Cited by 1,775Immune cells in cancerAmino Acid Enzymes and MetabolismBacterial Cancer Therapy

The DOI matches its Crossref record; 146 of the 146 references it cites were found in a registry or an index.

Regulation of immune responses by L-arginine metabolism

Bronte, Vincenzo, Zanovello, Paola·2005·Nature Reviews Immunology

Open this paper in CoChat — free account

Abstract

L-Arginine is an essential amino acid for birds and young mammals, and it is a conditionally essential amino acid for adult mammals, as it is important in situations in which requirements exceed production, such as pregnancy. Recent findings indicate that increased metabolism of L-arginine by myeloid cells can result in the impairment of lymphocyte responses to antigen during immune responses and tumour growth. Two enzymes that compete for L-arginine as a substrate - arginase and nitric-oxide synthase - are crucial components of this lymphocyte-suppression pathway, and the metabolic products of these enzymes are important moderators of T-cell function. This Review article focuses on the relevance of L-arginine metabolism by myeloid cells for immunity under physiological and pathological conditions.

Integrity signals

Registry

Crossref · 10.1038/nri1668

Cites

146 of 146 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Alternative activation of macrophages
Gordon, S. (2003) · Nature Reviews Immunology · doi:10.1038/nri978 · Cited by 6,189
Nitric oxide synthases: structure, function and inhibition
ALDERTON, W. K., COOPER, C. E., & KNOWLES, R. G. (2001) · Biochemical Journal · doi:10.1042/bj3570593 · Cited by 4,110
Blood Monocytes Consist of Two Principal Subsets with Distinct Migratory Properties
Geissmann, F., Jung, S., & Littman, D. R. (2003) · Immunity · doi:10.1016/s1074-7613(03)00174-2 · Cited by 3,504
Nitric oxide and the immune response
Bogdan, C. (2001) · Nature Immunology · doi:10.1038/ni1001-907 · Cited by 3,447
M-1/M-2 Macrophages and the Th1/Th2 Paradigm
Mills, C. D., Kincaid, K., Alt, J. M., Heilman, M. J., & Hill, A. M. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.164.12.6166 · Cited by 3,287
Arginine metabolism: nitric oxide and beyond
WU, G., & MORRIS, S. M. (1998) · Biochemical Journal · doi:10.1042/bj3360001 · Cited by 2,811
Ido expression by dendritic cells: tolerance and tryptophan catabolism
Mellor, A. L., & Munn, D. H. (2004) · Nature Reviews Immunology · doi:10.1038/nri1457 · Cited by 2,341
Evidence for a tumoral immune resistance mechanism based on tryptophan degradation by indoleamine 2,3-dioxygenase
Uyttenhove, C., Pilotte, L., Théate, I., Stroobant, V., Colau, D., Parmentier, N., Boon, T., & Van den Eynde, B. J. (2003) · Nature Medicine · doi:10.1038/nm934 · Cited by 2,305
Inhibition of T Cell Proliferation by Macrophage Tryptophan Catabolism
Munn, D. H., Shafizadeh, E., Attwood, J. T., Bondarev, I. E., Pashine, A., & Mellor, A. L. (1999) · The Journal of Experimental Medicine · doi:10.1084/jem.189.9.1363 · Cited by 1,640
Dendritic-cell control of pathogen-driven T-cell polarization
Kapsenberg, M. L. (2003) · Nature reviews. Immunology · doi:10.1038/nri1246 · Cited by 1,495

Flagged first, then by citations

Show all 146 references

Sorted by citations

Items 301–400 of 1,002

Myeloid-derived suppressor cell role in tumor-related inflammation
Dolcetti, L., Marigo, I., Mantelli, B., Peranzoni, E., Zanovello, P., & Bronte, V. (2008) · Cancer Letters · doi:10.1016/j.canlet.2008.03.012 · Cited by 122
Self-citation
Altered functions of natural killer cells in response to L-Arginine availability
Lamas, B., Vergnaud, J., Gonçalves-Mendes, N., Perche, O., Rossary, A., Vasson, M., & Farges, M. (2012) · Cellular Immunology · doi:10.1016/j.cellimm.2012.11.018 · Cited by 124
The novel immunosuppressive enzyme IL4I1 is expressed by neoplastic cells of several B-cell lymphomas and by tumor-associated macrophages
Carbonnelle-Puscian, A., Copie‐Bergman, C., Baia, M., Martin‐Garcia, N., Allory, Y., Haïoun, C., Cremades, A., Abd‐Alsamad, I., Farcet, J., Gaulard, P., et al. (2009) · Leukemia · doi:10.1038/leu.2008.380 · Cited by 117
Amino Acids As Mediators of Metabolic Cross Talk between Host and Pathogen
Ren, W., Rajendran, R., Zhao, Y., Tan, B., Wu, G., Bazer, F. W., Zhu, G., Peng, Y., Huang, X., Deng, J., et al. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00319 · Cited by 123
Physiological and pharmacological features of the non-saponin components in Korean Red Ginseng
Hyun, S. H., Kim, S. W., Seo, H. W., Youn, S.-H., Kyung, J.-S., Lee, Y. Y., In, G., Park, C.-K., & Han, C.-K. (2020) · Journal of Ginseng Research · doi:10.1016/j.jgr.2020.01.005 · Cited by 118
The Central Role of Arginine Catabolism in T-Cell Dysfunction and Increased Susceptibility to Infection After Physical Injury
Zhu, X., Pribis, J. P., Rodrı́guez, P. C., Morris, S. M., Yoram Vodovotz, B., Billiar, T. R., & Ochoa, J. B. (2013) · Annals of Surgery · doi:10.1097/sla.0b013e31828611f8 · Cited by 118
The essential role of the in situ immune reaction in human colorectal cancer
Pagès, F., Galon, J., & Fridman, W. H. (2008) · Journal of Leukocyte Biology · doi:10.1189/jlb.1107773 · Cited by 122
Multifunctional Nanodrug Mediates Synergistic Photodynamic Therapy and MDSCs‐Targeting Immunotherapy of Colon Cancer
Ding, D., Zhong, H., Liang, R., Lan, T., Zhu, X., Huang, S., Wang, Y., Shao, J., Shuai, X., & Wei, B. (2021) · Advanced Science · doi:10.1002/advs.202100712 · Cited by 117
Coxiella burnetii, the agent of Q fever, stimulates an atypical M2 activation program in human macrophages
Benoit, M. E., Barbarat, B., Bernard, A., Olive, D., & Mège, J. (2008) · European Journal of Immunology · doi:10.1002/eji.200738067 · Cited by 123
CD4+ T-cell differentiation and function: Unifying glycolysis, fatty acid oxidation, polyamines NAD mitochondria
Almeida, L., Dhillon-LaBrooy, A., Carriche, G. M., Berod, L., & Sparwasser, T. D. (2021) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2021.03.033 · Cited by 117
Induction and stability of human Th17 cells require endogenous NOS2 and cGMP-dependent NO signaling
Obermajer, N., Wong, J. L., Edwards, R. P., Chen, K., Scott, M. J., Khader, S. A., Kolls, J. K., Odunsi, K. O., Billiar, T. R., & Kaliński, P. (2013) · The Journal of Experimental Medicine · doi:10.1084/jem.20121277 · Cited by 120
Role of Tumor-Associated Myeloid Cells in Breast Cancer
Cha, Y. J., & Koo, J. S. (2020) · Cells · doi:10.3390/cells9081785 · Cited by 114
Expression of Cationic Amino Acid Transporter 2 Is Required for Myeloid-Derived Suppressor Cell–Mediated Control of T Cell Immunity
Bozkus, C. C., Elzey, B. D., Crist, S. A., Ellies, L. G., & Ratliff, T. L. (2015) · The Journal of Immunology · doi:10.4049/jimmunol.1500959 · Cited by 112
Metabolic Reprogramming of Immune Cells in the Tumor Microenvironment
Wang, J., He, Y., Hu, F., Hu, C., Sun, Y., Yang, K., & Yang, S. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252212223 · Cited by 122
Blockade of Myeloid-Derived Suppressor Cells after Induction of Lymphopenia Improves Adoptive T Cell Therapy in a Murine Model of Melanoma
Kodumudi, K. N., Weber, A. M., Sarnaik, A. A., & Pilon‐Thomas, S. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1200274 · Cited by 113
Immune escape mechanisms of intraocular tumors
Niederkorn, J. Y. (2009) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2009.06.002 · Cited by 111
Metabolism and TAM functions—it takes two to tango
Mazzone, M., Menga, A., & Castegna, A. (2017) · FEBS Journal · doi:10.1111/febs.14295 · Cited by 115
Breast cancer–derived GM-CSF regulates arginase 1 in myeloid cells to promote an immunosuppressive microenvironment
Su, X., Xu, Y., Fox, G. C., Xiang, J., Kwakwa, K. A., Davis, J. L., Belle, J. I., Lee, W., Wong, W., Fontana, F., et al. (2021) · Journal of Clinical Investigation · doi:10.1172/jci145296 · Cited by 109
Monocyte homeostasis and the plasticity of inflammatory monocytes
Mitchell, A. J., Roediger, B., & Weninger, W. (2014) · Cellular Immunology · doi:10.1016/j.cellimm.2014.05.010 · Cited by 117
Immunotherapy in breast cancer: Current status and future directions
(2019) · Advances in Cancer Research · doi:10.1016/bs.acr.2019.03.006 · Cited by 109
Myeloid-Derived Suppressor Cells in Colorectal Cancer
Siemińska, I., & Baran, J. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01526 · Cited by 115
Effective Immunotherapy against Murine Gliomas Using Type 1 Polarizing Dendritic Cells—Significant Roles of CXCL10
Fujita, M., Zhu, X., Ueda, R., Sasaki, K., Kohanbash, G., Kastenhuber, E. R., McDonald, H. A., Gibson, G. A., Watkins, S. C., Muthuswamy, R., et al. (2009) · Cancer Research · doi:10.1158/0008-5472.can-08-2915 · Cited by 109
Improving Antitumor Immune Responses by Circumventing Immunoregulatory Cells and Mechanisms
Lizee, G. A., Radvanyi, L. G., Overwijk, W. W., & Hwu, P. (2006) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-06-0944 · Cited by 109
Increased immunosuppression impairs tissue homeostasis with aging and age-related diseases
Salminen, A. (2020) · Journal of Molecular Medicine · doi:10.1007/s00109-020-01988-7 · Cited by 111
Galectin-3 Accelerates M2 Macrophage Infiltration and Angiogenesis in Tumors
Jia, W., Kidoya, H., Yamakawa, D., Naito, H., & Takakura, N. (2013) · American Journal Of Pathology · doi:10.1016/j.ajpath.2013.01.017 · Cited by 108
Modulators of arginine metabolism support cancer immunosurveillance
Capuano, G., Rigamonti, N., Grioni, M., Freschi, M., & Bellone, M. (2009) · BMC Immunology · doi:10.1186/1471-2172-10-1 · Cited by 107
Epigenetic control of macrophage polarization
Takeuch, O., & Akira, S. (2011) · European Journal of Immunology · doi:10.1002/eji.201141792 · Cited by 110
Targeting myeloid-derived suppressor cells for cancer immunotherapy
Liu, Y., Wei, G., Cheng, W. A., Dong, Z., Sun, H., Lee, V. Y., Cha, S.-C., Smith, D. L., Kwak, L. W., & Qin, H. (2018) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-018-2175-3 · Cited by 110
Myeloid-derived suppressor cells regulate T cell and B cell responses during autoimmune disease
Crook, K. R., Jin, M., Weeks, M. F., Rampersad, R. R., Baldi, R. M., Glekas, A. S., Shen, Y., Esserman, D. A., Little, P., Schwartz, T. A., et al. (2015) · Journal of Leukocyte Biology · doi:10.1189/jlb.4a0314-139r · Cited by 106
Unraveling the ECM-Immune Cell Crosstalk in Skin Diseases
Bhattacharjee, O., Ayyangar, U., Kurbet, A. S., Ashok, D., & Raghavan, S. (2019) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2019.00068 · Cited by 109
Host immune response against leishmaniasis and parasite persistence strategies: A review and assessment of recent research
Elmahallawy, E. K., Alkhaldi, A. A. M., & Saleh, A. A. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.111671 · Cited by 121
Myeloid-Derived Suppressor Cells Protect Islet Transplants by B7-H1 Mediated Enhancement of T Regulatory Cells
Chou, H.-S., Hsieh, C., Charles, R., Wang, L., Wagner, T., Fung, J. J., Qian, S., & Lu, L. L. (2011) · Transplantation · doi:10.1097/tp.0b013e31823ffd39 · Cited by 105
Dietary l -arginine supplementation attenuates lipopolysaccharide-induced inflammatory response in broiler chickens
Tan, J., Liu, S., Guo, Y., Applegate, T. J., & Eicher, S. D. (2013) · British Journal Of Nutrition · doi:10.1017/s0007114513003863 · Cited by 111
Vitamin D endocrinology on the cross-road between immunity and metabolism
Vanherwegen, A.-S., Gysemans, C. A., & Mathieu, C. (2017) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2017.04.018 · Cited by 107
Generation of myeloid-derived suppressor cells using prostaglandin E2
Obermajer, N., & Kaliński, P. (2012) · Transplantation Research · doi:10.1186/2047-1440-1-15 · Cited by 110
Myeloid-Derived Suppressor Cells Interact with Tumors in Terms of Myelopoiesis, Tumorigenesis and Immunosuppression: Thick as Thieves
Sevko, A., & Umansky, V. (2013) · Journal of Cancer · doi:10.7150/jca.5047 · Cited by 103
Generation, Translocation, and Action of Nitric Oxide in Living Systems
Tennyson, A. G., & Lippard, S. J. (2011) · Chemistry & Biology · doi:10.1016/j.chembiol.2011.09.009 · Cited by 104
T-cell death and cancer immune tolerance
Lu, B., & Finn, O. J. (2007) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4402274 · Cited by 106
Pegylated arginase I: a potential therapeutic approach in T-ALL
Hernandez, C. P., Morrow, K. D., Lopez-Barcons, L. A., Zabaleta, J., Sierra, R. A., Velasco, C., COLE, J. T., & Rodrı́guez, P. C. (2010) · Blood · doi:10.1182/blood-2009-12-258822 · Cited by 104
Exogenous IFN‐γ ex vivo shapes the alloreactive T‐cell repertoire by inhibition of Th17 responses and generation of functional Foxp3+ regulatory T cells
Feng, G. L., Gao, W., Strom, T. B., Oukka, M., Francis, R. S., Wood, K. J., & Bushell, A. (2008) · European Journal of Immunology · doi:10.1002/eji.200838411 · Cited by 106
Zoledronic acid impairs myeloid differentiation to tumour-associated macrophages in mesothelioma
Veltman, J. D., Lambers, M. E. H., van Nimwegen, M., Hendriks, R. W., Hoogsteden, H. C., Hegmans, J. P., & Aerts, J. G. J. V. (2010) · British Journal of Cancer · doi:10.1038/sj.bjc.6605814 · Cited by 104
DFMO and 5-azacytidine increase M1 macrophages in the tumor microenvironment of murine ovarian cancer
Travers, M., Brown, S. M., Dunworth, M., Holbert, C. E., Wiehagen, K. R., Bachman, K. E., Foley, J. R., Stone, M. L., Baylin, S. B., Casero, R. A., et al. (2019) · Cancer Research · doi:10.1158/0008-5472.can-18-4018 · Cited by 103
Amino Acid Catabolism: An Overlooked Area of Metabolism
Torres, N., Tobón‐Cornejo, S., Velázquez‐Villegas, L. A., Noriega, L. G., Alemán, G., & Tovar, A. R. (2023) · Nutrients · doi:10.3390/nu15153378 · Cited by 120
The Arginase II Gene Is an Anti-inflammatory Target of Liver X Receptor in Macrophages
Marathe, C., Bradley, M. N., Hong, C., López, F., de Galarreta, C. M. R., Tontonoz, P., & Castrillo, A. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m605237200 · Cited by 102
Myeloid-Derived Suppressor Cells: General Characteristics and Relevance to Clinical Management of Pancreatic Cancer
Goedegebuure, P. S., Mitchem, J. B., Porembka, M. R., Tan, M. C. B., Belt, B. A., Wang‐Gillam, A., Gillanders, W. E., Hawkins, W. G., & Linehan, D. C. (2011) · Current Cancer Drug Targets · doi:10.2174/156800911796191024 · Cited by 104
Cannabinoid receptor activation leads to massive mobilization of myeloid‐derived suppressor cells with potent immunosuppressive properties
Hegde, V. L., Nagarkatti, M., & Nagarkatti, P. S. (2010) · European Journal of Immunology · doi:10.1002/eji.201040667 · Cited by 106
Amino-acid sensing and degrading pathways in immune regulation
Grohmann, U., Mondanelli, G., Belladonna, M. L., Orabona, C., Pallotta, M. T., Iacono, A., Puccetti, P., & Volpi, C. (2017) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2017.05.004 · Cited by 105
Prostaglanin-E2 Potentiates the Suppressive Functions of Human Mononuclear Myeloid-Derived Suppressor Cells and Increases Their Capacity to Expand IL-10-Producing Regulatory T Cell Subsets
Tomić, S., Joksimović, B., Bekić, M., Vasiljević, M., Milanović, M., Čolić, M. J., & Vučević, D. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00475 · Cited by 106
Advances in Targeting the Innate and Adaptive Immune Systems to Cure Chronic Hepatitis B Virus Infection
Meng, Z., Chen, Y., & Lu, M. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2019.03127 · Cited by 103
Quantitative Assessment of Macrophage Functions in Repair and Fibrosis
Wynn, T. A., Barron, L., Thompson, R. W., Madala, S. K., Wilson, M. S., Cheever, A. W., & Ramalingam, T. R. (2011) · Current Protocols in Immunology · doi:10.1002/0471142735.im1422s93 · Cited by 106
Local Suppression of T Cell Responses by Arginase-Induced L-Arginine Depletion in Nonhealing Leishmaniasis
Modolell, M., Choi, B., Ryan, R. O., Hancock, M., Titus, R. G., Abebe, T., Hailu, A., Müller, I., Rogers, M. E., Bangham, C. R. M., et al. (2009) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0000480 · Cited by 102
Effect of First-Line Treatment on Myeloid-Derived Suppressor Cells’ Subpopulations in the Peripheral Blood of Patients with Non–Small Cell Lung Cancer
Koinis, F., Vetsika, E., Aggouraki, D., Skalidaki, E., Koutoulaki, A., Gkioulmpasani, M., Georgoulias, V., & Kotsakis, A. P. (2016) · Journal of Thoracic Oncology · doi:10.1016/j.jtho.2016.04.026 · Cited by 102
Cytosolic Branched Chain Aminotransferase (BCATc) Regulates mTORC1 Signaling and Glycolytic Metabolism in CD4+ T Cells
Ananieva, E. A., Patel, C. H., Drake, C. H., Powell, J. D., & Hutson, S. M. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.554113 · Cited by 101
Cancer Immunologists and Cancer Biologists: Why We Didn't Talk Then but Need to Now
Prendergast, G. C., & Jaffee, E. M. (2007) · Cancer Research · doi:10.1158/0008-5472.can-06-4626 · Cited by 102
Dermatomyositis With or Without Anti-Melanoma Differentiation-Associated Gene 5 Antibodies
Allenbach, Y., Leroux, G., Suárez‐Calvet, X., Preuße, C., Gallardo, E., Hervier, B., Rigolet, A., Hie, M., Pehl, D., Limal, N., et al. (2016) · American Journal Of Pathology · doi:10.1016/j.ajpath.2015.11.010 · Cited by 101
T Cells and Cancer: How Metabolism Shapes Immunity
Molon, B., Calì, B., & Viola, A. (2016) · Frontiers in Immunology · doi:10.3389/fimmu.2016.00020 · Cited by 104
Blood metabolomics analysis identifies abnormalities in the citric acid cycle, urea cycle, and amino acid metabolism in bipolar disorder
Yoshimi, N., Futamura, T., Kakumoto, K., Salehi, A. M., Sellgren, C. M., Holmén‐Larsson, J., Jakobsson, J., Pålsson, E., Landén, M., & Hashimoto, K. (2016) · BBA Clinical · doi:10.1016/j.bbacli.2016.03.008 · Cited by 100
Phagocytes as Corrupted Policemen in Cancer-Related Inflammation
Bonavita, E., Galdiero, M. R., Jaillon, S., & Mantovani, A. (2015) · Advances in cancer research · doi:10.1016/bs.acr.2015.04.013 · Cited by 102
Mitochondrial arginase-2 is a cell‑autonomous regulator of CD8+ T cell function and antitumor efficacy
Líndez, A.-A. M. I., Dunand-Sauthier, I., Conti, M., Gobet, F., Núñez, N. G., Hannich, J. T., Riezman, H., Geiger, R., Piersigilli, A., Hahn, K., et al. (2019) · JCI Insight · doi:10.1172/jci.insight.132975 · Cited by 107
Anti-inflammatory and immunosuppressive activation of human monocytes by a bioactive dendrimer
Fruchon, S., Poupot, M., Martinet, L., Turrin, C., Majoral, J., Fournié, J., Caminade, A., & Poupot, R. (2008) · Journal of Leukocyte Biology · doi:10.1189/jlb.0608371 · Cited by 100
Transduction with the Antioxidant Enzyme Catalase Protects Human T Cells against Oxidative Stress
Ando, T., Mimura, K., Johansson, C. C., Hanson, M., Mougiakakos, D., Larsson, C., da Palma, T. M., Sakurai, D., Norell, H., Li, M., et al. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.12.8382 · Cited by 100
Type I IFN Inhibits Alternative Macrophage Activation during Mycobacterium tuberculosis Infection and Leads to Enhanced Protection in the Absence of IFN-γ Signaling
Moreira-Teixeira, L., Sousa, J., McNab, F. W., Torrado, E., Cardoso, F., Machado, H., Castro, F., Cardoso, V., Gaifem, J., Wu, X., et al. (2016) · The Journal of Immunology · doi:10.4049/jimmunol.1600584 · Cited by 99
Auranofin radiosensitizes tumor cells through targeting thioredoxin reductase and resulting overproduction of reactive oxygen species
Wang, H., Bouzakoura, S., de Mey, S., Jiang, H., Ka, L. L., Dufait, I., Corbet, C., Verovski, V. N., Gevaert, T., Féron, O., et al. (2017) · Oncotarget · doi:10.18632/oncotarget.16113 · Cited by 98
Nitric oxide delivery to cancer: Why and how?
Sonveaux, P., Jordan, B. F., Gallez, B., & Féron, O. (2009) · European Journal of Cancer · doi:10.1016/j.ejca.2008.12.018 · Cited by 103
Cytokines and cell adhesion receptors in the regulation of immunity to Trypanosoma cruzi
Savino, W., Villa‐Verde, D. M. S., Mendes‐da‐Cruz, D. A., Silva, E., Pérez, A. R., Aoki, M. P., Bottasso, O. A., Guiñazú, N. L., Silva-Barbosa, S. D., & Gea, S. (2007) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2007.01.010 · Cited by 99
MDSCs in cancer: Conceiving new prognostic and therapeutic targets
Sanctis, F. D., Solito, S., Ugel, S., Molon, B., Bronte, V., & Marigo, I. (2015) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2015.08.001 · Cited by 101
Self-citation
Targeting tumor-associated macrophages to combat pancreatic cancer
Cui, R., Yue, W., Lattime, E. C., Stein, M. N., Xu, Q., & Tan, X. (2016) · Oncotarget · doi:10.18632/oncotarget.9383 · Cited by 101
Myeloid‐derived suppressor cells as effectors of immune suppression in cancer
Pyzer, A. R., Cole, L., Rosenblatt, J. M., & Avigan, D. (2016) · International Journal of Cancer · doi:10.1002/ijc.30232 · Cited by 101
Functional role and species-specific contribution of arginases in pulmonary fibrosis
Kitowska, K., Zakrzewicz, D., Königshoff, M., Chrobak, I., Grimminger, F., Seeger, W., Bulau, P., & Eickelberg, O. (2007) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00007.2007 · Cited by 99
Mechanisms of immunological tolerance
Waldmann, H. (2015) · Clinical Biochemistry · doi:10.1016/j.clinbiochem.2015.05.019 · Cited by 98
Arginine deficiency is involved in thrombocytopenia and immunosuppression in severe fever with thrombocytopenia syndrome
Li, X., Lu, Q., Chen, W., Xu, W. B., Liu, R., Zhang, S.-F., Du, J., Li, H., Yao, K., Zhai, D., et al. (2018) · Science Translational Medicine · doi:10.1126/scitranslmed.aat4162 · Cited by 97
The Intercellular Metabolic Interplay between Tumor and Immune Cells
Wang, T., Liu, G., & Wang, R. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00358 · Cited by 96
Exercise and possible molecular mechanisms of protection from vascular disease and diabetes: the central role of ROS and nitric oxide
Newsholme, P., de Bittencourt, P. I. H., Hagan, C. O., VITO, G. D., Murphy, C., & Krause, M. D. S. (2009) · Clinical Science · doi:10.1042/cs20090433 · Cited by 96
β-Catenin–mediated immune evasion pathway frequently operates in primary cutaneous melanomas
Nsengimana, J., Laye, J. P., Filia, A., O'Shea, S. J., Muralidhar, S., Poźniak, J., Droop, A., Chan, M., Walker, C., Parkinson, L., et al. (2018) · Journal of Clinical Investigation · doi:10.1172/jci95351 · Cited by 96
γδ T Cells and Tumor Microenvironment: From Immunosurveillance to Tumor Evasion
Presti, E. L., Pizzolato, G., Corsale, A. M., Caccamo, N., Sireci, G., Dieli, F., & Meraviglia, S. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.01395 · Cited by 95
Arginine: Master and Commander in Innate Immune Responses
Morris, S. M. (2010) · Science Signaling · doi:10.1126/scisignal.3135pe27 · Cited by 96
Oral vitamin D rapidly attenuates inflammation from sunburn: an interventional study
Scott, J. F., Das, L. M., Ahsanuddin, S., Qiu, Y., Binko, A. M., Traylor, Z. P., Debanne, S. M., Cooper, K. D., Boxer, R., & Lu, K. Q. (2017) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2017.04.040 · Cited by 95
Nutrient and Metabolic Sensing in T Cell Responses
Wei, J., Raynor, J. L., Nguyen, T.-L. M., & Chi, H. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00247 · Cited by 101
Novel GM-CSF signals via IFN-γR/IRF-1 and AKT/mTOR license monocytes for suppressor function
Ribechini, E., Hutchinson, J. A., Hergovits, S., Heuer, M., Lucas, J., Schleicher, U., Garrote, A.-L. J., Potter, S. J., Riquelme, P., Brackmann, H., et al. (2017) · Blood Advances · doi:10.1182/bloodadvances.2017006858 · Cited by 101
l -Arginine Ameliorates Lipopolysaccharide-Induced Intestinal Inflammation through Inhibiting the TLR4/NF-κB and MAPK Pathways and Stimulating β-Defensin Expression in Vivo and in Vitro
Lan, J. Q., Dou, X., Li, J., Yang, Y., Xue, C., Wang, C., Gao, N., & Shan, A. (2020) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.9b07611 · Cited by 100
The role of macrophage phenotype in regulating the response to radiation therapy
Shi, X., & Shiao, S. L. (2017) · Translational research · doi:10.1016/j.trsl.2017.11.002 · Cited by 99
Role of Neutrophils and Myeloid-Derived Suppressor Cells in Glioma Progression and Treatment Resistance
Khan, S., Mittal, S., McGee, K., Alfaro-Munoz, K. D., Majd, N., Balasubramaniyan, V., & de Groot, J. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21061954 · Cited by 99
The role of proto-oncogene Fra-1 in remodeling the tumor microenvironment in support of breast tumor cell invasion and progression
Luo, Y., Zhou, H., Krueger, J. S., Kaplan, C., Liao, D., Markowitz, D., Liu, C., Chen, T., Chuang, T. H., Xiang, R., et al. (2009) · Oncogene · doi:10.1038/onc.2009.308 · Cited by 94
Decidual macrophages and their roles at the maternal-fetal interface.
Houser, B. L. (2012) · Europe PMC (PubMed Central) · Cited by 94
Amino Acids and Their Metabolism in Atherosclerosis
Nitz, K., Lacy, M., & Atzler, D. (2019) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.118.311572 · Cited by 95
Myeloid-derived suppressor cells: mechanisms of action and recent advances in their role in transplant tolerance
Dilek, N., de Silly, R. V., Blancho, G., & Vanhove, B. (2012) · Frontiers in Immunology · doi:10.3389/fimmu.2012.00208 · Cited by 93
Regulation of Lymphocytes by Nitric Oxide
Bogdan, C. (2010) · Methods in molecular biology · doi:10.1007/978-1-60761-869-0_24 · Cited by 95
Transcriptome Analysis of Murine Macrophages in Response to Infection withStreptococcus pyogenesReveals an Unusual Activation Program
Goldmann, O., von Köckritz‐Blickwede, M., Höltje, C., Chhatwal, G. S., Geffers, R., & Medina, E. (2007) · Infection and Immunity · doi:10.1128/iai.00181-07 · Cited by 94
Atherosclerosis Linked to Aberrant Amino Acid Metabolism and Immunosuppressive Amino Acid Catabolizing Enzymes
Zarić, B. L., Radovanović, J., Gluvic, Z. M., Stewart, A. J., Essack, M., Motwalli, O., Gojobori, T., & Isenović, E. R. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.551758 · Cited by 94
Immunosuppressive Effects of Myeloid-Derived Suppressor Cells in Cancer and Immunotherapy
Krishnamoorthy, M., Gerhardt, L., & Vareki, S. M. (2021) · Cells · doi:10.3390/cells10051170 · Cited by 100
Revisiting the Mechanisms of Immune Evasion Employed by Human Parasites
Chulanetra, M., & Chaicumpa, W. (2021) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2021.702125 · Cited by 99
The calcium-binding protein complex S100A8/A9 has a crucial role in controlling macrophage-mediated renal repair following ischemia/reperfusion
Dessing, M. C., Tammaro, A., Pulskens, W. P. C., Teske, G. J. D., Butter, L. M., Claessen, N., van Eijk, M., van der Poll, T., Vogl, T., Roth, J., et al. (2014) · Kidney International · doi:10.1038/ki.2014.216 · Cited by 92
Gut microbiome-mediated metabolism effects on immunity in rural and urban African populations
Stražar, M., Temba, G. S., Vlamakis, H., Kullaya, V. I., Lyamuya, F., Mmbaga, B. T., Joosten, L. A. B., van der Ven, A. J. A. M., Netea, M. G., de Mast, Q., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-25213-2 · Cited by 91
Myeloid derived suppressor cells in physiological and pathological conditions: the good, the bad, and the ugly
Serafini, P. (2013) · Immunologic Research · doi:10.1007/s12026-013-8455-2 · Cited by 96
Immunomodulatory properties of mesenchymal stromal/stem cells: The link with metabolism
Li, H., Dai, H., & Li, J. (2022) · Journal of Advanced Research · doi:10.1016/j.jare.2022.05.012 · Cited by 94
Inhibition of Arginase I Activity by RNA Interference Attenuates IL-13-Induced Airways Hyperresponsiveness
Yang, M., Rangasamy, D., Matthaei, K. I., Frew, A. J., Zimmmermann, N., Mahalingam, S., Webb, D. C., Tremethick, D. J., Thompson, P. J., Hogan, S. P., et al. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.8.5595 · Cited by 92
Depletion of L -arginine induces autophagy as a cytoprotective response to endoplasmic reticulum stress in human T lymphocytes
García‐Navas, R., Munder, M., & Mollinedo, F. (2012) · Autophagy · doi:10.4161/auto.21315 · Cited by 93
Sequential expression of macrophage anti-microbial/inflammatory and wound healing markers following innate, alternative and classical activation
Menzies, F. M., Henriquez, F. L., Alexander, J., & Roberts, C. W. (2010) · Clinical and Experimental Immunology · doi:10.1111/j.1365-2249.2009.04086.x · Cited by 90
Involvement of local renin‐angiotensin system in immunosuppression of tumor microenvironment
Nakamura, K., Yaguchi, T., Ohmura, G., Kobayashi, A., Kawamura, N., Iwata, T., Kiniwa, Y., Okuyama, R., & Kawakami, Y. (2017) · Cancer Science · doi:10.1111/cas.13423 · Cited by 94
The targeting of immunosuppressive mechanisms in hematological malignancies
Andersen, M. H. (2014) · Leukemia · doi:10.1038/leu.2014.108 · Cited by 91

Authors: Bronte, V., & Zanovello, P.
Affiliations: University of Padua (IT)
Corresponding author: Bronte, Vincenzo
ORCID: Bronte, Vincenzo
Zanovello, Paola
Venue: Nature Reviews Immunology
Publisher: Springer Science and Business Media LLC
Published: 2005-08
Volume: 5
Issue: 8
Pages: 641-654
ISSN: 1474-1733 (ISSN-L)
1474-1741
DOI: 10.1038/nri1668
OpenAlex: W1977179270
Cited by: 1,775
References: 146
Citations by year: 2026: 69 · 2025: 78 · 2024: 75 · 2023: 96 · 2022: 81 · 2021: 114 · 2020: 100 · 2019: 92 · 2018: 97 · 2017: 89 · 2016: 119 · 2015: 92 · 2014: 95 · 2013: 96 · 2012: 97
FWCI: 3.93
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature reviews. Immunology (publishedVersion)
PubMed (publishedVersion)
Padua Research Archive (University of Padova) (submittedVersion)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Amino Acid Enzymes and Metabolism
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biotechnology › Bacterial Cancer Therapy
Keywords: arginine metabolism, immune regulation, arginase, nitric oxide synthase, myeloid cells, T cell function, lymphocyte suppression, tumor growth, immunosuppression, essential amino acids
MeSH terms: Animals, Arginase, Arginine, Humans, Immunity, Cellular, Suppressor Factors, Immunologic, T-Lymphocytes, Reactive Oxygen Species, Nitric Oxide Synthase, Myeloid Cells, Reactive Nitrogen Species

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Regulation of immune responses by L-arginine metabolism

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks