Cited by 741Cannabis and Cannabinoid ResearchInflammatory mediators and NSAID effectsNatural Compounds in Disease Treatment

The DOI matches its Crossref record; 132 of the 132 references it cites were found in a registry or an index.

Cannabinoid-based drugs as anti-inflammatory therapeutics

Klein, Thomas W.·2005·Nature Reviews Immunology

DOI 10.1038/nri1602

Open this paper in CoChat — free account

Abstract

In the nineteenth century, marijuana was prescribed by physicians for maladies ranging from eating disorders to rabies. However, as newer, more effective drugs were discovered and as the potential for abuse of marijuana was recognized, its use as a therapeutic became restricted, and only recently has its therapeutic potential been re-evaluated. Recent studies in animal models and in humans have produced promising results for the treatment of various disorders - such as obesity, cancer, and spasticity and tremor due to neuropathology - with drugs based on marijuana-derived cannabinoids. Moreover, as I discuss here, a wealth of information also indicates that these drugs have immunosuppressive and anti-inflammatory properties; therefore, on the basis of this mode of action, the therapeutic usefulness of these drugs in chronic inflammatory diseases is now being reassessed.

Integrity signals

Registry

Crossref · 10.1038/nri1602

Cites

132 of 132 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Toll-like receptor signalling
Akira, S., & Takeda, K. (2004) · Nature reviews. Immunology · doi:10.1038/nri1391 · Cited by 8,312
International Union of Pharmacology: Approaches to the Nomenclature of Voltage-Gated Ion Channels
Catterall, W. A., Chandy, K. G., Clapham, D. E., Gutman, G. A., Hofmann, F., Harmar, A. J., Abernethy, D. R., & Spedding, M. (2003) · Pharmacological Reviews · doi:10.1124/pr.55.4.5 · Cited by 7,126
Isolation and Structure of a Brain Constituent That Binds to the Cannabinoid Receptor
Devane, W. A., Hanuš, L., Breuer, A., Pertwee, R. G., Stevenson, L. A., Griffin, G., Gibson, D., Mandelbaum, A., Etinger, A., & Mechoulam, R. (1992) · Science · doi:10.1126/science.1470919 · Cited by 5,633
Molecular characterization of a peripheral receptor for cannabinoids
Munro, S., Thomas, K. L., & Abu-Shaar, M. (1993) · Nature · doi:10.1038/365061a0 · Cited by 5,092
Structure of a cannabinoid receptor and functional expression of the cloned cDNA
Matsuda, L. A., Lolait, S. J., Brownstein, M. J., Young, A. C., & Bonner, T. I. (1990) · Nature · doi:10.1038/346561a0 · Cited by 5,011
Identification of an endogenous 2-monoglyceride, present in canine gut, that binds to cannabinoid receptors
Mechoulam, R., Ben-Shabat, S., Hanus, L., Ligumsky, M., Kaminski, N. E., Schatz, A. R., Gopher, A., Almog, S., Martin, B. R., Compton, D. R., et al. (1995) · Biochemical Pharmacology · doi:10.1016/0006-2952(95)00109-d · Cited by 2,913
International Union of Pharmacology. XXVII. Classification of Cannabinoid Receptors
Howlett, A. C., Barth, F., Bonner, T. I., Cabral, G., Casellas, P., Devane, W. A., Felder, C. C., Herkenham, M., Mackie, K., Martin, B. R., et al. (2002) · Pharmacological Reviews · doi:10.1124/pr.54.2.161 · Cited by 2,819
Isolation, Structure, and Partial Synthesis of an Active Constituent of Hashish
Gaoni, Y., & Mechoulam, R. (1964) · Journal of the American Chemical Society · doi:10.1021/ja01062a046 · Cited by 2,389
Vanilloid receptors on sensory nerves mediate the vasodilator action of anandamide
Zygmunt, P. M., Petersson, J., Andersson, D. A., Chuang, H.-H., Sørgård, M., Di Marzo, V., Julius, D., & Högestätt, E. D. (1999) · Nature · doi:10.1038/22761 · Cited by 2,142
The molecular logic of endocannabinoid signalling
Piomelli, D. (2003) · Nature Reviews Neuroscience · doi:10.1038/nrn1247 · Cited by 1,957

Show all 128 references

Sorted by citations

The Endocannabinoid System as an Emerging Target of Pharmacotherapy
Pacher, P., Bátkai, S., & Kunos, G. (2006) · Pharmacological Reviews · doi:10.1124/pr.58.3.2 · Cited by 2,077
Distinct Risk Factor Profiles for Human Papillomavirus Type 16–Positive and Human Papillomavirus Type 16–Negative Head and Neck Cancers
Gillison, M. L., DʼSouza, G., Westra, W. H., Sugar, E. A., Xiao, W., Begum, S., & Viscidi, R. P. (2008) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djn025 · Cited by 1,548
Beta-caryophyllene is a dietary cannabinoid.
Gertsch, J., Leonti, M., Raduner, S., Racz, I., Chen, J.-Z., Xie, X.-Q., Altmann, K.-H., Karsak, M., & Zimmer, A. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0803601105 · Cited by 906
Targeting the endocannabinoid system: to enhance or reduce?
Marzo, V. D. (2008) · Nature Reviews Drug Discovery · doi:10.1038/nrd2553 · Cited by 822
Neuronal Control of Skin Function: The Skin as a Neuroimmunoendocrine Organ
Roosterman, D., Goerge, T., Schneider, S. W., Bunnett, N. W., & Steinhoff, M. S. (2006) · Physiological Reviews · doi:10.1152/physrev.00026.2005 · Cited by 693
From Phytocannabinoids to Cannabinoid Receptors and Endocannabinoids: Pleiotropic Physiological and Pathological Roles Through Complex Pharmacology
Ligresti, A., PETROCELLIS, L. D., & Marzo, V. D. (2016) · Physiological Reviews · doi:10.1152/physrev.00002.2016 · Cited by 505
The Endocannabinoid Anandamide Protects Neurons during CNS Inflammation by Induction of MKP-1 in Microglial Cells
Eljaschewitsch, E., Witting, A., Mawrin, C., Lee, T., Schmidt, P. M., Wolf, S., Hoertnagl, H., Raine, C. S., Schneider-Stock, R., Nitsch, R., et al. (2006) · Neuron · doi:10.1016/j.neuron.2005.11.027 · Cited by 445
Is lipid signaling through cannabinoid 2 receptors part of a protective system?
Pacher, P., & Mechoulam, R. (2011) · Progress in Lipid Research · doi:10.1016/j.plipres.2011.01.001 · Cited by 435
Novel cannabinoid receptors
Brown, A. J. (2007) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0707481 · Cited by 410
Emerging role of the cannabinoid receptor CB 2 in immune regulation: therapeutic prospects for neuroinflammation
Cabral, G. A., & Griffin-Thomas, L. (2009) · Expert Reviews in Molecular Medicine · doi:10.1017/s1462399409000957 · Cited by 408
“Journal of Neuroimmunology 83, 116-123 62 Klein, T.W., Newton, C. and Friedman, H. (1998) Cannabinoid receptors and immunity. Immunology Today 19, 373-381 63 Arata, S. et al. (1992) Enhanced growth of Legionella”
Influential
Modulating the endocannabinoid system in human health and disease – successes and failures
Pacher, P., & Kunos, G. (2013) · FEBS Journal · doi:10.1111/febs.12260 · Cited by 418
Steroid hormone receptor expression and function in microglia
Sierra, A., Gottfried‐Blackmore, A., Milner, T. A., McEwen, B. S., & Bulloch, K. (2008) · Glia · doi:10.1002/glia.20644 · Cited by 405
CB 1 and CB 2 Receptor Pharmacology
Howlett, A. C., & Abood, M. E. (2017) · Advances in pharmacology · doi:10.1016/bs.apha.2017.03.007 · Cited by 411
Cannabinoids and Pain: New Insights From Old Molecules
Vučković, S., Srebro, D., Vujović, K. S., Vučetić, Č., & Prostran, M. S. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.01259 · Cited by 440
Frontiers in pruritus research: scratching the brain for more effective itch therapy
Paus, R. (2006) · Journal of Clinical Investigation · doi:10.1172/jci28553 · Cited by 368
Endocannabinoids and the control of energy balance
Matias, I., & Marzo, V. D. (2006) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2006.11.006 · Cited by 367
Cannabinoid Receptors in the Central Nervous System: Their Signaling and Roles in Disease
Kendall, D. A., & Yudowski, G. A. (2017) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2016.00294 · Cited by 388
Bioactive lipids, inflammation and chronic diseases
Leuti, A., Fazio, D., Fava, M., Piccoli, A., Oddi, S., & Maccarrone, M. (2020) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2020.06.028 · Cited by 376
Cannabis and adolescent brain development.
Lubman, D. I., Cheetham, A., & Yücel, M. (2015) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2014.11.009 · Cited by 360
Attenuation of Allergic Contact Dermatitis Through the Endocannabinoid System
Karsak, M., Gaffal, E., Date, R., Wang‐Eckhardt, L., Rehnelt, J., Petrosino, S., Starowicz, K., Steuder, R., Schlicker, E., Cravatt, B. F., et al. (2007) · Science · doi:10.1126/science.1142265 · Cited by 338
The Endocannabinoid System: A Potential Target for the Treatment of Various Diseases
Lowe, H., Toyang, N., Steele, B., Bryant, J., & Ngwa, W. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22179472 · Cited by 303
The endogenous cannabinoid system: a budding source of targets for treating inflammatory and neuropathic pain
Donvito, G., Nass, S. R., Wilkerson, J. L., Curry, Z. A., Schurman, L. D., Kinsey, S. G., & Lichtman, A. H. (2018) · Neuropsychopharmacology · doi:10.1038/npp.2017.204 · Cited by 301
Cannabinoid receptors as novel targets for the treatment of melanoma
Blázquez, C., Carracedo, A., Barrado, L., Real, P. J., Fernández-Luna, J. L., Velasco, G., Malumbres, M., & Guzmán, M. (2006) · The FASEB Journal · doi:10.1096/fj.06-6638fje · Cited by 293
Cannabinoid CB 2 receptors in human brain inflammation
Benito, C., Tolón, R. M., Pazos, M. R., Núñez, E., Castillo, A. I., & Romero, J. (2007) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0707505 · Cited by 304
Cannabinoid receptor signaling in progenitor/stem cell proliferation and differentiation
Galve‐Roperh, I., Chiurchiù, V., Díaz-Alonso, J., Bari, M., Guzmán, M., & Maccarrone, M. (2013) · Progress in Lipid Research · doi:10.1016/j.plipres.2013.05.004 · Cited by 287
The endocannabinoid system of the skin in health and disease: novel perspectives and therapeutic opportunities
Bı́ró, T., Tóth, B. I., Haskó, G., Paus, R., & Pacher, P. (2009) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2009.05.004 · Cited by 286
Cannabinoid CB 2 receptors in the gastrointestinal tract: a regulatory system in states of inflammation
Wright, K. L., Duncan, M., & Sharkey, K. A. (2007) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0707486 · Cited by 269
CB2-receptor stimulation attenuates TNF-α-induced human endothelial cell activation, transendothelial migration of monocytes, and monocyte-endothelial adhesion
Rajesh, M., Mukhopadhyay, P., Bátkai, S., Haskó, G., Liaudet, L., Huffman, J. W., Csiszár, A., Ungvari, Z. I., Mackie, K., Chatterjee, S. B., et al. (2007) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00688.2007 · Cited by 262
Alkylamides from Echinacea Are a New Class of Cannabinomimetics
Raduner, S., Majewska, A., Chen, J., Xie, X., Hamon, J., Faller, B., Altmann, K., & Gertsch, J. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m601074200 · Cited by 260
Cannabinoid‐2 receptor mediates protection against hepatic ischemia/reperfusion injury
Bátkai, S., Osei‐Hyiaman, D., Pan, H., El-Assal, O. N., Rajesh, M., Mukhopadhyay, P., Hong, F., Harvey-White, J. D., Jafri, A., Haskó, G., et al. (2007) · The FASEB Journal · doi:10.1096/fj.06-7451com · Cited by 252
Prolonged oral cannabinoid administration prevents neuroinflammation, lowers β-amyloid levels and improves cognitive performance in Tg APP 2576 mice
Martín-Moreno, A. M., Brera, B., Spuch, C., Carro, E., García‐García, L., Delgado, M., Pozo, M. A., Innamorato, N. G., Cuadrado, A., & CEBALLOS, M. L. D. (2012) · Journal of Neuroinflammation · doi:10.1186/1742-2094-9-8 · Cited by 250
β-Caryophyllene Inhibits Dextran Sulfate Sodium-Induced Colitis in Mice through CB2 Receptor Activation and PPARγ Pathway
Bento, A. F., Marcon, R., Dutra, R. C., Claudino, R. F., Cola, M., Leite, D. F. P., & Calixto, J. Β. (2011) · American Journal Of Pathology · doi:10.1016/j.ajpath.2010.11.052 · Cited by 242
Endocannabinoids and immune regulation☆
Pandey, R., Mousawy, K. M., Nagarkatti, M., & Nagarkatti, P. S. (2009) · Pharmacological Research · doi:10.1016/j.phrs.2009.03.019 · Cited by 232
Cannabinoid CB2 Receptor Potentiates Obesity-Associated Inflammation, Insulin Resistance and Hepatic Steatosis
Deveaux, V., Cadoudal, T., Ichigotani, Y., Teixeira-Clerc, F., Louvet, A., Manin, S., Nhieu, J. T. V., Belot, M., Zimmer, A., Even, P. C., et al. (2009) · PLoS ONE · doi:10.1371/journal.pone.0005844 · Cited by 232
Cannabinoids in health and disease
Kogan, N. M., & Mechoulam, R. (2007) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2007.9.4/nkogan · Cited by 227
Endocannabinoids and cannabinoid receptors in ischaemia-reperfusion injury and preconditioning.
Pacher, P., & Haskó, G. (2008) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0707582 · Cited by 217
Cannabinoids inhibit human keratinocyte proliferation through a non-CB1/CB2 mechanism and have a potential therapeutic value in the treatment of psoriasis
Wilkinson, J. D., & Williamson, E. M. (2006) · Journal of Dermatological Science · doi:10.1016/j.jdermsci.2006.10.009 · Cited by 213
Cannabidiol attenuates high glucose-induced endothelial cell inflammatory response and barrier disruption
Rajesh, M., Mukhopadhyay, P., Bátkai, S., Haskó, G., Liaudet, L., Drel, V. R., Obrosova, I. G., & Pacher, P. (2007) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00236.2007 · Cited by 211
Cannabinoid receptor 2 mediates the retention of immature B cells in bone marrow sinusoids
Pereira, J. P., An, J., Xu, Y., Huang, Y., & Cyster, J. G. (2009) · Nature Immunology · doi:10.1038/ni.1710 · Cited by 210
The CB2 cannabinoid agonist AM‐1241 prolongs survival in a transgenic mouse model of amyotrophic lateral sclerosis when initiated at symptom onset
Shoemaker, J. L., Seely, K. A., Reed, R. L., Crow, J. P., & Prather, P. L. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.04346.x · Cited by 212
The endocannabinoid system is dysregulated in multiple sclerosis and in experimental autoimmune encephalomyelitis
Centonze, D., Bari, M., Rossi, S., Prosperetti, C., Furlan, R., Fezza, F., De Chiara, V., Battistini, L., Bernardi, G., Bernardini, S., et al. (2007) · Brain · doi:10.1093/brain/awm160 · Cited by 207
New horizons for newborn brain protection: enhancing endogenous neuroprotection
Hassell, K. J., Ezzati, M., Alconada, D. A., Hausenloy, D. J., & Robertson, N. J. (2015) · Archives of Disease in Childhood Fetal & Neonatal · doi:10.1136/archdischild-2014-306284 · Cited by 207
Cannabinoid Type 2 (CB2) Receptors Activation Protects against Oxidative Stress and Neuroinflammation Associated Dopaminergic Neurodegeneration in Rotenone Model of Parkinson's Disease
Javed, H., Azimullah, S., Haque, M. E., & Ojha, S. K. (2016) · Frontiers in Neuroscience · doi:10.3389/fnins.2016.00321 · Cited by 199
CB2 cannabinoid receptor agonists attenuate TNF‐α‐induced human vascular smooth muscle cell proliferation and migration
Rajesh, M., Mukhopadhyay, P., Haskó, G., Huffman, J. W., Mackie, K., & Pacher, P. (2007) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0707569 · Cited by 198
Activated Endocannabinoid System in Coronary Artery Disease and Antiinflammatory Effects of Cannabinoid 1 Receptor Blockade on Macrophages
Sugamura, K., Sugiyama, S., Nozaki, T., Matsuzawa, Y., Izumiya, Y., Miyata, K., Nakayama, M., Kaikita, K., Obata, T., Takeya, M., et al. (2008) · Circulation · doi:10.1161/circulationaha.108.811992 · Cited by 198
GPR55 regulates cannabinoid 2 receptor-mediated responses in human neutrophils
Balenga, N. A. B., Aflaki, E., Kargl, J., Platzer, W., Schröder, R. J., Blättermann, S., Kostenis, E., Brown, A. J., Heinemann, Á., & Waldhoer, M. (2011) · Cell Research · doi:10.1038/cr.2011.60 · Cited by 197
Unraveling the complexities of cannabinoid receptor 2 (CB2) immune regulation in health and disease
Basu, S., & Dittel, B. N. (2011) · Immunologic Research · doi:10.1007/s12026-011-8210-5 · Cited by 197
Cannabinoid Receptor Agonist-induced Apoptosis of Human Prostate Cancer Cells LNCaP Proceeds through Sustained Activation of ERK1/2 Leading to G1 Cell Cycle Arrest
Sarfaraz, S., Afaq, F., Adhami, V. M., Malik, A., & Mukhtar, H. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m603495200 · Cited by 188
Monoacylglycerol lipase inhibitors: modulators for lipid metabolism in cancer malignancy, neurological and metabolic disorders
Deng, H., & Li, W. (2019) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2019.10.006 · Cited by 189
The endocannabinoid system in targeting inflammatory neurodegenerative diseases
Centonze, D., Finazzi‐Agrò, A., Bernardi, G., & Maccarrone, M. (2007) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2007.02.004 · Cited by 182
The endocannabinoid system as a target for the treatment of neurodegenerative disease
Scotter, E. L., Abood, M. E., & Glass, M. (2010) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2010.00735.x · Cited by 188
Cortical grey matter volume reduction in people with schizophrenia is associated with neuro-inflammation
Zhang, Y.-Q., Catts, V. S., Sheedy, D. L., McCrossin, T., Kril, J. J., & Weickert, C. S. (2016) · Translational Psychiatry · doi:10.1038/tp.2016.238 · Cited by 176
Endotoxic fever: New concepts of its regulation suggest new approaches to its management
Blatteis, C. M. (2006) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2005.10.013 · Cited by 173
Cannabinoid-Induced Immune Suppression and Modulation of Antigen-Presenting Cells
Klein, T. W., & Cabral, G. A. (2006) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-005-9007-x · Cited by 172
Self-citation
Plant, Synthetic, and Endogenous Cannabinoids in Medicine
Marzo, V. D., & PETROCELLIS, L. D. (2005) · Annual Review of Medicine · doi:10.1146/annurev.med.57.011205.135648 · Cited by 173
Intracellular trafficking of anandamide: new concepts for signaling
Maccarrone, M., Dainese, E., & Oddi, S. (2010) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2010.05.008 · Cited by 173
The CB2 Cannabinoid Receptor Controls Myeloid Progenitor Trafficking
Palazuelos, J., Davoust, N., Julien, B., Hatterer, E., Aguado, T., Mechoulam, R., Benito, C., Romero, J., Silva, A., Guzmán, M., et al. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m707960200 · Cited by 168
Loss of Cannabinoid Receptor 1 Accelerates Intestinal Tumor Growth
Wang, D., Wang, H., Wei, N., Backlund, M. G., Dey, S. K., & DuBois, R. N. (2008) · Cancer Research · doi:10.1158/0008-5472.can-08-0896 · Cited by 166
Blockade of CB1 cannabinoid receptor alters gut microbiota and attenuates inflammation and diet-induced obesity
Mehrpouya‐Bahrami, P., Chitrala, K. N., Ganewatta, M. S., Tang, C., Murphy, E. A., Enos, R. T., Velázquez, K. T., McCellan, J., Nagarkatti, M., & Nagarkatti, P. S. (2017) · Scientific Reports · doi:10.1038/s41598-017-15154-6 · Cited by 168
The Endocannabinoid System and Plant-Derived Cannabinoids in Diabetes and Diabetic Complications
Horváth, B., Mukhopadhyay, P., Haskó, G., & Pacher, P. (2011) · American Journal Of Pathology · doi:10.1016/j.ajpath.2011.11.003 · Cited by 152
AM1241, a cannabinoid CB2 receptor selective compound, delays disease progression in a mouse model of amyotrophic lateral sclerosis
Kim, K., Moore, D. H., Makriyannis, A., & Abood, M. E. (2006) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2006.05.025 · Cited by 152
The Structure–Function Relationships of Classical Cannabinoids: CB1/CB2 Modulation
Bow, E. W., & Rimoldi, J. M. (2016) · Perspectives in Medicinal Chemistry · doi:10.4137/pmc.s32171 · Cited by 153
Cannabinoids and cancer: pros and cons of an antitumour strategy
Bifulco, M., Laezza, C., Pisanti, S., & Gazzerro, P. (2006) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0706632 · Cited by 153
CB 2 cannabinoid receptor agonist JWH-015 modulates human monocyte migration through defined intracellular signaling pathways
Montecucco, F., Burger, F., Mach, F., & Steffens, S. (2008) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01328.2007 · Cited by 153
Monoglyceride lipase as a drug target: At the crossroads of arachidonic acid metabolism and endocannabinoid signaling
Grabner, G. F., Zimmermann, R., Schicho, R., & Taschler, U. (2017) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2017.02.033 · Cited by 153
Pivotal Advance: Cannabinoid-2 receptor agonist HU-308 protects against hepatic ischemia/reperfusion injury by attenuating oxidative stress, inflammatory response, and apoptosis
Rajesh, M., Pan, H., Mukhopadhyay, P., Bátkai, S., Osei‐Hyiaman, D., Haskó, G., Liaudet, L., Gao, B., & Pacher, P. (2007) · Journal of Leukocyte Biology · doi:10.1189/jlb.0307180 · Cited by 154
Target regulation of PI3K/Akt/mTOR pathway by cannabidiol in treatment of experimental multiple sclerosis
Giacoppo, S., Pollastro, F., Grassi, G., Bramanti, P., & Mazzon, E. (2016) · Fitoterapia · doi:10.1016/j.fitote.2016.11.010 · Cited by 151
Docosahexaenoic acid and eicosapentaenoic acid are converted by 3T3-L1 adipocytes to N-acyl ethanolamines with anti-inflammatory properties
Balvers, M. G. J., Verhoeckx, K. C. M., Plastina, P., Wortelboer, H. M., Meijerink, J., & Witkamp, R. F. (2010) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2010.06.006 · Cited by 145
Palmitoylethanolamide: A Natural Compound for Health Management
Clayton, P., Hill, M., Bogoda, N. O., Subah, S., & Venkatesh, R. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22105305 · Cited by 153
Cannabinoid CB 2 receptors in the enteric nervous system modulate gastrointestinal contractility in lipopolysaccharide-treated rats
Duncan, M., Mouihate, A., Mackie, K., Keenan, C. M., Buckley, N. E., Davison, J. S., Patel, K. D., Pittman, Q. J., & Sharkey, K. A. (2008) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.90285.2008 · Cited by 145
Cannabinoids and autoimmune diseases: A systematic review
Katchan, V., David, P., & Shoenfeld, Y. (2016) · Autoimmunity Reviews · doi:10.1016/j.autrev.2016.02.008 · Cited by 147
The emerging role of the endocannabinoid system in cardiovascular disease
Pacher, P., & Steffens, S. (2009) · Seminars in Immunopathology · doi:10.1007/s00281-009-0145-8 · Cited by 142
Molecular Identification of Albumin and Hsp70 as Cytosolic Anandamide-Binding Proteins
Oddi, S., Fezza, F., Pasquariello, N., D'Agostino, A., Catanzaro, G., Simone, C. D., Rapino, C., Finazzi‐Agrò, A., & Maccarrone, M. (2009) · Chemistry & Biology · doi:10.1016/j.chembiol.2009.05.004 · Cited by 140
Current Aspects of the Endocannabinoid System and Targeted THC and CBD Phytocannabinoids as Potential Therapeutics for Parkinson’s and Alzheimer’s Diseases: a Review
Cooray, R., Gupta, V. B., & Suphioglu, C. (2020) · Molecular Neurobiology · doi:10.1007/s12035-020-02054-6 · Cited by 146
Cannabinoids, Endocannabinoids, and Related Analogs in Inflammation
BURSTEIN, S. H., & Zurier, R. B. (2009) · The AAPS Journal · doi:10.1208/s12248-009-9084-5 · Cited by 139
The effects of Morinda citrifolia L. (noni) on the immune system: Its molecular mechanisms of action
Palu, '. K., Kim, A. H., West, B. J., Deng, S., Jensen, J. C., & White, L. (2007) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2007.10.023 · Cited by 132
The endocannabinoid system as a key mediator during liver diseases: new insights and therapeutic openings
Mallat, A., Teixeira-Clerc, F., Deveaux, V., Manin, S., & Lotersztajn, S. (2011) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2011.01397.x · Cited by 131
Differential changes in GPR55 during microglial cell activation
Pietr, M., Kozela, E., Levy, R., Rimmerman, N., Lin, Y. H., Stella, N., Vogel, Z., & Juknat, A. (2009) · FEBS Letters · doi:10.1016/j.febslet.2009.05.028 · Cited by 134
The Endocannabinoid System and Neurogenesis in Health and Disease
Galve‐Roperh, I., Aguado, T., Palazuelos, J., & Guzmán, M. (2007) · The Neuroscientist · doi:10.1177/1073858406296407 · Cited by 129
Cannabis, the Endocannabinoid System and Immunity—the Journey from the Bedside to the Bench and Back
Almogi‐Hazan, O., & Or, R. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21124448 · Cited by 142
Pathophysiology and therapy of pruritus in allergic and atopic diseases
Buddenkotte, J., & Steinhoff, M. S. (2010) · Allergy · doi:10.1111/j.1398-9995.2010.01995.x · Cited by 126
Cannabinoid receptor 2 counteracts interleukin-17-induced immune and fibrogenic responses in mouse liver
Guillot, A., Hamdaoui, N., Bizy, A., Zoltani, K., Souktani, R., Zafrani, E., Mallat, A., Lotersztajn, S., & Lafdil, F. (2013) · Hepatology · doi:10.1002/hep.26598 · Cited by 126
The cannabinoid receptor CB2 exerts antifibrotic effects in experimental dermal fibrosis
Akhmetshina, A., Dees, C., Busch, N., Beer, J., Sarter, K., Zwerina, J., Zimmer, A., Distler, O., Schett, G. A., & Distler, J. H. W. (2009) · Arthritis & Rheumatism · doi:10.1002/art.24395 · Cited by 132
The endocannabinoid system is modulated in response to spinal cord injury in rats
García‐Ovejero, D., Arévalo‐Martín, Á., Petrosino, S., Docagne, F., Hagen, C., Bisogno, T., Watanabe, M., Guaza, C., Marzo, V. D., & Molina‐Holgado, E. (2008) · Neurobiology of Disease · doi:10.1016/j.nbd.2008.09.015 · Cited by 128
Cannabidiol reduces airway inflammation and fibrosis in experimental allergic asthma
Vuolo, F. S., Abreu, S. C., Michels, M., Xisto, D. G., Blanco, N. G., Hallak, J. E. C., Zuardi, A. W., Crippa, J. A., dos Reis, C. M., Bahl, M., et al. (2018) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2018.11.029 · Cited by 125
The Antitumor Activity of Plant-Derived Non-Psychoactive Cannabinoids
McAllister, S. D., Soroceanu, L., & Desprez, P. (2015) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-015-9608-y · Cited by 144
The therapeutic potential of cannabinoids for movement disorders
Kluger, B. M., Triolo, P. M., Jones, W. E., & Jankovic, J. J. (2015) · Movement Disorders · doi:10.1002/mds.26142 · Cited by 123
The endocannabinoid 2‐arachidonoyl glycerol induces death of hepatic stellate cells via mitochondrial reactive oxygen species
Siegmund, S., Qian, T., Minicis, S. D., Harvey-White, J. D., Kunos, G., Vinod, K. Y., Hungund, B. L., & Schwabe, R. F. (2007) · The FASEB Journal · doi:10.1096/fj.06-7717com · Cited by 126
The Endocannabinoid System and Extinction Learning
Lutz, B. (2007) · Molecular Neurobiology · doi:10.1007/s12035-007-8004-x · Cited by 124
The Endocannabinoid System and Its Relevance for Nutrition
Maccarrone, M., Gasperi, V., Catani, M. V., Diep, T. A., Dainese, E., Hansen, H. S., & Avigliano, L. (2010) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.012809.104701 · Cited by 122
Beneficial Paracrine Effects of Cannabinoid Receptor 2 on Liver Injury and Regeneration†
Teixeira-Clerc, F., Belot, M., Manin, S., Deveaux, V., Cadoudal, T., Chobert, M.-N., Louvet, A., Zimmer, A., Tordjmann, T., Mallat, A., et al. (2010) · Hepatology · doi:10.1002/hep.23779 · Cited by 124
Therapeutic potential of cannabinoid medicines
Robson, P. (2013) · Drug Testing and Analysis · doi:10.1002/dta.1529 · Cited by 126
Endocannabinoid, anandamide in gingival tissue regulates the periodontal inflammation through NF‐κB pathway inhibition
Nakajima, Y., Furuichi, Y., Biswas, K. K., Hashiguchi, T., Kawahara, K.-I., Yamaji, K., Uchimura, T., Izumi, Y., & Maruyama, I. (2006) · FEBS Letters · doi:10.1016/j.febslet.2005.12.079 · Cited by 121
Cortical neuroinflammation contributes to long-term cognitive dysfunctions following adolescent delta-9-tetrahydrocannabinol treatment in female rats
Zamberletti, E., Gabaglio, M., Prini, P., Rubino, T., & Parolaro, D. (2015) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2015.09.021 · Cited by 114
Endocannabinoids and neurodegenerative diseases
Micale, V., Mazzola, C., & Drago, F. (2007) · Pharmacological Research · doi:10.1016/j.phrs.2007.09.008 · Cited by 119
Endocannabinoids and Related Compounds: Walking Back and Forth between Plant Natural Products and Animal Physiology
Marzo, V. D., Bisogno, T., & PETROCELLIS, L. D. (2007) · Chemistry & Biology · doi:10.1016/j.chembiol.2007.05.014 · Cited by 118
Impact of Cannabis Treatment on the Quality of Life, Weight and Clinical Disease Activity in Inflammatory Bowel Disease Patients: A Pilot Prospective Study
Lahat, A., Lang, A., & Ben‐Horin, S. (2011) · Digestion · doi:10.1159/000332079 · Cited by 116
A Comprehensive Review on Cannabis sativa Ethnobotany, Phytochemistry, Molecular Docking and Biological Activities
Hourfane, S., Mechqoq, H., Bekkali, A. Y., Rocha, J. M., & Aouad, N. E. (2023) · Plants · doi:10.3390/plants12061245 · Cited by 133
Endocannabinoids: Friends and foes of reproduction
Maccarrone, M. (2009) · Progress in Lipid Research · doi:10.1016/j.plipres.2009.07.001 · Cited by 116
Cannabinoids and Endocannabinoids in Metabolic Disorders with Focus on Diabetes
Marzo, V. D., Piscitelli, F., & Mechoulam, R. (2011) · Handbook of experimental pharmacology · doi:10.1007/978-3-642-17214-4_4 · Cited by 121

Authors: Klein, T. W.
Affiliations: University of South Florida (US)
Corresponding author: Klein, Thomas W.
ORCID: Klein, Thomas W.
Venue: Nature Reviews Immunology
Publisher: Springer Science and Business Media LLC
Published: 2005-05
Volume: 5
Issue: 5
Pages: 400-411
ISSN: 1474-1733 (ISSN-L)
1474-1741
DOI: 10.1038/nri1602
OpenAlex: W2072422429
Cited by: 728
References: 128
Citations by year: 2026: 15 · 2025: 29 · 2024: 25 · 2023: 27 · 2022: 31 · 2021: 46 · 2020: 46 · 2019: 35 · 2018: 26 · 2017: 42 · 2016: 31 · 2015: 33 · 2014: 39 · 2013: 32 · 2012: 32
FWCI: 5.06
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature reviews. Immunology (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Pharmacology (medical) › Cannabis and Cannabinoid Research
Health Sciences › Medicine › Pharmacology (medical) › Inflammatory mediators and NSAID effects
Health Sciences › Medicine › Complementary and alternative medicine › Natural Compounds in Disease Treatment
Keywords: anti-inflammatory therapy, chronic inflammatory diseases, immunosuppression, cannabis, obesity, cancer, spasticity, tremor, neuropathology
MeSH terms: Animals, Anti-Inflammatory Agents, Cannabinoids, Cell Movement, T-Lymphocytes, Helper-Inducer, Humans, Immunity, Innate, Inflammation, Cytokines, Receptors, Cannabinoid

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Cannabinoid-based drugs as anti-inflammatory therapeutics

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks