Cited by 741Cannabis and Cannabinoid ResearchInflammatory mediators and NSAID effectsNatural Compounds in Disease Treatment

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Cannabinoid-based drugs as anti-inflammatory therapeutics

Klein, Thomas W.·2005·Nature Reviews Immunology

DOI 10.1038/nri1602

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Abstract

In the nineteenth century, marijuana was prescribed by physicians for maladies ranging from eating disorders to rabies. However, as newer, more effective drugs were discovered and as the potential for abuse of marijuana was recognized, its use as a therapeutic became restricted, and only recently has its therapeutic potential been re-evaluated. Recent studies in animal models and in humans have produced promising results for the treatment of various disorders - such as obesity, cancer, and spasticity and tremor due to neuropathology - with drugs based on marijuana-derived cannabinoids. Moreover, as I discuss here, a wealth of information also indicates that these drugs have immunosuppressive and anti-inflammatory properties; therefore, on the basis of this mode of action, the therapeutic usefulness of these drugs in chronic inflammatory diseases is now being reassessed.

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Toll-like receptor signalling
Akira, S., & Takeda, K. (2004) · Nature reviews. Immunology · doi:10.1038/nri1391 · Cited by 8,312
International Union of Pharmacology: Approaches to the Nomenclature of Voltage-Gated Ion Channels
Catterall, W. A., Chandy, K. G., Clapham, D. E., Gutman, G. A., Hofmann, F., Harmar, A. J., Abernethy, D. R., & Spedding, M. (2003) · Pharmacological Reviews · doi:10.1124/pr.55.4.5 · Cited by 7,126
Isolation and Structure of a Brain Constituent That Binds to the Cannabinoid Receptor
Devane, W. A., Hanuš, L., Breuer, A., Pertwee, R. G., Stevenson, L. A., Griffin, G., Gibson, D., Mandelbaum, A., Etinger, A., & Mechoulam, R. (1992) · Science · doi:10.1126/science.1470919 · Cited by 5,633
Molecular characterization of a peripheral receptor for cannabinoids
Munro, S., Thomas, K. L., & Abu-Shaar, M. (1993) · Nature · doi:10.1038/365061a0 · Cited by 5,092
Structure of a cannabinoid receptor and functional expression of the cloned cDNA
Matsuda, L. A., Lolait, S. J., Brownstein, M. J., Young, A. C., & Bonner, T. I. (1990) · Nature · doi:10.1038/346561a0 · Cited by 5,011
Identification of an endogenous 2-monoglyceride, present in canine gut, that binds to cannabinoid receptors
Mechoulam, R., Ben-Shabat, S., Hanus, L., Ligumsky, M., Kaminski, N. E., Schatz, A. R., Gopher, A., Almog, S., Martin, B. R., Compton, D. R., et al. (1995) · Biochemical Pharmacology · doi:10.1016/0006-2952(95)00109-d · Cited by 2,913
International Union of Pharmacology. XXVII. Classification of Cannabinoid Receptors
Howlett, A. C., Barth, F., Bonner, T. I., Cabral, G., Casellas, P., Devane, W. A., Felder, C. C., Herkenham, M., Mackie, K., Martin, B. R., et al. (2002) · Pharmacological Reviews · doi:10.1124/pr.54.2.161 · Cited by 2,819
Isolation, Structure, and Partial Synthesis of an Active Constituent of Hashish
Gaoni, Y., & Mechoulam, R. (1964) · Journal of the American Chemical Society · doi:10.1021/ja01062a046 · Cited by 2,389
Vanilloid receptors on sensory nerves mediate the vasodilator action of anandamide
Zygmunt, P. M., Petersson, J., Andersson, D. A., Chuang, H.-H., Sørgård, M., Di Marzo, V., Julius, D., & Högestätt, E. D. (1999) · Nature · doi:10.1038/22761 · Cited by 2,142
The molecular logic of endocannabinoid signalling
Piomelli, D. (2003) · Nature Reviews Neuroscience · doi:10.1038/nrn1247 · Cited by 1,957
Inflammation in Neurodegenerative Disease—A Double-Edged Sword
Wyss-Coray, T., & Mucke, L. (2002) · Neuron · doi:10.1016/s0896-6273(02)00794-8 · Cited by 1,235
The endocannabinoid system and its therapeutic exploitation
Marzo, V. D., Bifulco, M., & Petrocellis, L. D. (2004) · Nature Reviews Drug Discovery · doi:10.1038/nrd1495 · Cited by 1,090
Control of pain initiation by endogenous cannabinoids
Calignano, A., Rana, G. L., Giuffrida, A., & Piomelli, D. (1998) · Nature · doi:10.1038/28393 · Cited by 1,069
The Immunological Synapse
Bromley, S. K., Burack, R., Johnson, K. G., Somersalo, K., Sims, T. N., Sumen, C., Davis, M. M., Shaw, A. S., Allen, P. M., & Dustin, M. L. (2001) · Annual Review of Immunology · doi:10.1146/annurev.immunol.19.1.375 · Cited by 979
Chemokines: multiple levels of leukocyte migration control☆
Moser, B., Wolf, M., Walz, A., & Loetscher, P. (2004) · Trends in Immunology · doi:10.1016/j.it.2003.12.005 · Cited by 859
Induction and mechanism of action of transforming growth factor‐β‐secreting Th3 regulatory cells
Weiner, H. L. (2001) · Immunological Reviews · doi:10.1034/j.1600-065x.2001.1820117.x · Cited by 850
Cannabinoids for treatment of spasticity and other symptoms related to multiple sclerosis (CAMS study): multicentre randomised placebo-controlled trial
Zajicek, J., Fox, P., Sanders, H., Wright, D., Vickery, J., Nunn, A., & Thompson, A. (2003) · The Lancet · doi:10.1016/s0140-6736(03)14738-1 · Cited by 827
2-Arachidonyl glyceryl ether, an endogenous agonist of the cannabinoid CB 1 receptor
Hanuš, L., Abu‐Lafi, S., Fride, E., Breuer, A., Vogel, Z., Shalev, D. E., Kustanovich, I. M., & Mechoulam, R. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.061029898 · Cited by 761
An endogenous cannabinoid (2-AG) is neuroprotective after brain injury
Panikashvili, D., Simeonidou, C., Ben‐Shabat, S., Hanuš, L., Breuer, A., Mechoulam, R., & Shohami, E. (2001) · Nature · doi:10.1038/35097089 · Cited by 752
The Role of Excitotoxicity in Neurodegenerative Disease
Doble, A. (1999) · Pharmacology & Therapeutics · doi:10.1016/s0163-7258(98)00042-4 · Cited by 723
Cannabinoids: potential anticancer agents
Guzmán, M. (2003) · Nature reviews. Cancer · doi:10.1038/nrc1188 · Cited by 721
Anti-tumoral action of cannabinoids: Involvement of sustained ceramide accumulation and extracellular signal-regulated kinase activation
Galve‐Roperh, I., Sánchez, C., Cortés, M. L., del Pulgar, T. G., Izquierdo, M., & Guzmán, M. (2000) · Nature Medicine · doi:10.1038/73171 · Cited by 686
Nonpsychotropic Cannabinoid Receptors Regulate Microglial Cell Migration
Walter, L. M., Franklin, A., Witting, A., Wade, C. B., Xie, Y., Kunos, G., Mackie, K., & Stella, N. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-04-01398.2003 · Cited by 674
Modulation of transmitter release via presynaptic cannabinoid receptors
Schlicker, E., & Kathmann, M. (2001) · Trends in Pharmacological Sciences · doi:10.1016/s0165-6147(00)01805-8 · Cited by 671
A critical review of controlled clinical trials for peripheral neuropathic pain and complex regional pain syndromes
Kingery, W. S. (1997) · Pain · doi:10.1016/s0304-3959(97)00049-3 · Cited by 670
The nonpsychoactive cannabis constituent cannabidiol is an oral anti-arthritic therapeutic in murine collagen-induced arthritis
Malfait, A. M., Gallily, R., Sumariwalla, P. F., Malik, A. S., Andreakos, E., Mechoulam, R., & Feldmann, M. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.160105897 · Cited by 669
Cannabinoid physiology and pharmacology: 30 years of progress
Howlett, A. C., Breivogel, C. S., Childers, S. R., Deadwyler, S. A., Hampson, R. E., & Porrino, L. J. (2004) · Neuropharmacology · doi:10.1016/j.neuropharm.2004.07.030 · Cited by 608
Do cannabis-based medicinal extracts have general or specific effects on symptoms in multiple sclerosis? A double-blind, randomized, placebo-controlled study on 160 patients
Wade, D. T., Makela, P., Robson, P., House, H., & Bateman, C. (2004) · Multiple Sclerosis Journal · doi:10.1191/1352458504ms1082oa · Cited by 589
Cannabinoids control spasticity and tremor in a multiple sclerosis model
Baker, D., Pryce, G., Croxford, J., Brown, P., Pertwee, R., Huffman, J. W., & Layward, L. (2000) · Nature · doi:10.1038/35003583 · Cited by 546
Evidence for a New G Protein-Coupled Cannabinoid Receptor in Mouse Brain
Breivogel, C. S., Griffin, G., Marzo, V. D., & Martin, B. R. (2001) · Molecular Pharmacology · doi:10.1124/mol.60.1.155 · Cited by 538
The cannabinoid system and immune modulation
Klein, T., Newton, C. A., Larsen, K. A., Lu, L. D., Perkins, I., Nong, L., & Friedman, H. P. (2003) · Journal of Leukocyte Biology · doi:10.1189/jlb.0303101 · Cited by 533
Self-citation
A critical role for NF-κB in Gata3 expression and TH2 differentiation in allergic airway inflammation
Das, J., Chen, C.-H., Yang, L., Cohn, L., Ray, P., & Ray, A. (2001) · Nature Immunology · doi:10.1038/83158 · Cited by 518
Does the cannabinoid dronabinol reduce central pain in multiple sclerosis? Randomised double blind placebo controlled crossover trial
Svendsen, K. B., Jensen, T. S., & Bach, F. W. (2004) · BMJ · doi:10.1136/bmj.38149.566979.ae · Cited by 500
Activation of CB 2 cannabinoid receptors by AM1241 inhibits experimental neuropathic pain: Pain inhibition by receptors not present in the CNS
Ibrahim, M. M., Deng, H., Zvonok, A., Cockayne, D. A., Kwan, J., Mata, H. P., Vanderah, T. W., Lai, J., Porreca, F., Makriyannis, A., et al. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1834309100 · Cited by 491
The endogenous cannabinoid system protects against colonic inflammation
Massa, F., Marsicano, G., Hermann, H., Cannich, A., Monory, K., Cravatt, B. F., Ferri, G., Sibaev, A., Storr, M., & Lutz, B. (2004) · Journal of Clinical Investigation · doi:10.1172/jci19465 · Cited by 461
The endogenous cannabinoid anandamide inhibits human breast cancer cell proliferation
PETROCELLIS, L. D., Melck, D. J., Palmisano, A., Bisogno, T., Laezza, C., Bifulco, M., & Marzo, V. D. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.14.8375 · Cited by 412
Platelet‐ and macrophage‐derived endogenous cannabinoids are involved in endotoxin‐induced hypotension
Varga, K., Wagner, J. A., Bridgen, D. T., & Kunos, G. (1998) · The FASEB Journal · doi:10.1096/fasebj.12.11.1035 · Cited by 411
The endogenous cannabinoid system protects against colonic inflammation
Massa, F., Marsicano, G., Hermann, H., et al. (2004) · Journal of Clinical Investigation · doi:10.1172/jci200419465 · Cited by 387
Endocannabinoids control spasticity in a multiple sclerosis model
Baker, D., Pryce, G., Croxford, J. L., Brown, P., Pertwee, R. G., Makriyannis, A., Khanolkar, A. D., Layward, L., Fezza, F., Bisogno, T., et al. (2000) · The FASEB Journal · doi:10.1096/fj.00-0399fje · Cited by 378
Biosynthesis and degradation of anandamide and 2-arachidonoylglycerol and their possible physiological significance
Sugiura, T., Kobayashi, Y., Oka, S., & Waku, K. (2002) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1054/plef.2001.0356 · Cited by 351
The therapeutic potential of cannabis
Baker, D., Pryce, G., Giovannoni, G., & Thompson, A. J. (2003) · The Lancet Neurology · doi:10.1016/s1474-4422(03)00381-8 · Cited by 350
Differential expression of the CB2 cannabinoid receptor by rodent macrophages and macrophage-like cells in relation to cell activation
Carlisle, S. J., Marciano‐Cabral, F., Staab, A., LUDWICK, C., & Cabral, G. A. (2002) · International Immunopharmacology · doi:10.1016/s1567-5769(01)00147-3 · Cited by 347
Cannabinoids inhibit neurodegeneration in models of multiple sclerosis
Pryce, G., Ahmed, Z., Hankey, D. J. R., Jackson, S. J., Croxford, J. L., Pocock, J. M., Ledent, C. A., Petzold, A., Thompson, A. J., Giovannoni, G., et al. (2003) · Brain · doi:10.1093/brain/awg224 · Cited by 345
Cytokine production in the brain following closed head injury: dexanabinol (HU-211) is a novel TNF-α inhibitor and an effective neuroprotectant
Shohami, E., Gallily, R., Mechoulam, R., Bass, R., & Ben‐Hur, T. (1997) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(96)00181-6 · Cited by 332
Therapeutic Action of Cannabinoids in a Murine Model of Multiple Sclerosis
Arévalo‐Martín, Á., Vela, J. M., Molina‐Holgado, E., Borrell, J. I., & Guaza, C. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-07-02511.2003 · Cited by 316
Biosynthesis and inactivation of the endocannabinoid 2‐arachidonoylglycerol in circulating and tumoral macrophages
Marzo, V. D., Bisogno, T., PETROCELLIS, L. D., Melck, D. J., Orlando, P., Wagner, J. A., & Kunos, G. (1999) · European Journal of Biochemistry · doi:10.1046/j.1432-1327.1999.00631.x · Cited by 296
Cannabinoid receptors and the regulation of immune response
Berdyshev, E. V. (2000) · Chemistry and Physics of Lipids · doi:10.1016/s0009-3084(00)00195-x · Cited by 285
Cannabinoids ablate release of TNFα in rat microglial cells stimulated with lypopolysaccharide
Facchinetti, F., Giudice, E. D., Furegato, S., Passarotto, M., & Leon, A. (2002) · Glia · doi:10.1002/glia.10177 · Cited by 280
Efficacy, safety and tolerability of an orally administered cannabis extract in the treatment of spasticity in patients with multiple sclerosis: a randomized, double-blind, placebo-controlled, crossover study
Vaney, C., Heinzel‐Gutenbrunner, M., Jobin, P., Tschopp, F., Gattlen, B., Hagen, U., Schnelle, M., & Reif, M. (2004) · Multiple Sclerosis Journal · doi:10.1191/1352458504ms1048oa · Cited by 266
Cannabinoid CB1‐receptor mediated regulation of gastrointestinal motility in mice in a model of intestinal inflammation
Izzo, A. A., Fezza, F., Capasso, R., Bisogno, T., Pinto, L., Iuvone, T., Esposito, G., Mascolo, N., Marzo, V. D., & Capasso, F. (2001) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0704293 · Cited by 256
Heterologous desensitization of opioid receptors by chemokines inhibits chemotaxis and enhances the perception of pain
Szabó, I., Chen, X.-H., Li, X., Adler, M. W., Howard, O. M. Z., Oppenheim, J. J., & Rogers, T. J. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.102327699 · Cited by 256
Δ-9-Tetrahydrocannabinol Inhibits Antitumor Immunity by a CB2 Receptor-Mediated, Cytokine-Dependent Pathway
Zhu, L. X., Sharma, S. P., Stolina, M., Gardner, B. K., Roth, M. D., Tashkin, D. P., & Dubinett, S. M. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.165.1.373 · Cited by 252
Production of Eicosanoids and Other Oxylipins by Pathogenic Eukaryotic Microbes
Noverr, M. C., Erb‐Downward, J. R., & Huffnagle, G. B. (2003) · Clinical Microbiology Reviews · doi:10.1128/cmr.16.3.517-533.2003 · Cited by 247
Cannabinoid receptors and immunity
Klein, T., Newton, C. A., & Friedman, H. P. (1998) · Immunology Today · doi:10.1016/s0167-5699(98)01300-0 · Cited by 235
Self-citation
Δ9-Tetrahydrocannabinol regulates Th1/Th2 cytokine balance in activated human T cells
Yuan, M., Kiertscher, S. M., Cheng, Q., Zoumalan, R., Tashkin, D. P., & Roth, M. D. (2002) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(02)00370-3 · Cited by 234
Marijuana and Cocaine Impair Alveolar Macrophage Function and Cytokine Production
Baldwin, G. C., Tashkin, D. P., Buckley, D. M., PARK, A. N., Dubinett, S. M., & Roth, M. D. (1997) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.156.5.9704146 · Cited by 230
Cannabinoids and brain injury: therapeutic implications
Mechoulam, R. (2002) · Trends in Molecular Medicine · doi:10.1016/s1471-4914(02)02276-1 · Cited by 229
Effects of cannabinoids on LPS‐stimulated inflammatory mediator release from macrophages: Involvement of eicosanoids
Chang, Y., Lee, S. T., & Lin, W. (2001) · Journal of Cellular Biochemistry · doi:10.1002/jcb.1103 · Cited by 219
The Cannabinoid System and Cytokine Network
Klein, T., Lane, B., Newton, C. A., & Friedman, H. P. (2000) · Proceedings of The Society for Experimental Biology and Medicine · doi:10.1046/j.1525-1373.2000.22501.x · Cited by 218
Self-citation
Δ9-Tetrahydrocannabinol: a novel treatment for experimental autoimmune encephalomyelitis
Lyman, W. D., Sonett, J. R., Brosnan, C. F., Elkin, R., & Bornstein, M. B. (1989) · Journal of Neuroimmunology · doi:10.1016/0165-5728(89)90075-1 · Cited by 200
Cannabinol Derivatives: Binding to Cannabinoid Receptors and Inhibition of Adenylylcyclase
Rhee, M. H., Vogel, Z., Barg, J., Bayewitch, M. L., Levy, R., Hanuš, L., Breuer, A., & Mechoulam, R. (1997) · Journal of Medicinal Chemistry · doi:10.1021/jm970126f · Cited by 200
Immunoregulation of a viral model of multiple sclerosis using the synthetic cannabinoid R(+)WIN55,212
Croxford, J. L., & Miller, S. D. (2003) · Journal of Clinical Investigation · doi:10.1172/jci17652 · Cited by 197
Biosynthesis of anandamide and related acylethanolamides in mouse J774 macrophages and N18 neuroblastoma cells
Marzo, V. D., PETROCELLIS, L. D., Sepe, N., & BUONO, A. (1996) · Biochemical Journal · doi:10.1042/bj3160977 · Cited by 195
Endogenous Interleukin-1 Receptor Antagonist Mediates Anti-Inflammatory and Neuroprotective Actions of Cannabinoids in Neurons and Glia
Molina‐Holgado, F., Pinteaux, E., Moore, J. D., Molina‐Holgado, E., Guaza, C., Gibson, R. M., & Rothwell, N. J. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-16-06470.2003 · Cited by 192
Endocannabinoids as physiological regulators of colonic propulsion in mice
Pinto, L., Izzo, A. A., Mascolo, N., Capasso, F., Cascio, M. G., Bisogno, T., Marzo, V. D., Hospodar–Scott, K., & Brown, D. R. (2002) · Gastroenterology · doi:10.1053/gast.2002.34242 · Cited by 183
Presence and regulation of the endocannabinoid system in human dendritic cells
Matias, I., Pochard, P., Orlando, P., Salzet, M., Pestel, J., & Marzo, V. D. (2002) · European Journal of Biochemistry · doi:10.1046/j.1432-1033.2002.03078.x · Cited by 180
Neuroprotection by the Endogenous Cannabinoid Anandamide and Arvanil againstIn VivoExcitotoxicity in the Rat: Role of Vanilloid Receptors and Lipoxygenases
Veldhuis, W. B., van der Stelt, M., Wadman, M. W., van Zadelhoff, G., Maccarrone, M., Fezza, F., Veldink, G. A., Vliegenthart, J. F. G., Bär, P. R., Nicolay, K., et al. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-10-04127.2003 · Cited by 175
Cannabinoids and glaucoma
Tomida, I. (2004) · British Journal of Ophthalmology · doi:10.1136/bjo.2003.032250 · Cited by 172
Effects of Cannabinoid Receptor Agonist and Antagonist Ligands on Production of Inflammatory Cytokines and Anti-Inflammatory Interleukin-10 in Endotoxemic Mice
Smith, S. R., Terminelli, C., & Denhardt, G. (2000) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)39213-4 · Cited by 170
Cornerstone of peripheral tolerance: naturally occurring CD4+CD25+ regulatory T cells
Piccirillo, C. A., & Thornton, A. M. (2004) · Trends in Immunology · doi:10.1016/j.it.2004.04.009 · Cited by 167
CB1 and CB2 receptor-mediated signalling: a focus on endocannabinoids
McAllister, S. D., & Glass, M. (2002) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1054/plef.2001.0344 · Cited by 163
Lipopolysaccharide Downregulates Fatty Acid Amide Hydrolase Expression and Increases Anandamide Levels in Human Peripheral Lymphocytes
Maccarrone, M., PETROCELLIS, L. D., Bari, M., Fezza, F., Salvati, S., Marzo, V. D., & Finazzi‐Agrò, A. (2001) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.2001.2500 · Cited by 162
Dexanabinol (HU-211) in the treatment of severe closed head injury: A randomized, placebo-controlled, phase II clinical trial*
Knoller, N., Levi, L., Shoshan, I., Reichenthal, E., Razon, N., Rappaport, Z. H., & Biegon, A. R. (2002) · Critical Care Medicine · doi:10.1097/00003246-200203000-00009 · Cited by 161
Immunoregulation of a viral model of multiple sclerosis using the synthetic cannabinoid R(+)WIN55,212
Croxford, J. L., & Miller, S. D. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200317652 · Cited by 160
Δ9-Tetrahydrocannabinol Treatment Suppresses Immunity and Early IFN-γ, IL-12, and IL-12 Receptor β2 Responses to Legionella pneumophila Infection
Klein, T., Newton, C. A., Nakachi, N., & Friedman, H. P. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.164.12.6461 · Cited by 159
Self-citation
A new strategy to block tumor growth by inhibiting endocannabinoid inactivation
Bifulco, M., Laezza, C., Valenti, M., Ligresti, A., Portella, G., & Marzo, V. D. (2004) · The FASEB Journal · doi:10.1096/fj.04-1754fje · Cited by 154
Drugs and immunity: cannabinoids and their role in decreased resistance to infectious disease
Cabral, G. A., & Pettit, D. A. D. (1998) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(97)00227-0 · Cited by 151
Effects of cannabinoid receptor‐2 activation on accelerated gastrointestinal transit in lipopolysaccharide‐treated rats
Mathison, R., Ho, W., Pittman, Q. J., Davison, J. S., & Sharkey, K. A. (2004) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0705889 · Cited by 144
Secondary immunity to Legionella pneumophila and Th1 activity are suppressed by delta-9-tetrahydrocannabinol injection
Newton, C., Klein, T., & Friedman, H. P. (1994) · Infection and Immunity · doi:10.1128/iai.62.9.4015-4020.1994 · Cited by 140
Self-citation
A novel synthetic, nonpsychoactive cannabinoid acid (HU‐320) with antiinflammatory properties in murine collagen‐induced arthritis
Sumariwalla, P. F., Gallily, R., Tchilibon, S., Fride, E., Mechoulam, R., & Feldmann, M. (2004) · Arthritis & Rheumatism · doi:10.1002/art.20050 · Cited by 134
Clustering of MHC–peptide complexes prior to their engagement in the immunological synapse: lipid raft and tetraspan microdomains
Vogt, A. B., Spindeldreher, S., & Kropshofer, H. (2002) · Immunological Reviews · doi:10.1034/j.1600-065x.2002.18912.x · Cited by 131
Simultaneous Measurement of Anandamide and 2-Arachidonoylglycerol by Polymyxin B-Selective Adsorption and Subsequent High-Performance Liquid Chromatography Analysis: Increase in Endogenous Cannabinoids in the Sera of Patients with Endotoxic Shock
Wang, Y., Liu, Y., Ito, Y., Hashiguchi, T., Kitajima, I., Yamakuchi, M., Shimizu, H., Matsuo, S., Imaizumi, H., & Maruyama, I. (2001) · Analytical Biochemistry · doi:10.1006/abio.2001.5015 · Cited by 129
Activation and Binding of Peroxisome Proliferator-Activated Receptor γ by Synthetic Cannabinoid Ajulemic Acid
Liu, J., Li, H., Burstein, S. H., Zurier, R. B., & Chen, J. D. (2003) · Molecular Pharmacology · doi:10.1124/mol.63.5.983 · Cited by 129
Cannabinoid CB2 receptor activation reduces mouse myocardial ischemia-reperfusion injury: involvement of cytokine/chemokines and PMN
Filippo, C. D., Rossi, F., Rossi, S., & D’Amico, M. (2003) · Journal of Leukocyte Biology · doi:10.1189/jlb.0703303 · Cited by 129
Suppression of experimetal autoimmune encephalomyelitis by cannabinoids
Wirguin, I., Mechoulam, R., Breuer, A., Schezen, E., Weidenfeld, J., & Brenner, T. (1994) · Immunopharmacology · doi:10.1016/0162-3109(94)90056-6 · Cited by 116
Selective Diapedesis of Th1 Cells Induced by Endothelial Cell RANTES
Kawai, T., Seki, M., Hiromatsu, K., Eastcott, J. W., Watts, G. F. M., Sugai, M., Smith, D. J., Porcelli, S. A., & Taubman, M. A. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.163.6.3269 · Cited by 114
Win 55212-2, a cannabinoid receptor agonist, attenuates leukocyte/endothelial interactions in an experimental autoimmune encephalomyelitis model
Ni, X., Geller, E. B., Eppihimer, M. J., Eisenstein, T. K., Adler, M. W., & Tuma, R. F. (2004) · Multiple Sclerosis Journal · doi:10.1191/1352458504ms1009oa · Cited by 114
2-Arachidonoylglycerol, an endogenous cannabinoid receptor ligand, induces the migration of EoL-1 human eosinophilic leukemia cells and human peripheral blood eosinophils
Oka, S., Ikeda, S., Kishimoto, S., Gokoh, M., Shin, Y., Waku, K., & Sugiura, T. (2004) · Journal of Leukocyte Biology · doi:10.1189/jlb.0404252 · Cited by 109
Advances in pharmacotherapy for tobacco dependence
Foulds, J., Burke, M. V., Steinberg, M. B., Williams, J. M., & Ziedonis, D. M. (2004) · Expert Opinion on Emerging Drugs · doi:10.1517/eoed.9.1.39.32951 · Cited by 108
The Cannabinoid Acids
BURSTEIN, S. H. (1999) · Pharmacology & Therapeutics · doi:10.1016/s0163-7258(98)00069-2 · Cited by 107
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Derocq, J., Jbilo, O., Bouaboula, M., Ségui, M., Clère, C., & Casellas, P. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.21.15621 · Cited by 101
Differential expression of cannabinoid CB2 receptor mRNA in mouse immune cell subpopulations and following B cell stimulation
Lee, S. F., Newton, C. A., Widen, R. E., Friedman, H. P., & Klein, T. (2001) · European Journal of Pharmacology · doi:10.1016/s0014-2999(01)01122-0 · Cited by 100
Self-citation
Dimethylheptyl-THC-11 OIC acid: A nonpsychoactive antiinflammatory agent with a cannabinoid template structure
Zurier, R. B., Rossetti, R. G., Lane, J. H., Goldberg, J. M., Hunter, S. A., & BURSTEIN, S. H. (1998) · Arthritis & Rheumatism · doi:10.1002/1529-0131(199801)41:1 · Cited by 96
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Savinov, A. Y., Wong, F. S., & Chervonsky, A. V. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.167.11.6637 · Cited by 95
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The peripheral cannabinoid receptor Cb2, frequently expressed on AML blasts, either induces a neutrophilic differentiation block or confers abnormal migration properties in a ligand-dependent manner
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Delta 9-tetrahydrocannabinol injection induces cytokine-mediated mortality of mice infected with Legionella pneumophila.
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Self-citation
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Modulation of the Immune System in Cannabis Users
Pacifici, R. (2003) · JAMA · doi:10.1001/jama.289.15.1929-b · Cited by 71
Cannabinoid receptor proteins are increased in Jurkat, human T-cell line after mitogen activation.
Daaka, Y., Friedman, H. P., & Klein, T. (1996) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)12361-6 · Cited by 70
Self-citation
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Blanchard, D. K., Newton, C. A., Klein, T., Stewart, W. E., & Friedman, H. P. (1986) · International Journal of Immunopharmacology · doi:10.1016/0192-0561(86)90020-2 · Cited by 69
Self-citation
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Gallily, R., Yamin, A., Waksmann, Y., Ovadia, H., Weidenfeld, J., Bar-Joseph, A., Biegon, A. R., Mechoulam, R., & Shohami, E. (1997) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)37086-7 · Cited by 69
Modulation of the Immune System in Cannabis Users
Pacifici, R., Zuccaro, P., Pichini, S., et al. (2003) · JAMA · doi:10.1001/jama.289.15.1929-a · Cited by 68
Protection against septic shock and suppression of tumor necrosis factor alpha and nitric oxide production by dexanabinol (HU-211), a nonpsychotropic cannabinoid.
Gallily, R., Yamin, A., Waksmann, Y., Ovadia, H., Weidenfeld, J., Bar-Joseph, A., Biegon, A. R., Mechoulam, R., & Shohami, E. (1997) · PubMed · Cited by 67
Suppression of human monocyte interleukin-1β production by ajulemic acid, a nonpsychoactive cannabinoid
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γ-Irradiation Enhances Apoptosis Induced by Cannabidiol, a Non-psychotropic Cannabinoid, in Cultured HL-60 Myeloblastic Leukemia Cells
Gallily, R., Even-Chen, T., Katzavian, G., Lehmann, D., Dagan, A., & Mechoulam, R. (2003) · Leukemia & lymphoma/Leukemia and lymphoma · doi:10.1080/1042819031000103917 · Cited by 62
Functional assessment of neuronal cannabinoid receptors in the muscular layers of human ileum and colon
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Autocrine and Paracrine Regulation of Lymphocyte CB2 Receptor Expression by TGF-β
Gardner, B. K., Zu, L. X., Sharma, S. P., Liu, Q., Makriyannis, A., Tashkin, D. P., & Dubinett, S. M. (2002) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2001.6179 · Cited by 59
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1',1'-Dimethylheptyl-delta-8-tetrahydrocannabinol-11-oic acid: a novel, orally effective cannabinoid with analgesic and anti-inflammatory properties.
Dajani, E. Z., Larsen, K. R., Taylor, J., Dajani, N. E., Shahwan, T. G., Neeleman, S. D., Taylor, M., Dayton, M. T., & Mir, G. (1999) · PubMed · Cited by 57
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Newton, C. A. et al. The THC-induced suppression of TH1 polarization in response to Legionella pneumophila infection is not mediated by increases in corticosterone and PGE2. J. Leukoc. Biol. 76, 854-861
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Authors: Klein, T. W.
Affiliations: University of South Florida (US)
Corresponding author: Klein, Thomas W.
ORCID: Klein, Thomas W.
Venue: Nature Reviews Immunology
Publisher: Springer Science and Business Media LLC
Published: 2005-05
Volume: 5
Issue: 5
Pages: 400-411
ISSN: 1474-1733 (ISSN-L)
1474-1741
DOI: 10.1038/nri1602
OpenAlex: W2072422429
Cited by: 728
References: 128
Citations by year: 2026: 15 · 2025: 29 · 2024: 25 · 2023: 27 · 2022: 31 · 2021: 46 · 2020: 46 · 2019: 35 · 2018: 26 · 2017: 42 · 2016: 31 · 2015: 33 · 2014: 39 · 2013: 32 · 2012: 32
FWCI: 5.06
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature reviews. Immunology (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Pharmacology (medical) › Cannabis and Cannabinoid Research
Health Sciences › Medicine › Pharmacology (medical) › Inflammatory mediators and NSAID effects
Health Sciences › Medicine › Complementary and alternative medicine › Natural Compounds in Disease Treatment
Keywords: anti-inflammatory therapy, chronic inflammatory diseases, immunosuppression, cannabis, obesity, cancer, spasticity, tremor, neuropathology
MeSH terms: Animals, Anti-Inflammatory Agents, Cannabinoids, Cell Movement, T-Lymphocytes, Helper-Inducer, Humans, Immunity, Innate, Inflammation, Cytokines, Receptors, Cannabinoid

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