Precision medicine in pancreatic cancer — fact or fiction?

Projecting Cancer Incidence and Deaths to 2030: The Unexpected Burden of Thyroid, Liver, and Pancreas Cancers in the United States

Rahib, L., Smith, B. D., Aizenberg, R., Rosenzweig, A. B., Fleshman, J. M., & Matrisian, L. M. (2014) · Cancer Research · doi:10.1158/0008-5472.can-14-0155 · Cited by 7,094 · see citing works

The prognostic landscape of genes and infiltrating immune cells across human cancers

Gentles, A. J., Newman, A. M., Liu, C. L., Bratman, S. V., Feng, W., Kim, D., Nair, V. S., Xu, Y., Khuong, A., Hoang, C. D., et al. (2015) · Nature Medicine · doi:10.1038/nm.3909 · Cited by 3,097 · see citing works

Glypican-1 identifies cancer exosomes and detects early pancreatic cancer

Melo, S. A., Luecke, L. B., Kahlert, C., Fernandez, A. F., Gammon, S. T., Kaye, J., LeBleu, V. S., Mittendorf, E. A., Weitz, J., Rahbari, N., et al. (2015) · Nature · doi:10.1038/nature14581 · Cited by 2,880 · see citing works

Virtual microdissection identifies distinct tumor- and stroma-specific subtypes of pancreatic ductal adenocarcinoma

Moffitt, R. A., Marayati, R., Flate, E. L., Volmar, K. E., Loeza, S. G. H., Hoadley, K. A., Rashid, N. U., Williams, L. A., Eaton, S. C., Chung, A. H., et al. (2015) · Nature Genetics · doi:10.1038/ng.3398 · Cited by 2,194 · see citing works

Organoid models of human and mouse ductal pancreatic cancer

Boj, S. F., Hwang, C.-I., Baker, L. A., Chio, I. I. C., Engle, D. D., Corbo, V., Jager, M., Ponz-Sarvise, M., Tiriac, H., Spector, M. S., et al. (2015) · Cell · doi:10.1016/j.cell.2014.12.021 · Cited by 2,150 · see citing works

Ductal pancreatic cancer modeling and drug screening using human pluripotent stem cell– and patient-derived tumor organoids

Huang, L., Holtzinger, A., Jagan, I., BeGora, M. D., Lohse, I., Ngai, N., Nostro, M. C., Wang, R., Muthuswamy, L. B., Crawford, H. C., et al. (2015) · Nature Medicine · doi:10.1038/nm.3973 · Cited by 745 · see citing works

The Clinical Utility of CA 19-9 in Pancreatic Adenocarcinoma: Diagnostic and Prognostic Updates

Poruk, K. E., Gay, D., Brown, K. S., Mulvihill, J. D., Boucher, K. M., Scaife, C. L., Firpo, M. A., & Mulvihill, S. J. (2013) · Current Molecular Medicine · doi:10.2174/1566524011313030003 · Cited by 396 · see citing works

Cell-free DNA next-generation sequencing in pancreatobiliary carcinomas

Zill, O. A., Greene, C., Sebisanovic, D., Siew, L. M., Leng, J., Vu, M., Hendifar, A. E., Wang, Z., Atreya, C. E., Kelley, R. K., et al. (2015) · Cancer Discovery · doi:10.1158/2159-8290.cd-15-0274 · Cited by 282 · see citing works

Modelling the benefits of early diagnosis of pancreatic cancer using a biomarker signature

Ghatnekar, O., Andersson, R., Svensson, M., Persson, U., Ringdahl, U., Zeilon, P., & Borrebaeck, C. A. K. (2013) · International Journal of Cancer · doi:10.1002/ijc.28256 · Cited by 85 · see citing works

CA19-9 and CA242 as tumor markers for the diagnosis of pancreatic cancer: a meta-analysis

Gui, J., Yan, W., & Liu, X. (2013) · Clinical and Experimental Medicine · doi:10.1007/s10238-013-0234-9 · Cited by 81 · see citing works

Multiparametric plasma EV profiling facilitates diagnosis of pancreatic malignancy

Yang, K. S., Im, H., Hong, S., Pergolini, I., del Castillo, A. F., Wang, R., Clardy, S. M., Huang, C.-H., Pille, C., Ferrone, S., et al. (2017) · Science Translational Medicine · doi:10.1126/scitranslmed.aal3226 · Cited by 275 · see citing works

DNA damage repair as a target in pancreatic cancer: state-of-the-art and future perspectives

Perkhofer, L., Gout, J., Roger, É., de Almeida, F. K., Simões, C., Wiesmüller, L., Seufferlein, T. T. W., & Kleger, A. (2020) · Gut · doi:10.1136/gutjnl-2019-319984 · Cited by 204 · see citing works

Artificial Intelligence and Early Detection of Pancreatic Cancer: 2020 Summative Review

Kenner, B., Chari, S. T., Kelsen, D., Klimstra, D. S., Pandol, S. J., Rosenthal, M., Rustgi, A. K., Taylor, J. A., Yala, A., Abul-Husn, N., et al. (2021) · Pancreas · doi:10.1097/mpa.0000000000001762 · Cited by 158 · see citing works

Pancreatic cancer‐derived organoids – a disease modeling tool to predict drug response

Frappart, P., Walter, K., Gout, J., Beutel, A. K., Morawe, M., Arnold, F., Breunig, M., Barth, T. F. E., Marienfeld, R. B., Schulte, L.-A., et al. (2020) · United European Gastroenterology Journal · doi:10.1177/2050640620905183 · Cited by 85 · see citing works

Synergistic targeting and resistance to PARP inhibition in DNA damage repair-deficient pancreatic cancer

Gout, J., Perkhofer, L., Morawe, M., Arnold, F., Ihle, M., Biber, S., Lange, S., Roger, É., Kraus, J. M., Stifter, K., et al. (2020) · Gut · doi:10.1136/gutjnl-2019-319970 · Cited by 81 · see citing works

Highly Sensitive Exosome Detection for Early Diagnosis of Pancreatic Cancer Using Immunoassay Based on Hierarchical Surface‐Enhanced Raman Scattering Substrate

Li, J., Li, Y., Chen, S., Duan, W., Kong, X., Wang, Y., Zhou, L., Li, P., Zhang, C., Du, L., et al. (2022) · Small Methods · doi:10.1002/smtd.202200154 · Cited by 76 · see citing works

Early Detection of Pancreatic Cancer—a Defined Future Using Lessons From Other Cancers

Kenner, B. J., Chari, S. T., Maitra, A., Srivastava, S., Cleeter, D. F., Go, V. L. W., Rothschild, L. J., & Goldberg, A. E. (2016) · Pancreas · doi:10.1097/mpa.0000000000000701 · Cited by 67 · see citing works

Functional polymorphisms in LncRNA HOTAIR contribute to susceptibility of pancreatic cancer

Jiang, D., Xu, L., Ni, J., Zhang, J., Cai, M., & Shen, L. (2019) · Cancer Cell International · doi:10.1186/s12935-019-0761-x · Cited by 58 · see citing works

Detection of CTCs in portal vein was associated with intrahepatic metastases and prognosis in patients with advanced pancreatic cancer

Liu, X., Li, C., Li, J., Yu, T., Zhou, G., Cheng, J., Li, G., Zhou, Y., Lou, W., Wang, X., et al. (2018) · Journal of Cancer · doi:10.7150/jca.23989 · Cited by 58 · see citing works

Precision Immuno-Oncology: Prospects of Individualized Immunotherapy for Pancreatic Cancer

Zhang, J., Wolfgang, C. L., & Zheng, L. (2018) · Cancers · doi:10.3390/cancers10020039 · Cited by 50 · see citing works

Genomics and Precision Medicine for Clinicians and Scientists in Hypertension

Dominiczak, A. F., Delles, C., & Padmanabhan, S. (2017) · Hypertension · doi:10.1161/hypertensionaha.116.08252 · Cited by 38 · see citing works

Extracellular vesicle biomarkers for pancreatic cancer diagnosis: a systematic review and meta-analysis

Jia, E., Ren, N., Shi, X., Zhang, R., Yu, H., Yu, F., Qin, S., & Xue, J. (2022) · BMC Cancer · doi:10.1186/s12885-022-09463-x · Cited by 34 · see citing works

Circulating Tumor Cells Enumeration from the Portal Vein for Risk Stratification in Early Pancreatic Cancer Patients

Ruiz, F. J. P., Suárez, G., Pereira, S., Calero-Castro, F. J., González, J. T., Gómez, L. M. M., Bellido, C. B., Franco, C. C., Álamo-Martínez, J. M., Almoguera, F., et al. (2021) · Cancers · doi:10.3390/cancers13246153 · Cited by 30 · see citing works

Volatile organic compounds in bile can distinguish pancreatic cancer from chronic pancreatitis: a prospective observational study

Navaneethan, U., Spencer, C., Zhu, X., Vargo, J. J., Grove, D., & Dweik, R. A. (2020) · Endoscopy · doi:10.1055/a-1255-9169 · Cited by 25 · see citing works

Intratumoral neutrophil extracellular traps are associated with unfavorable clinical outcomes and immunogenic context in pancreatic ductal adenocarcinoma

Chen, X., Ma, H., Mo, S., Yu, S., Lu, Z., & Chen, J. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1027459 · Cited by 21 · see citing works

MCT4 as a potential therapeutic target to augment gemcitabine chemosensitivity in resected pancreatic cancer

Lee, S. H., Hwang, H. K., Lee, W. J., & Kang, C. M. (2021) · Cellular Oncology · doi:10.1007/s13402-021-00643-8 · Cited by 16 · see citing works

Utilizing Peptide Ligand GPCRs to Image and Treat Pancreatic Cancer

Matters, G. L., & Harms, J. F. (2018) · Biomedicines · doi:10.3390/biomedicines6020065 · Cited by 14 · see citing works

Analysis of the OX40/OX40L immunoregulatory axis combined with alternative immune checkpoint molecules in pancreatic ductal adenocarcinoma

Chen, X., Ma, H., Mo, S., Zhang, Y., Lu, Z., Yu, S., & Chen, J. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.942154 · Cited by 10 · see citing works

Expression of PD-L1 and VISTA in Intraductal Papillary Mucinous Neoplasm With Associated Invasive Carcinoma of the Pancreas

Mo, S., Zou, L., Hu, Y., Chang, X., & Chen, J. (2023) · Modern Pathology · doi:10.1016/j.modpat.2023.100223 · Cited by 8 · see citing works

Differential extracellular vesicle concentration and their biomarker expression of integrin αv/β5, EpCAM, and glypican-1 in pancreatic cancer models

Jacobson, R. I., Ha, S., Tani, S., Ghosh, S., Jarajapu, Y. P. R., Brand, R. E., Kim, J., & Choi, Y. (2024) · Scientific Reports · doi:10.1038/s41598-024-65209-8 · Cited by 7 · see citing works

Gene coexpression network approach to develop an immune prognostic model for pancreatic adenocarcinoma

Gu, X., Zhang, Q., Wu, X., Fan, Y., & Qian, J. (2021) · World Journal of Surgical Oncology · doi:10.1186/s12957-021-02201-w · Cited by 7 · see citing works

Organoidomics — falling star or new galaxy in pancreatic cancer?

Seufferlein, T. T. W., & Kleger, A. (2018) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-018-0052-3 · Cited by 6 · see citing works

Comparative Panel Sequencing of DNA Variants in cf-, ev- and tumorDNA for Pancreatic Ductal Adenocarcinoma Patients

Waldenmaier, M., Schulte, L.-A., Schönfelder, J., Fürstberger, A., Kraus, J. M., Daiß, N., Seibold, T., Morawe, M., Ettrich, T. J., Kestler, H. A., et al. (2022) · Cancers · doi:10.3390/cancers14041074 · Cited by 5 · see citing works

Challenges for Better Diagnosis and Management of Pancreatic and Biliary Tract Cancers Focusing on Blood Biomarkers: A Systematic Review

Tominaga, H., Matsuzaki, J., Oikawa, C., Toyoshima, K., Manabe, H., Ozawa, E., Shimamura, A., Yokoyama, R., Serizawa, Y., Ochiya, T., et al. (2021) · Cancers · doi:10.3390/cancers13164220 · Cited by 2 · see citing works

Precision medicine for diagnosis and treatment of osteosarcoma

Wang, R., Fu, F. H., & Wang, B. (2016) · Oncology and Translational Medicine · doi:10.1007/s10330-016-0149-5 · Cited by 1 · see citing works

Screening for Pancreatic Cancer in Individuals With New-onset Diabetes Mellitus

Lo, T. (2018) · The Journal for Nurse Practitioners · doi:10.1016/j.nurpra.2018.07.010 · Cited by 1 · see citing works

Anotação e caracterização de novos transcritos expressos no adenocarcinoma de pâncreas: RNAS não-codificadores longos associados a fenótipos tumorais e clínicos e formas alternativas de splicing

da Paixão, V. F. (2019) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.46.2019.tde-09032020-085211

The Role of Endoscopic Ultrasonography in the Diagnosis and Differential Diagnosis of Neoplastic Lesions

Hirooka, Y., Hashimoto, S., & Ohno, E. (2023) · doi:10.1002/9781119876007.ch128

Additional file 1 of Extracellular vesicle biomarkers for pancreatic cancer diagnosis: a systematic review and meta-analysis

Jia, E., Ren, N., Shi, X., Zhang, R., Yu, H., Yu, F., Qin, S., & Xue, J. (2022) · Figshare · doi:10.6084/m9.figshare.19845829

Additional file 4 of Extracellular vesicle biomarkers for pancreatic cancer diagnosis: a systematic review and meta-analysis

Jia, E., Ren, N., Shi, X., Zhang, R., Yu, H., Yu, F., Qin, S., & Xue, J. (2022) · Figshare · doi:10.6084/m9.figshare.19845838

Additional file 3 of Gene coexpression network approach to develop an immune prognostic model for pancreatic adenocarcinoma

Gu, X., Zhang, Q., Wu, X., Fan, Y., & Qian, J. (2021) · Figshare · doi:10.6084/m9.figshare.14404207

Additional file 1 of Gene coexpression network approach to develop an immune prognostic model for pancreatic adenocarcinoma

Gu, X., Zhang, Q., Wu, X., Fan, Y., & Qian, J. (2021) · Figshare · doi:10.6084/m9.figshare.14404201

Additional file 2 of Extracellular vesicle biomarkers for pancreatic cancer diagnosis: a systematic review and meta-analysis

Jia, E., Ren, N., Shi, X., Zhang, R., Yu, H., Yu, F., Qin, S., & Xue, J. (2022) · Figshare · doi:10.6084/m9.figshare.19845832

Additional file 2 of Gene coexpression network approach to develop an immune prognostic model for pancreatic adenocarcinoma

Gu, X., Zhang, Q., Wu, X., Fan, Y., & Qian, J. (2021) · Figshare · doi:10.6084/m9.figshare.14404204

Additional file 3 of Extracellular vesicle biomarkers for pancreatic cancer diagnosis: a systematic review and meta-analysis

Jia, E., Ren, N., Shi, X., Zhang, R., Yu, H., Yu, F., Qin, S., & Xue, J. (2022) · Figshare · doi:10.6084/m9.figshare.19845835

The role of pancreatic cancer-derived exosomes in cancer progress and their potential application as biomarkers

Jin, H., Wu, Y., & Tan, X. (2017) · Clinical & Translational Oncology · doi:10.1007/s12094-017-1625-2 · Cited by 41 · see citing works

Exosomes as prognostic biomarkers in pancreatic ductal adenocarcinoma—a systematic review and meta-analysis

Bunduc, Ș., Gede, N., Váncsa, S., Lillik, V., Kiss, S., Juhász, M. F., Erőss, B. M., Szakács, Z., Gheorghe, C., Mikó, A., et al. (2022) · Translational research · doi:10.1016/j.trsl.2022.01.001 · Cited by 25 · see citing works

Pancreatic Cancer Diagnosis and Management: Has the Time Come to Prick the Bubble?

Moutinho-Ribeiro, P., Macedo, G., & Melo, S. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2018.00779 · Cited by 41 · see citing works

P-25 A review of circulating exosomal biomarkers in the diagnosis of pancreatic cancer

Sha, M., Kunduzi, B., & Froghi, S. (2021) · Annals of Oncology · doi:10.1016/j.annonc.2021.05.080

The Role of Exosomes in Diagnosis and Therapy of Pancreatic Cancer

Biju, T. M., Doppalapudi, A., Zubieta, D., Baru, R., Shabnam, F., Yallapu, M. M., Sikander, M., & Chauhan, S. C. (2025) · ScholarWorks @ UTRGV (The University of Texas Rio Grande Valley)