-κB inactivation converts a hepatocyte cell line TNF-α response from proliferation to apoptosis
Xu, Y., Bialik, S., Jones, B., Iimuro, Y., Kitsis, R. N., Srinivasan, A. N., Brenner, D. A., & Czaja, M. J. (1998) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1998.275.4.c1058 · Cited by 187
Deletion of IKK2 in hepatocytes does not sensitize these cells to TNF-induced apoptosis but protects from ischemia/reperfusion injury
Luedde, T., Assmus, U., Wüstefeld, T., zu Vilsendorf, A. M., Roskams, T., Schmidt-Supprian, M., Rajewsky, K., Brenner, D. A., Manns, M. P., Pasparakis, M., et al. (2005) · Journal of Clinical Investigation · doi:10.1172/jci23493 · Cited by 178
Self-citation
Inhibition of NFκB in activated rat hepatic stellate cells by proteasome inhibitors and an IκB super-repressor
Hellerbrand, C., Jobin, C., Iimuro, Y., Licato, L. L., Sartor, R. B., & Brenner, D. A. (1998) · Hepatology · doi:10.1002/hep.510270514 · Cited by 170
NF-κB, an Evolutionarily Conserved Mediator of Immune and Inflammatory Responses
Xiao, C., & Ghosh, S. (2005) · Advances in Experimental Medicine and Biology · doi:10.1007/0-387-24180-9_5 · Cited by 167
The NF-κB p50:p50:HDAC-1 repressor complex orchestrates transcriptional inhibition of multiple pro-inflammatory genes
Elsharkawy, A. M., Oakley, F., Lin, F., Packham, G., Mann, D. A., & Mann, J. (2010) · Journal of Hepatology · doi:10.1016/j.jhep.2010.03.025 · Cited by 160
Chemokines in Liver Inflammation and Fibrosis
Wasmuth, H. E., Tacke, F., & Trautwein, C. (2010) · Seminars in Liver Disease · doi:10.1055/s-0030-1255351 · Cited by 159
Induction of Hepatitis by JNK-Mediated Expression of TNF-α
Das, M., Sabio, G., Jiang, F., Rincón, M., Flavell, R. A., & Davis, R. J. (2009) · Cell · doi:10.1016/j.cell.2008.11.017 · Cited by 158
NF-kappaB Inhibits Expression of the alpha1(I) Collagen Gene
Rippe, R. A., Schrum, L. W., Stefanovic, B., Solis-Herruzo, J. A., & Brenner, D. A. (1999) · DNA and Cell Biology · doi:10.1089/104454999314890 · Cited by 156
CD40 Activates NF-κB and c-Jun N-Terminal Kinase and Enhances Chemokine Secretion on Activated Human Hepatic Stellate Cells
Schwabe, R. F., Schnabl, B., Kweon, Y. O., & Brenner, D. A. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.166.11.6812 · Cited by 155
Self-citation
The combined absence of the transcription factors Rel and RelA leads to multiple hemopoietic cell defects
Grossmann, M., Metcalf, D., Merryfull, J., Beg, A. A., Baltimore, D., & Gerondakis, S. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.21.11848 · Cited by 152
Activation of NF-kappaB, AP-1 and STAT transcription factors is a frequent and early event in human hepatocellular carcinomas
Liu, P., Kimmoun, E., Legrand, A., Sauvanet, A., Degott, C., Lardeux, B. R., & Bernuau, D. (2002) · Journal of Hepatology · doi:10.1016/s0168-8278(02)00064-8 · Cited by 149
Role of TLR9 in hepatic stellate cells and experimental liver fibrosis
Gäbele, E., Mühlbauer, M., Dorn, C., Weiß, T. S., Froh, M., Schnabl, B., Wiest, R., Schölmerich, J., Obermeier, F., & Hellerbrand, C. (2008) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2008.08.096 · Cited by 148
The chemokine CCL21 modulates lymphocyte recruitment and fibrosis in chronic hepatitis C1 1The authors thank Wanda Delogu and Nadia Navari for skillful technical help, Dr. Roberto G. Romanelli for help in collecting liver biopsy specimens, and Dr. Mario Strazzabosco (Ospedali Riuniti di Bergamo, Italy) for providing part of the tissue samples with primary biliary cirrhosis.
Bonacchi, A., Petrai, I., DeFranco, R., Lazzeri, E., Annunziato, F., Efsen, E., Cosmi, L., Romagnani, P., Milani, S., Failli, P., et al. (2003) · Gastroenterology · doi:10.1016/s0016-5085(03)01194-6 · Cited by 147
Differential requirement for c‐Jun NH 2 ‐terminal kinase in TNF‐α‐and Fas‐mediated apoptosis in hepatocytes
Schwabe, R. F., Uchinami, H., Qian, T., Bennett, B. L., Lemasters, J. J., & Brenner, D. A. (2004) · The FASEB Journal · doi:10.1096/fj.03-0771fje · Cited by 141
Self-citation
Persistent activation of nuclear factor-κB in cultured rat hepatic stellate cells involves the induction of potentially novel rel-like factors and prolonged changes in the expression of IκB family proteins
Elsharkawy, A. M., Wright, M. C., Hay, R. T., Arthur, M. J. P., Hughes, T., Bahr, M. J., Degitz, K., & Mann, D. A. (1999) · Hepatology · doi:10.1002/hep.510300327 · Cited by 132
Repression of gene expression by unphosphorylated NF-κB p65 through epigenetic mechanismsPreprint
Dong, J., Jimi, E., Zhong, H., Hayden, M. S., & Ghosh, S. (2008) · Genes & Development · doi:10.1101/gad.1657408 · Cited by 132
Angiotensin II Activates IκB Kinase Phosphorylation of RelA at Ser536 to Promote Myofibroblast Survival and Liver Fibrosis
Oakley, F., Teoh, V. W. Y., Ching-A-Sue, G., Bataller, R. A., Colmenero, J., Jonsson, J. R., Eliopoulos, A. G., Watson, M. R., Manas, D., & Mann, D. A. (2009) · Gastroenterology · doi:10.1053/j.gastro.2009.02.081 · Cited by 127
Nuclear Factor-κB1 (p50) Limits the Inflammatory and Fibrogenic Responses to Chronic Injury
Oakley, F., Mann, J., Nailard, S., Smart, D. E., Mungalsingh, N., Constandinou, C., Ali, S., Wilson, S. J., Millward-Sadler, H., Iredale, J. P., et al. (2005) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)62291-2 · Cited by 123
Selective inactivation of NF-κB in the liver using NF-κB decoy suppresses CCl4-induced liver injury and fibrosis
Son, G., Iimuro, Y., Seki, E., Hirano, T., Kaneda, Y., & Fujimoto, J. (2007) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00185.2007 · Cited by 121
Hepatic NF-κB essential modulator deficiency prevents obesity-induced insulin resistance but synergizes with high-fat feeding in tumorigenesis
Wunderlich, F. T., Luedde, T., Singer, S., Schmidt‐Supprian, M., Baumgartl, J., Schirmacher, P., Pasparakis, M., & Brüning, J. C. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0707849104 · Cited by 112
Self-citation
Mechanism of processing of the NF-κB2 p100 precursor: identification of the specific polyubiquitin chain-anchoring lysine residue and analysis of the role of NEDD8-modification on the SCFβ-TrCP ubiquitin ligase
Amir, R. E., Haecker, H., Karin, M., & Ciechanover, A. J. (2003) · Oncogene · doi:10.1038/sj.onc.1207366 · Cited by 109
THE ROLE OF INTESTINAL BACTERIA IN THE DEVELOPMENT OF DIETARY CIRRHOSIS IN RATS
Rutenburg, A. M., Sonnenblick, E., Koven, I., Aprahamian, H. A., Reiner, L., & Fine, J. (1957) · The Journal of Experimental Medicine · doi:10.1084/jem.106.1.1 · Cited by 108
Liver NF‐κB and AP‐1 DNA Binding in Obese Patients
Videla, L. A., Tapia, G., Rodrigo, R., Pettinelli, P., Haim, D., Santibáñez, C., Araya, A. V., Smok, G., Csendes, A., Gutiérrez, L., et al. (2009) · Obesity · doi:10.1038/oby.2008.601 · Cited by 104
Vitronectin induces migration of activated T lymphocytes
Edwards, S., Price, K. H., & Adams, D. (2000) · Journal of Hepatology · doi:10.1016/s0168-8278(00)81190-3 · Cited by 100
Reversibility of Cirrhosis in Patients Cured of Thalassemia by Bone Marrow Transplantation
Muretto, P., Angelucci, E., & Lucarelli, G. (2002) · Annals of Internal Medicine · doi:10.7326/0003-4819-136-9-200205070-00009 · Cited by 99
INFLUENCE OF NEOMYCIN AND INGESTED ENDOTOXIN IN THE PATHOGENESIS OF CHOLINE DEFICIENCY CIRRHOSIS IN THE ADULT RAT
Broitman, S. A., Gottlieb, L. S., & Zamcheck, N. (1964) · The Journal of Experimental Medicine · doi:10.1084/jem.119.4.633 · Cited by 99
p38α MAPK inhibits JNK activation and collaborates with IκB kinase 2 to prevent endotoxin‐induced liver failure
Heinrichsdorff, J., Luedde, T., Perdiguero, E., Nebreda, Á. R., & Pasparakis, M. (2008) · EMBO Reports · doi:10.1038/embor.2008.149 · Cited by 99
Self-citation
Constitutively active NF-κB triggers systemic TNFα-dependent inflammation and localized TNFα-independent inflammatory diseasePreprint
Dong, J., Jimi, E., Zeiss, C. J., Hayden, M. S., & Ghosh, S. (2010) · Genes & Development · doi:10.1101/gad.1958410 · Cited by 96
Normal epidermal differentiation but impaired skin-barrier formation upon keratinocyte-restricted IKK1 ablation
Gareus, R., Huth, M., Breiden, B., Nenci, A., Rösch, N., Haase, I., Bloch, W., Sandhoff, K., & Pasparakis, M. (2007) · Nature Cell Biology · doi:10.1038/ncb1560 · Cited by 96
Intracellular survival pathways in the liver
Luedde, T., & Trautwein, C. (2006) · Liver International · doi:10.1111/j.1478-3231.2006.01366.x · Cited by 95
Self-citation
IKK1 and IKK2 cooperate to maintain bile duct integrity in the liver
Luedde, T., Heinrichsdorff, J., Lorenzi, R. D., Vos, R. D., Roskams, T., & Pasparakis, M. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0800198105 · Cited by 90
Self-citation
Signaling Pathways in Liver Diseases
Dufour, J., Trautwein, C., Graf, R., & Clavien, P. (2005) · Springer eBooks · doi:10.1007/b138739 · Cited by 70
Inhibitor of nuclear factor kappaB kinase deficiency enhances oxidative stress and prolongs c-Jun NH2-terminal kinase activation induced by arsenic.
Chen, F., Castranova, V., Li, Z., Karin, M., & Shi, X. (2003) · PubMed · Cited by 64
the C-Rel Subunit of Nuclear Factor-κB Regulates Murine Liver Inflammation, Wound-Healing, and Hepatocyte Proliferation
Gieling, R. G., Elsharkawy, A. M., Caamaño, J., Cowie, D. E., Wright, M. C., Ebrahimkhani, M. R., Burt, A. D., Mann, J., Raychaudhuri, P., Liou, H., et al. (2009) · Hepatology · doi:10.1002/hep.23385 · Cited by 58
Nuclear factor-κB in the liver of patients with chronic hepatitis C: Decreased RelA expression is associated with enhanced fibrosis progression
Boya, P., Larrea, E., Sola, I., Majano, P. L., Jiménez, C., Civeira, M.-P., & Prìeto, J. (2001) · Hepatology · doi:10.1053/jhep.2001.29002 · Cited by 49
Increased Expression of iASPP, Regulated by Hepatitis B Virus X Protein-Mediated NF-κB Activation, in Hepatocellular Carcinoma
Lu, B., Guo, H., Zhao, J., Wang, C., Wu, G., Pang, M., Tong, X., Bu, F., Liang, A., Hou, S., et al. (2010) · Gastroenterology · doi:10.1053/j.gastro.2010.06.049 · Cited by 48
The hepatitis B viral X protein activates NF‐κB signaling pathway through the up‐regulation of TBK1
Kim, H., Lee, S. H., & Jung, G. (2009) · FEBS Letters · doi:10.1016/j.febslet.2009.11.091 · Cited by 46
Hepatitis B virus X protein upregulates expression of calpain small subunit 1 via nuclear facter‐κB/p65 in hepatoma cells
Zhang, F., Wang, Q., Ye, L., Feng, Y.-M., & Zhang, X. (2010) · Journal of Medical Virology · doi:10.1002/jmv.21753 · Cited by 45
Helicobacter pylori-induced H,K-ATPase α-subunit gene repression is mediated by NF-κB p50 homodimer promoter binding
Saha, A., Hammond, C. E., Trojanowska, M. E., & Smolka, A. J. (2008) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00431.2007 · Cited by 30
Analysis of the IKKβ/NF‐κB signaling pathway during embryonic angiogenesis
Hou, Y., Fu, L., Karin, M., & Ostrowski, M. C. (2008) · Developmental Dynamics · doi:10.1002/dvdy.21723 · Cited by 19
NF-κB
Luedde, T., & Trautwein, C. (2009) · Springer eBooks · doi:10.1007/978-3-642-00150-5_13 · Cited by 1
Self-citation

Sorted by citations

Bile acid-microbiota crosstalk in gastrointestinal inflammation and carcinogenesis
Jia, W., Xie, G., & Jia, W. (2018) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2017.119 · Cited by 1,924
Promotion of Hepatocellular Carcinoma by the Intestinal Microbiota and TLR4
Dapito, D. H., Mencin, A., Gwak, G.-Y., Pradere, J.-P., Jang, M.-K., Mederacke, I., Caviglia, J. M., Khiabanian, H., Adeyemi, A., Bataller, R., et al. (2012) · Cancer Cell · doi:10.1016/j.ccr.2012.02.007 · Cited by 1,346
Self-citation
Liver Fibrosis: Mechanistic Concepts and Therapeutic Perspectives
Roehlen, N., Crouchet, E., & Baumert, T. F. (2020) · Cells · doi:10.3390/cells9040875 · Cited by 1,237
Macrophage heterogeneity in liver injury and fibrosis
Tacke, F., & Zimmermann, H. W. (2014) · Journal of Hepatology · doi:10.1016/j.jhep.2013.12.025 · Cited by 1,061
Hepatic inflammation and fibrosis: Functional links and key pathways
Seki, E., & Schwabe, R. F. (2015) · Hepatology · doi:10.1002/hep.27332 · Cited by 972
Self-citation

See all 1,345

Authors: Luedde, T., & Schwabe, R. F.
Affiliations: Universitätsklinikum Aachen (DE)
Columbia University Irving Medical Center (US)
Corresponding author: Luedde, Tom
Schwabe, Robert F.
ORCID: Luedde, Tom
Schwabe, Robert F.
Venue: Nature Reviews Gastroenterology & Hepatology
Publisher: Springer Science and Business Media LLC
Published: 2011-02
Volume: 8
Issue: 2
Pages: 108-118
ISSN: 1759-5045 (ISSN-L)
1759-5053
DOI: 10.1038/nrgastro.2010.213
PMC: PMC3295539
OpenAlex: W1976777085
Cited by: 1,345
References: 137
Citations by year: 2026: 97 · 2025: 99 · 2024: 119 · 2023: 109 · 2022: 122 · 2021: 156 · 2020: 120 · 2019: 95 · 2018: 79 · 2017: 76 · 2016: 66 · 2015: 68 · 2014: 51 · 2013: 38 · 2012: 42
FWCI: 5.65
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
Locations: Nature Reviews Gastroenterology & Hepatology (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health (5u54ca126513-03)
National Institute on Alcohol Abuse and Alcoholism (R01AA020211)
National Cancer Institute (U54 CA126513.)
National Institute of Diabetes and Digestive and Kidney Diseases (R01DK076920)
National Center for Complementary and Integrative Health (R21AT003878)
Topics: Health Sciences › Medicine › Hepatology › Liver physiology and pathology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
Health Sciences › Medicine › Hepatology › Hepatocellular Carcinoma Treatment and Prognosis
Keywords: NF-κB, liver fibrosis, hepatocellular carcinoma, chronic liver disease, liver cirrhosis, chronic liver injury, liver inflammation, hepatocytes, non-parenchymal liver cells, NF-κB inhibition, hepatocyte viability
MeSH terms: Cell Survival, Fibrosis, Carcinoma, Hepatocellular, Homeostasis, Humans, Liver, Liver Neoplasms, NF-kappa B, Hepatocytes

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

NF-κB in the liver—linking injury, fibrosis and hepatocellular carcinoma

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks