The Gut-Brain Axis in Inflammatory Bowel Disease—Current and Future Perspectives

Induction of Pluripotent Stem Cells from Adult Human Fibroblasts by Defined Factors

Takahashi, K., Tanabe, K., Ohnuki, M., Narita, M., Ichisaka, T., Tomoda, K., & Yamanaka, S. (2007) · Cell · doi:10.1016/j.cell.2007.11.019 · Cited by 20,221 · see citing works

Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche

Sato, T., Vries, R. G., Snippert, H. J., van de Wetering, M., Barker, N., Stange, D. E., van Es, J. H., Abo, A., Kujala, P., Peters, P. J., et al. (2009) · Nature · doi:10.1038/nature07935 · Cited by 7,204 · see citing works

Cerebral organoids model human brain development and microcephaly

Lancaster, M. A., Renner, M., Martin, C.-A., Wenzel, D., Bicknell, L. S., Hurles, M. E., Homfray, T., Penninger, J. M., Jackson, A. P., & Knoblich, J. A. (2013) · Nature · doi:10.1038/nature12517 · Cited by 5,372 · see citing works

A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease

Ogura, Y., Bonen, D. K., Inohara, N., Nicolae, D. L., Chen, F. F., Ramos, R., Britton, H., Moran, T., Karaliuskas, R., Duerr, R. H., et al. (2001) · Nature · doi:10.1038/35079114 · Cited by 5,030 · see citing works

Gut microbiota regulate motor deficits and neuroinflammation in a model of Parkinson's disease

Sampson, T. R., Debelius, J. W., Thron, T., Janssen, S., Shastri, G. G., Ilhan, Z. E., Challis, C., Schretter, C. E., Rocha, S., Gradinaru, V., et al. (2016) · Cell · doi:10.1016/j.cell.2016.11.018 · Cited by 3,622 · see citing works

Host microbiota constantly control maturation and function of microglia in the CNS

Erny, D., Hrabě de Angelis, A. L., Jaitin, D., Wieghofer, P., Staszewski, O., David, E., Keren-Shaul, H., Mahlakoiv, T., Jakobshagen, K., Buch, T., et al. (2015) · Nature Neuroscience · doi:10.1038/nn.4030 · Cited by 3,569 · see citing works

Cortisone in Ulcerative Colitis

Truelove, S. C., & Witts, L. J. (1955) · BMJ · doi:10.1136/bmj.2.4947.1041 · Cited by 2,793 · see citing works

Cytokines in inflammatory bowel disease

Neurath, M. F. (2014) · Nature Reviews Immunology · doi:10.1038/nri3661 · Cited by 2,706 · see citing works

Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis

The International Multiple Sclerosis Genetics Consortium & The Wellcome Trust Case Control Consortium 2 (2011) · Nature · doi:10.1038/nature10251 · Cited by 2,697 · see citing works

Genetics and pathogenesis of inflammatory bowel disease

Khor, B., Gardet, A., & Xavier, R. J. (2011) · Nature · doi:10.1038/nature10209 · Cited by 2,629 · see citing works

Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease

the NIDDK IBD Genetics Consortium, Barrett, J. C., the Belgian-French IBD Consortium, the Wellcome Trust Case Control Consortium, Hansoul, S., Nicolae, D. L., Cho, J. H., Duerr, R. H., Rioux, J. D., Brant, S. R., et al. (2008) · Nature Genetics · doi:10.1038/ng.175 · Cited by 2,593 · see citing works

Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci

Franke, A., McGovern, D. P. B., Barrett, J. C., Wang, K., Radford-Smith, G. L., Ahmad, T., Lees, C. W., Balschun, T., Lee, J., Roberts, R., et al. (2010) · Nature Genetics · doi:10.1038/ng.717 · Cited by 2,520 · see citing works

Identification of novel risk loci, causal insights, and heritable risk for Parkinson's disease: a meta-analysis of genome-wide association studies

Nalls, M. A., Blauwendraat, C., Vallerga, C. L., Heilbron, K., Bandres-Ciga, S., Chang, D., Tan, M., Kia, D. A., Noyce, A. J., Xue, A., et al. (2019) · The Lancet Neurology · doi:10.1016/s1474-4422(19)30320-5 · Cited by 2,454 · see citing works

Microbial tryptophan catabolites in health and disease

Roager, H. M., & Licht, T. R. (2018) · Nature Communications · doi:10.1038/s41467-018-05470-4 · Cited by 2,236 · see citing works

The gut microbiota–brain axis in behaviour and brain disorders

Morais, L. H., Schreiber, H. L., & Mazmanian, S. K. (2021) · Nature Reviews Microbiology · doi:10.1038/s41579-020-00460-0 · Cited by 2,149 · see citing works

In vitro differentiation of transplantable neural precursors from human embryonic stem cells

Zhang, S., Wernig, M., Duncan, I. D., Brüstle, O., & Thomson, J. A. (2001) · Nature Biotechnology · doi:10.1038/nbt1201-1129 · Cited by 1,916 · see citing works

Stem cells, self-renewal, and differentiation in the intestinal epithelium.

van der Flier, L. G., & Clevers, H. (2009) · Annual Review of Physiology · doi:10.1146/annurev.physiol.010908.163145 · Cited by 1,859 · see citing works

Directed differentiation of human pluripotent stem cells into intestinal tissue in vitro

Spence, J., Mayhew, C., Rankin, S., Kuhar, M., Vallance, J. E., Tolle, K., Hoskins, E. E., Kalinichenko, V., Wells, S., Zorn, A., et al. (2010) · Nature · doi:10.1038/nature09691 · Cited by 1,850 · see citing works

Functional cortical neurons and astrocytes from human pluripotent stem cells in 3D culture

Paşca, A. M., Sloan, S. A., Clarke, L. E., Tian, Y., Makinson, C. D., Huber, N., Kim, C. H., Park, J.-Y., O'Rourke, N. A., Nguyen, K. D., et al. (2015) · Nature Methods · doi:10.1038/nmeth.3415 · Cited by 1,609 · see citing works

Type I interferons and microbial metabolites of tryptophan modulate astrocyte activity and central nervous system inflammation via the aryl hydrocarbon receptor

Rothhammer, V., Mascanfroni, I. D., Bunse, L., Takenaka, M. C., Kenison, J. E., Mayo, L., Chao, C.-C., Patel, B., Yan, R., Blain, M., et al. (2016) · Nature Medicine · doi:10.1038/nm.4106 · Cited by 1,559 · see citing works

A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells

Cadwell, K., Liu, J. Y., Brown, S. L., Miyoshi, H., Loh, J., Lennerz, J. K., Kishi, C., Kc, W., Carrero, J. A., Hunt, S., et al. (2008) · Nature · doi:10.1038/nature07416 · Cited by 1,542 · see citing works

Induced pluripotent stem cell technology: a decade of progress.

Shi, Y., Inoue, H., Wu, J. C., & Yamanaka, S. (2017) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2016.245 · Cited by 1,525 · see citing works

Self-Organized Formation of Polarized Cortical Tissues from ESCs and Its Active Manipulation by Extrinsic Signals

Eiraku, M., Watanabe, K., Matsuo-Takasaki, M., Kawada, M., Yonemura, S., Matsumura, M., Wataya, T., Nishiyama, A., Muguruma, K., & Sasai, Y. (2008) · Cell Stem Cell · doi:10.1016/j.stem.2008.09.002 · Cited by 1,522 · see citing works

Transneuronal Propagation of Pathologic α-Synuclein from the Gut to the Brain Models Parkinson’s Disease

Kim, S., Kwon, S.-H., Kam, T.-I., Panicker, N., Karuppagounder, S. S., Lee, S., Lee, J. H., Kim, W. R., Kook, M., Foss, C. A., et al. (2019) · Neuron · doi:10.1016/j.neuron.2019.05.035 · Cited by 1,397 · see citing works

ETIOLOGY AND PATHOGENESIS OF PARKINSON'S DISEASE

Olanow, C. W., & Tatton, W. G. (1999) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.22.1.123 · Cited by 1,394 · see citing works

Assembly of functionally integrated human forebrain spheroids

Birey, F., Andersen, J., Makinson, C. D., Islam, S., Wei, W., Huber, N., Fan, H. C., Metzler, K. R. C., Panagiotakos, G., Thom, N., et al. (2017) · Nature · doi:10.1038/nature22330 · Cited by 1,365 · see citing works

Proinflammatory T-cell responses to gut microbiota promote experimental autoimmune encephalomyelitis

Lee, Y. K., Menezes, J. S., Umesaki, Y., & Mazmanian, S. K. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1000082107 · Cited by 1,323 · see citing works

Alterations of the human gut microbiome in multiple sclerosis

Jangi, S., Gandhi, R., Cox, L. M., Li, N., von Glehn, F., Yan, R., Patel, B., Mazzola, M. A., Liu, S., Glanz, B. L., et al. (2016) · Nature Communications · doi:10.1038/ncomms12015 · Cited by 1,307 · see citing works

Commensal microbiota and myelin autoantigen cooperate to trigger autoimmune demyelination

Berer, K., Mues, M., Koutrolos, M., Rasbi, Z. A., Boziki, M., Johner, C., Wekerle, H., & Krishnamoorthy, G. (2011) · Nature · doi:10.1038/nature10554 · Cited by 1,251 · see citing works

Vitamin B₁₂Deficiency

Stabler, S. P. (2013) · New England Journal of Medicine · doi:10.1056/nejmcp1113996 · Cited by 1,224 · see citing works

An in vivo model of functional and vascularized human brain organoids

Mansour, A. A., Gonçalves, J. T., Bloyd, C. W., Li, H., Fernandes, S., Quang, D., Johnston, S., Parylak, S. L., Jin, X., & Gage, F. H. (2018) · Nature Biotechnology · doi:10.1038/nbt.4127 · Cited by 1,211 · see citing works

Human cerebral organoids recapitulate gene expression programs of fetal neocortex development

Camp, J. G., Badsha, F., Florio, M., Kanton, S., Gerber, T., Wilsch-Bräuninger, M., Lewitus, E., Sykes, A., Hevers, W., Lancaster, M., et al. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1520760112 · Cited by 1,130 · see citing works

Association between insertion mutation in NOD2 gene and Crohn's disease in German and British populations

Hampe, J., Cuthbert, A. P., Croucher, P. J. P., Mirza, M. M., Mascheretti, S., Fisher, S. A., Frenzel, H., King, K., Hasselmeyer, A., Macpherson, A. J., et al. (2001) · The Lancet · doi:10.1016/s0140-6736(00)05063-7 · Cited by 1,090 · see citing works

Epithelial NEMO links innate immunity to chronic intestinal inflammation

Nenci, A., Becker, C., Wullaert, A., Gareus, R., Loo, G., Danese, S., Huth, M., Nikolaev, A., Neufert, C. F., Madison, B., et al. (2007) · Nature · doi:10.1038/nature05698 · Cited by 1,077 · see citing works

Microglial control of astrocytes in response to microbial metabolites

Rothhammer, V., Borucki, D. M., Tjon, E. C., Takenaka, M. C., Chao, C.-C., Ardura-Fabregat, A., de Lima, K. A., Gutiérrez-Vázquez, C., Hewson, P., Staszewski, O., et al. (2018) · Nature · doi:10.1038/s41586-018-0119-x · Cited by 1,051 · see citing works

Gut bacteria from multiple sclerosis patients modulate human T cells and exacerbate symptoms in mouse models

Cekanaviciute, E., Yoo, B. B., Runia, T. F., Debelius, J. W., Singh, S., Nelson, C., Kanner, R., Bencosme, Y., Lee, Y. K., Hauser, S. L., et al. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1711235114 · Cited by 1,040 · see citing works

Self-organization of axial polarity, inside-out layer pattern, and species-specific progenitor dynamics in human ES cell–derived neocortex

Kadoshima, T., Sakaguchi, H., Nakano, T., Soen, M., Ando, S., Eiraku, M., & Sasai, Y. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1315710110 · Cited by 999 · see citing works

Engineering of human brain organoids with a functional vascular-like system

Çakır, B., Xiang, Y., Tanaka, Y., Kural, M. H., Parent, M. J., Kang, Y., Chapeton, K., Patterson, B., Yuan, Y., He, C., et al. (2019) · Nature Methods · doi:10.1038/s41592-019-0586-5 · Cited by 959 · see citing works

Multiple sclerosis patients have a distinct gut microbiota compared to healthy controls

Chen, J., Chia, N., Kalari, K. R., Yao, J. Z., Novotna, M., Paz Soldan, M. M., Luckey, D. H., Marietta, E. V., Jeraldo, P. R., Chen, X., et al. (2016) · Scientific Reports · doi:10.1038/srep28484 · Cited by 933 · see citing works

Gut microbiota from multiple sclerosis patients enables spontaneous autoimmune encephalomyelitis in mice

Berer, K., Gerdes, L. A., Cekanaviciute, E., Jia, X., Xiao, L., Xia, Z., Liu, C., Klotz, L., Stauffer, U., Baranzini, S. E., et al. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1711233114 · Cited by 933 · see citing works

Dietary fatty acids directly impact central nervous system autoimmunity via the small intestine

Haghikia, A., Jörg, S., Duscha, A., Berg, J., Manzel, A., Waschbisch, A., Hammer, A., Lee, D.-H., May, C., Wilck, N., et al. (2015) · Immunity · doi:10.1016/j.immuni.2015.09.007 · Cited by 927 · see citing works

Enterochromaffin cells are gut chemosensors that couple to sensory neural pathways

Bellono, N. W., Bayrer, J. R., Leitch, D. B., Castro, J., Zhang, C., O’Donnell, T. A., Brierley, S. M., Ingraham, H. A., & Julius, D. (2017) · Cell · doi:10.1016/j.cell.2017.05.034 · Cited by 910 · see citing works

Influence of Tryptophan and Serotonin on Mood and Cognition with a Possible Role of the Gut-Brain Axis

Jenkins, T., Nguyen, J., Polglaze, K., & Bertrand, P. (2016) · Nutrients · doi:10.3390/nu8010056 · Cited by 904 · see citing works

Virus-Plus-Susceptibility Gene Interaction Determines Crohn's Disease Gene Atg16L1 Phenotypes in Intestine

Cadwell, K., Patel, K., Maloney, N. S., Liu, T., Ng, A., Storer, C. E., Head, R. D., Xavier, R. J., Stappenbeck, T. S., & Virgin, H. W. (2010) · Cell · doi:10.1016/j.cell.2010.05.009 · Cited by 897 · see citing works

α-synuclein toxicity in neurodegeneration: mechanism and therapeutic strategies

Wong, Y. C., & Krainc, D. (2017) · Nature Medicine · doi:10.1038/nm.4269 · Cited by 897 · see citing works

Caspase-8 regulates TNF-α-induced epithelial necroptosis and terminal ileitis

Günther, C., Martini, E., Wittkopf, N., Amann, K., Weigmann, B., Neumann, H., Waldner, M. J., Hedrick, S. Μ., Tenzer, S., Neurath, M. F., et al. (2011) · Nature · doi:10.1038/nature10400 · Cited by 882 · see citing works

Midbrain-like Organoids from Human Pluripotent Stem Cells Contain Functional Dopaminergic and Neuromelanin-Producing Neurons

Jo, J., Xiao, Y., Sun, A. X., Cukuroglu, E., Tran, H.-D., Göke, J., Tan, Z. Y., Saw, T. Y., Tan, C.-P., Lokman, H., et al. (2016) · Cell Stem Cell · doi:10.1016/j.stem.2016.07.005 · Cited by 861 · see citing works

Role of the gut microbiota in health and chronic gastrointestinal disease: understanding a hidden metabolic organ

Guinane, C. M., & Cotter, P. D. (2013) · Therapeutic Advances in Gastroenterology · doi:10.1177/1756283x13482996 · Cited by 846 · see citing works

In Vitro Expansion of Human Gastric Epithelial Stem Cells and Their Responses to Bacterial Infection

Bartfeld, S., Bayram, T., van de Wetering, M., Huch, M., Begthel, H., Kujala, P., Vries, R., Peters, P. J., & Clevers, H. (2015) · Gastroenterology · doi:10.1053/j.gastro.2014.09.042 · Cited by 820 · see citing works

Vertebrate Endoderm Development and Organ Formation

Zorn, A. M., & Wells, J. M. (2009) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.042308.113344 · Cited by 812 · see citing works

Dysbiosis in the Gut Microbiota of Patients with Multiple Sclerosis, with a Striking Depletion of Species Belonging to Clostridia XIVa and IV Clusters

Miyake, S., Kim, S., Suda, W., Oshima, K., Nakamura, M., Matsuoka, T., Chihara, N., Tomita, A., Sato, W., Kim, S.-W., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0137429 · Cited by 809 · see citing works

Fused cerebral organoids model interactions between brain regions

Bagley, J. A., Reumann, D., Bian, S., Lévi-Strauss, J., & Knoblich, J. A. (2017) · Nature Methods · doi:10.1038/nmeth.4304 · Cited by 790 · see citing works

Common genetic variation in the HLA region is associated with late-onset sporadic Parkinson's disease

Hamza, T. H., Zabetian, C. P., Tenesa, A., Laederach, A., Montimurro, J. S., Yearout, D., Kay, D. M., Doheny, K. F., Paschall, J. E., Pugh, E., et al. (2010) · Nature Genetics · doi:10.1038/ng.642 · Cited by 779 · see citing works

Pathway paradigms revealed from the genetics of inflammatory bowel disease

Graham, D. B., & Xavier, R. J. (2020) · Nature · doi:10.1038/s41586-020-2025-2 · Cited by 769 · see citing works

Discovery and inhibition of an interspecies gut bacterial pathway for Levodopa metabolism

Maini Rekdal, V., Bess, E. N., Bisanz, J. E., Turnbaugh, P. J., & Balskus, E. P. (2019) · Science · doi:10.1126/science.aau6323 · Cited by 753 · see citing works

Paneth cells as a site of origin for intestinal inflammation

Adolph, T. E., Tomczak, M. F., Niederreiter, L., Ko, H.-J., Böck, J., Martinez-Naves, E., Glickman, J. N., Tschurtschenthaler, M., Hartwig, J., Hosomi, S., et al. (2013) · Nature · doi:10.1038/nature12599 · Cited by 732 · see citing works

Targeting immune cell circuits and trafficking in inflammatory bowel disease

Neurath, M. F. (2019) · Nature Immunology · doi:10.1038/s41590-019-0415-0 · Cited by 703 · see citing works

Inflammatory bowel diseases (IBD) and the microbiome-searching the crime scene for clues

Lee, M., & Chang, E. B. (2021) · Gastroenterology · doi:10.1053/j.gastro.2020.09.056 · Cited by 645 · see citing works

Engineered human pluripotent-stem-cell-derived intestinal tissues with a functional enteric nervous system

Workman, M. J., Mahé, M. M., Trisno, S. L., Poling, H. M., Watson, C. L., Sundaram, N., Chang, C., Schiesser, J. V., Aubert, P., Stanley, E. G., et al. (2016) · Nature Medicine · doi:10.1038/nm.4233 · Cited by 632 · see citing works

The bowel and beyond: The enteric nervous system in neurological disorders

Rao, M., & Gershon, M. D. (2016) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2016.107 · Cited by 629 · see citing works

Enteric nervous system: sensory transduction, neural circuits and gastrointestinal motility

Spencer, N. J., & Hu, H. (2020) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-020-0271-2 · Cited by 607 · see citing works

Generation of Functional Human 3D Cortico-Motor Assembloids

Andersen, J., Revah, O., Miura, Y., Thom, N., Amin, N. D., Kelley, K. W., Singh, M., Chen, X., Thete, M. V., Walczak, E. M., et al. (2020) · Cell · doi:10.1016/j.cell.2020.11.017 · Cited by 593 · see citing works

The Human and Mouse Enteric Nervous System at Single-Cell Resolution

Drokhlyansky, E., Smillie, C. S., Wittenberghe, N. V., Ericsson, M., Griffin, G. K., Eraslan, G., Dionne, D. A., Cuoco, M. S., Goder-Reiser, M. N., Sharova, T. Y., et al. (2020) · Cell · doi:10.1016/j.cell.2020.08.003 · Cited by 585 · see citing works

Induced pluripotent stem cells in disease modelling and drug discovery

Rowe, R. G., & Daley, G. Q. (2019) · Nature reviews genetics · doi:10.1038/s41576-019-0100-z · Cited by 568 · see citing works

The nasal and gut microbiome in Parkinson's disease and idiopathic rapid eye movement sleep behavior disorder

Heintz‐Buschart, A., Pandey, U., Wicke, T., Sixel‐Döring, F., Janzen, A., Sittig‐Wiegand, E., Trenkwalder, C., Oertel, W. H., Mollenhauer, B., & Wilmes, P. (2018) · Movement Disorders · doi:10.1002/mds.27105 · Cited by 554 · see citing works

Generation of functional hippocampal neurons from self-organizing human embryonic stem cell-derived dorsomedial telencephalic tissue

Sakaguchi, H., Kadoshima, T., Soen, M., Narii, N., Ishida, Y., Ohgushi, M., Takahashi, J., Eiraku, M., & Sasai, Y. (2015) · Nature Communications · doi:10.1038/ncomms9896 · Cited by 542 · see citing works

Cortisone in Ulcerative Colitis

Truelove, S. C., & Witts, L. J. (1954) · BMJ · doi:10.1136/bmj.2.4884.375 · Cited by 538 · see citing works

Modeling human cortical development in vitro using induced pluripotent stem cells

Mariani, J., Simonini, M. V., Palejev, D., Tomasini, L., Coppola, G., Szekely, A. M., Horvath, T. L., & Vaccarino, F. M. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1202944109 · Cited by 526 · see citing works

Development of an enhanced human gastrointestinal epithelial culture system to facilitate patient-based assays

VanDussen, K. L., Marinshaw, J. M., Shaikh, N., Miyoshi, H., Moon, C., Tarr, P. I., Ciorba, M. A., & Stappenbeck, T. S. (2015) · Gut · doi:10.1136/gutjnl-2013-306651 · Cited by 525 · see citing works

Intestinal infection triggers Parkinson's disease-like symptoms in Pink1(-/-) mice

Matheoud, D., Cannon, T., Voisin, A., Penttinen, A.-M., Ramet, L., Fahmy, A. M., Ducrot, C., Laplante, A., Bourque, M.-J., Zhu, L., et al. (2019) · Nature · doi:10.1038/s41586-019-1405-y · Cited by 496 · see citing works

Cytokines in Inflammatory Bowel Disease

Rogler, G., & Andus, T. (1998) · World Journal of Surgery · doi:10.1007/s002689900401 · Cited by 483 · see citing works

Organoids: Modeling Development and the Stem Cell Niche in a Dish

Kretzschmar, K., & Clevers, H. C. (2016) · Developmental Cell · doi:10.1016/j.devcel.2016.08.014 · Cited by 480 · see citing works

Genetics in Parkinson disease: Mendelian versus non‐Mendelian inheritance

Hernandez, D. G., Reed, X., & Singleton, A. B. (2016) · Journal of Neurochemistry · doi:10.1111/jnc.13593 · Cited by 448 · cited 2× · see citing works

LRRK2 in Parkinson disease: challenges of clinical trials

TOLOSA, E. S., Vila, M., Klein, C., & Rascol, O. (2020) · Nature Reviews Neurology · doi:10.1038/s41582-019-0301-2 · Cited by 443 · see citing works

Central Role of the Gut Epithelial Barrier in the Pathogenesis of Chronic Intestinal Inflammation: Lessons Learned from Animal Models and Human Genetics

Pastorelli, L., Salvo, C. D., Mercado, J. R., Vecchi, M. L., & Pizarro, T. T. (2013) · Frontiers in Immunology · doi:10.3389/fimmu.2013.00280 · Cited by 434 · see citing works

Generating human intestinal tissue from pluripotent stem cells in vitro

McCracken, K. W., Howell, J. C., Wells, J. M., & Spence, J. R. (2011) · Nature Protocols · doi:10.1038/nprot.2011.410 · Cited by 433 · see citing works

Genetics of Inflammatory Bowel Diseases

McGovern, D. P. B., Kugathasan, S., & Cho, J. H. (2015) · Gastroenterology · doi:10.1053/j.gastro.2015.08.001 · Cited by 428 · see citing works

Human CNS barrier-forming organoids with cerebrospinal fluid production

Pellegrini, L., Bonfio, C., Chadwick, J., Begum, F., Skehel, M., & Lancaster, M. A. (2020) · Science · doi:10.1126/science.aaz5626 · Cited by 412 · see citing works

Lactobacillus accelerates ISCs regeneration to protect the integrity of intestinal mucosa through activation of STAT3 signaling pathway induced by LPLs secretion of IL-22

Hou, Q., Ye, L., Liu, H., Huang, L., Yang, Q., Turner, J. R., & Yu, Q. (2018) · Cell Death and Differentiation · doi:10.1038/s41418-018-0070-2 · Cited by 403 · see citing works

Vascularized human cortical organoids (vOrganoids) model cortical development in vivo

Shi, Y., Sun, L., Liu, J., Zhong, S., Wang, M., Li, R., Li, P., Guo, L., Fang, A., Chen, R., et al. (2020) · PLoS Biology · doi:10.1371/journal.pbio.3000705 · Cited by 401 · see citing works

Unraveling gut microbiota in Parkinson's disease and atypical parkinsonism

Barichella, M., Severgnini, M., Cilia, R., Cassani, E., Bolliri, C., Caronni, S., Ferri, V., Cancello, R., Ceccarani, C., Faierman, S., et al. (2019) · Movement Disorders · doi:10.1002/mds.27581 · Cited by 393 · see citing works

Next-generation regenerative medicine: organogenesis from stem cells in 3D culture.

Sasai, Y. (2013) · Cell Stem Cell · doi:10.1016/j.stem.2013.04.009 · Cited by 388 · see citing works

Anti–Tumor Necrosis Factor Therapy and Incidence of Parkinson Disease Among Patients With Inflammatory Bowel Disease

Peter, I., Dubinsky, M., Bressman, S., Park, A., Lu, C., Chen, N., & Wang, A. (2018) · JAMA Neurology · doi:10.1001/jamaneurol.2018.0605 · Cited by 386 · see citing works

The mucosal immune system: master regulator of bidirectional gut-brain communications

Powell, N., Walker, M. M., & Talley, N. J. (2017) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2016.191 · Cited by 379 · see citing works

Disease modelling in human organoids

Lancaster, M. A., & Huch, M. (2019) · Disease Models & Mechanisms · doi:10.1242/dmm.039347 · Cited by 379 · see citing works

The role of inflammation in irritable bowel syndrome (IBS)

Ng, Q. X., Soh, A. Y. S., Loke, W., Lim, D. Y., & Yeo, W. S. (2018) · Journal of Inflammation Research · doi:10.2147/jir.s174982 · Cited by 360 · see citing works

Genome-wide pleiotropy between Parkinson disease and autoimmune diseases

Witoelar, A., Jansen, I. E., Wang, Y., Desikan, R. S., Gibbs, J. R., Blauwendraat, C., Thompson, W. K., Hernandez, D. G., Djurovic, S., Schork, A. J., et al. (2017) · JAMA Neurology · doi:10.1001/jamaneurol.2017.0469 · Cited by 352 · see citing works

Gut microbiota in early pediatric multiple sclerosis: a case−control study

Tremlett, H. L., Fadrosh, D. W., Faruqi, A. A., Zhu, F., Hart, J., Roalstad, S., Graves, J., Lynch, S. V., & Waubant, E. L. (2016) · European Journal of Neurology · doi:10.1111/ene.13026 · Cited by 347 · see citing works

High frequency of intestinal T _H 17 cells correlates with microbiota alterations and disease activity in multiple sclerosis

Cosorich, I., Dalla-Costa, G., Sorini, C., Ferrarese, R., Messina, M. J., Dolpady, J., Radice, E., Mariani, A., Testoni, P. A., Canducci, F., et al. (2017) · Science Advances · doi:10.1126/sciadv.1700492 · Cited by 338 · see citing works

Epithelial Cell Shedding and Barrier Function

Williams, J. M., Duckworth, C. A., Burkitt, M. D., Watson, A. J. M., Campbell, B. J., & Pritchard, D. M. (2014) · Veterinary Pathology · doi:10.1177/0300985814559404 · Cited by 332 · see citing works

Th17 lymphocytes induce neuronal cell death in a human iPSC-based model of Parkinson's disease

Sommer, A., Marxreiter, F., Krach, F., Fadler, T., Grosch, J., Maroni, M., Graef, D., Eberhardt, E., Riemenschneider, M. J., Yeo, G. W., et al. (2018) · Cell Stem Cell · doi:10.1016/j.stem.2018.06.015 · Cited by 332 · see citing works

Inflammatory bowel disease increases the risk of Parkinson’s disease: a Danish nationwide cohort study 1977–2014

Villumsen, M., Aznar, S., Pakkenberg, B., Jess, T., & Brudek, T. (2018) · Gut · doi:10.1136/gutjnl-2017-315666 · Cited by 315 · see citing works

Evidence for bidirectional and trans-synaptic parasympathetic and sympathetic propagation of alpha-synuclein in rats

Van Den Berge, N., Ferreira, N., Gram, H., Mikkelsen, T. W., Alstrup, A. K. O., Casadei, N., Tsung-Pin, P., Riess, O., Nyengaard, J. R., Tamgüney, G., et al. (2019) · Acta Neuropathologica · doi:10.1007/s00401-019-02040-w · Cited by 300 · see citing works

Deriving human ENS lineages for cell therapy and drug discovery in Hirschsprung disease

Fattahi, F., Steinbeck, J. A., Kriks, S., Tchieu, J. H., Zimmer, B., Kishinevsky, S., Zeltner, N., Mica, Y., El-Nachef, W. N., Zhao, H., et al. (2016) · Nature · doi:10.1038/nature16951 · Cited by 299 · see citing works

Food, immunity, and the microbiome

Tilg, H., & Moschen, A. R. (2015) · Gastroenterology · doi:10.1053/j.gastro.2014.12.036 · Cited by 292 · see citing works

T cell responses in the central nervous system

Korn, T., & Kallies, A. (2017) · Nature Reviews Immunology · doi:10.1038/nri.2016.144 · Cited by 268 · see citing works

Gut microorganisms act together to exacerbate inflammation in spinal cords

Miyauchi, E., Kim, S.-W., Suda, W., Kawasumi, M., Onawa, S., Taguchi-Atarashi, N., Morita, H., Taylor, T. D., Hattori, M., & Ohno, H. (2020) · Nature · doi:10.1038/s41586-020-2634-9 · Cited by 268 · see citing works

Increased Risk for Demyelinating Diseases in Patients With Inflammatory Bowel Disease

Gupta, G., Gelfand, J. M., & Lewis, J. D. (2005) · Gastroenterology · doi:10.1053/j.gastro.2005.06.022 · Cited by 266 · see citing works

An intestinal organ culture system uncovers a role for the nervous system in microbe-immune crosstalk

Yissachar, N., Zhou, Y., Ung, L., Lai, N. Y., Mohan, J. F., Ehrlicher, A., Weitz, D. A., Kasper, D. L., Chiu, I. M., Mathis, D., et al. (2017) · Cell · doi:10.1016/j.cell.2017.02.009 · Cited by 242 · see citing works

A common role for Atg16L1, Atg5, and Atg7 in small intestinal Paneth cells and Crohn disease

Cadwell, K., Patel, K. K., Komatsu, M., Virgin, IV, & Stappenbeck, T. S. (2009) · Autophagy · doi:10.4161/auto.5.2.7560 · Cited by 224 · see citing works

TRPA1 and Substance P Mediate Colitis in Mice

Engel, M. A., Leffler, A., Niedermirtl, F., Babeș, A., Zimmermann, K., Filipović, M. R., Izydorczyk, I., Eberhardt, M. J., Kichko, T. I., Mueller–Tribbensee, S. M., et al. (2011) · Gastroenterology · doi:10.1053/j.gastro.2011.07.002 · Cited by 218 · see citing works

Ulcerative colitis exacerbates lipopolysaccharide‐induced damage to the nigral dopaminergic system: potential risk factor in Parkinson`s disease

Villarán, R. F., Espinosa‐Oliva, A. M., Soto, M. S., de Pablos, R. M., Argüelles, S., Delgado‐Cortés, M. J., Sobrino, V., van Rooijen, N., Venero, J. L., Herrera, A. J., et al. (2010) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2010.06879.x · Cited by 214 · see citing works

[On the pathogenesis of ulcerative colitis].

Polchak, I., Vokurka, V., & Skálová, M. (1960) · PubMed · Cited by 208 · see citing works

Tracing the temporal-spatial transcriptome landscapes of the human fetal digestive tract using single-cell RNA-sequencing

Gao, S., Yan, L., Wang, R., Li, J., Yong, J., Zhou, X., Wei, Y., Wu, X., Wang, X., Fan, X., et al. (2018) · Nature Cell Biology · doi:10.1038/s41556-018-0105-4 · Cited by 208 · see citing works

Commensal bacteria direct selective cargo sorting to promote symbiosis

Zhang, Q., Pan, Y., Yan, R., Zeng, B., Wang, H., Zhang, X., Li, W., Wei, H., & Liu, Z. (2015) · Nature Immunology · doi:10.1038/ni.3233 · Cited by 206 · see citing works

Intestinal Barrier Dysfunction Develops at the Onset of Experimental Autoimmune Encephalomyelitis, and Can Be Induced by Adoptive Transfer of Auto-Reactive T Cells

Nouri, M., Bredberg, A. C. A., Weström, B. R., & Lavasani, S. (2014) · PLoS ONE · doi:10.1371/journal.pone.0106335 · Cited by 206 · see citing works

Enteric Nervous System-Derived IL-18 Orchestrates Mucosal Barrier Immunity

Jarret, A. P., Jackson, R. P., Duizer, C., Healy, M. E., Zhao, J., Rone, J. M., Bielecki, P., Sefik, E., Roulis, M., Rice, T., et al. (2020) · Cell · doi:10.1016/j.cell.2019.12.016 · Cited by 204 · see citing works

Association Between Parkinsonʼs Disease and Inflammatory Bowel Disease

Lin, J.-C., Lin, C., Hsu, C.-W., Lin, C., & Kao, C. (2016) · Inflammatory Bowel Diseases · doi:10.1097/mib.0000000000000735 · Cited by 203 · see citing works

Targeting sphingosine-1-phosphate signaling in immune-mediated diseases: beyond multiple sclerosis

Pérez-Jeldres, T., Alvarez-Lobos, M., & Rivera-Nieves, J. (2021) · Drugs · doi:10.1007/s40265-021-01528-8 · Cited by 197 · see citing works

Identification of sensory nerve cells in a peripheral organ (the intestine) of a mammal

Kunze, W., Bornstein, J. C., & Furness, J. B. (1995) · Neuroscience · doi:10.1016/0306-4522(95)00067-s · Cited by 191 · see citing works

Inflammatory Bowel Disease and Parkinson’s Disease: A Nationwide Swedish Cohort Study

Weimers, P., Halfvarson, J., Sachs, M. C., Saunders-Pullman, R. J., Ludvigsson, J. F., Peter, I., Burisch, J. M., & Olén, O. (2018) · Inflammatory Bowel Diseases · doi:10.1093/ibd/izy190 · Cited by 175 · see citing works

Parkinson’s Disease and the Gastrointestinal Microbiome

Lubomski, M., Tan, A. H., Lim, S.-Y., Holmes, A. J., Davis, R. L., & Sue, C. M. (2020) · Journal of Neurology · doi:10.1007/s00415-019-09320-1 · Cited by 172 · see citing works

Increasing Comparability and Utility of Gut Microbiome Studies in Parkinson’s Disease: A Systematic Review

Boertien, J. M., Pereira, P. A. B., Aho, V. T. E., & Scheperjans, F. (2019) · Journal of Parkinson s Disease · doi:10.3233/jpd-191711 · Cited by 169 · see citing works

RNA Sensing by Gut Piezo1 Is Essential for Systemic Serotonin Synthesis

Sugisawa, E., Takayama, Y., Takemura, N., Kondo, T., Hatakeyama, S., Kumagai, Y., Sunagawa, M., Tominaga, M., & Maruyama, K. (2020) · Cell · doi:10.1016/j.cell.2020.06.022 · Cited by 160 · see citing works

Interleukin-33 Promotes Serotonin Release from Enterochromaffin Cells for Intestinal Homeostasis

Chen, Z., Luo, J., Li, J., Kim, G., Stewart, A., Urban, J. F., Huang, Y., Chen, S., Wu, L., Chesler, A. T., et al. (2020) · Immunity · doi:10.1016/j.immuni.2020.10.014 · Cited by 156 · see citing works

New insights into IL-6 family cytokines in metabolism, hepatology and gastroenterology

Giraldez, M. D., Carneros, D., Garbers, C., Rose-John, S., & Bustos, M. (2021) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-021-00473-x · Cited by 156 · see citing works

Development of the intrinsic and extrinsic innervation of the gut

Uesaka, T., Young, H. M., Pachnis, V., & Enomoto, H. (2016) · Developmental Biology · doi:10.1016/j.ydbio.2016.04.016 · Cited by 153 · see citing works

Gastrointestinal tract modeling using organoids engineered with cellular and microbiota niches

Min, S., Kim, S., & Cho, S. (2020) · Experimental & Molecular Medicine · doi:10.1038/s12276-020-0386-0 · Cited by 145 · see citing works

<i>Helicobacter pylori</i> targets cancer-associated apical-junctional constituents in gastroids and gastric epithelial cells

Wroblewski, L. E., Piazuelo, M. B., Chaturvedi, R., Schumacher, M., Aihara, E., Feng, R., Noto, J. M., Delgado, A., Israel, D. A., Zavros, Y., et al. (2015) · Gut · doi:10.1136/gutjnl-2014-307650 · Cited by 143 · see citing works

The risk of Parkinson’s disease in inflammatory bowel disease: A systematic review and meta-analysis

Zhu, F., Li, C., Gong, J., Zhu, W., Gu, L., & Li, N. (2019) · Digestive and Liver Disease · doi:10.1016/j.dld.2018.09.017 · Cited by 136 · see citing works

Polarised epithelial monolayers of the gastric mucosa reveal insights into mucosal homeostasis and defence against infection

Boccellato, F., Wölffling, S., Imai‐Matsushima, A., Sanchez, G., Goosmann, C., Schmid, M., Berger, H., Morey, P., Denecke, C., Ordemann, J., et al. (2018) · Gut · doi:10.1136/gutjnl-2017-314540 · Cited by 133 · see citing works

Host–microbiota interactions in inflammatory bowel disease

Neurath, M. F. (2019) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-019-0248-1 · Cited by 129 · see citing works

Interactions between host genetics and gut microbiota determine susceptibility to CNS autoimmunity

Montgomery, T. L., Künstner, A., Kennedy, J. J., Fang, Q., Asarian, L., Culp‐Hill, R., D’Alessandro, A., Teuscher, C., Busch, H. S., & Krementsov, D. N. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2002817117 · Cited by 117 · see citing works

Gut feelings about smoking and coffee in Parkinson's disease

Derkinderen, P., Shannon, K. M., & Brundin, P. (2014) · Movement Disorders · doi:10.1002/mds.25882 · Cited by 115 · see citing works

Multiple sclerosis and inflammatory bowel diseases: a systematic review and meta-analysis

Kosmidou, M. S., Katsanos, A. H., Katsanos, K. H., Kyritsis, A. P., Tsivgoulis, G. K., Christodoulou, D. K., & Giannopoulos, S. (2016) · Journal of Neurology · doi:10.1007/s00415-016-8340-8 · Cited by 115 · see citing works

Chronic Mild Gut Inflammation Accelerates Brain Neuropathology and Motor Dysfunction in α-Synuclein Mutant Mice

Kishimoto, Y., Zhu, W. S., Hosoda, W., Sen, J. M., & Mattson, M. P. (2019) · NeuroMolecular Medicine · doi:10.1007/s12017-019-08539-5 · Cited by 115 · see citing works

Associations between the gut microbiota and host immune markers in pediatric multiple sclerosis and controls

Tremlett, H. L., Fadrosh, D. W., Faruqi, A. A., Hart, J., Roalstad, S., Graves, J. S., Spencer, C. M., Lynch, S. V., Zamvil, S. S., & Waubant, E. L. (2016) · BMC Neurology · doi:10.1186/s12883-016-0703-3 · Cited by 114 · see citing works

Induced organoids derived from patients with ulcerative colitis recapitulate colitic reactivity

Sarvestani, S. K., Signs, S. A., Hu, B., Yeu, Y., Feng, H., Ni, Y., Hill, D. R., Fisher, R. C., Ferrandon, S., DeHaan, R. K., et al. (2021) · Nature Communications · doi:10.1038/s41467-020-20351-5 · Cited by 113 · see citing works

Glymphatic System as a Gateway to Connect Neurodegeneration From Periphery to CNS

Natale, G., Limanaqi, F., Busceti, C. L., Mastroiacovo, F., Nicoletti, F., Puglisi‐Allegra, S., & Fornai, F. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.639140 · Cited by 113 · see citing works

Meta-analysis of published studies identified eight additional common susceptibility loci for Crohnʼs disease and ulcerative colitis

Umeno, J., Asano, K., Matsushita, T., Matsumoto, T., Kiyohara, Y., Iida, M., Nakamura, Y., Kamatani, N., & Kubo, M. (2011) · Inflammatory Bowel Diseases · doi:10.1002/ibd.21651 · Cited by 112 · see citing works

Generation of mesenchyme free intestinal organoids from human induced pluripotent stem cells

Mithal, A., Capilla, A., Heinze, D. M., Berical, A. C., Villacorta-Martín, C., Vedaie, M., Jacob, A., Abo, K. M., Szymaniak, A. D., Peasley, M., et al. (2020) · Nature Communications · doi:10.1038/s41467-019-13916-6 · Cited by 111 · see citing works

Interleukin-33 Induces the Enzyme Tryptophan Hydroxylase 1 to Promote Inflammatory Group 2 Innate Lymphoid Cell-Mediated Immunity

Flamar, A.-L., Klose, C. S. N., Moeller, J. B., Mahlakõiv, T., Bessman, N. J., Zhang, W., Moriyama, S., Stokic-Trtica, V., Rankin, L. C., Putzel, G., et al. (2020) · Immunity · doi:10.1016/j.immuni.2020.02.009 · Cited by 108 · see citing works

Role of sensory neurons in colitis: increasing evidence for a neuroimmune link in the gut

Engel, M. A., Becker, C., Reeh, P. W., & Neurath, M. F. (2010) · Inflammatory Bowel Diseases · doi:10.1002/ibd.21422 · Cited by 104 · see citing works

Cortical Inflammation is Increased in a DSS-Induced Colitis Mouse Model

Han, Y., Zhao, T., Cheng, X., Zhao, M., Gong, S.-H., Zhao, Y., Wu, H., Fan, M., & Zhu, L. (2018) · Neuroscience Bulletin · doi:10.1007/s12264-018-0288-5 · Cited by 98 · see citing works

Intestinal Stem Cell Growth and Differentiation on a Tubular Scaffold with Evaluation in Small and Large Animals

Shaffiey, S. A., Jia, H., Keane, T. J., Costello, C. M., Wasserman, D., Quidgley-Martin, M., Dziki, J. L., Badylak, S. F., Sodhi, C. P., March, J. C., et al. (2015) · Regenerative Medicine · doi:10.2217/rme.15.70 · Cited by 96 · see citing works

Interferon Lambda Promotes Paneth Cell Death Via STAT1 Signaling in Mice and Is Increased in Inflamed Ileal Tissues of Patients With Crohn’s Disease

Günther, C., Ruder, B., Stolzer, I., Dorner, H., He, G.-W., Chiriac, M. T., Aden, K., Strigli, A., Bittel, M., Zeißig, S., et al. (2019) · Gastroenterology · doi:10.1053/j.gastro.2019.07.031 · Cited by 95 · see citing works

The proximodistal aggravation of colitis depends on substance P released from TRPV1-expressing sensory neurons

Engel, M. A., Khalil, M., Mueller–Tribbensee, S. M., Becker, C., Neuhuber, W., Neurath, M. F., & Reeh, P. W. (2011) · Journal of Gastroenterology · doi:10.1007/s00535-011-0495-6 · Cited by 94 · see citing works

Human Intestinal Tissue with Adult Stem Cell Properties Derived from Pluripotent Stem Cells

Forster, R. E., Chiba, K., Schaeffer, L., Regalado, S. G., Lai, C. S., Gao, Q., Kiani, S., Farin, H. F., Clevers, H. C., Cost, G. J., et al. (2014) · Stem Cell Reports · doi:10.1016/j.stemcr.2014.05.001 · Cited by 88 · see citing works

Gut-Selective Integrin-Targeted Therapies for Inflammatory Bowel Disease

Lamb, C. A., O’Byrne, S., Keir, M. E., & Butcher, E. C. (2018) · Journal of Crohn s and Colitis · doi:10.1093/ecco-jcc/jjy060 · Cited by 85 · see citing works

TREM Receptors Connecting Bowel Inflammation to Neurodegenerative Disorders

Natale, G., Biagioni, F., Busceti, C. L., Gambardella, S., Limanaqi, F., & Fornai, F. (2019) · Cells · doi:10.3390/cells8101124 · Cited by 82 · see citing works

Generation of intestinal organoids derived from human pluripotent stem cells for drug testing

Yoshida, S., Miwa, H., Kawachi, T., Kume, S., & Takahashi, K. (2020) · Scientific Reports · doi:10.1038/s41598-020-63151-z · Cited by 82 · see citing works

Neurologic Complications in Patients with Inflammatory Bowel Disease

Singh, S., Kumar, N., Loftus, E. V., & Kane, S. V. (2012) · Inflammatory Bowel Diseases · doi:10.1002/ibd.23011 · Cited by 78 · see citing works

The Neuromodulation of the Intestinal Immune System and Its Relevance in Inflammatory Bowel Disease

Giovangiulio, M. D., Verheijden, S., Bosmans, G., Stakenborg, N., Boeckxstaens, G., & Matteoli, G. (2015) · Frontiers in Immunology · doi:10.3389/fimmu.2015.00590 · Cited by 75 · see citing works

The roles and functions of Paneth cells in Crohn’s disease: A critical review

Yang, E., & Shen, J. (2020) · Cell Proliferation · doi:10.1111/cpr.12958 · Cited by 71 · see citing works

Pathogenesis of ulcerative colitis.

WARREN, S., & SOMMERS, S. C. (1949) · PubMed · Cited by 67 · see citing works

LRRK2 but not ATG16L1 is associated with Paneth cell defect in Japanese Crohn’s disease patients

Liu, T., Naito, T., Liu, Z., VanDussen, K. L., Haritunians, T., Li, D., Endo, K., Kawai, Y., Nagasaki, M., Kinouchi, Y., et al. (2017) · JCI Insight · doi:10.1172/jci.insight.91917 · Cited by 67 · see citing works

Persistent central inflammation and region specific cellular activation accompany depression- and anxiety-like behaviours during the resolution phase of experimental colitis

Dempsey, E., Abautret-Daly, Á., Docherty, N. G., Medina, C., & Harkin, A. (2019) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2019.05.007 · Cited by 67 · see citing works

Vagal innervation of the stomach reassessed: brain−gut connectome uses smart terminals

Powley, T. L., Jaffey, D., McAdams, J. L., Baronowsky, E. A., Black, D., Chesney, L., Evans, C., & Phillips, R. J. (2019) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.14138 · Cited by 67 · see citing works

Derivation of enteric neuron lineages from human pluripotent stem cells

Barber, K., Studer, L., & Fattahi, F. (2019) · Nature Protocols · doi:10.1038/s41596-019-0141-y · Cited by 66 · see citing works

Vedolizumab for the Treatment of IBD: A Selective Therapeutic Approach Targeting Pathogenic a4b7 Cells

Jovani, M., & Danese, S. (2013) · Current Drug Targets · doi:10.2174/13894501113146660206 · Cited by 64 · see citing works

Intestinal epithelial Caspase-8 signaling is essential to prevent necroptosis during Salmonella Typhimurium induced enteritis

Hefele, M., Stolzer, I., Ruder, B., He, G.-W., Mahapatro, M., Wirtz, S. J., Neurath, M. F., & Günther, C. (2018) · Mucosal Immunology · doi:10.1038/s41385-018-0011-x · Cited by 53 · see citing works

THE PATHOGENESIS OF ULCERATIVE COLITIS

McGovern, V. J., & Archer, G. T. L. (1957) · Australasian Annals of Medicine · doi:10.1111/imj.1957.6.1.68 · Cited by 50 · see citing works

Modulation of sphingosine-1-phosphate in ulcerative colitis

ARGOLLO, M. C., Furfaro, F., Gilardi, D., Roda, G., Allocca, M., Peyrin‐Biroulet, L., & Danese, S. (2020) · Expert Opinion on Biological Therapy · doi:10.1080/14712598.2020.1732919 · Cited by 46 · see citing works

Loss-of-Function Rodent Models for Parkin and PINK1

Oliveras-Salvá, M., Rompuy, A. V., Heeman, B., den Haute, C. V., & Baekelandt, V. (2011) · Journal of Parkinson s Disease · doi:10.3233/jpd-2011-11041 · Cited by 43 · see citing works

&lt;p&gt;Colonic inflammation affects myenteric alpha-synuclein in nonhuman primates&lt;/p&gt;

Resnikoff, H., Metzger, J. M., Lopez, M., Bondarenko, V., Mejia, A., Simmons, H. A., & Emborg, M. E. (2019) · Journal of Inflammation Research · doi:10.2147/jir.s196552 · Cited by 42 · see citing works

Multiple sclerosis and inflammatory bowel diseases: what we know and what we would need to know!

Alkhawajah, M. M., Caminero, A. B., Freeman, H. J., & Oger, J. J.-F. (2012) · Multiple Sclerosis Journal · doi:10.1177/1352458512461393 · Cited by 38 · see citing works

Changes in Gastrointestinal Microbiome Composition in PD: A Pivotal Role of Covariates

Cosma-Grigorov, A., Meixner, H., Mrochen, A., Wirtz, S., Winkler, J., & Marxreiter, F. (2020) · Frontiers in Neurology · doi:10.3389/fneur.2020.01041 · Cited by 38 · see citing works

The evidence for fungus in Crohn’s disease pathogenesis

Miyoshi, J., Sofia, M., & Pierre, J. F. (2018) · Clinical Journal of Gastroenterology · doi:10.1007/s12328-018-0886-9 · Cited by 35 · see citing works

Genetic variants associated with Crohn's disease

Michail, S. K., Bultron, & DePaolo, R. W. (2013) · The Application of Clinical Genetics · doi:10.2147/tacg.s33966 · Cited by 29 · see citing works

Functional Brain Imaging Reveals Rapid Blockade of Abdominal Pain Response Upon Anti-TNF Therapy in Crohn’s Disease

Heß, A., Roesch, J., Saake, M., Sergeeva, M., Hirschmann, S., Neumann, H., Dörfler, A., Neurath, M. F., & Atreya, R. N. (2015) · Gastroenterology · doi:10.1053/j.gastro.2015.05.063 · Cited by 29 · see citing works

Sphingosine-1-Phosphate Lyase Inhibition Alters the S1P Gradient and Ameliorates Crohn’s-Like Ileitis by Suppressing Thymocyte Maturation

Karuppuchamy, T., Tyler, C. J., Lundborg, L. R., Pérez-Jeldres, T., Kimball, A. K., Clambey, E. T., Jedlicka, P., & Rivera–Nieves, J. (2019) · Inflammatory Bowel Diseases · doi:10.1093/ibd/izz174 · Cited by 29 · see citing works

Association between ulcerative colitis and multiple sclerosis

Pokorny, C., Beran, R. G., & Pokorny, M. J. (2007) · Internal Medicine Journal · doi:10.1111/j.1445-5994.2007.01452.x · Cited by 28 · see citing works

Hepatocyte turnover and regeneration: Virtually a virtuoso performance

Alison, M. R., & Lin, W. (2011) · Hepatology · doi:10.1002/hep.24252 · Cited by 23 · see citing works

Use of anti-TNF-α therapy in Crohn's disease is associated with increased incidence of multiple sclerosis

Avasarala, J., Guduru, Z., McLouth, C. J., Wilburn, A., Talbert, J., Sutton, P., & Sokola, B. S. (2021) · Multiple Sclerosis and Related Disorders · doi:10.1016/j.msard.2021.102942 · Cited by 21 · see citing works

What gastroenterologists and hepatologists should know about organoids in 2019

Günther, C., Brevini, T., Sampaziotis, F., & Neurath, M. F. (2019) · Digestive and Liver Disease · doi:10.1016/j.dld.2019.02.020 · Cited by 19 · see citing works

Correction: Lactobacillus accelerates ISCs regeneration to protect the integrity of intestinal mucosa through activation of STAT3 signaling pathway induced by LPLs secretion of IL-22

Hou, Q., Ye, L., Liu, H., Huang, L., Yang, Q., Turner, J. R., & Yu, Q. (2020) · Cell Death and Differentiation · doi:10.1038/s41418-020-00630-w · Cited by 17 · see citing works

Inflammatory bowel disease and demyelination: more than just a coincidence?

Katsanos, A. H., & Katsanos, K. H. (2014) · Expert Review of Clinical Immunology · doi:10.1586/1744666x.2014.885381 · Cited by 11 · see citing works

Modulation of the extrinsic cell death signaling pathway by viral Flip induces acute-death mediated liver failure

Bittel, M., Kremer, A. E., Stürzl, M., Wirtz, S. J., Stolzer, I., Neurath, M. F., Ballon, G., & Günther, C. (2019) · Cell Death and Disease · doi:10.1038/s41419-019-2115-y · Cited by 6 · see citing works

The butyrate-producing and spore-forming bacterial genus Coprococcus as a potential biomarker for neurological disorders

Notting, F., Pirovano, W., Sybesma, W., & Kort, R. (2023) · Gut Microbiome · doi:10.1017/gmb.2023.14 · Cited by 133 · see citing works

New and Emerging Treatments for Inflammatory Bowel Disease

Higashiyama, M., & Hokari, R. (2022) · Digestion · doi:10.1159/000527422 · Cited by 111 · see citing works

Advances in Brain–Gut–Microbiome Interactions: A Comprehensive Update on Signaling Mechanisms, Disorders, and Therapeutic Implications

Dong, T. S., & Mayer, E. A. (2024) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2024.01.024 · Cited by 84 · see citing works

Gut inflammation promotes microbiota-specific CD4 T cell-mediated neuroinflammation

White, Z., Cabrera, I., Mei, L., Clevenger, M. H., Ochoa-Raya, A., Kapustka, I., Dominguez, J. R., Zhou, J., Koster, K. P., Anwar, S., et al. (2025) · Nature · doi:10.1038/s41586-025-09120-w · Cited by 66 · see citing works

Updating the Classification of Chronic Inflammatory Enteropathies in Dogs

Dupouy-Manescau, N., Méric, T., Sénécat, O., Drut, A., Valentin, S., Leal, R. O., & Hernandez, J. L. (2024) · Animals · doi:10.3390/ani14050681 · Cited by 58 · see citing works

Postbiotics: An alternative and innovative intervention for the therapy of inflammatory bowel disease

Kavita, K., Om, H., Chand, U., & Kushawaha, P. K. (2023) · Microbiological Research · doi:10.1016/j.micres.2023.127550 · Cited by 56 · see citing works

Unveiling the gut-brain axis: structural and functional analogies between the gut and the choroid plexus vascular and immune barriers

Carloni, S., & Rescigno, M. (2022) · Seminars in Immunopathology · doi:10.1007/s00281-022-00955-3 · Cited by 54 · see citing works

Inflammatory Bowel Disease and Neurodegenerative Diseases

Kim, J. S., Chen, M., Wang, H. E., Lu, C., Wang, Y., & Zhang, B. (2023) · Gut and Liver · doi:10.5009/gnl220523 · Cited by 53 · see citing works

Impact of Microbiome–Brain Communication on Neuroinflammation and Neurodegeneration

Stolzer, I., Scherer, E., Süß, P., Rothhammer, V., Winner, B., Neurath, M. F., & Günther, C. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241914925 · Cited by 47 · see citing works

Do interventions for mood improve inflammatory biomarkers in inflammatory bowel disease?: a systematic review and meta-analysis

Seaton, N., Hudson, J. L., Harding, S., Norton, S., Mondelli, V., Jones, A. S. K., & Moss-Morris, R. E. (2024) · EBioMedicine · doi:10.1016/j.ebiom.2023.104910 · Cited by 45 · see citing works

Chronic inflammation in post-acute sequelae of COVID-19 modulates gut microbiome: a review of literature on COVID-19 sequelae and gut dysbiosis

Iqbal, N. T., Khan, H., Khalid, A., Mahmood, S. F., Nasir, N., Khanum, I., de Siqueira, I. C., & A, W. C. V. V. (2025) · Molecular Medicine · doi:10.1186/s10020-024-00986-6 · Cited by 44 · see citing works

Are neurodegenerative diseases associated with an increased risk of inflammatory bowel disease? A two-sample Mendelian randomization study

Cui, G., Li, S., Ye, H., Yang, Y., Huang, Q., Chu, Y., Shi, Z., & Zhang, X. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.956005 · Cited by 40 · see citing works

Interorgan communication networks in the kidney–lung axis

Komaru, Y., Bai, Y. Z., Kreisel, D., & Herrlich, A. (2023) · Nature Reviews Nephrology · doi:10.1038/s41581-023-00760-7 · Cited by 40 · see citing works

Mutant LRRK2 exacerbates immune response and neurodegeneration in a chronic model of experimental colitis

Cabezudo, D., Tsafaras, G., Acker, E. V., den Haute, C. V., & Baekelandt, V. (2023) · Acta Neuropathologica · doi:10.1007/s00401-023-02595-9 · Cited by 35 · see citing works

Therapeutic Effects of Baicalin on Diseases Related to Gut–Brain Axis Dysfunctions

Hu, Q., Hou, S., Xiong, B., Wen, Y., Wang, J., Zeng, J., Ma, X., & Wang, F. (2023) · Molecules · doi:10.3390/molecules28186501 · Cited by 31 · see citing works

A leaky gut dysregulates gene networks in the brain associated with immune activation, oxidative stress, and myelination in a mouse model of colitis

Boles, J. S., Krueger, M. E., Jernigan, J. E., Cole, C. L., Neighbarger, N. K., Huarte, O. U., & Tansey, M. G. (2024) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2024.02.007 · Cited by 31 · see citing works

Psychiatric Comorbidities of Inflammatory Bowel Disease: It Is a Matter of Microglia’s Gut Feeling

Fakhfouri, G., Mijailović, N. R., & Rahimian, R. (2024) · Cells · doi:10.3390/cells13020177 · Cited by 30 · see citing works

Enteric Nervous System Alterations in Inflammatory Bowel Disease: Perspectives and Implications

Suman, S. (2024) · Gastrointestinal Disorders · doi:10.3390/gidisord6020025 · Cited by 29 · see citing works

Enteric Glia and Brain Astroglia: Complex Communication in Health and Disease along the Gut-Brain Axis

D’Antongiovanni, V., Pellegrini, C., Antonioli, L., Ippolito, C., Segnani, C., Benvenuti, L., d’Amati, A., Errede, M., Virgintino, D., Fornai, M., et al. (2023) · The Neuroscientist · doi:10.1177/10738584231163460 · Cited by 28 · see citing works

Effects of psychological stress on inflammatory bowel disease via affecting the microbiota–gut–brain axis

Chen, Y., Chen, X., Lin, S., Huang, S., Li, L., Hong, M., Li­, ­., Ma, L., & Ma, J. (2025) · Chinese Medical Journal · doi:10.1097/cm9.0000000000003389 · Cited by 29 · see citing works

Association between Childhood Onset Inflammatory Bowel Disease and Psychiatric Comorbidities in Adulthood

Sălcudean, A., Nan, A. G., Bodo, C. R., Cosma, M. C., Strete, E. G., & Lica, M. M. (2023) · Diagnostics · doi:10.3390/diagnostics13111868 · Cited by 24 · see citing works

Structural characterization of Hericium coralloides polysaccharide and its neuroprotective function in Alzheimer's disease

Guan, Y., Wang, C., Li, L., Dai, X., Liu, Y., Hsiang, T., Liu, S., & Wang, D. (2024) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2024.133865 · Cited by 24 · see citing works

Gut–Brain Interactions and Their Impact on Astrocytes in the Context of Multiple Sclerosis and Beyond

Zißler, J., Rothhammer, V., & Linnerbauer, M. (2024) · Cells · doi:10.3390/cells13060497 · Cited by 24 · see citing works

Biologics, Small Molecules and More in Inflammatory Bowel Disease: The Present and the Future

Manrai, M., Jha, A. A., Dawra, S., & Pachisia, A. V. (2024) · Future Pharmacology · doi:10.3390/futurepharmacol4010017 · Cited by 22 · see citing works

Estimation of the bidirectional relationship between schizophrenia and inflammatory bowel disease using the mendelian randomization approach

Li, Q., He, X., Gao, F., Fan, Y., Zhao, B., Ma, Q., Yan, B., Wang, W., Ma, X., & Yang, J. (2022) · Schizophrenia · doi:10.1038/s41537-022-00244-w · Cited by 22 · see citing works

Connecting the Dots: The Cerebral Lymphatic System as a Bridge Between the Central Nervous System and Peripheral System in Health and Disease

Zhao, H., Sun, M., Zhang, Y., Kong, W., Fan, L., Wang, K., Xu, Q., Chen, B., Dong, J., Shi, Y., et al. (2023) · Aging and Disease · doi:10.14336/ad.2023.0516 · Cited by 21 · see citing works

Gut Microbiota Modulation of Short Bowel Syndrome and the Gut–Brain Axis

Carter, J., Bettag, J., Morfin, S., Manithody, C., Nagarapu, A., Jain, A., Nazzal, H., Prem, S., Unes, M., McHale, M., et al. (2023) · Nutrients · doi:10.3390/nu15112581 · Cited by 21 · see citing works

Early-life gut inflammation drives sex-dependent shifts in the microbiome-endocrine-brain axis

Sullivan, O., Sie, C., Ng, K. M., Cotton, S., Rosete, C., Hamden, J. E., Singh, A. P., Lee, K., Choudhary, J., Kim, J. A., et al. (2024) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2024.12.003 · Cited by 20 · see citing works

Systemic Consequences of Inflammatory Bowel Disease Beyond Immune-Mediated Manifestations

Caballero-Mateos, A. M., Brunet, E., & Gros, B. (2025) · Journal of Clinical Medicine · doi:10.3390/jcm14227984 · Cited by 17 · see citing works

Underneath the Gut–Brain Axis in IBD—Evidence of the Non-Obvious

Boldyreva, L. V., Evtushenko, A. A., Lvova, M. N., Morozova, K. N., & Владимировна, К. Е. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252212125 · Cited by 16 · see citing works

Mechanisms of interorgan crosstalk in health and disease

Herrlich, A., Kefaloyianni, E., & Rose‐John, S. (2022) · FEBS Letters · doi:10.1002/1873-3468.14313 · Cited by 15 · see citing works

Gut-to-brain spreading of pathology in synucleinopathies: A focus on molecular signalling mediators

Schmitt, V., Masanetz, R. K., Weidenfeller, M., Ebbinghaus, L. S., Süß, P., Rosshart, S. P., von Hörsten, S., Zunke, F., Winkler, J., & Xiang, W. (2023) · Behavioural Brain Research · doi:10.1016/j.bbr.2023.114574 · Cited by 16 · see citing works

The gut-brain axis: Correlation of choroid plexus volume and permeability with inflammatory biomarkers in Crohn's disease

Bonifacio, C., Savini, G., Reca, C., Garoli, F., Levi, R., Vatteroni, G., Balzarini, L., Allocca, M., Furfaro, F., Buono, A. D., et al. (2024) · Neurobiology of Disease · doi:10.1016/j.nbd.2024.106416 · Cited by 15 · see citing works

Enterogenic dementia: defining the gut–brain axis and the role of inflammatory bowel disease in cognitive impairment

Alshammari, F. F., Al-Kuraishy, H. M., Shokr, M. M., Papadakis, M., Alexiou, A. T., & Batiha, G. E. (2025) · Inflammopharmacology · doi:10.1007/s10787-025-01940-6 · Cited by 14 · see citing works

Rice bran extract mitigates depressive-like behavior in dextran sulfate sodium-induced colitis: Involvement of the gut-brain axis and Sirt1 signaling pathway

Shendy, H. M., Mohamed, S. S., El-Haleim, E. A. A., Galal, O., Wadie, W., Helal, A. M., & Khayyal, M. T. (2023) · Food and Chemical Toxicology · doi:10.1016/j.fct.2023.114386 · Cited by 14 · see citing works

Cell-derived biomimetic drug delivery system for inflammatory bowel disease therapy

Yang, W., Lin, P., Gao, R., Fang, Z., Wang, Z., Ma, Z., Shi, J., & Yu, W.-Y. (2024) · Materials Today Bio · doi:10.1016/j.mtbio.2024.101332 · Cited by 14 · see citing works

The relationships between depression, inflammation and self-reported disease activity in IBD and their impact on healthcare usage

Seaton, N., Wileman, V., Norton, C. S., Hudson, J. L., Mondelli, V., & Moss-Morris, R. E. (2025) · BMC Gastroenterology · doi:10.1186/s12876-025-03691-8 · Cited by 14 · see citing works

Proof-of-Concept Human Organ-on-Chip Study: First Step of Platform to Assess Neuro-Immunological Communication Involved in Inflammatory Bowel Diseases

Gabriel-Segard, T., Rontard, J., Miny, L., Dubuisson, L., Batut, A., Debis, D., Gleyzes, M., Francois, F., Larramendy, F., Soriano, A., et al. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241310568 · Cited by 14 · see citing works

Inflammatory biomarkers and psychological variables to assess quality of life in patients with inflammatory bowel disease: a cross-sectional study

González-Moret, R., Cebolla, A., Almodóvar-Fernández, I., Navarrete, J., García-Esparza, M. Á., Soria, J. M., & Lisón, J. F. (2024) · Annals of Medicine · doi:10.1080/07853890.2024.2357738 · Cited by 13 · see citing works

Exploring Gut–Brain Interaction Disorders: Mechanisms and Translational Therapies Crossing Neurology to Gastroenterology

Vasilev, G., Miteva, D., Gulinac, M., Chervenkov, L., Kitanova, M., & Velikova, T. V. (2024) · Gastroenterology Insights · doi:10.3390/gastroent15030041 · Cited by 14 · see citing works

The functional landscape of the appendix microbiome under conditions of health and disease

Sagor, M. S., Islam, T., Tamanna, N. T., Bappy, M. K. I., Danishuddin, M., Haque, M. A., & Lackner, M. K. (2025) · Gut Pathogens · doi:10.1186/s13099-025-00696-2 · Cited by 13 · see citing works

Targeting the gut-brain axis for therapeutic adherence in patients with inflammatory bowel disease: a review on the role of psychotherapy

Gravina, A. G., Pellegrino, R., Palladino, G., Mazzarella, C., Federico, P., Arboretto, G., D'Onofrio, R., Olivieri, S., Zagaria, G., Durante, T., et al. (2023) · Brain-Apparatus Communication A Journal of Bacomics · doi:10.1080/27706710.2023.2181101 · Cited by 13 · see citing works

Recent advances in cell-based in vitro models for predicting drug permeability across brain, intestinal, and pulmonary barriers

Eltanameli, B., Piñeiro-Llanes, J., & Cristofoletti, R. (2024) · Expert Opinion on Drug Metabolism & Toxicology · doi:10.1080/17425255.2024.2366390 · Cited by 12 · see citing works

Microbiome-based therapeutics for ocular diseases

Berzack, S., & Galor, A. (2024) · Clinical and Experimental Optometry · doi:10.1080/08164622.2024.2422479 · Cited by 12 · see citing works

The Role of Intestinal Microbiota and Probiotics Supplementation in Multiple Sclerosis Management

Hasaniani, N., Rahimi, S. M., Akbari, M., Sadati, F., Pournajaf, A., & Rostami-Mansoor, S. (2024) · Neuroscience · doi:10.1016/j.neuroscience.2024.05.013 · Cited by 11 · see citing works

The impact of anti-inflammatory therapy on Parkinson's disease incidence: A retrospective cohort study

Potashman, M. H., Haas, J. S., Pandit, A. A., Stafkey-Mailey, D., Coric, V., Singer, W., & L’Italien, G. J. (2024) · Parkinsonism & Related Disorders · doi:10.1016/j.parkreldis.2024.107194 · Cited by 10 · see citing works

Advancements in Immunomodulatory Therapies for IBD and Their Interplay With the Gut–Brain Axis: An Updated Review of Current Literature and Beyond

Jha, M., Waheed, A., Hooti, J. A., Nair, S., Najam, A., Mal, M. M., Tummala, N., Shariq, A. S., Hurairah, A., & Daniel, M. G. (2025) · Health Science Reports · doi:10.1002/hsr2.71157 · Cited by 11 · see citing works

IL ‐4‐ JAK1 ‐ STAT6 Pathway Mediates Electroacupuncture's Effect on Microglial M2 Polarization to Treat Inflammatory Bowel Disease With Comorbid Depression

Cao, S., Yang, J., Chen, L., Li, Z., Lv, J., Huang, Y., Xu, Z., Lu, P., Liu, J., Liu, Q., et al. (2025) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.70572 · Cited by 9 · see citing works

The Role of the Gut-Brain Axis in Diseases

Chen, J. W., Xu, Y., & Cao, P. (2025) · Physiology · doi:10.1152/physiol.00016.2025 · Cited by 9 · see citing works

The role of microbiota derived metabolites in modulating diabetic inflammation: a systematic review

Karthick, V., Thamarai, R., Amalraj, S., Kalimuthu, N., & Manimegalai, G. (2026) · Journal of Molecular Histology · doi:10.1007/s10735-026-10775-6 · Cited by 10 · see citing works

Targeting the Gut–Brain Axis with Plant-Derived Essential Oils: Phytocannabinoids and Beyond

Camarda, L., Mattioli, L., Corazza, I., Marzetti, C., & Budriesi, R. (2025) · Nutrients · doi:10.3390/nu17091578 · Cited by 8 · see citing works

Assessment of glymphatic dysfunction in ulcerative colitis using DKI-ALPS: An innovative imaging biomarker

Bao, C., Ma, Y., Li, M., Li, Y., Zhang, C., Liu, X., Fan, R., Cui, W., Fan, X., Zheng, F., et al. (2025) · Journal of Neuroradiology · doi:10.1016/j.neurad.2025.101402 · Cited by 7 · see citing works

Preserved central cholinergic functioning to transcranial magnetic stimulation in de novo patients with celiac disease

Lanza, G., Fisicaro, F., D’Agate, C. C., Ferri, R., Cantone, M., Falzone, L., Pennisi, G., Bella, R., Hadjivassiliou, M., & Pennisi, M. (2021) · PLoS ONE · doi:10.1371/journal.pone.0261373 · Cited by 7 · see citing works

Effect of fecal microbiota transplantation on ulcerative colitis model in rats: The gut–brain axis

Morshedbak, M., Rahimi, K., & Tabandeh, M. R. (2025) · Heliyon · doi:10.1016/j.heliyon.2025.e42430 · Cited by 6 · see citing works

The prevalence of myasthenia gravis is increased in inflammatory bowel disease

Leitão, A. M. F., Thomas, F. P., de Souza, M. H. L. P., Braga, L. L. B. C., & Gondim, F. D. A. A. (2025) · Arquivos de Neuro-Psiquiatria · doi:10.1055/s-0045-1807717 · Cited by 6 · see citing works

Gut: The gate and key to brain

Zhang, X., & Yang, Y. (2025) · Chinese Medical Journal · doi:10.1097/cm9.0000000000003767 · Cited by 6 · see citing works

The impact of cognitive functions, psychological disorders, and coping strategies on quality of life and disease outcomes in patients with inflammatory bowel diseases: A cross-sectional study

Almarzouki, A. F., Alluhaibi, W., Salman, B., Almuhaiyawi, M., Alreemi, M., & Alsahafi, M. (2024) · Medicine · doi:10.1097/md.0000000000038982 · Cited by 6 · see citing works

Integrated Approaches in the Management of Gastrointestinal Disorders: A Biopsychosocial Perspective

Chughtai, M. A., Kerimkulova, M. K., Mushtaq, O., Anand, V. H., Rehman, A., Shehryar, A., Hassan, B. D., Islam, R., Islam, H., Mansoor, M., et al. (2024) · Cureus · doi:10.7759/cureus.60962 · Cited by 6 · see citing works

Altered functional network topology properties to detect anxiety and depression caused by Crohn’s disease and disease severity

Yang, J., Yue, K., Sun, J., Pan, C., Wu, X., Cheng, Y., Wu, X., & Shi, H. (2024) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2024.111187 · Cited by 5 · see citing works

The gut-brain connection in inflammatory bowel disease: Mechanisms, mental health, and therapeutic horizons

Kumar, G., Yadav, S., Dwivedi, S., Sharma, A., & Kosey, S. (2026) · Gastroenterology & Endoscopy · doi:10.1016/j.gande.2026.02.001 · Cited by 5 · see citing works

Microbiome crosstalk and nutrition: the interplay between gut microbiota-organ axis and dietary factors

Çelik, M. N., Dazıroğlu, M. E. Ç., Atabılen, B., Nanì, M. F., Romano, B., Ağagündüz, D., & Capasso, R. (2026) · Food Research International · doi:10.1016/j.foodres.2026.118945 · Cited by 5 · see citing works

Cerebral hemodynamic changes to transcranial Doppler sonography in celiac disease: A pilot study

Fisicaro, F., Lanza, G., D’Agate, C. C., Pennisi, M., Cantone, M., Pennisi, G., Hadjivassiliou, M., & Bella, R. (2022) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2022.931727 · Cited by 6 · see citing works

Psychological distress predicts disease activity in inflammatory bowel disease: Results from the mind-body IBD longitudinal study

Seaton, N., Hudson, J. L., Mondelli, V., Raymond, L., Schmill, P., Hart, A. L., & Moss-Morris, R. E. (2025) · Brain Behavior & Immunity - Health · doi:10.1016/j.bbih.2025.101147 · Cited by 4 · see citing works

Microplastics and the gut-brain axis: Unraveling neurotoxic mechanisms and health implications

Farooq, U., Muhammad, Z., Yang, Q., Usman, M., Qu, Z., Zou, B., & Liu, N. (2026) · The Innovation Medicine · doi:10.59717/j.xinn-med.2026.100190 · Cited by 4 · see citing works

Bidirectional regulation of the gut–brain axis by an oral nanotherapeutic suppresses colonic inflammation and associated behavioral deficits

Chen, Y., Feng, Y., Hu, T., Li, D., Chen, X., Xu, J., Cheng, L., Corke, H., Zhang, B.-B., & Yang, Q. (2026) · Chemical Engineering Journal · doi:10.1016/j.cej.2026.175675 · Cited by 4 · see citing works

Vascular Disease Is Associated With Differences in Brain Structure and Lower Cognitive Functioning in Inflammatory Bowel Disease: A Cross-Sectional Study

Patel, R., Marrie, R. A., Bernstein, C. N., Bolton, J. M., Graff, L. A., Marriott, J. J., Figley, C. R., Kornelsen, J., Mazerolle, E. L., Helmick, C. A., et al. (2023) · Inflammatory Bowel Diseases · doi:10.1093/ibd/izad204 · Cited by 4 · see citing works

Analysis of the Efficacy of Different Obesity Surgeries in Patients with Metabolic Syndrome

Qi, T., Ding, Y., Dai, X., He, J., Zhang, H., & Wu, L. (2025) · Obesity Surgery · doi:10.1007/s11695-025-07673-3 · Cited by 4 · see citing works

Unearthing the Potential Therapeutic Effects of Oxyresveratrol Based on Intrinsic Links between Pharmacological Effects: Implications for the Gut–Liver–Brain Axis

Zhao, L., Duan, Y., Li, Z., Li, J., & Li, S. (2024) · Pharmaceuticals · doi:10.3390/ph17081063 · Cited by 4 · see citing works

Complex gut–brain interactions underlying inflammatory bowel disease-related depression have translational implications in regenerative medicine: a narrative review

Fu, H., & Liu, Y. (2024) · Regenerative medicine reports . · doi:10.4103/regenmed.regenmed-d-24-00006 · Cited by 5 · see citing works

Gut-brain connection in schizophrenia: A narrative review

Iqbal, A., Bokhari, S. F. H., Rehman, M. U., Sattar, S. M. F., Bakht, D., Dost, W., & Basit, A. (2025) · World Journal of Psychiatry · doi:10.5498/wjp.v15.i5.103751 · Cited by 4 · see citing works

Exploring the dual role of Mangifera indica L. in regulating immune response and pain persistence in inflammatory bowel disease

Lucarini, E., Schettino, A., Marigliano, N., Ciampi, C., Smimmo, M., Romano, F., Paolillo, A., Izzo, L., Begum, J., Mansour, A. A., et al. (2025) · Pharmacological Research · doi:10.1016/j.phrs.2025.107773 · Cited by 3 · see citing works

Review study of alteration functional activities and networks in ulcerative colitis using resting-state fMRI

Alyami, A. S. (2025) · Frontiers in Neurology · doi:10.3389/fneur.2025.1608371 · Cited by 3 · see citing works

From Gut to Metabolism

Tariq, R., Sterling, R. K., Afzali, A., & Sanyal, A. J. (2026) · Journal of Clinical Gastroenterology · doi:10.1097/mcg.0000000000002359 · Cited by 4 · see citing works

Understanding the Tripartite Relationship Between Dietary Practices, Psychological Well-Being, and Disease Experience in Greek Patients with IBD: A Mixed-Methods Exploration

Strongylou, D. E., Svolos, V., Vlachou, A., Zoupa, E., Vakouftsi, V. R., Ntanou, A., Argyriou, K., Kapsoritakis, A., Bonoti, F., & Androutsos, O. (2026) · Nutrients · doi:10.3390/nu18091439 · Cited by 3 · see citing works

Traditional clinical symptoms and signs: Kampo pattern diagnosis in modern gastrointestinal disease

Zedler, P., Büntzel, J., Kuchta, K., Yamaoka, D., Sato, N., Watanabe, K., & Cameron, S. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1426491 · Cited by 3 · see citing works

Evidence linking gut-brain axis and Crohn’s disease, focusing on neurotrophic dysfunctions and radiological imaging analysis - a systematic review

Silva, J. F. (2024) · American Journal of Translational Research · doi:10.62347/owyy4960 · Cited by 2 · see citing works

Fatigue Is Strongly Associated with Depressive Symptoms in Patients with Inflammatory Bowel Disease

Mona, R., Göldi, A., Schneider, T., Panne, I., Egger, A., Niess, J. H., & Hruz, P. L. (2025) · Inflammatory Intestinal Diseases · doi:10.1159/000545572 · Cited by 2 · see citing works

Strain-specific responses to dextran sulfate sodium-induced ulcerative colitis in BALB/c and C57BL/6 mice: Comparative analysis of local versus extra-intestinal manifestations

Tiwari, P., & Jena, G. (2025) · Inflammation Research · doi:10.1007/s00011-025-02072-x · Cited by 2 · see citing works

From the gut to the brain: Potential novel avenues for IBD treatment via serotonergic pathways

Ibgui, S., Lints, D., & Milling, S. W. F. (2025) · Pharmacological Research · doi:10.1016/j.phrs.2025.108059 · Cited by 2 · see citing works

Trimetazidine Attenuates Ulcerative Colitis-Linked Extrapyramidal Dysfunction by Mediated Dectin-1/LRRK2/α-Synuclein Autophagy Axis

Mahmoud, S. H., Hamad, S. M., Seiwan, A. N., El-Waseef, D. A. E.-D. A., El-Kharashi, O. A., Elshaer, A. M., Sindi, E. R., Al-Hazani, T. M. I., Ezzat, S. F., Essmat, A., et al. (2025) · Microscopy and Microanalysis · doi:10.1093/mam/ozaf118 · Cited by 2 · see citing works

Inflammatory bowel disease and white matter microstructure: A bidirectional Mendelian randomization study

Yu, J., Xie, W., & Wang, P. (2024) · Brain Research · doi:10.1016/j.brainres.2024.149206 · Cited by 2 · see citing works

Developing and Evaluating a Bundled Digital Tool to Improve Complex Care and Self-Management of Patients With Inflammatory Bowel Disease: Protocol for a Hybrid Effectiveness-Implementation Study

Chappell, K. D., Fox, M., Armstrong, T. S., Ajibulu, L., Seow, C. H., Montaño‐Loza, A. J., Kroeker, K. I., Kaplan, G. G., Novak, K. L., Ma, C., et al. (2025) · JMIR Research Protocols · doi:10.2196/65659 · Cited by 2 · see citing works

Glucagon in the gut – brain axis

Parikh, R. M., Saboo, B., Mohan, V., Basit, A., Gupta, A. S., Panda, J. K., Bhartia, M., & Topsever, P. (2023) · Journal of Diabetology · doi:10.4103/jod.jod_103_23 · Cited by 1 · see citing works

Inflammatory Bowel Diseases and Gut Microbiota

Jana, B. K., Singh, M., Sarkar, T., Sadhu, P., Chetia, D., & Mazumder, B. (2025) · BENTHAM SCIENCE PUBLISHERS eBooks · doi:10.2174/9789815324549125010005 · Cited by 1 · see citing works

Emotional Disturbances and Crohn's Disease

Lastretti, M., D’Aleo, E., Pica, R., Nitto, D. D., Carta, M. G., & Faa, G. (2025) · Clinical Practice and Epidemiology in Mental Health · doi:10.2174/0117450179410096250926135151 · Cited by 1 · see citing works

Chinese Yam ( Dioscorea ) Improves Psychiatric Comorbidities of Colitis Mice Through Regulating 5‐HT Metabolism

Cui, Y., Zhou, Y., Zhang, X., Luo, Y., Ma, C., Dong, L., Hu, X., Li, D., Wang, L., & Chen, F. (2026) · Food Frontiers · doi:10.1002/fft2.70224 · Cited by 1 · see citing works

Triple-emulsion microfluidic Core–Shell hydrogel microcapsules for oral pentoxifylline Delivery: Ameliorating colitis and rebalancing gut microbiome

Park, J.-Y., Jeong, H.-S., Lim, S.-R., Jung, W.-K., Je, J., Choi, C., & Lee, S. (2026) · Materials Today Bio · doi:10.1016/j.mtbio.2026.102881 · Cited by 1 · see citing works

Advances in inflammatory bowel disease (IBD): Immune mechanisms, preclinical models, and emerging therapeutic strategies

Aggarwal, S., Haloi, P., Agarwal, M. K., Saroj, P., Sharma, N., & Kalita, P. (2026) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2026.108420 · Cited by 1 · see citing works

Host–Microbiome Immune Interaction Networks: A Comparative Evolutionary Perspective Across Worms, Mice, and Humans

Tai, X., Zhang, Y., Yang, H., & Zou, W. (2026) · Pathogens · doi:10.3390/pathogens15070733 · Cited by 1 · see citing works

The development of an ingestible biosensor for the characterization of gut metabolites related to major depressive disorder: hypothesis and theory

Densil, A., George, M. E., Mahdi, H., Chami, A., Mark, A., Luo, C., Wang, Y., Ali, A., Tang, P., Dong, A., et al. (2023) · Frontiers in Systems Biology · doi:10.3389/fsysb.2023.1274184 · Cited by 1 · see citing works

A Transcriptomic Evaluation of Neuroactive Receptors in the Colon of a Dextran Sodium Sulphate Pig Model of Colitis

Ryan, M. T., O’Doherty, J. V., & Sweeney, T. (2024) · Nutraceuticals · doi:10.3390/nutraceuticals4030023 · Cited by 1 · see citing works

Crohn’s disease, irritable bowel syndrome, and chronic fatigue: the importance of communication and symptom management—a case report

Haedrich, J., & Huber, R. (2025) · Journal of Medical Case Reports · doi:10.1186/s13256-024-05010-3 · Cited by 1 · see citing works

Developing and Evaluating a Bundled Digital Tool to Improve Complex Care and Self-management of Patients with Inflammatory Bowel Disease: Protocol for a Hybrid Effectiveness-Implementation Study (Preprint)Preprint

Chappell, K. D., Fox, M., Armstrong, T. S., Ajibulu, L., Seow, C. H., Montaño‐Loza, A. J., Kroeker, K. I., Kaplan, G. G., Novak, K. L., Ma, C., et al. (2024) · doi:10.2196/preprints.65659 · Cited by 1 · see citing works

Autoimmune Diseases of the GI Tract Part I: Etiology and Pathophysiology

Al-Ruweidi, M. K. A. A., Khater, N., Alkaabi, H. R., Hasan, M., & Yalcin, H. C. (2022) · IntechOpen eBooks · doi:10.5772/intechopen.106184

Magnetic Resonance Neuroimaging of Inflammatory Bowel Disease

Tangsujaritvijit, T. (2022) · Science Insights · doi:10.15354/si.22.re103

Increased Prevalence of Myasthenia Gravis in a Cohort of Patients with Inflammatory Bowel DiseasePreprint

Leitão, A. M. F., Gondim, F. D. A. A., Thomas, F. P., de Souza, M. H. L. P., & Braga, L. L. B. C. (2023) · Research Square · doi:10.21203/rs.3.rs-3411846/v1

UNDERSTANDING THE INTERPLAY BETWEEN ANXIETY AND ULCERATIVE COLITIS: PREVALENCE, BIDIRECTIONAL RELATIONSHIP, MECHANISMS, AND INFLUENTIAL FACTORS

(2023) · International Journal of Biology Pharmacy and Allied Sciences · doi:10.31032/ijbpas/2023/12.10.1031

Potential therapeutic application of probiotics in the treatment of neuropathic pain: A mechanistic aspects of brain-gut axis

Mishra, M., Subhan, A., Mishra, R., Mazumder, A., Kumar, B., & Joshi, K. (2023) · Trends in Immunotherapy · doi:10.24294/ti.v7.i2.2280

N,N,N′,N′-Tetrakis(2-pyridylmethyl)ethylenediamine induces endothelium-dependent hyperpolarization-mediated vasorelaxation via store-operated calcium entry mechanism in healthy and intestinal inflammatory mice

Zhang, L., Rong, S., Wang, J., Wan, H., Xu, F., & Dong, H. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e33994

Crosstalk between brain and the gastrointestinal system

Agarwal, C., & Koerner, I. P. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-22268-9.00011-9

Inflammatory Bowel Disease and Neurodegenerative Diseases

Kim, J. S., Chen, M., Wang, H. E., Lu, C., Wang, Y., & Zhang, B. (2023) · Gut and Liver · doi:10.5009/gnl220523 · Cited by 53 · see citing works

Gut–Brain Axis-Mediated Neurological Manifestations in Inflammatory Bowel Disease: Mechanisms and Disease Spectrum

Sun, B., Wang, G., Li, X., Liu, H., Xv, H., Wu, Q., Li, H., Ye, X., Wang, X., & Tong, M. (2026) · Journal of Neurogastroenterology and Motility · doi:10.5056/jnm25167

Microbiota-gut-brain axis and its affect inflammatory bowel disease: Pathophysiological concepts and insights for clinicians

Sinagra, E., Utzeri, E., Morreale, G. C., Fabbri, C., Pace, F., & Anderloni, A. A. (2020) · World Journal of Clinical Cases · doi:10.12998/wjcc.v8.i6.1013 · Cited by 82 · see citing works

Gut-brain axis interacts with immunomodulation in inflammatory bowel disease

Ye, X., Zhang, M., Zhang, N., Wei, H., & Wang, B. (2023) · Biochemical Pharmacology · doi:10.1016/j.bcp.2023.115949 · Cited by 13 · see citing works

The gut—brain axis in IBD: an investigator’s perspective

Collins, S. M., Weingarten, H. P., & McHugh, K. (1994) · Springer eBooks · doi:10.1007/978-94-009-0371-5_26