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Tuning immune responses: diversity and adaptation of the immunological synapse

Friedl, Peter, den Boer, Annemieke Th., Gunzer, Matthias·2005·Nature Reviews Immunology

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Abstract

The onset and regulation of a specific immune response results from communication between T cells and antigen-presenting cells (APCs), which form molecular interactions at the site of cell-cell contact--and this is known as the immunological synapse. Initially, the immunological synapse was viewed as a stereotypical adhesion and signalling device with a defined molecular structure and signalling processes. However, as we discuss here, T-cell-APC interactions comprise a diverse range of contact modes and distinct molecular arrangements. These diverse interaction modes might define a molecular code, in which the differences in timing, spacing and molecular composition of the signalling platform determine the outcome of T-cell-APC interactions.

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The infectious synapse formed between mature dendritic cells and CD4+T cells is independent of the presence of the HIV-1 envelope glycoprotein
Rodriguez-Plata, M. T., Puigdomènech, I., Izquierdo-Useros, N., Puertas, M. C., Carrillo, J., Erkizia, I., Clotet, B., Blanco, J., & Martinez-Picado, J. (2013) · Retrovirology · doi:10.1186/1742-4690-10-42 · Cited by 45
RhoH Regulates Subcellular Localization of ZAP-70 and Lck in T Cell Receptor Signaling
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ARAP, a Novel Adaptor Protein, Is Required for TCR Signaling and Integrin-Mediated Adhesion
Jung, S. H., Yoo, E. H., Yu, M. J., Song, H. M., Kang, H. Y., Cho, J.-Y., & Lee, J. R. (2016) · The Journal of Immunology · doi:10.4049/jimmunol.1501913 · Cited by 19

See all 276

Authors: Friedl, P., den Boer, A. T., & Gunzer, M.
Venue: Nature Reviews Immunology
Publisher: Springer Science and Business Media LLC
Published: 2005-07-01
Volume: 5
Issue: 7
Pages: 532-545
ISSN: 1474-1733
1474-1741
DOI: 10.1038/nri1647
Cited by: 276
References: 117
Language: en
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)

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Tuning immune responses: diversity and adaptation of the immunological synapse

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