Cited by 1,775Immune cells in cancerAmino Acid Enzymes and MetabolismBacterial Cancer Therapy

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Regulation of immune responses by L-arginine metabolism

Bronte, Vincenzo, Zanovello, Paola·2005·Nature Reviews Immunology

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Abstract

L-Arginine is an essential amino acid for birds and young mammals, and it is a conditionally essential amino acid for adult mammals, as it is important in situations in which requirements exceed production, such as pregnancy. Recent findings indicate that increased metabolism of L-arginine by myeloid cells can result in the impairment of lymphocyte responses to antigen during immune responses and tumour growth. Two enzymes that compete for L-arginine as a substrate - arginase and nitric-oxide synthase - are crucial components of this lymphocyte-suppression pathway, and the metabolic products of these enzymes are important moderators of T-cell function. This Review article focuses on the relevance of L-arginine metabolism by myeloid cells for immunity under physiological and pathological conditions.

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Authors: Bronte, V., & Zanovello, P.
Affiliations: University of Padua (IT)
Corresponding author: Bronte, Vincenzo
ORCID: Bronte, Vincenzo
Zanovello, Paola
Venue: Nature Reviews Immunology
Publisher: Springer Science and Business Media LLC
Published: 2005-08
Volume: 5
Issue: 8
Pages: 641-654
ISSN: 1474-1733 (ISSN-L)
1474-1741
DOI: 10.1038/nri1668
OpenAlex: W1977179270
Cited by: 1,775
References: 146
Citations by year: 2026: 69 · 2025: 78 · 2024: 75 · 2023: 96 · 2022: 81 · 2021: 114 · 2020: 100 · 2019: 92 · 2018: 97 · 2017: 89 · 2016: 119 · 2015: 92 · 2014: 95 · 2013: 96 · 2012: 97
FWCI: 3.93
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature reviews. Immunology (publishedVersion)
PubMed (publishedVersion)
Padua Research Archive (University of Padova) (submittedVersion)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Amino Acid Enzymes and Metabolism
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biotechnology › Bacterial Cancer Therapy
Keywords: arginine metabolism, immune regulation, arginase, nitric oxide synthase, myeloid cells, T cell function, lymphocyte suppression, tumor growth, immunosuppression, essential amino acids
MeSH terms: Animals, Arginase, Arginine, Humans, Immunity, Cellular, Suppressor Factors, Immunologic, T-Lymphocytes, Reactive Oxygen Species, Nitric Oxide Synthase, Myeloid Cells, Reactive Nitrogen Species

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Regulation of immune responses by L-arginine metabolism

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