The DOI matches its Crossref record; 43 of the 43 references it cites were found in a registry or an index.
Epigenetic control of CD8+ T cell differentiation
Open accessAbstract
Upon stimulation, small numbers of naive CD8+ T cells proliferate and differentiate into a variety of memory and effector cell types. CD8+ T cells can persist for years and kill tumour cells and virally infected cells. The functional and phenotypic changes that occur during CD8+ T cell differentiation are well characterized, but the epigenetic states that underlie these changes are incompletely understood. Here, we review the epigenetic processes that direct CD8+ T cell differentiation and function. We focus on epigenetic modification of DNA and associated histones at genes and their regulatory elements. We also describe structural changes in chromatin organization that affect gene expression. Finally, we examine the translational potential of epigenetic interventions to improve CD8+ T cell function in individuals with chronic infections and cancer.
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TOX is a critical regulator of tumour-specific T cell differentiation
Scott, A. C., Dündar, F., Zumbo, P., Chandran, S. S., Klebanoff, C. A., Shakiba, M., Trivedi, P., Menocal, L., Appleby, H., Camara, S., et al. (2019) · Nature · doi:10.1038/s41586-019-1324-y · Cited by 1,106
CD8+ T cell differentiation and dysfunction in cancer
Philip, M., & Schietinger, A. (2022) · Nature Reviews Immunology · doi:10.1038/s41577-021-00574-3 · Cited by 1,052
Biology and regulation of IL-2: from molecular mechanisms to human therapy
Spolski, R., Li, P., & Leonard, W. J. (2018) · Nature Reviews Immunology · doi:10.1038/s41577-018-0046-y · Cited by 637
NF‐κB signaling in inflammation and cancer
Zhang, T., Ma, C., Zhang, Z., Zhang, H., & Hu, H. (2021) · MedComm · doi:10.1002/mco2.104 · Cited by 574
Fates of CD8+ T cells in Tumor Microenvironment
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Metadata
- Authors
- Henning, A. N., Roychoudhuri, R., & Restifo, N. P.
- Venue
- Nature Reviews Immunology
- Published
- 2018-01-30
- Volume
- 18
- Issue
- 5
- Pages
- 340-356
- ISSN
- 1474-1733 (ISSN-L)
- 1474-1741
- OpenAlex
- W2785594347
- Cited by
- 510
- References
- 43
- FWCI
- 4.44
- Type
- journal article
- Language
- en
- Open access
- green
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- Henning, A. N., Roychoudhuri, R., & Restifo, N. P. (2018). Epigenetic control of CD8+ T cell differentiation. Nature Reviews Immunology. https://doi.org/10.1038/nri.2017.146
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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