The DOI matches its Crossref record; 131 of the 131 references it cites were found in a registry or an index.
Cannabinoid-based drugs as anti-inflammatory therapeutics
Abstract
In the nineteenth century, marijuana was prescribed by physicians for maladies ranging from eating disorders to rabies. However, as newer, more effective drugs were discovered and as the potential for abuse of marijuana was recognized, its use as a therapeutic became restricted, and only recently has its therapeutic potential been re-evaluated. Recent studies in animal models and in humans have produced promising results for the treatment of various disorders - such as obesity, cancer, and spasticity and tremor due to neuropathology - with drugs based on marijuana-derived cannabinoids. Moreover, as I discuss here, a wealth of information also indicates that these drugs have immunosuppressive and anti-inflammatory properties; therefore, on the basis of this mode of action, the therapeutic usefulness of these drugs in chronic inflammatory diseases is now being reassessed.
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“Thus, in addition to proinflammatory cytokines, activated immune cells produce and release antiinflammatory mediators, including interleukin-10 (IL-10), which are regulated by the endocannabinoid system (Klein, 2005).”
From The endogenous cannabinoid system: a budding source of targets for treating inflammatory and neuropathic pain (2018) · cites this paper as Klein, 2005
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“However, cannabinoids may also increase production of proinflammatory cytokines, depending on the model, dose, and drug probe (Klein, 2005).”
From The endogenous cannabinoid system: a budding source of targets for treating inflammatory and neuropathic pain (2018) · cites this paper as Klein, 2005
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The Endocannabinoid System as an Emerging Target of Pharmacotherapy
Pacher, P., Bátkai, S., & Kunos, G. (2006) · Pharmacological Reviews · doi:10.1124/pr.58.3.2 · Cited by 2,077
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Neuronal Control of Skin Function: The Skin as a Neuroimmunoendocrine Organ
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Metadata
- Authors
- Klein, T. W.
- Affiliations
- University of South Florida (US)
- Corresponding author
- Klein, Thomas W.
- ORCID
- Klein, Thomas W.
- Venue
- Nature Reviews Immunology
- Published
- 2005-05
- Volume
- 5
- Issue
- 5
- Pages
- 400-411
- ISSN
- 1474-1733 (ISSN-L)
- 1474-1741
- OpenAlex
- W2072422429
- Cited by
- 728
- References
- 128
- Citations by year
- 2026: 15 · 2025: 29 · 2024: 25 · 2023: 27 · 2022: 31 · 2021: 46 · 2020: 46 · 2019: 35 · 2018: 26 · 2017: 42 · 2016: 31 · 2015: 33 · 2014: 39 · 2013: 32 · 2012: 32
- FWCI
- 5.06
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature reviews. Immunology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pharmacology (medical) › Cannabis and Cannabinoid Research
- Health Sciences › Medicine › Pharmacology (medical) › Inflammatory mediators and NSAID effects
- Health Sciences › Medicine › Complementary and alternative medicine › Natural Compounds in Disease Treatment
- Keywords
- anti-inflammatory therapy, chronic inflammatory diseases, immunosuppression, cannabis, obesity, cancer, spasticity, tremor, neuropathology
- MeSH terms
- Animals, Anti-Inflammatory Agents, Cannabinoids, Cell Movement, T-Lymphocytes, Helper-Inducer, Humans, Immunity, Innate, Inflammation, Cytokines, Receptors, Cannabinoid
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